Amino acid dipepetide frequency for Amycolatopsis arida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.735AlaAla: 22.735 ± 0.193	0.956AlaCys: 0.956 ± 0.026	8.524AlaAsp: 8.524 ± 0.07	10.483AlaGlu: 10.483 ± 0.094	3.317AlaPhe: 3.317 ± 0.046	14.757AlaGly: 14.757 ± 0.101	2.772AlaHis: 2.772 ± 0.046	3.645AlaIle: 3.645 ± 0.05	2.263AlaLys: 2.263 ± 0.042	14.766AlaLeu: 14.766 ± 0.132	2.404AlaMet: 2.404 ± 0.038	2.01AlaAsn: 2.01 ± 0.036	6.841AlaPro: 6.841 ± 0.073	3.087AlaGln: 3.087 ± 0.051	11.322AlaArg: 11.322 ± 0.093	5.088AlaSer: 5.088 ± 0.063	7.489AlaThr: 7.489 ± 0.074	13.106AlaVal: 13.106 ± 0.116	1.847AlaTrp: 1.847 ± 0.034	2.168AlaTyr: 2.168 ± 0.031	0.001AlaXaa: 0.001 ± 0.001
Cys	1.156CysAla: 1.156 ± 0.024	0.105CysCys: 0.105 ± 0.009	0.418CysAsp: 0.418 ± 0.017	0.323CysGlu: 0.323 ± 0.015	0.213CysPhe: 0.213 ± 0.01	0.899CysGly: 0.899 ± 0.023	0.206CysHis: 0.206 ± 0.012	0.106CysIle: 0.106 ± 0.008	0.076CysLys: 0.076 ± 0.008	0.694CysLeu: 0.694 ± 0.021	0.094CysMet: 0.094 ± 0.007	0.105CysAsn: 0.105 ± 0.008	0.549CysPro: 0.549 ± 0.02	0.168CysGln: 0.168 ± 0.009	0.68CysArg: 0.68 ± 0.022	0.382CysSer: 0.382 ± 0.015	0.431CysThr: 0.431 ± 0.016	0.702CysVal: 0.702 ± 0.019	0.131CysTrp: 0.131 ± 0.009	0.186CysTyr: 0.186 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.345AspAla: 7.345 ± 0.081	0.394AspCys: 0.394 ± 0.015	3.477AspAsp: 3.477 ± 0.047	3.986AspGlu: 3.986 ± 0.045	1.475AspPhe: 1.475 ± 0.031	5.851AspGly: 5.851 ± 0.065	1.382AspHis: 1.382 ± 0.028	1.7AspIle: 1.7 ± 0.036	0.831AspLys: 0.831 ± 0.023	6.2AspLeu: 6.2 ± 0.067	0.744AspMet: 0.744 ± 0.02	0.935AspAsn: 0.935 ± 0.032	4.862AspPro: 4.862 ± 0.063	1.566AspGln: 1.566 ± 0.034	5.423AspArg: 5.423 ± 0.06	2.103AspSer: 2.103 ± 0.041	3.204AspThr: 3.204 ± 0.043	5.499AspVal: 5.499 ± 0.065	0.861AspTrp: 0.861 ± 0.024	1.172AspTyr: 1.172 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.472GluAla: 6.472 ± 0.071	0.367GluCys: 0.367 ± 0.015	2.413GluAsp: 2.413 ± 0.035	3.004GluGlu: 3.004 ± 0.048	1.686GluPhe: 1.686 ± 0.034	3.89GluGly: 3.89 ± 0.051	1.896GluHis: 1.896 ± 0.035	2.131GluIle: 2.131 ± 0.042	1.024GluLys: 1.024 ± 0.028	8.048GluLeu: 8.048 ± 0.073	0.832GluMet: 0.832 ± 0.023	0.853GluAsn: 0.853 ± 0.024	4.003GluPro: 4.003 ± 0.064	2.105GluGln: 2.105 ± 0.035	6.453GluArg: 6.453 ± 0.082	2.311GluSer: 2.311 ± 0.037	2.512GluThr: 2.512 ± 0.037	5.42GluVal: 5.42 ± 0.051	0.901GluTrp: 0.901 ± 0.025	1.011GluTyr: 1.011 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.954PheAla: 3.954 ± 0.049	0.248PheCys: 0.248 ± 0.012	1.991PheAsp: 1.991 ± 0.04	1.174PheGlu: 1.174 ± 0.022	0.797PhePhe: 0.797 ± 0.026	3.176PheGly: 3.176 ± 0.051	0.611PheHis: 0.611 ± 0.02	0.525PheIle: 0.525 ± 0.018	0.315PheLys: 0.315 ± 0.015	2.647PheLeu: 2.647 ± 0.043	0.303PheMet: 0.303 ± 0.013	0.47PheAsn: 0.47 ± 0.02	1.353PhePro: 1.353 ± 0.025	0.579PheGln: 0.579 ± 0.02	1.972PheArg: 1.972 ± 0.033	1.236PheSer: 1.236 ± 0.024	1.975PheThr: 1.975 ± 0.039	2.51PheVal: 2.51 ± 0.04	0.395PheTrp: 0.395 ± 0.016	0.568PheTyr: 0.568 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	11.46GlyAla: 11.46 ± 0.102	0.84GlyCys: 0.84 ± 0.022	5.063GlyAsp: 5.063 ± 0.06	5.44GlyGlu: 5.44 ± 0.064	2.849GlyPhe: 2.849 ± 0.04	9.105GlyGly: 9.105 ± 0.091	2.172GlyHis: 2.172 ± 0.042	3.163GlyIle: 3.163 ± 0.055	1.879GlyLys: 1.879 ± 0.035	9.477GlyLeu: 9.477 ± 0.099	2.161GlyMet: 2.161 ± 0.033	1.672GlyAsn: 1.672 ± 0.036	5.318GlyPro: 5.318 ± 0.061	2.642GlyGln: 2.642 ± 0.053	8.217GlyArg: 8.217 ± 0.066	4.797GlySer: 4.797 ± 0.059	6.14GlyThr: 6.14 ± 0.071	8.619GlyVal: 8.619 ± 0.079	1.881GlyTrp: 1.881 ± 0.037	2.447GlyTyr: 2.447 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.708HisAla: 2.708 ± 0.04	0.214HisCys: 0.214 ± 0.012	1.335HisAsp: 1.335 ± 0.029	1.175HisGlu: 1.175 ± 0.027	0.585HisPhe: 0.585 ± 0.018	2.486HisGly: 2.486 ± 0.044	0.659HisHis: 0.659 ± 0.017	0.525HisIle: 0.525 ± 0.019	0.272HisLys: 0.272 ± 0.015	2.382HisLeu: 2.382 ± 0.037	0.277HisMet: 0.277 ± 0.013	0.342HisAsn: 0.342 ± 0.014	1.838HisPro: 1.838 ± 0.032	0.619HisGln: 0.619 ± 0.019	2.273HisArg: 2.273 ± 0.042	0.891HisSer: 0.891 ± 0.023	1.163HisThr: 1.163 ± 0.028	1.912HisVal: 1.912 ± 0.032	0.355HisTrp: 0.355 ± 0.013	0.491HisTyr: 0.491 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.584IleAla: 4.584 ± 0.063	0.244IleCys: 0.244 ± 0.013	2.044IleAsp: 2.044 ± 0.035	1.812IleGlu: 1.812 ± 0.038	0.625IlePhe: 0.625 ± 0.019	3.375IleGly: 3.375 ± 0.049	0.526IleHis: 0.526 ± 0.019	0.793IleIle: 0.793 ± 0.024	0.51IleLys: 0.51 ± 0.017	2.135IleLeu: 2.135 ± 0.041	0.366IleMet: 0.366 ± 0.016	0.627IleAsn: 0.627 ± 0.021	1.586IlePro: 1.586 ± 0.032	0.641IleGln: 0.641 ± 0.019	2.162IleArg: 2.162 ± 0.036	1.414IleSer: 1.414 ± 0.028	2.128IleThr: 2.128 ± 0.039	2.712IleVal: 2.712 ± 0.045	0.328IleTrp: 0.328 ± 0.015	0.537IleTyr: 0.537 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.067LysAla: 2.067 ± 0.041	0.082LysCys: 0.082 ± 0.008	0.836LysAsp: 0.836 ± 0.025	0.85LysGlu: 0.85 ± 0.024	0.356LysPhe: 0.356 ± 0.015	1.232LysGly: 1.232 ± 0.03	0.357LysHis: 0.357 ± 0.015	0.658LysIle: 0.658 ± 0.022	0.44LysLys: 0.44 ± 0.021	1.599LysLeu: 1.599 ± 0.035	0.254LysMet: 0.254 ± 0.013	0.321LysAsn: 0.321 ± 0.014	1.05LysPro: 1.05 ± 0.028	0.484LysGln: 0.484 ± 0.019	1.214LysArg: 1.214 ± 0.028	0.749LysSer: 0.749 ± 0.021	0.864LysThr: 0.864 ± 0.027	1.611LysVal: 1.611 ± 0.035	0.212LysTrp: 0.212 ± 0.011	0.322LysTyr: 0.322 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	17.435LeuAla: 17.435 ± 0.144	0.796LeuCys: 0.796 ± 0.025	7.132LeuAsp: 7.132 ± 0.074	4.404LeuGlu: 4.404 ± 0.053	2.583LeuPhe: 2.583 ± 0.047	10.006LeuGly: 10.006 ± 0.098	2.141LeuHis: 2.141 ± 0.037	2.619LeuIle: 2.619 ± 0.044	1.197LeuLys: 1.197 ± 0.031	11.785LeuLeu: 11.785 ± 0.128	1.28LeuMet: 1.28 ± 0.03	1.439LeuAsn: 1.439 ± 0.032	6.777LeuPro: 6.777 ± 0.071	1.706LeuGln: 1.706 ± 0.032	10.196LeuArg: 10.196 ± 0.08	4.757LeuSer: 4.757 ± 0.066	6.43LeuThr: 6.43 ± 0.062	10.619LeuVal: 10.619 ± 0.106	1.244LeuTrp: 1.244 ± 0.032	1.64LeuTyr: 1.64 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.203MetAla: 2.203 ± 0.028	0.104MetCys: 0.104 ± 0.008	0.763MetAsp: 0.763 ± 0.022	0.6MetGlu: 0.6 ± 0.019	0.456MetPhe: 0.456 ± 0.014	1.158MetGly: 1.158 ± 0.026	0.304MetHis: 0.304 ± 0.014	0.604MetIle: 0.604 ± 0.02	0.269MetLys: 0.269 ± 0.012	1.698MetLeu: 1.698 ± 0.032	0.235MetMet: 0.235 ± 0.012	0.346MetAsn: 0.346 ± 0.015	1.099MetPro: 1.099 ± 0.028	0.303MetGln: 0.303 ± 0.013	1.413MetArg: 1.413 ± 0.031	1.229MetSer: 1.229 ± 0.029	1.453MetThr: 1.453 ± 0.03	1.44MetVal: 1.44 ± 0.03	0.19MetTrp: 0.19 ± 0.011	0.248MetTyr: 0.248 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.053AsnAla: 2.053 ± 0.042	0.151AsnCys: 0.151 ± 0.01	0.84AsnAsp: 0.84 ± 0.023	0.771AsnGlu: 0.771 ± 0.024	0.433AsnPhe: 0.433 ± 0.016	1.649AsnGly: 1.649 ± 0.035	0.35AsnHis: 0.35 ± 0.016	0.521AsnIle: 0.521 ± 0.02	0.29AsnLys: 0.29 ± 0.015	1.667AsnLeu: 1.667 ± 0.034	0.225AsnMet: 0.225 ± 0.011	0.38AsnAsn: 0.38 ± 0.019	1.41AsnPro: 1.41 ± 0.039	0.477AsnGln: 0.477 ± 0.018	1.316AsnArg: 1.316 ± 0.026	0.767AsnSer: 0.767 ± 0.023	1.035AsnThr: 1.035 ± 0.024	1.43AsnVal: 1.43 ± 0.032	0.248AsnTrp: 0.248 ± 0.012	0.382AsnTyr: 0.382 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	9.313ProAla: 9.313 ± 0.095	0.375ProCys: 0.375 ± 0.015	4.7ProAsp: 4.7 ± 0.066	4.679ProGlu: 4.679 ± 0.057	1.576ProPhe: 1.576 ± 0.033	6.898ProGly: 6.898 ± 0.081	1.329ProHis: 1.329 ± 0.028	1.548ProIle: 1.548 ± 0.029	0.954ProLys: 0.954 ± 0.026	5.311ProLeu: 5.311 ± 0.06	1.016ProMet: 1.016 ± 0.024	1.091ProAsn: 1.091 ± 0.028	4.507ProPro: 4.507 ± 0.074	1.222ProGln: 1.222 ± 0.032	4.82ProArg: 4.82 ± 0.053	2.816ProSer: 2.816 ± 0.044	3.539ProThr: 3.539 ± 0.044	5.824ProVal: 5.824 ± 0.064	0.935ProTrp: 0.935 ± 0.022	1.142ProTyr: 1.142 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.132GlnAla: 3.132 ± 0.047	0.16GlnCys: 0.16 ± 0.01	1.018GlnAsp: 1.018 ± 0.027	1.059GlnGlu: 1.059 ± 0.028	0.635GlnPhe: 0.635 ± 0.019	1.806GlnGly: 1.806 ± 0.035	0.614GlnHis: 0.614 ± 0.02	0.837GlnIle: 0.837 ± 0.02	0.375GlnLys: 0.375 ± 0.015	2.958GlnLeu: 2.958 ± 0.046	0.337GlnMet: 0.337 ± 0.015	0.38GlnAsn: 0.38 ± 0.017	1.761GlnPro: 1.761 ± 0.039	0.987GlnGln: 0.987 ± 0.036	2.671GlnArg: 2.671 ± 0.044	0.98GlnSer: 0.98 ± 0.024	0.979GlnThr: 0.979 ± 0.025	2.304GlnVal: 2.304 ± 0.036	0.383GlnTrp: 0.383 ± 0.016	0.483GlnTyr: 0.483 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	11.573ArgAla: 11.573 ± 0.099	0.708ArgCys: 0.708 ± 0.02	4.775ArgAsp: 4.775 ± 0.046	5.079ArgGlu: 5.079 ± 0.057	2.64ArgPhe: 2.64 ± 0.042	6.671ArgGly: 6.671 ± 0.062	2.373ArgHis: 2.373 ± 0.038	3.125ArgIle: 3.125 ± 0.042	1.482ArgLys: 1.482 ± 0.033	9.661ArgLeu: 9.661 ± 0.101	2.039ArgMet: 2.039 ± 0.033	1.421ArgAsn: 1.421 ± 0.026	5.812ArgPro: 5.812 ± 0.064	2.367ArgGln: 2.367 ± 0.037	9.602ArgArg: 9.602 ± 0.097	4.045ArgSer: 4.045 ± 0.051	5.088ArgThr: 5.088 ± 0.058	7.221ArgVal: 7.221 ± 0.079	1.661ArgTrp: 1.661 ± 0.034	2.009ArgTyr: 2.009 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.207SerAla: 6.207 ± 0.056	0.383SerCys: 0.383 ± 0.014	2.176SerAsp: 2.176 ± 0.037	2.031SerGlu: 2.031 ± 0.035	1.346SerPhe: 1.346 ± 0.03	5.348SerGly: 5.348 ± 0.07	0.781SerHis: 0.781 ± 0.022	1.282SerIle: 1.282 ± 0.03	0.675SerLys: 0.675 ± 0.024	4.018SerLeu: 4.018 ± 0.047	0.978SerMet: 0.978 ± 0.026	0.739SerAsn: 0.739 ± 0.022	2.924SerPro: 2.924 ± 0.044	0.915SerGln: 0.915 ± 0.023	3.535SerArg: 3.535 ± 0.05	2.262SerSer: 2.262 ± 0.051	3.047SerThr: 3.047 ± 0.042	4.051SerVal: 4.051 ± 0.052	0.841SerTrp: 0.841 ± 0.021	1.007SerTyr: 1.007 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.177ThrAla: 8.177 ± 0.084	0.388ThrCys: 0.388 ± 0.016	3.415ThrAsp: 3.415 ± 0.05	3.577ThrGlu: 3.577 ± 0.049	1.6ThrPhe: 1.6 ± 0.035	6.467ThrGly: 6.467 ± 0.069	1.11ThrHis: 1.11 ± 0.025	1.799ThrIle: 1.799 ± 0.035	0.97ThrLys: 0.97 ± 0.022	5.529ThrLeu: 5.529 ± 0.062	0.98ThrMet: 0.98 ± 0.027	0.947ThrAsn: 0.947 ± 0.026	3.809ThrPro: 3.809 ± 0.06	1.168ThrGln: 1.168 ± 0.025	4.17ThrArg: 4.17 ± 0.054	2.848ThrSer: 2.848 ± 0.048	3.7ThrThr: 3.7 ± 0.055	6.239ThrVal: 6.239 ± 0.064	0.88ThrTrp: 0.88 ± 0.024	1.11ThrTyr: 1.11 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	13.005ValAla: 13.005 ± 0.1	0.767ValCys: 0.767 ± 0.021	6.116ValAsp: 6.116 ± 0.063	5.316ValGlu: 5.316 ± 0.059	2.462ValPhe: 2.462 ± 0.037	7.697ValGly: 7.697 ± 0.071	2.044ValHis: 2.044 ± 0.035	2.667ValIle: 2.667 ± 0.044	1.263ValLys: 1.263 ± 0.028	11.355ValLeu: 11.355 ± 0.107	1.133ValMet: 1.133 ± 0.024	1.679ValAsn: 1.679 ± 0.039	6.026ValPro: 6.026 ± 0.06	1.756ValGln: 1.756 ± 0.032	8.28ValArg: 8.28 ± 0.078	4.153ValSer: 4.153 ± 0.044	5.703ValThr: 5.703 ± 0.058	9.87ValVal: 9.87 ± 0.093	1.104ValTrp: 1.104 ± 0.026	1.514ValTyr: 1.514 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.654TrpAla: 1.654 ± 0.028	0.167TrpCys: 0.167 ± 0.01	0.724TrpAsp: 0.724 ± 0.018	0.601TrpGlu: 0.601 ± 0.017	0.515TrpPhe: 0.515 ± 0.018	0.947TrpGly: 0.947 ± 0.024	0.406TrpHis: 0.406 ± 0.016	0.508TrpIle: 0.508 ± 0.018	0.225TrpLys: 0.225 ± 0.013	1.988TrpLeu: 1.988 ± 0.04	0.281TrpMet: 0.281 ± 0.011	0.314TrpAsn: 0.314 ± 0.013	0.943TrpPro: 0.943 ± 0.025	0.516TrpGln: 0.516 ± 0.017	1.661TrpArg: 1.661 ± 0.034	0.849TrpSer: 0.849 ± 0.021	0.939TrpThr: 0.939 ± 0.026	1.171TrpVal: 1.171 ± 0.026	0.393TrpTrp: 0.393 ± 0.016	0.304TrpTyr: 0.304 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.347TyrAla: 2.347 ± 0.043	0.177TyrCys: 0.177 ± 0.008	1.248TyrAsp: 1.248 ± 0.032	0.969TyrGlu: 0.969 ± 0.023	0.65TyrPhe: 0.65 ± 0.02	1.921TyrGly: 1.921 ± 0.036	0.469TyrHis: 0.469 ± 0.019	0.393TyrIle: 0.393 ± 0.019	0.246TyrLys: 0.246 ± 0.012	2.27TyrLeu: 2.27 ± 0.041	0.175TyrMet: 0.175 ± 0.011	0.325TyrAsn: 0.325 ± 0.013	1.126TyrPro: 1.126 ± 0.027	0.552TyrGln: 0.552 ± 0.019	1.969TyrArg: 1.969 ± 0.035	0.873TyrSer: 0.873 ± 0.024	1.062TyrThr: 1.062 ± 0.029	1.651TyrVal: 1.651 ± 0.032	0.314TyrTrp: 0.314 ± 0.016	0.427TyrTyr: 0.427 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 5663 proteins (1734616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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