Amino acid dipepetide frequency for Candidatus Paraburkholderia sp. 4M-K11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.574AlaAla: 18.574 ± 0.136	1.458AlaCys: 1.458 ± 0.027	6.514AlaAsp: 6.514 ± 0.051	5.934AlaGlu: 5.934 ± 0.065	4.481AlaPhe: 4.481 ± 0.042	10.893AlaGly: 10.893 ± 0.071	3.147AlaHis: 3.147 ± 0.037	5.776AlaIle: 5.776 ± 0.053	3.556AlaLys: 3.556 ± 0.043	14.863AlaLeu: 14.863 ± 0.095	3.374AlaMet: 3.374 ± 0.04	3.51AlaAsn: 3.51 ± 0.043	6.401AlaPro: 6.401 ± 0.061	6.232AlaGln: 6.232 ± 0.056	9.612AlaArg: 9.612 ± 0.083	7.918AlaSer: 7.918 ± 0.078	6.422AlaThr: 6.422 ± 0.059	8.868AlaVal: 8.868 ± 0.064	1.888AlaTrp: 1.888 ± 0.033	2.713AlaTyr: 2.713 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.411CysAla: 1.411 ± 0.026	0.149CysCys: 0.149 ± 0.01	0.521CysAsp: 0.521 ± 0.014	0.563CysGlu: 0.563 ± 0.015	0.344CysPhe: 0.344 ± 0.012	1.013CysGly: 1.013 ± 0.023	0.247CysHis: 0.247 ± 0.011	0.402CysIle: 0.402 ± 0.014	0.214CysLys: 0.214 ± 0.009	0.818CysLeu: 0.818 ± 0.019	0.214CysMet: 0.214 ± 0.01	0.245CysAsn: 0.245 ± 0.01	0.457CysPro: 0.457 ± 0.014	0.221CysGln: 0.221 ± 0.01	0.655CysArg: 0.655 ± 0.018	0.536CysSer: 0.536 ± 0.014	0.504CysThr: 0.504 ± 0.013	0.895CysVal: 0.895 ± 0.021	0.128CysTrp: 0.128 ± 0.007	0.238CysTyr: 0.238 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.841AspAla: 7.841 ± 0.066	0.487AspCys: 0.487 ± 0.016	2.968AspAsp: 2.968 ± 0.043	3.357AspGlu: 3.357 ± 0.04	1.932AspPhe: 1.932 ± 0.03	4.436AspGly: 4.436 ± 0.043	1.12AspHis: 1.12 ± 0.025	2.398AspIle: 2.398 ± 0.033	1.408AspLys: 1.408 ± 0.025	5.094AspLeu: 5.094 ± 0.048	1.17AspMet: 1.17 ± 0.023	1.24AspAsn: 1.24 ± 0.026	2.901AspPro: 2.901 ± 0.04	1.55AspGln: 1.55 ± 0.025	3.051AspArg: 3.051 ± 0.033	2.38AspSer: 2.38 ± 0.034	2.705AspThr: 2.705 ± 0.037	4.185AspVal: 4.185 ± 0.043	0.903AspTrp: 0.903 ± 0.021	1.556AspTyr: 1.556 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	6.997GluAla: 6.997 ± 0.056	0.419GluCys: 0.419 ± 0.015	2.188GluAsp: 2.188 ± 0.03	2.44GluGlu: 2.44 ± 0.034	1.747GluPhe: 1.747 ± 0.026	3.612GluGly: 3.612 ± 0.045	1.488GluHis: 1.488 ± 0.026	2.744GluIle: 2.744 ± 0.037	1.722GluLys: 1.722 ± 0.031	5.362GluLeu: 5.362 ± 0.059	1.208GluMet: 1.208 ± 0.024	1.431GluAsn: 1.431 ± 0.025	2.493GluPro: 2.493 ± 0.036	2.345GluGln: 2.345 ± 0.037	5.096GluArg: 5.096 ± 0.058	2.687GluSer: 2.687 ± 0.03	2.811GluThr: 2.811 ± 0.032	3.51GluVal: 3.51 ± 0.039	0.706GluTrp: 0.706 ± 0.018	1.183GluTyr: 1.183 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.823PheAla: 4.823 ± 0.058	0.423PheCys: 0.423 ± 0.015	2.61PheAsp: 2.61 ± 0.03	2.101PheGlu: 2.101 ± 0.027	1.414PhePhe: 1.414 ± 0.027	3.746PheGly: 3.746 ± 0.039	0.738PheHis: 0.738 ± 0.019	1.542PheIle: 1.542 ± 0.026	0.968PheLys: 0.968 ± 0.02	2.862PheLeu: 2.862 ± 0.039	0.841PheMet: 0.841 ± 0.019	1.164PheAsn: 1.164 ± 0.025	1.529PhePro: 1.529 ± 0.027	0.991PheGln: 0.991 ± 0.023	1.955PheArg: 1.955 ± 0.027	2.23PheSer: 2.23 ± 0.033	1.923PheThr: 1.923 ± 0.028	3.122PheVal: 3.122 ± 0.038	0.514PheTrp: 0.514 ± 0.016	0.962PheTyr: 0.962 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.408GlyAla: 10.408 ± 0.084	0.826GlyCys: 0.826 ± 0.018	3.889GlyAsp: 3.889 ± 0.047	4.444GlyGlu: 4.444 ± 0.041	3.403GlyPhe: 3.403 ± 0.044	6.992GlyGly: 6.992 ± 0.078	1.968GlyHis: 1.968 ± 0.029	4.193GlyIle: 4.193 ± 0.043	3.177GlyLys: 3.177 ± 0.038	7.934GlyLeu: 7.934 ± 0.059	2.231GlyMet: 2.231 ± 0.033	2.519GlyAsn: 2.519 ± 0.039	3.052GlyPro: 3.052 ± 0.039	2.825GlyGln: 2.825 ± 0.033	5.131GlyArg: 5.131 ± 0.048	4.65GlySer: 4.65 ± 0.055	4.782GlyThr: 4.782 ± 0.059	6.911GlyVal: 6.911 ± 0.058	1.31GlyTrp: 1.31 ± 0.027	2.513GlyTyr: 2.513 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	3.366HisAla: 3.366 ± 0.042	0.293HisCys: 0.293 ± 0.011	1.36HisAsp: 1.36 ± 0.026	1.313HisGlu: 1.313 ± 0.025	0.942HisPhe: 0.942 ± 0.019	2.241HisGly: 2.241 ± 0.035	0.623HisHis: 0.623 ± 0.018	0.882HisIle: 0.882 ± 0.021	0.529HisLys: 0.529 ± 0.016	2.158HisLeu: 2.158 ± 0.033	0.53HisMet: 0.53 ± 0.015	0.575HisAsn: 0.575 ± 0.016	1.463HisPro: 1.463 ± 0.027	0.625HisGln: 0.625 ± 0.015	1.536HisArg: 1.536 ± 0.022	1.107HisSer: 1.107 ± 0.022	1.148HisThr: 1.148 ± 0.021	1.758HisVal: 1.758 ± 0.026	0.417HisTrp: 0.417 ± 0.013	0.708HisTyr: 0.708 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.873IleAla: 6.873 ± 0.062	0.452IleCys: 0.452 ± 0.015	3.308IleAsp: 3.308 ± 0.042	3.281IleGlu: 3.281 ± 0.038	1.438IlePhe: 1.438 ± 0.027	4.672IleGly: 4.672 ± 0.048	0.898IleHis: 0.898 ± 0.019	1.453IleIle: 1.453 ± 0.027	1.271IleLys: 1.271 ± 0.026	3.155IleLeu: 3.155 ± 0.039	0.751IleMet: 0.751 ± 0.019	1.35IleAsn: 1.35 ± 0.029	2.004IlePro: 2.004 ± 0.031	1.206IleGln: 1.206 ± 0.023	2.712IleArg: 2.712 ± 0.037	2.468IleSer: 2.468 ± 0.035	2.279IleThr: 2.279 ± 0.027	4.343IleVal: 4.343 ± 0.046	0.524IleTrp: 0.524 ± 0.015	1.073IleTyr: 1.073 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.553LysAla: 3.553 ± 0.044	0.169LysCys: 0.169 ± 0.008	1.441LysAsp: 1.441 ± 0.028	1.35LysGlu: 1.35 ± 0.026	0.869LysPhe: 0.869 ± 0.021	2.075LysGly: 2.075 ± 0.035	0.662LysHis: 0.662 ± 0.018	1.484LysIle: 1.484 ± 0.026	1.137LysLys: 1.137 ± 0.028	3.243LysLeu: 3.243 ± 0.04	0.728LysMet: 0.728 ± 0.021	0.829LysAsn: 0.829 ± 0.02	1.89LysPro: 1.89 ± 0.028	1.162LysGln: 1.162 ± 0.026	2.304LysArg: 2.304 ± 0.032	1.678LysSer: 1.678 ± 0.026	1.724LysThr: 1.724 ± 0.028	2.162LysVal: 2.162 ± 0.036	0.38LysTrp: 0.38 ± 0.013	0.696LysTyr: 0.696 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.553LeuAla: 14.553 ± 0.107	1.068LeuCys: 1.068 ± 0.02	5.893LeuAsp: 5.893 ± 0.056	5.187LeuGlu: 5.187 ± 0.054	3.502LeuPhe: 3.502 ± 0.042	8.097LeuGly: 8.097 ± 0.065	2.307LeuHis: 2.307 ± 0.028	4.464LeuIle: 4.464 ± 0.048	3.185LeuLys: 3.185 ± 0.036	9.504LeuLeu: 9.504 ± 0.082	2.213LeuMet: 2.213 ± 0.029	2.751LeuAsn: 2.751 ± 0.037	5.661LeuPro: 5.661 ± 0.046	3.231LeuGln: 3.231 ± 0.035	7.028LeuArg: 7.028 ± 0.059	6.01LeuSer: 6.01 ± 0.088	5.433LeuThr: 5.433 ± 0.05	7.412LeuVal: 7.412 ± 0.065	1.119LeuTrp: 1.119 ± 0.02	2.27LeuTyr: 2.27 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.574MetAla: 2.574 ± 0.036	0.192MetCys: 0.192 ± 0.009	0.953MetAsp: 0.953 ± 0.018	0.951MetGlu: 0.951 ± 0.018	0.73MetPhe: 0.73 ± 0.021	1.648MetGly: 1.648 ± 0.031	0.557MetHis: 0.557 ± 0.016	1.077MetIle: 1.077 ± 0.02	1.026MetLys: 1.026 ± 0.021	2.605MetLeu: 2.605 ± 0.033	0.576MetMet: 0.576 ± 0.016	0.944MetAsn: 0.944 ± 0.017	1.462MetPro: 1.462 ± 0.026	1.023MetGln: 1.023 ± 0.017	1.796MetArg: 1.796 ± 0.029	1.655MetSer: 1.655 ± 0.027	1.572MetThr: 1.572 ± 0.026	1.471MetVal: 1.471 ± 0.025	0.204MetTrp: 0.204 ± 0.008	0.407MetTyr: 0.407 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.776AsnAla: 3.776 ± 0.047	0.268AsnCys: 0.268 ± 0.01	1.468AsnAsp: 1.468 ± 0.025	1.376AsnGlu: 1.376 ± 0.022	1.016AsnPhe: 1.016 ± 0.021	2.772AsnGly: 2.772 ± 0.045	0.57AsnHis: 0.57 ± 0.015	1.218AsnIle: 1.218 ± 0.024	0.66AsnLys: 0.66 ± 0.014	2.704AsnLeu: 2.704 ± 0.033	0.582AsnMet: 0.582 ± 0.018	0.865AsnAsn: 0.865 ± 0.025	1.84AsnPro: 1.84 ± 0.026	0.961AsnGln: 0.961 ± 0.022	1.779AsnArg: 1.779 ± 0.028	1.462AsnSer: 1.462 ± 0.033	1.525AsnThr: 1.525 ± 0.027	2.332AsnVal: 2.332 ± 0.035	0.427AsnTrp: 0.427 ± 0.013	0.766AsnTyr: 0.766 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.811ProAla: 6.811 ± 0.062	0.375ProCys: 0.375 ± 0.013	3.118ProAsp: 3.118 ± 0.038	3.125ProGlu: 3.125 ± 0.037	1.925ProPhe: 1.925 ± 0.028	4.508ProGly: 4.508 ± 0.054	1.28ProHis: 1.28 ± 0.022	2.004ProIle: 2.004 ± 0.03	1.376ProLys: 1.376 ± 0.022	5.121ProLeu: 5.121 ± 0.046	1.134ProMet: 1.134 ± 0.023	1.43ProAsn: 1.43 ± 0.027	2.451ProPro: 2.451 ± 0.04	1.991ProGln: 1.991 ± 0.031	2.928ProArg: 2.928 ± 0.034	2.733ProSer: 2.733 ± 0.035	2.486ProThr: 2.486 ± 0.034	4.251ProVal: 4.251 ± 0.045	0.692ProTrp: 0.692 ± 0.018	1.239ProTyr: 1.239 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.737GlnAla: 4.737 ± 0.056	0.31GlnCys: 0.31 ± 0.011	1.394GlnAsp: 1.394 ± 0.025	1.375GlnGlu: 1.375 ± 0.027	1.314GlnPhe: 1.314 ± 0.022	2.61GlnGly: 2.61 ± 0.031	0.984GlnHis: 0.984 ± 0.019	1.979GlnIle: 1.979 ± 0.029	1.085GlnLys: 1.085 ± 0.023	3.761GlnLeu: 3.761 ± 0.041	1.024GlnMet: 1.024 ± 0.018	0.963GlnAsn: 0.963 ± 0.024	2.063GlnPro: 2.063 ± 0.033	1.896GlnGln: 1.896 ± 0.037	2.975GlnArg: 2.975 ± 0.043	2.096GlnSer: 2.096 ± 0.027	2.075GlnThr: 2.075 ± 0.033	2.432GlnVal: 2.432 ± 0.035	0.597GlnTrp: 0.597 ± 0.016	1.025GlnTyr: 1.025 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.657ArgAla: 8.657 ± 0.069	0.663ArgCys: 0.663 ± 0.017	3.695ArgAsp: 3.695 ± 0.043	4.5ArgGlu: 4.5 ± 0.052	2.83ArgPhe: 2.83 ± 0.037	4.643ArgGly: 4.643 ± 0.049	1.929ArgHis: 1.929 ± 0.029	3.545ArgIle: 3.545 ± 0.042	2.032ArgLys: 2.032 ± 0.029	7.202ArgLeu: 7.202 ± 0.072	1.768ArgMet: 1.768 ± 0.029	1.885ArgAsn: 1.885 ± 0.028	2.957ArgPro: 2.957 ± 0.038	2.431ArgGln: 2.431 ± 0.034	5.247ArgArg: 5.247 ± 0.064	3.435ArgSer: 3.435 ± 0.042	3.508ArgThr: 3.508 ± 0.033	5.306ArgVal: 5.306 ± 0.049	1.049ArgTrp: 1.049 ± 0.022	2.032ArgTyr: 2.032 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.233SerAla: 7.233 ± 0.068	0.484SerCys: 0.484 ± 0.015	2.669SerAsp: 2.669 ± 0.034	2.581SerGlu: 2.581 ± 0.038	2.154SerPhe: 2.154 ± 0.03	5.531SerGly: 5.531 ± 0.058	1.232SerHis: 1.232 ± 0.022	2.716SerIle: 2.716 ± 0.033	1.557SerLys: 1.557 ± 0.025	5.661SerLeu: 5.661 ± 0.067	1.353SerMet: 1.353 ± 0.021	1.772SerAsn: 1.772 ± 0.033	2.877SerPro: 2.877 ± 0.036	1.846SerGln: 1.846 ± 0.027	3.603SerArg: 3.603 ± 0.041	3.44SerSer: 3.44 ± 0.062	3.271SerThr: 3.271 ± 0.101	4.4SerVal: 4.4 ± 0.045	0.741SerTrp: 0.741 ± 0.018	1.304SerTyr: 1.304 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.947ThrAla: 5.947 ± 0.064	0.454ThrCys: 0.454 ± 0.013	2.551ThrAsp: 2.551 ± 0.029	2.286ThrGlu: 2.286 ± 0.035	2.007ThrPhe: 2.007 ± 0.027	4.919ThrGly: 4.919 ± 0.069	1.273ThrHis: 1.273 ± 0.023	2.522ThrIle: 2.522 ± 0.036	1.209ThrLys: 1.209 ± 0.024	6.532ThrLeu: 6.532 ± 0.059	1.16ThrMet: 1.16 ± 0.021	1.445ThrAsn: 1.445 ± 0.032	3.558ThrPro: 3.558 ± 0.041	2.078ThrGln: 2.078 ± 0.031	3.547ThrArg: 3.547 ± 0.036	3.093ThrSer: 3.093 ± 0.058	2.897ThrThr: 2.897 ± 0.048	4.197ThrVal: 4.197 ± 0.051	0.714ThrTrp: 0.714 ± 0.016	1.235ThrTyr: 1.235 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	9.755ValAla: 9.755 ± 0.065	0.854ValCys: 0.854 ± 0.017	4.175ValAsp: 4.175 ± 0.044	4.205ValGlu: 4.205 ± 0.042	2.801ValPhe: 2.801 ± 0.036	5.55ValGly: 5.55 ± 0.054	1.623ValHis: 1.623 ± 0.027	3.553ValIle: 3.553 ± 0.041	2.395ValLys: 2.395 ± 0.041	7.869ValLeu: 7.869 ± 0.066	1.753ValMet: 1.753 ± 0.028	2.327ValAsn: 2.327 ± 0.034	4.014ValPro: 4.014 ± 0.048	2.527ValGln: 2.527 ± 0.032	5.173ValArg: 5.173 ± 0.056	4.67ValSer: 4.67 ± 0.049	4.494ValThr: 4.494 ± 0.042	6.128ValVal: 6.128 ± 0.062	0.988ValTrp: 0.988 ± 0.021	1.748ValTyr: 1.748 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.239TrpAla: 1.239 ± 0.026	0.166TrpCys: 0.166 ± 0.007	0.591TrpAsp: 0.591 ± 0.014	0.512TrpGlu: 0.512 ± 0.014	0.559TrpPhe: 0.559 ± 0.013	0.926TrpGly: 0.926 ± 0.021	0.411TrpHis: 0.411 ± 0.011	0.709TrpIle: 0.709 ± 0.02	0.427TrpLys: 0.427 ± 0.012	1.93TrpLeu: 1.93 ± 0.035	0.363TrpMet: 0.363 ± 0.012	0.453TrpAsn: 0.453 ± 0.013	0.682TrpPro: 0.682 ± 0.017	0.656TrpGln: 0.656 ± 0.018	1.239TrpArg: 1.239 ± 0.024	0.832TrpSer: 0.832 ± 0.018	0.725TrpThr: 0.725 ± 0.018	0.946TrpVal: 0.946 ± 0.021	0.212TrpTrp: 0.212 ± 0.009	0.354TrpTyr: 0.354 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.009TyrAla: 3.009 ± 0.034	0.266TyrCys: 0.266 ± 0.009	1.376TyrAsp: 1.376 ± 0.026	1.306TyrGlu: 1.306 ± 0.019	1.051TyrPhe: 1.051 ± 0.021	2.275TyrGly: 2.275 ± 0.036	0.515TyrHis: 0.515 ± 0.017	0.849TyrIle: 0.849 ± 0.018	0.606TyrLys: 0.606 ± 0.015	2.511TyrLeu: 2.511 ± 0.036	0.449TyrMet: 0.449 ± 0.013	0.669TyrAsn: 0.669 ± 0.017	1.222TyrPro: 1.222 ± 0.022	0.895TyrGln: 0.895 ± 0.02	1.946TyrArg: 1.946 ± 0.032	1.346TyrSer: 1.346 ± 0.025	1.338TyrThr: 1.338 ± 0.025	1.975TyrVal: 1.975 ± 0.028	0.42TyrTrp: 0.42 ± 0.013	0.708TyrTyr: 0.708 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 7801 proteins (2532828 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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