Amino acid dipepetide frequency for Changjiang narna-like virus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.87AlaAla: 10.87 ± 5.664
0.906AlaCys: 0.906 ± 0.453
3.623AlaAsp: 3.623 ± 1.813
3.623AlaGlu: 3.623 ± 0.227
3.623AlaPhe: 3.623 ± 1.813
6.341AlaGly: 6.341 ± 6.344
0.906AlaHis: 0.906 ± 0.453
2.717AlaIle: 2.717 ± 0.226
3.623AlaLys: 3.623 ± 2.946
7.246AlaLeu: 7.246 ± 1.132
2.717AlaMet: 2.717 ± 0.857
2.717AlaAsn: 2.717 ± 1.813
1.812AlaPro: 1.812 ± 0.907
2.717AlaGln: 2.717 ± 0.226
6.341AlaArg: 6.341 ± 0.001
4.529AlaSer: 4.529 ± 2.492
4.529AlaThr: 4.529 ± 0.68
2.717AlaVal: 2.717 ± 1.813
1.812AlaTrp: 1.812 ± 0.907
3.623AlaTyr: 3.623 ± 2.946
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.906CysHis: 0.906 ± 0.453
0.906CysIle: 0.906 ± 0.453
1.812CysLys: 1.812 ± 0.68
0.0CysLeu: 0.0 ± 0.0
0.906CysMet: 0.906 ± 0.453
0.0CysAsn: 0.0 ± 0.0
2.717CysPro: 2.717 ± 0.226
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.906CysThr: 0.906 ± 0.453
0.0CysVal: 0.0 ± 0.0
0.906CysTrp: 0.906 ± 0.453
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.623AspAla: 3.623 ± 1.813
0.0AspCys: 0.0 ± 0.0
1.812AspAsp: 1.812 ± 0.907
1.812AspGlu: 1.812 ± 0.68
0.906AspPhe: 0.906 ± 0.453
2.717AspGly: 2.717 ± 0.226
1.812AspHis: 1.812 ± 2.266
0.906AspIle: 0.906 ± 1.133
0.0AspLys: 0.0 ± 0.0
5.435AspLeu: 5.435 ± 2.72
0.0AspMet: 0.0 ± 0.0
1.812AspAsn: 1.812 ± 0.68
3.623AspPro: 3.623 ± 0.227
1.812AspGln: 1.812 ± 0.68
2.717AspArg: 2.717 ± 1.36
2.717AspSer: 2.717 ± 0.226
3.623AspThr: 3.623 ± 1.813
4.529AspVal: 4.529 ± 0.906
0.0AspTrp: 0.0 ± 0.0
1.812AspTyr: 1.812 ± 0.907
0.0AspXaa: 0.0 ± 0.0
Glu
2.717GluAla: 2.717 ± 1.36
0.0GluCys: 0.0 ± 0.0
4.529GluAsp: 4.529 ± 0.68
2.717GluGlu: 2.717 ± 1.36
6.341GluPhe: 6.341 ± 1.587
2.717GluGly: 2.717 ± 1.36
0.906GluHis: 0.906 ± 0.453
1.812GluIle: 1.812 ± 0.907
3.623GluLys: 3.623 ± 0.227
4.529GluLeu: 4.529 ± 0.68
1.812GluMet: 1.812 ± 0.907
1.812GluAsn: 1.812 ± 0.907
1.812GluPro: 1.812 ± 0.907
1.812GluGln: 1.812 ± 0.907
2.717GluArg: 2.717 ± 0.226
2.717GluSer: 2.717 ± 1.36
2.717GluThr: 2.717 ± 1.813
1.812GluVal: 1.812 ± 2.266
1.812GluTrp: 1.812 ± 0.907
1.812GluTyr: 1.812 ± 0.907
0.0GluXaa: 0.0 ± 0.0
Phe
0.906PheAla: 0.906 ± 1.133
0.906PheCys: 0.906 ± 0.453
1.812PheAsp: 1.812 ± 2.266
1.812PheGlu: 1.812 ± 0.907
0.0PhePhe: 0.0 ± 0.0
4.529PheGly: 4.529 ± 0.68
0.0PheHis: 0.0 ± 0.0
1.812PheIle: 1.812 ± 0.907
0.906PheLys: 0.906 ± 0.453
7.246PheLeu: 7.246 ± 2.04
0.906PheMet: 0.906 ± 0.453
2.717PheAsn: 2.717 ± 1.36
5.435PhePro: 5.435 ± 2.72
3.623PheGln: 3.623 ± 1.813
3.623PheArg: 3.623 ± 1.813
5.435PheSer: 5.435 ± 0.453
3.623PheThr: 3.623 ± 1.359
0.906PheVal: 0.906 ± 1.133
0.906PheTrp: 0.906 ± 0.453
0.906PheTyr: 0.906 ± 0.453
0.0PheXaa: 0.0 ± 0.0
Gly
9.964GlyAla: 9.964 ± 1.359
1.812GlyCys: 1.812 ± 0.68
3.623GlyAsp: 3.623 ± 0.227
5.435GlyGlu: 5.435 ± 2.039
2.717GlyPhe: 2.717 ± 0.226
8.152GlyGly: 8.152 ± 0.907
2.717GlyHis: 2.717 ± 1.813
3.623GlyIle: 3.623 ± 0.227
2.717GlyLys: 2.717 ± 0.226
6.341GlyLeu: 6.341 ± 1.587
1.812GlyMet: 1.812 ± 0.68
2.717GlyAsn: 2.717 ± 3.399
5.435GlyPro: 5.435 ± 1.134
1.812GlyGln: 1.812 ± 0.68
2.717GlyArg: 2.717 ± 0.226
2.717GlySer: 2.717 ± 1.813
0.906GlyThr: 0.906 ± 0.453
6.341GlyVal: 6.341 ± 6.344
0.906GlyTrp: 0.906 ± 1.133
1.812GlyTyr: 1.812 ± 0.907
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
2.717HisGlu: 2.717 ± 1.36
0.906HisPhe: 0.906 ± 0.453
0.0HisGly: 0.0 ± 0.0
1.812HisHis: 1.812 ± 0.68
1.812HisIle: 1.812 ± 0.68
0.906HisLys: 0.906 ± 0.453
0.906HisLeu: 0.906 ± 0.453
2.717HisMet: 2.717 ± 1.813
0.906HisAsn: 0.906 ± 1.133
1.812HisPro: 1.812 ± 0.68
0.0HisGln: 0.0 ± 0.0
1.812HisArg: 1.812 ± 0.907
2.717HisSer: 2.717 ± 0.226
3.623HisThr: 3.623 ± 1.359
1.812HisVal: 1.812 ± 0.907
0.906HisTrp: 0.906 ± 1.133
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.435IleAla: 5.435 ± 2.039
0.0IleCys: 0.0 ± 0.0
0.906IleAsp: 0.906 ± 0.453
1.812IleGlu: 1.812 ± 0.907
4.529IlePhe: 4.529 ± 2.267
4.529IleGly: 4.529 ± 0.68
0.0IleHis: 0.0 ± 0.0
0.906IleIle: 0.906 ± 0.453
0.906IleLys: 0.906 ± 1.133
8.152IleLeu: 8.152 ± 0.907
0.0IleMet: 0.0 ± 0.0
1.812IleAsn: 1.812 ± 0.907
3.623IlePro: 3.623 ± 2.946
0.906IleGln: 0.906 ± 0.453
2.717IleArg: 2.717 ± 0.226
1.812IleSer: 1.812 ± 0.68
4.529IleThr: 4.529 ± 0.906
2.717IleVal: 2.717 ± 0.226
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
5.435LysAla: 5.435 ± 0.453
0.0LysCys: 0.0 ± 0.0
2.717LysAsp: 2.717 ± 1.36
2.717LysGlu: 2.717 ± 1.36
3.623LysPhe: 3.623 ± 0.227
3.623LysGly: 3.623 ± 1.813
1.812LysHis: 1.812 ± 0.907
3.623LysIle: 3.623 ± 1.813
3.623LysLys: 3.623 ± 1.359
3.623LysLeu: 3.623 ± 0.227
0.906LysMet: 0.906 ± 0.453
4.529LysAsn: 4.529 ± 2.492
2.717LysPro: 2.717 ± 0.226
0.0LysGln: 0.0 ± 0.0
2.717LysArg: 2.717 ± 0.226
5.435LysSer: 5.435 ± 0.453
0.906LysThr: 0.906 ± 1.133
5.435LysVal: 5.435 ± 1.134
0.906LysTrp: 0.906 ± 0.453
2.717LysTyr: 2.717 ± 1.36
0.0LysXaa: 0.0 ± 0.0
Leu
3.623LeuAla: 3.623 ± 1.359
1.812LeuCys: 1.812 ± 0.907
6.341LeuAsp: 6.341 ± 0.001
6.341LeuGlu: 6.341 ± 1.587
3.623LeuPhe: 3.623 ± 1.359
4.529LeuGly: 4.529 ± 2.267
3.623LeuHis: 3.623 ± 0.227
4.529LeuIle: 4.529 ± 0.68
3.623LeuLys: 3.623 ± 0.227
8.152LeuLeu: 8.152 ± 0.907
3.623LeuMet: 3.623 ± 1.619
4.529LeuAsn: 4.529 ± 0.906
7.246LeuPro: 7.246 ± 3.627
3.623LeuGln: 3.623 ± 0.227
5.435LeuArg: 5.435 ± 1.134
7.246LeuSer: 7.246 ± 3.627
7.246LeuThr: 7.246 ± 0.454
2.717LeuVal: 2.717 ± 1.36
0.906LeuTrp: 0.906 ± 0.453
0.906LeuTyr: 0.906 ± 0.453
0.0LeuXaa: 0.0 ± 0.0
Met
3.623MetAla: 3.623 ± 1.359
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
2.717MetPhe: 2.717 ± 0.226
1.812MetGly: 1.812 ± 0.68
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.812MetLys: 1.812 ± 0.907
2.717MetLeu: 2.717 ± 1.36
1.812MetMet: 1.812 ± 0.907
0.906MetAsn: 0.906 ± 0.453
0.906MetPro: 0.906 ± 0.453
0.906MetGln: 0.906 ± 1.133
3.623MetArg: 3.623 ± 1.813
0.906MetSer: 0.906 ± 0.453
1.812MetThr: 1.812 ± 0.68
3.623MetVal: 3.623 ± 0.227
0.906MetTrp: 0.906 ± 0.453
0.906MetTyr: 0.906 ± 0.453
0.0MetXaa: 0.0 ± 0.0
Asn
2.717AsnAla: 2.717 ± 1.813
0.0AsnCys: 0.0 ± 0.0
0.906AsnAsp: 0.906 ± 0.453
1.812AsnGlu: 1.812 ± 0.68
1.812AsnPhe: 1.812 ± 0.68
5.435AsnGly: 5.435 ± 2.039
0.906AsnHis: 0.906 ± 0.453
2.717AsnIle: 2.717 ± 0.226
1.812AsnLys: 1.812 ± 0.68
0.0AsnLeu: 0.0 ± 0.0
0.906AsnMet: 0.906 ± 0.453
0.906AsnAsn: 0.906 ± 0.453
1.812AsnPro: 1.812 ± 0.68
0.906AsnGln: 0.906 ± 0.453
3.623AsnArg: 3.623 ± 1.813
5.435AsnSer: 5.435 ± 2.039
4.529AsnThr: 4.529 ± 4.079
1.812AsnVal: 1.812 ± 0.68
0.0AsnTrp: 0.0 ± 0.0
3.623AsnTyr: 3.623 ± 0.227
0.0AsnXaa: 0.0 ± 0.0
Pro
3.623ProAla: 3.623 ± 1.359
0.0ProCys: 0.0 ± 0.0
0.906ProAsp: 0.906 ± 1.133
3.623ProGlu: 3.623 ± 1.813
1.812ProPhe: 1.812 ± 0.907
2.717ProGly: 2.717 ± 0.226
2.717ProHis: 2.717 ± 1.813
2.717ProIle: 2.717 ± 0.226
0.906ProLys: 0.906 ± 0.453
7.246ProLeu: 7.246 ± 2.04
1.812ProMet: 1.812 ± 0.907
2.717ProAsn: 2.717 ± 0.226
7.246ProPro: 7.246 ± 2.04
0.906ProGln: 0.906 ± 0.453
3.623ProArg: 3.623 ± 0.227
5.435ProSer: 5.435 ± 1.134
1.812ProThr: 1.812 ± 0.68
9.964ProVal: 9.964 ± 3.4
0.906ProTrp: 0.906 ± 0.453
1.812ProTyr: 1.812 ± 0.907
0.0ProXaa: 0.0 ± 0.0
Gln
1.812GlnAla: 1.812 ± 0.907
0.0GlnCys: 0.0 ± 0.0
0.906GlnAsp: 0.906 ± 1.133
2.717GlnGlu: 2.717 ± 1.36
0.906GlnPhe: 0.906 ± 0.453
0.906GlnGly: 0.906 ± 0.453
0.0GlnHis: 0.0 ± 0.0
0.906GlnIle: 0.906 ± 0.453
1.812GlnLys: 1.812 ± 0.68
9.964GlnLeu: 9.964 ± 0.228
0.906GlnMet: 0.906 ± 0.453
0.0GlnAsn: 0.0 ± 0.0
0.0GlnPro: 0.0 ± 0.0
2.717GlnGln: 2.717 ± 1.813
2.717GlnArg: 2.717 ± 1.36
0.906GlnSer: 0.906 ± 1.133
0.906GlnThr: 0.906 ± 0.453
1.812GlnVal: 1.812 ± 0.907
0.906GlnTrp: 0.906 ± 1.133
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
3.623ArgAla: 3.623 ± 0.227
0.906ArgCys: 0.906 ± 1.133
5.435ArgAsp: 5.435 ± 1.134
3.623ArgGlu: 3.623 ± 0.227
2.717ArgPhe: 2.717 ± 1.36
4.529ArgGly: 4.529 ± 2.492
1.812ArgHis: 1.812 ± 0.68
3.623ArgIle: 3.623 ± 1.813
5.435ArgLys: 5.435 ± 2.72
4.529ArgLeu: 4.529 ± 2.267
2.717ArgMet: 2.717 ± 0.226
3.623ArgAsn: 3.623 ± 0.227
2.717ArgPro: 2.717 ± 1.36
3.623ArgGln: 3.623 ± 1.813
7.246ArgArg: 7.246 ± 1.132
0.906ArgSer: 0.906 ± 0.453
2.717ArgThr: 2.717 ± 0.226
2.717ArgVal: 2.717 ± 0.226
3.623ArgTrp: 3.623 ± 0.227
2.717ArgTyr: 2.717 ± 0.226
0.0ArgXaa: 0.0 ± 0.0
Ser
6.341SerAla: 6.341 ± 0.001
0.906SerCys: 0.906 ± 0.453
0.906SerAsp: 0.906 ± 0.453
1.812SerGlu: 1.812 ± 0.907
7.246SerPhe: 7.246 ± 2.04
5.435SerGly: 5.435 ± 5.211
0.0SerHis: 0.0 ± 0.0
4.529SerIle: 4.529 ± 2.492
6.341SerLys: 6.341 ± 3.173
1.812SerLeu: 1.812 ± 0.907
2.717SerMet: 2.717 ± 1.36
5.435SerAsn: 5.435 ± 2.039
0.906SerPro: 0.906 ± 0.453
0.0SerGln: 0.0 ± 0.0
5.435SerArg: 5.435 ± 2.039
7.246SerSer: 7.246 ± 1.132
3.623SerThr: 3.623 ± 0.227
9.964SerVal: 9.964 ± 1.359
1.812SerTrp: 1.812 ± 0.68
0.906SerTyr: 0.906 ± 0.453
0.0SerXaa: 0.0 ± 0.0
Thr
3.623ThrAla: 3.623 ± 1.359
0.0ThrCys: 0.0 ± 0.0
3.623ThrAsp: 3.623 ± 1.813
1.812ThrGlu: 1.812 ± 0.907
0.906ThrPhe: 0.906 ± 1.133
6.341ThrGly: 6.341 ± 4.758
1.812ThrHis: 1.812 ± 0.907
3.623ThrIle: 3.623 ± 2.946
9.058ThrLys: 9.058 ± 2.947
2.717ThrLeu: 2.717 ± 0.226
0.906ThrMet: 0.906 ± 1.133
0.906ThrAsn: 0.906 ± 1.133
2.717ThrPro: 2.717 ± 1.36
0.906ThrGln: 0.906 ± 1.133
4.529ThrArg: 4.529 ± 0.68
4.529ThrSer: 4.529 ± 0.906
1.812ThrThr: 1.812 ± 0.68
2.717ThrVal: 2.717 ± 0.226
0.906ThrTrp: 0.906 ± 0.453
3.623ThrTyr: 3.623 ± 1.359
0.0ThrXaa: 0.0 ± 0.0
Val
6.341ValAla: 6.341 ± 3.172
0.0ValCys: 0.0 ± 0.0
1.812ValAsp: 1.812 ± 0.68
3.623ValGlu: 3.623 ± 0.227
1.812ValPhe: 1.812 ± 0.68
7.246ValGly: 7.246 ± 1.132
0.906ValHis: 0.906 ± 0.453
0.906ValIle: 0.906 ± 0.453
3.623ValLys: 3.623 ± 1.359
5.435ValLeu: 5.435 ± 1.134
0.0ValMet: 0.0 ± 0.0
1.812ValAsn: 1.812 ± 0.907
8.152ValPro: 8.152 ± 0.679
2.717ValGln: 2.717 ± 1.36
3.623ValArg: 3.623 ± 0.227
6.341ValSer: 6.341 ± 3.172
3.623ValThr: 3.623 ± 1.359
4.529ValVal: 4.529 ± 0.906
0.906ValTrp: 0.906 ± 0.453
3.623ValTyr: 3.623 ± 1.359
0.0ValXaa: 0.0 ± 0.0
Trp
0.906TrpAla: 0.906 ± 1.133
0.0TrpCys: 0.0 ± 0.0
0.906TrpAsp: 0.906 ± 0.453
1.812TrpGlu: 1.812 ± 0.907
1.812TrpPhe: 1.812 ± 0.907
0.0TrpGly: 0.0 ± 0.0
2.717TrpHis: 2.717 ± 0.226
1.812TrpIle: 1.812 ± 0.68
1.812TrpLys: 1.812 ± 0.907
0.906TrpLeu: 0.906 ± 0.453
0.906TrpMet: 0.906 ± 0.453
0.906TrpAsn: 0.906 ± 0.453
0.906TrpPro: 0.906 ± 1.133
0.906TrpGln: 0.906 ± 1.133
0.906TrpArg: 0.906 ± 0.453
0.906TrpSer: 0.906 ± 0.453
0.906TrpThr: 0.906 ± 0.453
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.717TyrAla: 2.717 ± 1.813
1.812TyrCys: 1.812 ± 0.907
0.906TyrAsp: 0.906 ± 1.133
0.906TyrGlu: 0.906 ± 0.453
0.0TyrPhe: 0.0 ± 0.0
2.717TyrGly: 2.717 ± 0.226
0.0TyrHis: 0.0 ± 0.0
1.812TyrIle: 1.812 ± 0.68
2.717TyrLys: 2.717 ± 1.36
2.717TyrLeu: 2.717 ± 0.226
0.0TyrMet: 0.0 ± 0.0
0.906TyrAsn: 0.906 ± 1.133
0.906TyrPro: 0.906 ± 0.453
0.906TyrGln: 0.906 ± 0.453
2.717TyrArg: 2.717 ± 0.226
5.435TyrSer: 5.435 ± 2.72
2.717TyrThr: 2.717 ± 1.36
0.906TyrVal: 0.906 ± 1.133
0.0TyrTrp: 0.0 ± 0.0
1.812TyrTyr: 1.812 ± 0.907
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1105 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski