Amino acid dipepetide frequency for Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.114AlaAla: 17.114 ± 0.194	1.101AlaCys: 1.101 ± 0.033	6.477AlaAsp: 6.477 ± 0.084	6.836AlaGlu: 6.836 ± 0.091	4.277AlaPhe: 4.277 ± 0.064	9.51AlaGly: 9.51 ± 0.096	2.321AlaHis: 2.321 ± 0.042	6.758AlaIle: 6.758 ± 0.086	4.84AlaLys: 4.84 ± 0.087	12.938AlaLeu: 12.938 ± 0.135	3.486AlaMet: 3.486 ± 0.058	3.292AlaAsn: 3.292 ± 0.065	5.894AlaPro: 5.894 ± 0.1	4.166AlaGln: 4.166 ± 0.061	8.764AlaArg: 8.764 ± 0.112	6.976AlaSer: 6.976 ± 0.082	6.529AlaThr: 6.529 ± 0.087	8.461AlaVal: 8.461 ± 0.093	1.395AlaTrp: 1.395 ± 0.038	2.491AlaTyr: 2.491 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.002CysAla: 1.002 ± 0.033	0.129CysCys: 0.129 ± 0.011	0.5CysAsp: 0.5 ± 0.023	0.439CysGlu: 0.439 ± 0.019	0.31CysPhe: 0.31 ± 0.017	0.895CysGly: 0.895 ± 0.03	0.24CysHis: 0.24 ± 0.014	0.418CysIle: 0.418 ± 0.022	0.232CysLys: 0.232 ± 0.015	0.734CysLeu: 0.734 ± 0.027	0.174CysMet: 0.174 ± 0.014	0.209CysAsn: 0.209 ± 0.013	0.451CysPro: 0.451 ± 0.021	0.206CysGln: 0.206 ± 0.012	0.543CysArg: 0.543 ± 0.022	0.48CysSer: 0.48 ± 0.022	0.418CysThr: 0.418 ± 0.019	0.689CysVal: 0.689 ± 0.028	0.118CysTrp: 0.118 ± 0.01	0.191CysTyr: 0.191 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.617AspAla: 6.617 ± 0.088	0.456AspCys: 0.456 ± 0.02	3.237AspAsp: 3.237 ± 0.063	3.457AspGlu: 3.457 ± 0.067	2.047AspPhe: 2.047 ± 0.044	4.638AspGly: 4.638 ± 0.078	1.328AspHis: 1.328 ± 0.041	3.243AspIle: 3.243 ± 0.059	2.002AspLys: 2.002 ± 0.042	5.707AspLeu: 5.707 ± 0.074	1.227AspMet: 1.227 ± 0.027	1.479AspAsn: 1.479 ± 0.034	3.235AspPro: 3.235 ± 0.059	1.631AspGln: 1.631 ± 0.043	3.899AspArg: 3.899 ± 0.056	2.308AspSer: 2.308 ± 0.054	2.691AspThr: 2.691 ± 0.059	4.195AspVal: 4.195 ± 0.063	0.867AspTrp: 0.867 ± 0.025	1.443AspTyr: 1.443 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.271GluAla: 7.271 ± 0.086	0.352GluCys: 0.352 ± 0.018	2.588GluAsp: 2.588 ± 0.052	2.829GluGlu: 2.829 ± 0.066	1.774GluPhe: 1.774 ± 0.037	4.104GluGly: 4.104 ± 0.063	1.223GluHis: 1.223 ± 0.034	3.512GluIle: 3.512 ± 0.06	2.416GluLys: 2.416 ± 0.049	4.978GluLeu: 4.978 ± 0.065	1.518GluMet: 1.518 ± 0.039	1.555GluAsn: 1.555 ± 0.043	2.598GluPro: 2.598 ± 0.055	2.116GluGln: 2.116 ± 0.044	5.027GluArg: 5.027 ± 0.083	2.565GluSer: 2.565 ± 0.048	3.379GluThr: 3.379 ± 0.059	3.744GluVal: 3.744 ± 0.057	0.667GluTrp: 0.667 ± 0.025	0.94GluTyr: 0.94 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.556PheAla: 4.556 ± 0.06	0.369PheCys: 0.369 ± 0.021	2.521PheAsp: 2.521 ± 0.053	2.067PheGlu: 2.067 ± 0.043	1.369PhePhe: 1.369 ± 0.042	3.672PheGly: 3.672 ± 0.07	0.734PheHis: 0.734 ± 0.028	1.853PheIle: 1.853 ± 0.041	1.168PheLys: 1.168 ± 0.03	3.251PheLeu: 3.251 ± 0.063	0.801PheMet: 0.801 ± 0.025	1.163PheAsn: 1.163 ± 0.033	1.577PhePro: 1.577 ± 0.04	1.005PheGln: 1.005 ± 0.029	2.213PheArg: 2.213 ± 0.041	2.242PheSer: 2.242 ± 0.042	2.092PheThr: 2.092 ± 0.05	2.944PheVal: 2.944 ± 0.061	0.512PheTrp: 0.512 ± 0.023	0.895PheTyr: 0.895 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	8.8GlyAla: 8.8 ± 0.102	0.789GlyCys: 0.789 ± 0.029	4.171GlyAsp: 4.171 ± 0.087	4.691GlyGlu: 4.691 ± 0.063	3.508GlyPhe: 3.508 ± 0.061	6.847GlyGly: 6.847 ± 0.114	1.9GlyHis: 1.9 ± 0.037	4.552GlyIle: 4.552 ± 0.067	3.481GlyLys: 3.481 ± 0.065	8.196GlyLeu: 8.196 ± 0.095	2.038GlyMet: 2.038 ± 0.047	2.147GlyAsn: 2.147 ± 0.053	3.306GlyPro: 3.306 ± 0.052	2.565GlyGln: 2.565 ± 0.056	5.674GlyArg: 5.674 ± 0.076	4.539GlySer: 4.539 ± 0.07	4.527GlyThr: 4.527 ± 0.071	6.085GlyVal: 6.085 ± 0.084	1.288GlyTrp: 1.288 ± 0.042	2.257GlyTyr: 2.257 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.481HisAla: 2.481 ± 0.048	0.238HisCys: 0.238 ± 0.016	1.284HisAsp: 1.284 ± 0.037	1.084HisGlu: 1.084 ± 0.03	0.821HisPhe: 0.821 ± 0.028	1.905HisGly: 1.905 ± 0.045	0.598HisHis: 0.598 ± 0.033	1.006HisIle: 1.006 ± 0.031	0.556HisLys: 0.556 ± 0.023	2.034HisLeu: 2.034 ± 0.044	0.47HisMet: 0.47 ± 0.021	0.498HisAsn: 0.498 ± 0.022	1.32HisPro: 1.32 ± 0.033	0.624HisGln: 0.624 ± 0.024	1.482HisArg: 1.482 ± 0.039	0.993HisSer: 0.993 ± 0.027	0.871HisThr: 0.871 ± 0.028	1.527HisVal: 1.527 ± 0.04	0.321HisTrp: 0.321 ± 0.018	0.546HisTyr: 0.546 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.707IleAla: 7.707 ± 0.087	0.518IleCys: 0.518 ± 0.02	3.787IleAsp: 3.787 ± 0.054	3.776IleGlu: 3.776 ± 0.064	1.745IlePhe: 1.745 ± 0.045	5.144IleGly: 5.144 ± 0.078	0.975IleHis: 0.975 ± 0.031	2.482IleIle: 2.482 ± 0.051	1.828IleLys: 1.828 ± 0.046	4.542IleLeu: 4.542 ± 0.068	1.005IleMet: 1.005 ± 0.029	1.55IleAsn: 1.55 ± 0.042	2.399IlePro: 2.399 ± 0.045	1.249IleGln: 1.249 ± 0.035	3.392IleArg: 3.392 ± 0.057	3.072IleSer: 3.072 ± 0.061	2.908IleThr: 2.908 ± 0.057	4.779IleVal: 4.779 ± 0.074	0.63IleTrp: 0.63 ± 0.026	1.219IleTyr: 1.219 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.752LysAla: 4.752 ± 0.074	0.178LysCys: 0.178 ± 0.012	1.97LysAsp: 1.97 ± 0.05	1.834LysGlu: 1.834 ± 0.039	1.098LysPhe: 1.098 ± 0.035	2.793LysGly: 2.793 ± 0.056	0.704LysHis: 0.704 ± 0.026	2.079LysIle: 2.079 ± 0.048	1.714LysLys: 1.714 ± 0.053	3.692LysLeu: 3.692 ± 0.055	0.882LysMet: 0.882 ± 0.031	1.098LysAsn: 1.098 ± 0.032	2.515LysPro: 2.515 ± 0.055	1.161LysGln: 1.161 ± 0.034	2.736LysArg: 2.736 ± 0.047	2.216LysSer: 2.216 ± 0.047	2.366LysThr: 2.366 ± 0.048	2.744LysVal: 2.744 ± 0.048	0.42LysTrp: 0.42 ± 0.018	0.703LysTyr: 0.703 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.084LeuAla: 13.084 ± 0.125	0.819LeuCys: 0.819 ± 0.03	5.648LeuAsp: 5.648 ± 0.069	4.69LeuGlu: 4.69 ± 0.061	3.64LeuPhe: 3.64 ± 0.068	7.806LeuGly: 7.806 ± 0.086	1.835LeuHis: 1.835 ± 0.044	5.223LeuIle: 5.223 ± 0.074	3.888LeuLys: 3.888 ± 0.061	8.927LeuLeu: 8.927 ± 0.13	2.38LeuMet: 2.38 ± 0.046	2.71LeuAsn: 2.71 ± 0.046	5.47LeuPro: 5.47 ± 0.084	2.721LeuGln: 2.721 ± 0.051	6.869LeuArg: 6.869 ± 0.084	6.327LeuSer: 6.327 ± 0.083	5.711LeuThr: 5.711 ± 0.079	7.241LeuVal: 7.241 ± 0.085	1.072LeuTrp: 1.072 ± 0.037	1.948LeuTyr: 1.948 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.93MetAla: 2.93 ± 0.054	0.164MetCys: 0.164 ± 0.012	1.044MetAsp: 1.044 ± 0.032	1.015MetGlu: 1.015 ± 0.033	0.734MetPhe: 0.734 ± 0.026	1.578MetGly: 1.578 ± 0.036	0.442MetHis: 0.442 ± 0.02	1.411MetIle: 1.411 ± 0.043	1.093MetLys: 1.093 ± 0.03	2.438MetLeu: 2.438 ± 0.047	0.684MetMet: 0.684 ± 0.027	0.755MetAsn: 0.755 ± 0.024	1.524MetPro: 1.524 ± 0.037	0.864MetGln: 0.864 ± 0.027	1.811MetArg: 1.811 ± 0.04	1.732MetSer: 1.732 ± 0.039	1.861MetThr: 1.861 ± 0.04	1.673MetVal: 1.673 ± 0.036	0.229MetTrp: 0.229 ± 0.015	0.332MetTyr: 0.332 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.343AsnAla: 3.343 ± 0.054	0.242AsnCys: 0.242 ± 0.015	1.576AsnAsp: 1.576 ± 0.046	1.508AsnGlu: 1.508 ± 0.035	1.043AsnPhe: 1.043 ± 0.027	2.598AsnGly: 2.598 ± 0.062	0.534AsnHis: 0.534 ± 0.021	1.525AsnIle: 1.525 ± 0.04	0.888AsnLys: 0.888 ± 0.027	2.666AsnLeu: 2.666 ± 0.055	0.633AsnMet: 0.633 ± 0.022	0.839AsnAsn: 0.839 ± 0.032	1.846AsnPro: 1.846 ± 0.044	0.766AsnGln: 0.766 ± 0.03	1.863AsnArg: 1.863 ± 0.044	1.311AsnSer: 1.311 ± 0.041	1.35AsnThr: 1.35 ± 0.039	2.147AsnVal: 2.147 ± 0.048	0.46AsnTrp: 0.46 ± 0.019	0.718AsnTyr: 0.718 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.398ProAla: 6.398 ± 0.093	0.334ProCys: 0.334 ± 0.017	3.491ProAsp: 3.491 ± 0.062	3.308ProGlu: 3.308 ± 0.053	2.002ProPhe: 2.002 ± 0.046	4.248ProGly: 4.248 ± 0.061	1.1ProHis: 1.1 ± 0.031	2.452ProIle: 2.452 ± 0.047	1.941ProLys: 1.941 ± 0.047	4.725ProLeu: 4.725 ± 0.066	1.157ProMet: 1.157 ± 0.037	1.561ProAsn: 1.561 ± 0.037	2.926ProPro: 2.926 ± 0.073	1.878ProGln: 1.878 ± 0.045	3.105ProArg: 3.105 ± 0.074	3.039ProSer: 3.039 ± 0.057	2.649ProThr: 2.649 ± 0.051	4.071ProVal: 4.071 ± 0.059	0.679ProTrp: 0.679 ± 0.025	1.208ProTyr: 1.208 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.963GlnAla: 3.963 ± 0.073	0.225GlnCys: 0.225 ± 0.014	1.441GlnAsp: 1.441 ± 0.042	1.347GlnGlu: 1.347 ± 0.036	1.105GlnPhe: 1.105 ± 0.032	2.263GlnGly: 2.263 ± 0.047	0.659GlnHis: 0.659 ± 0.025	1.995GlnIle: 1.995 ± 0.039	1.161GlnLys: 1.161 ± 0.029	2.777GlnLeu: 2.777 ± 0.051	0.799GlnMet: 0.799 ± 0.028	0.99GlnAsn: 0.99 ± 0.034	1.837GlnPro: 1.837 ± 0.045	1.255GlnGln: 1.255 ± 0.041	2.561GlnArg: 2.561 ± 0.058	1.878GlnSer: 1.878 ± 0.041	1.81GlnThr: 1.81 ± 0.046	2.223GlnVal: 2.223 ± 0.054	0.426GlnTrp: 0.426 ± 0.021	0.656GlnTyr: 0.656 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.048ArgAla: 8.048 ± 0.11	0.538ArgCys: 0.538 ± 0.025	4.045ArgAsp: 4.045 ± 0.072	4.387ArgGlu: 4.387 ± 0.072	2.808ArgPhe: 2.808 ± 0.049	4.942ArgGly: 4.942 ± 0.075	1.645ArgHis: 1.645 ± 0.04	4.153ArgIle: 4.153 ± 0.069	2.728ArgLys: 2.728 ± 0.046	7.538ArgLeu: 7.538 ± 0.096	1.802ArgMet: 1.802 ± 0.039	2.016ArgAsn: 2.016 ± 0.04	3.466ArgPro: 3.466 ± 0.075	2.452ArgGln: 2.452 ± 0.052	5.629ArgArg: 5.629 ± 0.091	3.627ArgSer: 3.627 ± 0.058	3.618ArgThr: 3.618 ± 0.054	4.889ArgVal: 4.889 ± 0.077	0.947ArgTrp: 0.947 ± 0.032	1.813ArgTyr: 1.813 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.449SerAla: 6.449 ± 0.08	0.481SerCys: 0.481 ± 0.021	3.103SerAsp: 3.103 ± 0.056	3.061SerGlu: 3.061 ± 0.05	2.376SerPhe: 2.376 ± 0.051	5.353SerGly: 5.353 ± 0.072	1.156SerHis: 1.156 ± 0.035	3.019SerIle: 3.019 ± 0.051	1.868SerLys: 1.868 ± 0.05	5.513SerLeu: 5.513 ± 0.076	1.357SerMet: 1.357 ± 0.034	1.525SerAsn: 1.525 ± 0.04	2.902SerPro: 2.902 ± 0.049	1.739SerGln: 1.739 ± 0.039	3.855SerArg: 3.855 ± 0.065	3.262SerSer: 3.262 ± 0.067	2.826SerThr: 2.826 ± 0.049	4.183SerVal: 4.183 ± 0.061	0.746SerTrp: 0.746 ± 0.028	1.319SerTyr: 1.319 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.248ThrAla: 6.248 ± 0.084	0.457ThrCys: 0.457 ± 0.02	2.927ThrAsp: 2.927 ± 0.051	2.73ThrGlu: 2.73 ± 0.052	2.166ThrPhe: 2.166 ± 0.054	4.775ThrGly: 4.775 ± 0.072	1.086ThrHis: 1.086 ± 0.034	3.145ThrIle: 3.145 ± 0.056	1.841ThrLys: 1.841 ± 0.041	6.083ThrLeu: 6.083 ± 0.08	1.219ThrMet: 1.219 ± 0.034	1.386ThrAsn: 1.386 ± 0.038	3.405ThrPro: 3.405 ± 0.053	1.594ThrGln: 1.594 ± 0.044	3.596ThrArg: 3.596 ± 0.057	3.136ThrSer: 3.136 ± 0.058	3.096ThrThr: 3.096 ± 0.057	4.37ThrVal: 4.37 ± 0.074	0.631ThrTrp: 0.631 ± 0.022	1.21ThrTyr: 1.21 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.186ValAla: 9.186 ± 0.096	0.62ValCys: 0.62 ± 0.025	3.896ValAsp: 3.896 ± 0.057	4.41ValGlu: 4.41 ± 0.054	2.727ValPhe: 2.727 ± 0.054	5.441ValGly: 5.441 ± 0.08	1.394ValHis: 1.394 ± 0.038	4.193ValIle: 4.193 ± 0.079	2.746ValLys: 2.746 ± 0.053	7.372ValLeu: 7.372 ± 0.095	1.928ValMet: 1.928 ± 0.043	2.033ValAsn: 2.033 ± 0.042	3.865ValPro: 3.865 ± 0.063	2.111ValGln: 2.111 ± 0.041	5.103ValArg: 5.103 ± 0.08	4.408ValSer: 4.408 ± 0.063	4.537ValThr: 4.537 ± 0.067	6.137ValVal: 6.137 ± 0.076	0.903ValTrp: 0.903 ± 0.032	1.508ValTyr: 1.508 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.157TrpAla: 1.157 ± 0.037	0.125TrpCys: 0.125 ± 0.01	0.549TrpAsp: 0.549 ± 0.029	0.501TrpGlu: 0.501 ± 0.021	0.495TrpPhe: 0.495 ± 0.02	0.829TrpGly: 0.829 ± 0.03	0.319TrpHis: 0.319 ± 0.018	0.716TrpIle: 0.716 ± 0.027	0.521TrpLys: 0.521 ± 0.023	1.604TrpLeu: 1.604 ± 0.04	0.342TrpMet: 0.342 ± 0.017	0.435TrpAsn: 0.435 ± 0.016	0.689TrpPro: 0.689 ± 0.025	0.564TrpGln: 0.564 ± 0.02	1.157TrpArg: 1.157 ± 0.036	0.845TrpSer: 0.845 ± 0.031	0.726TrpThr: 0.726 ± 0.027	0.79TrpVal: 0.79 ± 0.026	0.223TrpTrp: 0.223 ± 0.017	0.264TrpTyr: 0.264 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.521TyrAla: 2.521 ± 0.052	0.246TyrCys: 0.246 ± 0.015	1.452TyrAsp: 1.452 ± 0.039	1.189TyrGlu: 1.189 ± 0.032	0.958TyrPhe: 0.958 ± 0.028	2.02TyrGly: 2.02 ± 0.042	0.463TyrHis: 0.463 ± 0.019	0.972TyrIle: 0.972 ± 0.028	0.747TyrLys: 0.747 ± 0.028	2.292TyrLeu: 2.292 ± 0.048	0.412TyrMet: 0.412 ± 0.017	0.617TyrAsn: 0.617 ± 0.026	1.043TyrPro: 1.043 ± 0.031	0.705TyrGln: 0.705 ± 0.027	1.809TyrArg: 1.809 ± 0.038	1.137TyrSer: 1.137 ± 0.028	1.136TyrThr: 1.136 ± 0.039	1.626TyrVal: 1.626 ± 0.039	0.316TyrTrp: 0.316 ± 0.016	0.613TyrTyr: 0.613 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3624 proteins (1130278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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