Amino acid dipepetide frequency for Streptococcus phage Javan310

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.211AlaAla: 4.211 ± 1.202
0.358AlaCys: 0.358 ± 0.186
5.465AlaAsp: 5.465 ± 0.642
4.928AlaGlu: 4.928 ± 1.02
2.867AlaPhe: 2.867 ± 0.558
4.749AlaGly: 4.749 ± 0.835
1.254AlaHis: 1.254 ± 0.363
5.286AlaIle: 5.286 ± 0.924
5.465AlaLys: 5.465 ± 0.868
6.541AlaLeu: 6.541 ± 0.705
3.046AlaMet: 3.046 ± 0.682
3.942AlaAsn: 3.942 ± 0.559
0.806AlaPro: 0.806 ± 0.349
3.315AlaGln: 3.315 ± 0.534
2.778AlaArg: 2.778 ± 0.607
4.659AlaSer: 4.659 ± 0.706
4.121AlaThr: 4.121 ± 0.885
4.48AlaVal: 4.48 ± 0.753
0.896AlaTrp: 0.896 ± 0.43
1.792AlaTyr: 1.792 ± 0.403
0.0AlaXaa: 0.0 ± 0.0
Cys
0.179CysAla: 0.179 ± 0.127
0.09CysCys: 0.09 ± 0.102
0.269CysAsp: 0.269 ± 0.154
0.358CysGlu: 0.358 ± 0.21
0.179CysPhe: 0.179 ± 0.118
0.627CysGly: 0.627 ± 0.251
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.627CysLys: 0.627 ± 0.22
0.269CysLeu: 0.269 ± 0.152
0.269CysMet: 0.269 ± 0.177
0.358CysAsn: 0.358 ± 0.202
0.09CysPro: 0.09 ± 0.078
0.179CysGln: 0.179 ± 0.131
0.448CysArg: 0.448 ± 0.211
0.448CysSer: 0.448 ± 0.257
0.09CysThr: 0.09 ± 0.099
0.269CysVal: 0.269 ± 0.159
0.0CysTrp: 0.0 ± 0.0
0.269CysTyr: 0.269 ± 0.153
0.0CysXaa: 0.0 ± 0.0
Asp
3.315AspAla: 3.315 ± 0.499
0.448AspCys: 0.448 ± 0.228
3.763AspAsp: 3.763 ± 0.604
4.211AspGlu: 4.211 ± 0.88
3.853AspPhe: 3.853 ± 0.534
5.107AspGly: 5.107 ± 0.652
0.986AspHis: 0.986 ± 0.344
5.645AspIle: 5.645 ± 0.727
6.361AspLys: 6.361 ± 0.521
5.913AspLeu: 5.913 ± 0.81
1.882AspMet: 1.882 ± 0.367
2.419AspAsn: 2.419 ± 0.469
2.061AspPro: 2.061 ± 0.416
2.061AspGln: 2.061 ± 0.423
2.061AspArg: 2.061 ± 0.413
3.584AspSer: 3.584 ± 0.47
2.688AspThr: 2.688 ± 0.697
4.211AspVal: 4.211 ± 0.753
0.896AspTrp: 0.896 ± 0.339
2.688AspTyr: 2.688 ± 0.549
0.0AspXaa: 0.0 ± 0.0
Glu
5.913GluAla: 5.913 ± 0.872
0.806GluCys: 0.806 ± 0.303
4.301GluAsp: 4.301 ± 0.638
7.078GluGlu: 7.078 ± 0.916
3.674GluPhe: 3.674 ± 0.765
3.853GluGly: 3.853 ± 0.49
0.448GluHis: 0.448 ± 0.201
6.182GluIle: 6.182 ± 0.81
6.899GluLys: 6.899 ± 0.715
8.781GluLeu: 8.781 ± 1.0
2.33GluMet: 2.33 ± 0.526
5.197GluAsn: 5.197 ± 0.637
1.434GluPro: 1.434 ± 0.404
4.211GluGln: 4.211 ± 0.775
2.867GluArg: 2.867 ± 0.585
4.569GluSer: 4.569 ± 0.541
3.584GluThr: 3.584 ± 0.555
4.928GluVal: 4.928 ± 0.681
0.986GluTrp: 0.986 ± 0.275
2.957GluTyr: 2.957 ± 0.589
0.0GluXaa: 0.0 ± 0.0
Phe
2.957PheAla: 2.957 ± 0.516
0.448PheCys: 0.448 ± 0.196
3.942PheAsp: 3.942 ± 0.502
3.942PheGlu: 3.942 ± 0.621
1.523PhePhe: 1.523 ± 0.413
3.853PheGly: 3.853 ± 0.647
0.448PheHis: 0.448 ± 0.162
2.957PheIle: 2.957 ± 0.63
4.211PheLys: 4.211 ± 0.62
3.315PheLeu: 3.315 ± 0.646
0.806PheMet: 0.806 ± 0.304
2.957PheAsn: 2.957 ± 0.482
1.254PhePro: 1.254 ± 0.327
1.344PheGln: 1.344 ± 0.319
1.882PheArg: 1.882 ± 0.46
2.33PheSer: 2.33 ± 0.357
2.419PheThr: 2.419 ± 0.659
2.061PheVal: 2.061 ± 0.589
0.358PheTrp: 0.358 ± 0.195
1.702PheTyr: 1.702 ± 0.418
0.0PheXaa: 0.0 ± 0.0
Gly
3.584GlyAla: 3.584 ± 0.77
0.09GlyCys: 0.09 ± 0.085
4.032GlyAsp: 4.032 ± 0.535
4.211GlyGlu: 4.211 ± 0.438
3.674GlyPhe: 3.674 ± 0.59
4.211GlyGly: 4.211 ± 0.715
0.538GlyHis: 0.538 ± 0.217
4.928GlyIle: 4.928 ± 0.812
6.093GlyLys: 6.093 ± 0.734
6.272GlyLeu: 6.272 ± 0.766
1.882GlyMet: 1.882 ± 0.402
3.584GlyAsn: 3.584 ± 0.643
1.254GlyPro: 1.254 ± 0.246
3.046GlyGln: 3.046 ± 0.581
1.882GlyArg: 1.882 ± 0.38
5.197GlySer: 5.197 ± 0.775
3.674GlyThr: 3.674 ± 0.612
2.867GlyVal: 2.867 ± 0.661
1.165GlyTrp: 1.165 ± 0.269
2.24GlyTyr: 2.24 ± 0.663
0.0GlyXaa: 0.0 ± 0.0
His
0.717HisAla: 0.717 ± 0.22
0.09HisCys: 0.09 ± 0.091
0.986HisAsp: 0.986 ± 0.344
0.896HisGlu: 0.896 ± 0.313
0.986HisPhe: 0.986 ± 0.262
0.896HisGly: 0.896 ± 0.284
0.358HisHis: 0.358 ± 0.15
0.896HisIle: 0.896 ± 0.271
0.269HisLys: 0.269 ± 0.128
0.896HisLeu: 0.896 ± 0.298
0.358HisMet: 0.358 ± 0.223
0.448HisAsn: 0.448 ± 0.219
0.806HisPro: 0.806 ± 0.367
0.358HisGln: 0.358 ± 0.157
0.538HisArg: 0.538 ± 0.209
0.986HisSer: 0.986 ± 0.281
0.896HisThr: 0.896 ± 0.205
0.627HisVal: 0.627 ± 0.222
0.09HisTrp: 0.09 ± 0.102
0.448HisTyr: 0.448 ± 0.249
0.0HisXaa: 0.0 ± 0.0
Ile
4.659IleAla: 4.659 ± 0.819
0.627IleCys: 0.627 ± 0.275
5.107IleAsp: 5.107 ± 0.894
6.541IleGlu: 6.541 ± 0.81
3.046IlePhe: 3.046 ± 0.599
4.39IleGly: 4.39 ± 0.676
0.717IleHis: 0.717 ± 0.245
2.688IleIle: 2.688 ± 0.552
6.63IleLys: 6.63 ± 0.928
4.838IleLeu: 4.838 ± 0.765
1.344IleMet: 1.344 ± 0.364
4.032IleAsn: 4.032 ± 0.584
2.15IlePro: 2.15 ± 0.382
3.136IleGln: 3.136 ± 0.5
2.598IleArg: 2.598 ± 0.466
3.315IleSer: 3.315 ± 0.691
4.928IleThr: 4.928 ± 0.564
3.494IleVal: 3.494 ± 0.486
0.448IleTrp: 0.448 ± 0.203
2.24IleTyr: 2.24 ± 0.426
0.0IleXaa: 0.0 ± 0.0
Lys
7.257LysAla: 7.257 ± 0.855
0.0LysCys: 0.0 ± 0.0
3.853LysAsp: 3.853 ± 0.762
9.139LysGlu: 9.139 ± 1.064
2.778LysPhe: 2.778 ± 0.425
3.763LysGly: 3.763 ± 0.444
1.254LysHis: 1.254 ± 0.425
5.734LysIle: 5.734 ± 0.761
6.989LysLys: 6.989 ± 0.949
6.989LysLeu: 6.989 ± 0.718
3.226LysMet: 3.226 ± 0.455
5.913LysAsn: 5.913 ± 0.63
2.15LysPro: 2.15 ± 0.399
4.211LysGln: 4.211 ± 0.53
4.121LysArg: 4.121 ± 0.711
4.659LysSer: 4.659 ± 0.527
5.017LysThr: 5.017 ± 0.624
4.39LysVal: 4.39 ± 0.523
1.434LysTrp: 1.434 ± 0.459
2.957LysTyr: 2.957 ± 0.488
0.0LysXaa: 0.0 ± 0.0
Leu
6.809LeuAla: 6.809 ± 0.648
0.358LeuCys: 0.358 ± 0.155
5.197LeuAsp: 5.197 ± 0.784
7.257LeuGlu: 7.257 ± 0.86
3.853LeuPhe: 3.853 ± 0.691
5.197LeuGly: 5.197 ± 1.204
0.896LeuHis: 0.896 ± 0.321
5.197LeuIle: 5.197 ± 0.721
7.885LeuLys: 7.885 ± 0.817
6.272LeuLeu: 6.272 ± 0.738
1.792LeuMet: 1.792 ± 0.387
5.465LeuAsn: 5.465 ± 0.89
1.702LeuPro: 1.702 ± 0.362
3.942LeuGln: 3.942 ± 0.746
2.957LeuArg: 2.957 ± 0.546
6.451LeuSer: 6.451 ± 0.916
5.376LeuThr: 5.376 ± 0.906
5.824LeuVal: 5.824 ± 0.841
0.896LeuTrp: 0.896 ± 0.273
2.688LeuTyr: 2.688 ± 0.553
0.0LeuXaa: 0.0 ± 0.0
Met
1.792MetAla: 1.792 ± 0.452
0.0MetCys: 0.0 ± 0.0
1.165MetAsp: 1.165 ± 0.286
2.33MetGlu: 2.33 ± 0.379
0.986MetPhe: 0.986 ± 0.321
0.806MetGly: 0.806 ± 0.224
0.269MetHis: 0.269 ± 0.146
1.971MetIle: 1.971 ± 0.428
2.33MetLys: 2.33 ± 0.39
1.882MetLeu: 1.882 ± 0.478
0.717MetMet: 0.717 ± 0.218
2.061MetAsn: 2.061 ± 0.445
0.986MetPro: 0.986 ± 0.327
0.538MetGln: 0.538 ± 0.191
0.986MetArg: 0.986 ± 0.311
2.24MetSer: 2.24 ± 0.364
2.688MetThr: 2.688 ± 0.435
1.344MetVal: 1.344 ± 0.388
0.09MetTrp: 0.09 ± 0.08
0.358MetTyr: 0.358 ± 0.186
0.0MetXaa: 0.0 ± 0.0
Asn
3.942AsnAla: 3.942 ± 0.961
0.269AsnCys: 0.269 ± 0.154
4.032AsnAsp: 4.032 ± 0.7
2.957AsnGlu: 2.957 ± 0.657
2.061AsnPhe: 2.061 ± 0.389
5.017AsnGly: 5.017 ± 0.733
0.986AsnHis: 0.986 ± 0.286
3.494AsnIle: 3.494 ± 0.559
5.555AsnLys: 5.555 ± 0.748
4.301AsnLeu: 4.301 ± 0.613
1.075AsnMet: 1.075 ± 0.332
4.032AsnAsn: 4.032 ± 0.507
2.061AsnPro: 2.061 ± 0.414
2.957AsnGln: 2.957 ± 0.523
2.15AsnArg: 2.15 ± 0.336
3.942AsnSer: 3.942 ± 0.674
3.674AsnThr: 3.674 ± 0.469
3.674AsnVal: 3.674 ± 0.612
0.806AsnTrp: 0.806 ± 0.259
1.344AsnTyr: 1.344 ± 0.369
0.0AsnXaa: 0.0 ± 0.0
Pro
1.254ProAla: 1.254 ± 0.323
0.0ProCys: 0.0 ± 0.0
1.434ProAsp: 1.434 ± 0.347
3.046ProGlu: 3.046 ± 0.569
1.075ProPhe: 1.075 ± 0.293
1.254ProGly: 1.254 ± 0.343
0.269ProHis: 0.269 ± 0.15
1.702ProIle: 1.702 ± 0.374
1.613ProLys: 1.613 ± 0.446
1.971ProLeu: 1.971 ± 0.492
0.448ProMet: 0.448 ± 0.183
1.523ProAsn: 1.523 ± 0.41
0.627ProPro: 0.627 ± 0.233
1.165ProGln: 1.165 ± 0.303
0.986ProArg: 0.986 ± 0.282
2.15ProSer: 2.15 ± 0.421
3.136ProThr: 3.136 ± 0.52
1.882ProVal: 1.882 ± 0.521
0.358ProTrp: 0.358 ± 0.17
0.538ProTyr: 0.538 ± 0.244
0.0ProXaa: 0.0 ± 0.0
Gln
3.405GlnAla: 3.405 ± 0.778
0.269GlnCys: 0.269 ± 0.173
1.792GlnAsp: 1.792 ± 0.406
3.494GlnGlu: 3.494 ± 0.542
2.061GlnPhe: 2.061 ± 0.39
3.046GlnGly: 3.046 ± 0.417
0.538GlnHis: 0.538 ± 0.169
2.15GlnIle: 2.15 ± 0.394
3.584GlnLys: 3.584 ± 0.631
4.838GlnLeu: 4.838 ± 0.576
0.717GlnMet: 0.717 ± 0.246
2.24GlnAsn: 2.24 ± 0.469
1.165GlnPro: 1.165 ± 0.418
2.419GlnGln: 2.419 ± 0.57
2.419GlnArg: 2.419 ± 0.423
2.778GlnSer: 2.778 ± 0.449
2.867GlnThr: 2.867 ± 0.558
1.613GlnVal: 1.613 ± 0.409
0.627GlnTrp: 0.627 ± 0.211
1.254GlnTyr: 1.254 ± 0.366
0.0GlnXaa: 0.0 ± 0.0
Arg
1.882ArgAla: 1.882 ± 0.403
0.09ArgCys: 0.09 ± 0.1
2.598ArgAsp: 2.598 ± 0.622
3.942ArgGlu: 3.942 ± 0.684
1.792ArgPhe: 1.792 ± 0.447
2.15ArgGly: 2.15 ± 0.457
1.075ArgHis: 1.075 ± 0.306
2.509ArgIle: 2.509 ± 0.445
3.315ArgLys: 3.315 ± 0.711
4.211ArgLeu: 4.211 ± 0.719
1.434ArgMet: 1.434 ± 0.422
1.792ArgAsn: 1.792 ± 0.368
1.254ArgPro: 1.254 ± 0.332
1.523ArgGln: 1.523 ± 0.319
1.702ArgArg: 1.702 ± 0.429
2.24ArgSer: 2.24 ± 0.513
2.24ArgThr: 2.24 ± 0.366
1.523ArgVal: 1.523 ± 0.381
0.358ArgTrp: 0.358 ± 0.149
2.419ArgTyr: 2.419 ± 0.379
0.0ArgXaa: 0.0 ± 0.0
Ser
4.928SerAla: 4.928 ± 1.097
0.269SerCys: 0.269 ± 0.16
4.569SerAsp: 4.569 ± 0.706
4.48SerGlu: 4.48 ± 0.658
2.957SerPhe: 2.957 ± 0.368
4.569SerGly: 4.569 ± 0.667
0.717SerHis: 0.717 ± 0.206
4.928SerIle: 4.928 ± 0.673
5.286SerLys: 5.286 ± 0.848
4.928SerLeu: 4.928 ± 0.592
1.344SerMet: 1.344 ± 0.356
3.046SerAsn: 3.046 ± 0.444
1.613SerPro: 1.613 ± 0.404
2.24SerGln: 2.24 ± 0.428
2.778SerArg: 2.778 ± 0.58
4.301SerSer: 4.301 ± 0.669
3.494SerThr: 3.494 ± 0.531
3.674SerVal: 3.674 ± 0.543
0.269SerTrp: 0.269 ± 0.189
2.24SerTyr: 2.24 ± 0.391
0.0SerXaa: 0.0 ± 0.0
Thr
5.734ThrAla: 5.734 ± 1.27
0.09ThrCys: 0.09 ± 0.092
3.494ThrAsp: 3.494 ± 0.582
3.942ThrGlu: 3.942 ± 0.518
3.046ThrPhe: 3.046 ± 0.531
4.48ThrGly: 4.48 ± 0.766
0.806ThrHis: 0.806 ± 0.274
4.032ThrIle: 4.032 ± 0.83
4.301ThrLys: 4.301 ± 0.633
6.003ThrLeu: 6.003 ± 0.814
0.717ThrMet: 0.717 ± 0.179
3.226ThrAsn: 3.226 ± 0.439
2.24ThrPro: 2.24 ± 0.579
2.33ThrGln: 2.33 ± 0.511
2.15ThrArg: 2.15 ± 0.485
3.315ThrSer: 3.315 ± 0.418
4.032ThrThr: 4.032 ± 0.546
4.121ThrVal: 4.121 ± 0.611
0.986ThrTrp: 0.986 ± 0.252
1.344ThrTyr: 1.344 ± 0.362
0.0ThrXaa: 0.0 ± 0.0
Val
4.838ValAla: 4.838 ± 0.578
0.448ValCys: 0.448 ± 0.212
4.48ValAsp: 4.48 ± 0.627
4.928ValGlu: 4.928 ± 0.727
1.613ValPhe: 1.613 ± 0.335
3.763ValGly: 3.763 ± 0.429
0.627ValHis: 0.627 ± 0.302
3.494ValIle: 3.494 ± 0.601
5.107ValLys: 5.107 ± 0.581
3.853ValLeu: 3.853 ± 0.815
1.434ValMet: 1.434 ± 0.453
2.778ValAsn: 2.778 ± 0.636
1.882ValPro: 1.882 ± 0.408
2.15ValGln: 2.15 ± 0.508
2.867ValArg: 2.867 ± 0.355
3.226ValSer: 3.226 ± 0.528
2.957ValThr: 2.957 ± 0.392
4.569ValVal: 4.569 ± 0.834
0.448ValTrp: 0.448 ± 0.237
2.15ValTyr: 2.15 ± 0.33
0.0ValXaa: 0.0 ± 0.0
Trp
0.896TrpAla: 0.896 ± 0.265
0.09TrpCys: 0.09 ± 0.076
0.358TrpAsp: 0.358 ± 0.155
0.806TrpGlu: 0.806 ± 0.292
0.627TrpPhe: 0.627 ± 0.292
0.986TrpGly: 0.986 ± 0.256
0.0TrpHis: 0.0 ± 0.0
1.075TrpIle: 1.075 ± 0.411
0.806TrpLys: 0.806 ± 0.217
0.896TrpLeu: 0.896 ± 0.301
0.269TrpMet: 0.269 ± 0.14
1.254TrpAsn: 1.254 ± 0.452
0.179TrpPro: 0.179 ± 0.127
0.448TrpGln: 0.448 ± 0.19
0.806TrpArg: 0.806 ± 0.24
0.627TrpSer: 0.627 ± 0.305
0.538TrpThr: 0.538 ± 0.207
0.627TrpVal: 0.627 ± 0.257
0.0TrpTrp: 0.0 ± 0.0
0.269TrpTyr: 0.269 ± 0.154
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.688TyrAla: 2.688 ± 0.422
0.179TyrCys: 0.179 ± 0.131
3.315TyrAsp: 3.315 ± 0.517
2.509TyrGlu: 2.509 ± 0.463
2.061TyrPhe: 2.061 ± 0.488
1.702TyrGly: 1.702 ± 0.368
0.358TyrHis: 0.358 ± 0.169
2.061TyrIle: 2.061 ± 0.539
2.509TyrLys: 2.509 ± 0.348
3.136TyrLeu: 3.136 ± 0.68
0.358TyrMet: 0.358 ± 0.146
2.061TyrAsn: 2.061 ± 0.43
0.717TyrPro: 0.717 ± 0.209
1.702TyrGln: 1.702 ± 0.322
1.075TyrArg: 1.075 ± 0.344
1.613TyrSer: 1.613 ± 0.402
1.971TyrThr: 1.971 ± 0.474
1.434TyrVal: 1.434 ± 0.382
0.448TyrTrp: 0.448 ± 0.21
0.717TyrTyr: 0.717 ± 0.281
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski