Amino acid dipepetide frequency for Edwardsiella phage ETP-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.902AlaAla: 9.902 ± 1.201
0.686AlaCys: 0.686 ± 0.279
6.018AlaAsp: 6.018 ± 0.84
6.018AlaGlu: 6.018 ± 0.65
3.047AlaPhe: 3.047 ± 0.59
6.932AlaGly: 6.932 ± 0.799
1.295AlaHis: 1.295 ± 0.255
4.266AlaIle: 4.266 ± 0.707
5.256AlaLys: 5.256 ± 0.9
7.16AlaLeu: 7.16 ± 0.77
4.037AlaMet: 4.037 ± 0.505
4.494AlaAsn: 4.494 ± 0.53
3.275AlaPro: 3.275 ± 0.588
3.961AlaGln: 3.961 ± 0.566
5.561AlaArg: 5.561 ± 0.636
6.246AlaSer: 6.246 ± 0.87
5.408AlaThr: 5.408 ± 0.714
6.475AlaVal: 6.475 ± 0.544
2.057AlaTrp: 2.057 ± 0.573
3.885AlaTyr: 3.885 ± 0.463
0.0AlaXaa: 0.0 ± 0.0
Cys
1.371CysAla: 1.371 ± 0.365
0.152CysCys: 0.152 ± 0.096
0.609CysAsp: 0.609 ± 0.225
0.609CysGlu: 0.609 ± 0.197
0.381CysPhe: 0.381 ± 0.179
0.457CysGly: 0.457 ± 0.204
0.381CysHis: 0.381 ± 0.193
0.686CysIle: 0.686 ± 0.233
1.066CysLys: 1.066 ± 0.258
0.838CysLeu: 0.838 ± 0.251
0.152CysMet: 0.152 ± 0.098
0.609CysAsn: 0.609 ± 0.231
0.229CysPro: 0.229 ± 0.119
0.381CysGln: 0.381 ± 0.148
0.076CysArg: 0.076 ± 0.08
0.609CysSer: 0.609 ± 0.215
0.457CysThr: 0.457 ± 0.203
0.914CysVal: 0.914 ± 0.26
0.229CysTrp: 0.229 ± 0.118
0.381CysTyr: 0.381 ± 0.173
0.0CysXaa: 0.0 ± 0.0
Asp
6.17AspAla: 6.17 ± 0.758
0.609AspCys: 0.609 ± 0.211
4.19AspAsp: 4.19 ± 0.611
3.809AspGlu: 3.809 ± 0.572
3.047AspPhe: 3.047 ± 0.472
4.266AspGly: 4.266 ± 0.596
0.381AspHis: 0.381 ± 0.144
3.885AspIle: 3.885 ± 0.633
4.19AspLys: 4.19 ± 0.55
5.027AspLeu: 5.027 ± 0.637
1.904AspMet: 1.904 ± 0.465
2.361AspAsn: 2.361 ± 0.457
3.047AspPro: 3.047 ± 0.45
1.295AspGln: 1.295 ± 0.348
2.133AspArg: 2.133 ± 0.407
3.656AspSer: 3.656 ± 0.473
4.113AspThr: 4.113 ± 0.546
5.256AspVal: 5.256 ± 0.514
0.914AspTrp: 0.914 ± 0.246
2.438AspTyr: 2.438 ± 0.391
0.0AspXaa: 0.0 ± 0.0
Glu
6.399GluAla: 6.399 ± 0.951
0.762GluCys: 0.762 ± 0.296
3.58GluAsp: 3.58 ± 0.378
3.656GluGlu: 3.656 ± 0.53
2.59GluPhe: 2.59 ± 0.355
3.809GluGly: 3.809 ± 0.414
1.523GluHis: 1.523 ± 0.34
1.828GluIle: 1.828 ± 0.405
2.514GluLys: 2.514 ± 0.384
8.531GluLeu: 8.531 ± 0.784
1.447GluMet: 1.447 ± 0.307
1.371GluAsn: 1.371 ± 0.281
1.6GluPro: 1.6 ± 0.303
2.818GluGln: 2.818 ± 0.517
2.895GluArg: 2.895 ± 0.592
2.438GluSer: 2.438 ± 0.337
3.428GluThr: 3.428 ± 0.525
4.951GluVal: 4.951 ± 0.637
0.762GluTrp: 0.762 ± 0.186
2.895GluTyr: 2.895 ± 0.585
0.0GluXaa: 0.0 ± 0.0
Phe
2.209PheAla: 2.209 ± 0.409
0.533PheCys: 0.533 ± 0.181
3.199PheAsp: 3.199 ± 0.511
2.361PheGlu: 2.361 ± 0.438
0.838PhePhe: 0.838 ± 0.226
3.504PheGly: 3.504 ± 0.641
0.533PheHis: 0.533 ± 0.236
2.133PheIle: 2.133 ± 0.432
1.752PheLys: 1.752 ± 0.399
3.047PheLeu: 3.047 ± 0.54
0.457PheMet: 0.457 ± 0.172
2.285PheAsn: 2.285 ± 0.417
0.838PhePro: 0.838 ± 0.268
0.914PheGln: 0.914 ± 0.221
1.98PheArg: 1.98 ± 0.363
2.133PheSer: 2.133 ± 0.382
2.285PheThr: 2.285 ± 0.595
1.828PheVal: 1.828 ± 0.337
0.762PheTrp: 0.762 ± 0.236
1.143PheTyr: 1.143 ± 0.256
0.0PheXaa: 0.0 ± 0.0
Gly
6.17GlyAla: 6.17 ± 0.892
0.914GlyCys: 0.914 ± 0.269
3.809GlyAsp: 3.809 ± 0.544
5.256GlyGlu: 5.256 ± 0.699
2.895GlyPhe: 2.895 ± 0.469
4.951GlyGly: 4.951 ± 0.773
0.99GlyHis: 0.99 ± 0.249
4.19GlyIle: 4.19 ± 0.528
5.18GlyLys: 5.18 ± 0.722
6.246GlyLeu: 6.246 ± 0.965
1.295GlyMet: 1.295 ± 0.29
4.19GlyAsn: 4.19 ± 0.508
1.447GlyPro: 1.447 ± 0.299
2.514GlyGln: 2.514 ± 0.519
3.047GlyArg: 3.047 ± 0.408
5.256GlySer: 5.256 ± 0.685
4.799GlyThr: 4.799 ± 0.776
5.713GlyVal: 5.713 ± 0.646
0.99GlyTrp: 0.99 ± 0.302
2.895GlyTyr: 2.895 ± 0.49
0.0GlyXaa: 0.0 ± 0.0
His
1.447HisAla: 1.447 ± 0.389
0.076HisCys: 0.076 ± 0.071
0.686HisAsp: 0.686 ± 0.251
0.533HisGlu: 0.533 ± 0.177
0.914HisPhe: 0.914 ± 0.336
0.914HisGly: 0.914 ± 0.251
0.229HisHis: 0.229 ± 0.109
1.066HisIle: 1.066 ± 0.343
1.371HisLys: 1.371 ± 0.321
0.99HisLeu: 0.99 ± 0.292
0.305HisMet: 0.305 ± 0.148
1.371HisAsn: 1.371 ± 0.29
0.457HisPro: 0.457 ± 0.19
0.609HisGln: 0.609 ± 0.276
0.609HisArg: 0.609 ± 0.186
1.143HisSer: 1.143 ± 0.243
0.762HisThr: 0.762 ± 0.174
1.066HisVal: 1.066 ± 0.29
0.0HisTrp: 0.0 ± 0.0
1.219HisTyr: 1.219 ± 0.333
0.0HisXaa: 0.0 ± 0.0
Ile
4.342IleAla: 4.342 ± 0.518
0.457IleCys: 0.457 ± 0.194
3.885IleAsp: 3.885 ± 0.498
3.428IleGlu: 3.428 ± 0.49
1.371IlePhe: 1.371 ± 0.278
2.818IleGly: 2.818 ± 0.579
0.381IleHis: 0.381 ± 0.159
2.361IleIle: 2.361 ± 0.459
3.275IleLys: 3.275 ± 0.446
3.275IleLeu: 3.275 ± 0.618
1.447IleMet: 1.447 ± 0.321
2.438IleAsn: 2.438 ± 0.432
1.295IlePro: 1.295 ± 0.245
1.752IleGln: 1.752 ± 0.336
1.98IleArg: 1.98 ± 0.298
2.742IleSer: 2.742 ± 0.398
3.199IleThr: 3.199 ± 0.485
3.809IleVal: 3.809 ± 0.385
0.381IleTrp: 0.381 ± 0.16
1.523IleTyr: 1.523 ± 0.3
0.0IleXaa: 0.0 ± 0.0
Lys
7.008LysAla: 7.008 ± 0.657
0.609LysCys: 0.609 ± 0.201
3.428LysAsp: 3.428 ± 0.474
3.123LysGlu: 3.123 ± 0.604
1.904LysPhe: 1.904 ± 0.353
4.113LysGly: 4.113 ± 0.939
1.523LysHis: 1.523 ± 0.429
2.057LysIle: 2.057 ± 0.377
2.666LysLys: 2.666 ± 0.524
8.074LysLeu: 8.074 ± 0.769
1.219LysMet: 1.219 ± 0.319
1.676LysAsn: 1.676 ± 0.357
2.666LysPro: 2.666 ± 0.55
2.59LysGln: 2.59 ± 0.452
3.428LysArg: 3.428 ± 0.569
3.047LysSer: 3.047 ± 0.346
3.428LysThr: 3.428 ± 0.508
4.418LysVal: 4.418 ± 0.499
0.762LysTrp: 0.762 ± 0.22
2.666LysTyr: 2.666 ± 0.371
0.0LysXaa: 0.0 ± 0.0
Leu
9.826LeuAla: 9.826 ± 0.773
0.609LeuCys: 0.609 ± 0.192
6.551LeuAsp: 6.551 ± 0.652
5.484LeuGlu: 5.484 ± 0.61
1.676LeuPhe: 1.676 ± 0.279
5.713LeuGly: 5.713 ± 0.834
2.057LeuHis: 2.057 ± 0.501
2.666LeuIle: 2.666 ± 0.546
4.951LeuLys: 4.951 ± 0.675
7.77LeuLeu: 7.77 ± 0.798
2.285LeuMet: 2.285 ± 0.352
4.037LeuAsn: 4.037 ± 0.409
4.113LeuPro: 4.113 ± 0.588
4.875LeuGln: 4.875 ± 0.671
4.418LeuArg: 4.418 ± 0.459
5.789LeuSer: 5.789 ± 0.591
5.408LeuThr: 5.408 ± 0.605
7.084LeuVal: 7.084 ± 0.738
0.99LeuTrp: 0.99 ± 0.25
3.504LeuTyr: 3.504 ± 0.471
0.0LeuXaa: 0.0 ± 0.0
Met
2.514MetAla: 2.514 ± 0.507
0.229MetCys: 0.229 ± 0.117
1.676MetAsp: 1.676 ± 0.436
0.686MetGlu: 0.686 ± 0.201
0.914MetPhe: 0.914 ± 0.238
0.914MetGly: 0.914 ± 0.278
0.457MetHis: 0.457 ± 0.169
0.99MetIle: 0.99 ± 0.258
1.219MetLys: 1.219 ± 0.274
2.666MetLeu: 2.666 ± 0.401
0.457MetMet: 0.457 ± 0.229
1.143MetAsn: 1.143 ± 0.253
1.371MetPro: 1.371 ± 0.336
1.371MetGln: 1.371 ± 0.338
1.828MetArg: 1.828 ± 0.398
2.514MetSer: 2.514 ± 0.538
2.438MetThr: 2.438 ± 0.306
0.914MetVal: 0.914 ± 0.283
0.305MetTrp: 0.305 ± 0.163
0.914MetTyr: 0.914 ± 0.246
0.0MetXaa: 0.0 ± 0.0
Asn
3.885AsnAla: 3.885 ± 0.523
0.99AsnCys: 0.99 ± 0.329
2.057AsnAsp: 2.057 ± 0.428
2.895AsnGlu: 2.895 ± 0.418
1.143AsnPhe: 1.143 ± 0.415
4.494AsnGly: 4.494 ± 0.682
0.533AsnHis: 0.533 ± 0.195
2.209AsnIle: 2.209 ± 0.365
2.742AsnLys: 2.742 ± 0.396
4.266AsnLeu: 4.266 ± 0.494
1.447AsnMet: 1.447 ± 0.293
1.752AsnAsn: 1.752 ± 0.405
2.133AsnPro: 2.133 ± 0.379
1.98AsnGln: 1.98 ± 0.335
1.143AsnArg: 1.143 ± 0.405
2.895AsnSer: 2.895 ± 0.416
2.514AsnThr: 2.514 ± 0.368
3.428AsnVal: 3.428 ± 0.515
0.457AsnTrp: 0.457 ± 0.158
1.752AsnTyr: 1.752 ± 0.372
0.0AsnXaa: 0.0 ± 0.0
Pro
2.818ProAla: 2.818 ± 0.468
0.229ProCys: 0.229 ± 0.103
2.438ProAsp: 2.438 ± 0.463
2.895ProGlu: 2.895 ± 0.55
0.686ProPhe: 0.686 ± 0.253
2.59ProGly: 2.59 ± 0.463
0.152ProHis: 0.152 ± 0.09
1.6ProIle: 1.6 ± 0.329
2.742ProLys: 2.742 ± 0.617
1.98ProLeu: 1.98 ± 0.441
1.295ProMet: 1.295 ± 0.388
1.98ProAsn: 1.98 ± 0.352
0.99ProPro: 0.99 ± 0.262
1.752ProGln: 1.752 ± 0.327
1.523ProArg: 1.523 ± 0.264
3.428ProSer: 3.428 ± 0.588
2.971ProThr: 2.971 ± 0.656
3.504ProVal: 3.504 ± 0.46
0.381ProTrp: 0.381 ± 0.157
0.914ProTyr: 0.914 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
5.027GlnAla: 5.027 ± 0.937
0.457GlnCys: 0.457 ± 0.202
1.904GlnAsp: 1.904 ± 0.462
2.438GlnGlu: 2.438 ± 0.375
1.523GlnPhe: 1.523 ± 0.373
2.361GlnGly: 2.361 ± 0.396
0.609GlnHis: 0.609 ± 0.194
1.523GlnIle: 1.523 ± 0.344
1.371GlnLys: 1.371 ± 0.26
4.418GlnLeu: 4.418 ± 0.578
0.99GlnMet: 0.99 ± 0.2
1.6GlnAsn: 1.6 ± 0.33
1.752GlnPro: 1.752 ± 0.306
3.885GlnGln: 3.885 ± 0.59
2.971GlnArg: 2.971 ± 0.599
2.057GlnSer: 2.057 ± 0.339
1.98GlnThr: 1.98 ± 0.365
3.047GlnVal: 3.047 ± 0.463
0.762GlnTrp: 0.762 ± 0.222
1.828GlnTyr: 1.828 ± 0.404
0.0GlnXaa: 0.0 ± 0.0
Arg
4.266ArgAla: 4.266 ± 0.511
0.381ArgCys: 0.381 ± 0.138
2.438ArgAsp: 2.438 ± 0.449
3.199ArgGlu: 3.199 ± 0.596
1.752ArgPhe: 1.752 ± 0.369
3.656ArgGly: 3.656 ± 0.456
0.838ArgHis: 0.838 ± 0.243
2.971ArgIle: 2.971 ± 0.492
2.818ArgLys: 2.818 ± 0.532
3.504ArgLeu: 3.504 ± 0.449
0.99ArgMet: 0.99 ± 0.295
2.133ArgAsn: 2.133 ± 0.407
1.828ArgPro: 1.828 ± 0.344
2.666ArgGln: 2.666 ± 0.366
1.98ArgArg: 1.98 ± 0.442
2.438ArgSer: 2.438 ± 0.428
2.895ArgThr: 2.895 ± 0.451
4.799ArgVal: 4.799 ± 0.583
0.838ArgTrp: 0.838 ± 0.312
1.828ArgTyr: 1.828 ± 0.306
0.0ArgXaa: 0.0 ± 0.0
Ser
5.865SerAla: 5.865 ± 0.783
0.533SerCys: 0.533 ± 0.175
4.951SerAsp: 4.951 ± 0.564
3.352SerGlu: 3.352 ± 0.528
3.352SerPhe: 3.352 ± 0.501
6.551SerGly: 6.551 ± 0.752
0.686SerHis: 0.686 ± 0.221
2.666SerIle: 2.666 ± 0.408
3.961SerLys: 3.961 ± 0.614
4.951SerLeu: 4.951 ± 0.688
1.143SerMet: 1.143 ± 0.353
2.057SerAsn: 2.057 ± 0.392
2.057SerPro: 2.057 ± 0.374
2.209SerGln: 2.209 ± 0.394
2.971SerArg: 2.971 ± 0.59
4.647SerSer: 4.647 ± 0.777
3.809SerThr: 3.809 ± 0.6
3.58SerVal: 3.58 ± 0.604
0.686SerTrp: 0.686 ± 0.197
2.285SerTyr: 2.285 ± 0.393
0.0SerXaa: 0.0 ± 0.0
Thr
5.637ThrAla: 5.637 ± 0.712
0.229ThrCys: 0.229 ± 0.123
3.732ThrAsp: 3.732 ± 0.419
2.666ThrGlu: 2.666 ± 0.513
2.895ThrPhe: 2.895 ± 0.477
6.627ThrGly: 6.627 ± 1.076
0.762ThrHis: 0.762 ± 0.231
3.732ThrIle: 3.732 ± 0.414
4.951ThrLys: 4.951 ± 0.617
5.104ThrLeu: 5.104 ± 0.628
1.523ThrMet: 1.523 ± 0.439
2.133ThrAsn: 2.133 ± 0.322
2.666ThrPro: 2.666 ± 0.492
2.361ThrGln: 2.361 ± 0.366
3.047ThrArg: 3.047 ± 0.426
2.895ThrSer: 2.895 ± 0.527
3.961ThrThr: 3.961 ± 0.594
4.19ThrVal: 4.19 ± 0.576
0.762ThrTrp: 0.762 ± 0.27
2.057ThrTyr: 2.057 ± 0.364
0.0ThrXaa: 0.0 ± 0.0
Val
7.084ValAla: 7.084 ± 0.719
1.143ValCys: 1.143 ± 0.321
4.266ValAsp: 4.266 ± 0.602
4.647ValGlu: 4.647 ± 0.448
2.361ValPhe: 2.361 ± 0.443
4.57ValGly: 4.57 ± 0.571
1.447ValHis: 1.447 ± 0.277
3.275ValIle: 3.275 ± 0.516
4.647ValLys: 4.647 ± 0.414
7.008ValLeu: 7.008 ± 0.655
2.057ValMet: 2.057 ± 0.441
3.656ValAsn: 3.656 ± 0.558
3.58ValPro: 3.58 ± 0.545
2.971ValGln: 2.971 ± 0.531
3.275ValArg: 3.275 ± 0.457
5.789ValSer: 5.789 ± 0.795
4.647ValThr: 4.647 ± 0.469
6.399ValVal: 6.399 ± 1.021
0.686ValTrp: 0.686 ± 0.227
3.123ValTyr: 3.123 ± 0.59
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.284
0.229TrpCys: 0.229 ± 0.109
0.99TrpAsp: 0.99 ± 0.344
0.686TrpGlu: 0.686 ± 0.216
0.381TrpPhe: 0.381 ± 0.164
0.686TrpGly: 0.686 ± 0.214
0.305TrpHis: 0.305 ± 0.159
0.305TrpIle: 0.305 ± 0.149
0.609TrpLys: 0.609 ± 0.226
1.6TrpLeu: 1.6 ± 0.382
0.305TrpMet: 0.305 ± 0.138
0.914TrpAsn: 0.914 ± 0.283
0.609TrpPro: 0.609 ± 0.227
0.152TrpGln: 0.152 ± 0.096
0.914TrpArg: 0.914 ± 0.263
0.381TrpSer: 0.381 ± 0.175
0.914TrpThr: 0.914 ± 0.245
1.98TrpVal: 1.98 ± 0.614
0.076TrpTrp: 0.076 ± 0.082
0.457TrpTyr: 0.457 ± 0.242
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.275TyrAla: 3.275 ± 0.446
0.762TyrCys: 0.762 ± 0.24
2.285TyrAsp: 2.285 ± 0.434
2.057TyrGlu: 2.057 ± 0.411
1.066TyrPhe: 1.066 ± 0.298
2.895TyrGly: 2.895 ± 0.45
0.686TyrHis: 0.686 ± 0.205
1.752TyrIle: 1.752 ± 0.397
3.123TyrLys: 3.123 ± 0.395
3.352TyrLeu: 3.352 ± 0.501
0.686TyrMet: 0.686 ± 0.218
2.514TyrAsn: 2.514 ± 0.417
0.914TyrPro: 0.914 ± 0.303
1.447TyrGln: 1.447 ± 0.317
2.438TyrArg: 2.438 ± 0.399
2.209TyrSer: 2.209 ± 0.448
2.514TyrThr: 2.514 ± 0.331
3.275TyrVal: 3.275 ± 0.504
0.457TyrTrp: 0.457 ± 0.174
1.676TyrTyr: 1.676 ± 0.411
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (13129 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski