Amino acid dipepetide frequency for Altererythrobacter sp. TH136

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.034AlaAla: 20.034 ± 0.28
1.103AlaCys: 1.103 ± 0.04
7.727AlaAsp: 7.727 ± 0.114
8.427AlaGlu: 8.427 ± 0.13
4.326AlaPhe: 4.326 ± 0.078
12.036AlaGly: 12.036 ± 0.151
2.434AlaHis: 2.434 ± 0.067
6.63AlaIle: 6.63 ± 0.092
3.818AlaLys: 3.818 ± 0.081
14.401AlaLeu: 14.401 ± 0.188
3.684AlaMet: 3.684 ± 0.063
3.084AlaAsn: 3.084 ± 0.054
6.428AlaPro: 6.428 ± 0.122
4.788AlaGln: 4.788 ± 0.083
10.253AlaArg: 10.253 ± 0.15
6.638AlaSer: 6.638 ± 0.092
6.318AlaThr: 6.318 ± 0.094
8.792AlaVal: 8.792 ± 0.111
1.722AlaTrp: 1.722 ± 0.053
2.5AlaTyr: 2.5 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
1.086CysAla: 1.086 ± 0.041
0.087CysCys: 0.087 ± 0.012
0.587CysAsp: 0.587 ± 0.023
0.439CysGlu: 0.439 ± 0.027
0.267CysPhe: 0.267 ± 0.019
0.906CysGly: 0.906 ± 0.032
0.216CysHis: 0.216 ± 0.016
0.338CysIle: 0.338 ± 0.024
0.169CysLys: 0.169 ± 0.014
0.687CysLeu: 0.687 ± 0.03
0.123CysMet: 0.123 ± 0.012
0.198CysAsn: 0.198 ± 0.015
0.4CysPro: 0.4 ± 0.024
0.221CysGln: 0.221 ± 0.019
0.545CysArg: 0.545 ± 0.029
0.44CysSer: 0.44 ± 0.021
0.409CysThr: 0.409 ± 0.022
0.579CysVal: 0.579 ± 0.03
0.092CysTrp: 0.092 ± 0.011
0.142CysTyr: 0.142 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.765AspAla: 7.765 ± 0.107
0.478AspCys: 0.478 ± 0.024
3.421AspAsp: 3.421 ± 0.087
3.816AspGlu: 3.816 ± 0.077
2.067AspPhe: 2.067 ± 0.054
5.47AspGly: 5.47 ± 0.097
1.328AspHis: 1.328 ± 0.046
2.511AspIle: 2.511 ± 0.062
1.869AspLys: 1.869 ± 0.055
5.917AspLeu: 5.917 ± 0.082
1.273AspMet: 1.273 ± 0.039
1.287AspAsn: 1.287 ± 0.043
3.925AspPro: 3.925 ± 0.071
1.981AspGln: 1.981 ± 0.057
5.022AspArg: 5.022 ± 0.085
2.393AspSer: 2.393 ± 0.055
2.717AspThr: 2.717 ± 0.063
3.96AspVal: 3.96 ± 0.072
1.094AspTrp: 1.094 ± 0.043
1.553AspTyr: 1.553 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
7.955GluAla: 7.955 ± 0.117
0.361GluCys: 0.361 ± 0.023
3.14GluAsp: 3.14 ± 0.07
3.387GluGlu: 3.387 ± 0.081
1.769GluPhe: 1.769 ± 0.044
4.746GluGly: 4.746 ± 0.089
1.245GluHis: 1.245 ± 0.047
2.972GluIle: 2.972 ± 0.068
1.818GluLys: 1.818 ± 0.049
5.833GluLeu: 5.833 ± 0.094
1.453GluMet: 1.453 ± 0.045
1.411GluAsn: 1.411 ± 0.043
2.937GluPro: 2.937 ± 0.061
2.297GluGln: 2.297 ± 0.063
5.463GluArg: 5.463 ± 0.093
2.268GluSer: 2.268 ± 0.049
3.064GluThr: 3.064 ± 0.072
4.124GluVal: 4.124 ± 0.071
0.89GluTrp: 0.89 ± 0.032
1.077GluTyr: 1.077 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
5.049PheAla: 5.049 ± 0.081
0.327PheCys: 0.327 ± 0.021
2.652PheAsp: 2.652 ± 0.062
2.016PheGlu: 2.016 ± 0.051
1.183PhePhe: 1.183 ± 0.05
3.639PheGly: 3.639 ± 0.074
0.64PheHis: 0.64 ± 0.026
1.385PheIle: 1.385 ± 0.043
0.826PheLys: 0.826 ± 0.03
2.936PheLeu: 2.936 ± 0.069
0.711PheMet: 0.711 ± 0.033
0.964PheAsn: 0.964 ± 0.035
1.474PhePro: 1.474 ± 0.041
0.902PheGln: 0.902 ± 0.033
2.095PheArg: 2.095 ± 0.046
1.925PheSer: 1.925 ± 0.054
2.054PheThr: 2.054 ± 0.049
2.665PheVal: 2.665 ± 0.062
0.482PheTrp: 0.482 ± 0.026
0.865PheTyr: 0.865 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
10.543GlyAla: 10.543 ± 0.138
0.867GlyCys: 0.867 ± 0.033
5.037GlyAsp: 5.037 ± 0.094
5.535GlyGlu: 5.535 ± 0.088
3.563GlyPhe: 3.563 ± 0.067
8.532GlyGly: 8.532 ± 0.185
1.864GlyHis: 1.864 ± 0.052
4.142GlyIle: 4.142 ± 0.075
3.413GlyLys: 3.413 ± 0.079
8.579GlyLeu: 8.579 ± 0.109
2.349GlyMet: 2.349 ± 0.057
2.258GlyAsn: 2.258 ± 0.073
3.739GlyPro: 3.739 ± 0.072
3.124GlyGln: 3.124 ± 0.059
6.459GlyArg: 6.459 ± 0.097
4.932GlySer: 4.932 ± 0.091
5.003GlyThr: 5.003 ± 0.091
6.2GlyVal: 6.2 ± 0.093
1.64GlyTrp: 1.64 ± 0.047
2.172GlyTyr: 2.172 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
2.441HisAla: 2.441 ± 0.065
0.23HisCys: 0.23 ± 0.018
1.176HisAsp: 1.176 ± 0.038
1.05HisGlu: 1.05 ± 0.037
0.784HisPhe: 0.784 ± 0.031
1.997HisGly: 1.997 ± 0.053
0.553HisHis: 0.553 ± 0.028
0.785HisIle: 0.785 ± 0.032
0.448HisLys: 0.448 ± 0.021
1.901HisLeu: 1.901 ± 0.051
0.412HisMet: 0.412 ± 0.026
0.444HisAsn: 0.444 ± 0.024
1.361HisPro: 1.361 ± 0.043
0.555HisGln: 0.555 ± 0.031
1.493HisArg: 1.493 ± 0.052
0.92HisSer: 0.92 ± 0.038
0.751HisThr: 0.751 ± 0.033
1.324HisVal: 1.324 ± 0.046
0.352HisTrp: 0.352 ± 0.02
0.531HisTyr: 0.531 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
7.459IleAla: 7.459 ± 0.092
0.365IleCys: 0.365 ± 0.025
3.916IleAsp: 3.916 ± 0.066
3.506IleGlu: 3.506 ± 0.075
1.314IlePhe: 1.314 ± 0.043
4.874IleGly: 4.874 ± 0.097
0.862IleHis: 0.862 ± 0.033
1.79IleIle: 1.79 ± 0.052
1.195IleLys: 1.195 ± 0.042
3.412IleLeu: 3.412 ± 0.072
0.854IleMet: 0.854 ± 0.035
1.265IleAsn: 1.265 ± 0.045
2.157IlePro: 2.157 ± 0.058
1.057IleGln: 1.057 ± 0.033
2.977IleArg: 2.977 ± 0.058
2.354IleSer: 2.354 ± 0.047
2.332IleThr: 2.332 ± 0.059
3.921IleVal: 3.921 ± 0.064
0.518IleTrp: 0.518 ± 0.027
0.892IleTyr: 0.892 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
3.821LysAla: 3.821 ± 0.073
0.152LysCys: 0.152 ± 0.014
1.534LysAsp: 1.534 ± 0.053
1.214LysGlu: 1.214 ± 0.044
0.865LysPhe: 0.865 ± 0.035
2.366LysGly: 2.366 ± 0.077
0.56LysHis: 0.56 ± 0.025
1.383LysIle: 1.383 ± 0.045
1.05LysLys: 1.05 ± 0.057
3.194LysLeu: 3.194 ± 0.068
0.711LysMet: 0.711 ± 0.034
0.769LysAsn: 0.769 ± 0.032
1.805LysPro: 1.805 ± 0.055
0.899LysGln: 0.899 ± 0.034
2.241LysArg: 2.241 ± 0.057
1.527LysSer: 1.527 ± 0.04
1.534LysThr: 1.534 ± 0.053
2.164LysVal: 2.164 ± 0.056
0.397LysTrp: 0.397 ± 0.025
0.581LysTyr: 0.581 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
15.074LeuAla: 15.074 ± 0.216
0.751LeuCys: 0.751 ± 0.035
6.143LeuAsp: 6.143 ± 0.094
5.33LeuGlu: 5.33 ± 0.093
3.424LeuPhe: 3.424 ± 0.065
8.467LeuGly: 8.467 ± 0.118
1.738LeuHis: 1.738 ± 0.051
4.558LeuIle: 4.558 ± 0.082
2.951LeuLys: 2.951 ± 0.069
9.552LeuLeu: 9.552 ± 0.142
2.138LeuMet: 2.138 ± 0.051
2.272LeuAsn: 2.272 ± 0.06
5.555LeuPro: 5.555 ± 0.09
2.768LeuGln: 2.768 ± 0.06
6.795LeuArg: 6.795 ± 0.101
5.892LeuSer: 5.892 ± 0.092
5.874LeuThr: 5.874 ± 0.093
7.486LeuVal: 7.486 ± 0.11
1.164LeuTrp: 1.164 ± 0.037
1.85LeuTyr: 1.85 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
3.092MetAla: 3.092 ± 0.069
0.177MetCys: 0.177 ± 0.014
1.117MetAsp: 1.117 ± 0.041
1.114MetGlu: 1.114 ± 0.039
0.64MetPhe: 0.64 ± 0.034
1.888MetGly: 1.888 ± 0.047
0.448MetHis: 0.448 ± 0.025
1.293MetIle: 1.293 ± 0.039
0.88MetLys: 0.88 ± 0.031
2.485MetLeu: 2.485 ± 0.06
0.596MetMet: 0.596 ± 0.027
0.682MetAsn: 0.682 ± 0.03
1.364MetPro: 1.364 ± 0.048
0.704MetGln: 0.704 ± 0.034
1.756MetArg: 1.756 ± 0.044
1.387MetSer: 1.387 ± 0.037
1.637MetThr: 1.637 ± 0.048
1.562MetVal: 1.562 ± 0.048
0.229MetTrp: 0.229 ± 0.014
0.276MetTyr: 0.276 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.215AsnAla: 3.215 ± 0.067
0.237AsnCys: 0.237 ± 0.018
1.274AsnAsp: 1.274 ± 0.044
1.141AsnGlu: 1.141 ± 0.041
0.931AsnPhe: 0.931 ± 0.036
2.198AsnGly: 2.198 ± 0.064
0.486AsnHis: 0.486 ± 0.025
1.059AsnIle: 1.059 ± 0.045
0.585AsnLys: 0.585 ± 0.029
2.491AsnLeu: 2.491 ± 0.056
0.487AsnMet: 0.487 ± 0.029
0.611AsnAsn: 0.611 ± 0.031
1.732AsnPro: 1.732 ± 0.054
0.81AsnGln: 0.81 ± 0.034
1.851AsnArg: 1.851 ± 0.052
1.191AsnSer: 1.191 ± 0.047
1.121AsnThr: 1.121 ± 0.038
1.782AsnVal: 1.782 ± 0.053
0.386AsnTrp: 0.386 ± 0.024
0.613AsnTyr: 0.613 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
7.403ProAla: 7.403 ± 0.121
0.321ProCys: 0.321 ± 0.021
3.725ProAsp: 3.725 ± 0.064
3.619ProGlu: 3.619 ± 0.065
1.925ProPhe: 1.925 ± 0.052
4.93ProGly: 4.93 ± 0.076
1.002ProHis: 1.002 ± 0.036
2.248ProIle: 2.248 ± 0.06
1.396ProLys: 1.396 ± 0.043
5.154ProLeu: 5.154 ± 0.087
1.094ProMet: 1.094 ± 0.035
1.185ProAsn: 1.185 ± 0.047
2.901ProPro: 2.901 ± 0.092
1.873ProGln: 1.873 ± 0.046
3.296ProArg: 3.296 ± 0.075
2.64ProSer: 2.64 ± 0.066
2.553ProThr: 2.553 ± 0.059
4.331ProVal: 4.331 ± 0.081
0.655ProTrp: 0.655 ± 0.028
1.021ProTyr: 1.021 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
4.398GlnAla: 4.398 ± 0.077
0.221GlnCys: 0.221 ± 0.016
1.523GlnAsp: 1.523 ± 0.049
1.401GlnGlu: 1.401 ± 0.042
1.161GlnPhe: 1.161 ± 0.037
2.684GlnGly: 2.684 ± 0.06
0.634GlnHis: 0.634 ± 0.028
1.713GlnIle: 1.713 ± 0.046
0.805GlnLys: 0.805 ± 0.035
3.313GlnLeu: 3.313 ± 0.067
0.815GlnMet: 0.815 ± 0.03
0.713GlnAsn: 0.713 ± 0.029
1.971GlnPro: 1.971 ± 0.047
1.205GlnGln: 1.205 ± 0.043
2.767GlnArg: 2.767 ± 0.068
1.735GlnSer: 1.735 ± 0.053
1.649GlnThr: 1.649 ± 0.047
2.625GlnVal: 2.625 ± 0.06
0.469GlnTrp: 0.469 ± 0.028
0.624GlnTyr: 0.624 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
9.202ArgAla: 9.202 ± 0.135
0.523ArgCys: 0.523 ± 0.026
4.395ArgAsp: 4.395 ± 0.081
4.709ArgGlu: 4.709 ± 0.077
3.06ArgPhe: 3.06 ± 0.067
5.393ArgGly: 5.393 ± 0.1
1.566ArgHis: 1.566 ± 0.051
3.886ArgIle: 3.886 ± 0.073
2.155ArgLys: 2.155 ± 0.049
8.192ArgLeu: 8.192 ± 0.114
1.96ArgMet: 1.96 ± 0.056
1.699ArgAsn: 1.699 ± 0.046
3.665ArgPro: 3.665 ± 0.075
2.604ArgGln: 2.604 ± 0.059
5.882ArgArg: 5.882 ± 0.111
3.832ArgSer: 3.832 ± 0.072
3.698ArgThr: 3.698 ± 0.077
5.051ArgVal: 5.051 ± 0.083
1.266ArgTrp: 1.266 ± 0.038
1.756ArgTyr: 1.756 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.517SerAla: 6.517 ± 0.094
0.412SerCys: 0.412 ± 0.026
3.148SerAsp: 3.148 ± 0.064
2.86SerGlu: 2.86 ± 0.068
1.926SerPhe: 1.926 ± 0.044
5.688SerGly: 5.688 ± 0.109
0.906SerHis: 0.906 ± 0.037
2.349SerIle: 2.349 ± 0.05
1.353SerLys: 1.353 ± 0.045
5.035SerLeu: 5.035 ± 0.08
1.159SerMet: 1.159 ± 0.043
1.252SerAsn: 1.252 ± 0.045
2.753SerPro: 2.753 ± 0.068
1.704SerGln: 1.704 ± 0.047
3.614SerArg: 3.614 ± 0.074
2.795SerSer: 2.795 ± 0.067
2.624SerThr: 2.624 ± 0.058
3.635SerVal: 3.635 ± 0.073
0.759SerTrp: 0.759 ± 0.031
1.174SerTyr: 1.174 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
6.604ThrAla: 6.604 ± 0.097
0.39ThrCys: 0.39 ± 0.027
2.882ThrAsp: 2.882 ± 0.064
2.525ThrGlu: 2.525 ± 0.061
1.877ThrPhe: 1.877 ± 0.056
5.392ThrGly: 5.392 ± 0.094
0.924ThrHis: 0.924 ± 0.037
2.721ThrIle: 2.721 ± 0.062
1.17ThrLys: 1.17 ± 0.039
5.596ThrLeu: 5.596 ± 0.093
1.219ThrMet: 1.219 ± 0.044
1.257ThrAsn: 1.257 ± 0.043
3.308ThrPro: 3.308 ± 0.067
1.458ThrGln: 1.458 ± 0.054
3.55ThrArg: 3.55 ± 0.064
2.668ThrSer: 2.668 ± 0.058
2.578ThrThr: 2.578 ± 0.061
4.338ThrVal: 4.338 ± 0.088
0.62ThrTrp: 0.62 ± 0.028
1.14ThrTyr: 1.14 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
9.632ValAla: 9.632 ± 0.125
0.599ValCys: 0.599 ± 0.026
4.225ValAsp: 4.225 ± 0.075
4.48ValGlu: 4.48 ± 0.085
2.309ValPhe: 2.309 ± 0.057
5.662ValGly: 5.662 ± 0.082
1.329ValHis: 1.329 ± 0.045
3.83ValIle: 3.83 ± 0.08
1.937ValLys: 1.937 ± 0.059
7.055ValLeu: 7.055 ± 0.108
1.61ValMet: 1.61 ± 0.045
1.897ValAsn: 1.897 ± 0.054
4.11ValPro: 4.11 ± 0.063
2.09ValGln: 2.09 ± 0.057
5.26ValArg: 5.26 ± 0.086
4.037ValSer: 4.037 ± 0.071
4.554ValThr: 4.554 ± 0.074
5.499ValVal: 5.499 ± 0.083
0.878ValTrp: 0.878 ± 0.035
1.357ValTyr: 1.357 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.323TrpAla: 1.323 ± 0.042
0.119TrpCys: 0.119 ± 0.015
0.713TrpAsp: 0.713 ± 0.027
0.569TrpGlu: 0.569 ± 0.03
0.624TrpPhe: 0.624 ± 0.031
1.003TrpGly: 1.003 ± 0.038
0.322TrpHis: 0.322 ± 0.019
0.646TrpIle: 0.646 ± 0.027
0.398TrpLys: 0.398 ± 0.022
1.893TrpLeu: 1.893 ± 0.062
0.333TrpMet: 0.333 ± 0.021
0.434TrpAsn: 0.434 ± 0.024
0.7TrpPro: 0.7 ± 0.03
0.688TrpGln: 0.688 ± 0.033
1.365TrpArg: 1.365 ± 0.039
0.878TrpSer: 0.878 ± 0.036
0.765TrpThr: 0.765 ± 0.034
0.847TrpVal: 0.847 ± 0.035
0.248TrpTrp: 0.248 ± 0.017
0.292TrpTyr: 0.292 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.531TyrAla: 2.531 ± 0.067
0.212TyrCys: 0.212 ± 0.016
1.512TyrAsp: 1.512 ± 0.046
1.072TyrGlu: 1.072 ± 0.039
0.775TyrPhe: 0.775 ± 0.03
2.081TyrGly: 2.081 ± 0.062
0.45TyrHis: 0.45 ± 0.026
0.779TyrIle: 0.779 ± 0.034
0.532TyrLys: 0.532 ± 0.03
2.155TyrLeu: 2.155 ± 0.053
0.344TyrMet: 0.344 ± 0.022
0.518TyrAsn: 0.518 ± 0.03
0.986TyrPro: 0.986 ± 0.041
0.697TyrGln: 0.697 ± 0.032
1.813TyrArg: 1.813 ± 0.053
1.211TyrSer: 1.211 ± 0.042
0.984TyrThr: 0.984 ± 0.035
1.463TyrVal: 1.463 ± 0.041
0.297TyrTrp: 0.297 ± 0.021
0.54TyrTyr: 0.54 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2460 proteins (781755 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski