Amino acid dipepetide frequency for Lebombo virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.26AlaAla: 5.26 ± 1.309
0.638AlaCys: 0.638 ± 0.348
3.825AlaAsp: 3.825 ± 0.881
3.507AlaGlu: 3.507 ± 0.812
2.55AlaPhe: 2.55 ± 0.841
3.188AlaGly: 3.188 ± 0.636
1.594AlaHis: 1.594 ± 0.473
3.347AlaIle: 3.347 ± 0.671
4.941AlaLys: 4.941 ± 1.076
9.723AlaLeu: 9.723 ± 1.66
3.985AlaMet: 3.985 ± 0.682
2.231AlaAsn: 2.231 ± 0.592
4.144AlaPro: 4.144 ± 0.824
2.391AlaGln: 2.391 ± 0.692
4.941AlaArg: 4.941 ± 0.971
3.825AlaSer: 3.825 ± 0.657
4.303AlaThr: 4.303 ± 1.241
4.463AlaVal: 4.463 ± 1.028
1.275AlaTrp: 1.275 ± 0.406
2.869AlaTyr: 2.869 ± 0.834
0.0AlaXaa: 0.0 ± 0.0
Cys
0.638CysAla: 0.638 ± 0.203
0.159CysCys: 0.159 ± 0.135
0.956CysAsp: 0.956 ± 0.391
0.478CysGlu: 0.478 ± 0.222
0.638CysPhe: 0.638 ± 0.516
1.116CysGly: 1.116 ± 0.541
0.0CysHis: 0.0 ± 0.0
0.319CysIle: 0.319 ± 0.174
0.478CysLys: 0.478 ± 0.29
0.319CysLeu: 0.319 ± 0.185
0.478CysMet: 0.478 ± 0.227
0.319CysAsn: 0.319 ± 0.196
0.478CysPro: 0.478 ± 0.345
0.159CysGln: 0.159 ± 0.164
0.319CysArg: 0.319 ± 0.295
0.638CysSer: 0.638 ± 0.314
0.319CysThr: 0.319 ± 0.197
0.956CysVal: 0.956 ± 0.436
0.159CysTrp: 0.159 ± 0.147
1.116CysTyr: 1.116 ± 0.386
0.0CysXaa: 0.0 ± 0.0
Asp
4.782AspAla: 4.782 ± 0.755
0.797AspCys: 0.797 ± 0.317
3.825AspAsp: 3.825 ± 1.015
5.1AspGlu: 5.1 ± 0.704
2.391AspPhe: 2.391 ± 0.626
3.666AspGly: 3.666 ± 0.256
0.638AspHis: 0.638 ± 0.329
2.869AspIle: 2.869 ± 0.571
3.507AspLys: 3.507 ± 0.853
4.941AspLeu: 4.941 ± 0.598
1.913AspMet: 1.913 ± 0.387
0.956AspAsn: 0.956 ± 0.315
3.666AspPro: 3.666 ± 0.544
1.594AspGln: 1.594 ± 0.589
4.782AspArg: 4.782 ± 0.635
3.188AspSer: 3.188 ± 0.598
3.347AspThr: 3.347 ± 0.549
6.057AspVal: 6.057 ± 0.746
1.275AspTrp: 1.275 ± 0.524
2.391AspTyr: 2.391 ± 0.852
0.0AspXaa: 0.0 ± 0.0
Glu
5.419GluAla: 5.419 ± 0.772
0.638GluCys: 0.638 ± 0.338
5.738GluAsp: 5.738 ± 0.955
6.376GluGlu: 6.376 ± 1.372
2.71GluPhe: 2.71 ± 0.582
4.463GluGly: 4.463 ± 0.845
1.753GluHis: 1.753 ± 0.638
3.825GluIle: 3.825 ± 0.663
4.463GluLys: 4.463 ± 0.66
3.825GluLeu: 3.825 ± 0.806
2.072GluMet: 2.072 ± 0.242
1.594GluAsn: 1.594 ± 0.376
2.71GluPro: 2.71 ± 0.576
2.072GluGln: 2.072 ± 0.497
5.1GluArg: 5.1 ± 0.979
3.985GluSer: 3.985 ± 0.585
2.231GluThr: 2.231 ± 0.736
5.738GluVal: 5.738 ± 0.87
1.116GluTrp: 1.116 ± 0.288
1.594GluTyr: 1.594 ± 0.404
0.0GluXaa: 0.0 ± 0.0
Phe
2.231PheAla: 2.231 ± 0.792
0.159PheCys: 0.159 ± 0.155
2.71PheAsp: 2.71 ± 0.849
2.391PheGlu: 2.391 ± 0.497
2.391PhePhe: 2.391 ± 0.501
2.71PheGly: 2.71 ± 0.401
0.956PheHis: 0.956 ± 0.506
1.594PheIle: 1.594 ± 0.366
1.434PheLys: 1.434 ± 0.477
3.188PheLeu: 3.188 ± 0.565
0.956PheMet: 0.956 ± 0.437
1.594PheAsn: 1.594 ± 0.53
0.956PhePro: 0.956 ± 0.333
1.753PheGln: 1.753 ± 0.732
3.188PheArg: 3.188 ± 0.552
3.507PheSer: 3.507 ± 0.945
2.55PheThr: 2.55 ± 0.654
3.028PheVal: 3.028 ± 0.718
0.478PheTrp: 0.478 ± 0.209
1.753PheTyr: 1.753 ± 0.485
0.0PheXaa: 0.0 ± 0.0
Gly
3.825GlyAla: 3.825 ± 0.781
0.797GlyCys: 0.797 ± 0.5
4.303GlyAsp: 4.303 ± 1.127
5.26GlyGlu: 5.26 ± 1.356
1.753GlyPhe: 1.753 ± 0.616
5.419GlyGly: 5.419 ± 1.636
0.956GlyHis: 0.956 ± 0.347
2.072GlyIle: 2.072 ± 0.47
3.347GlyLys: 3.347 ± 0.754
5.1GlyLeu: 5.1 ± 0.984
2.869GlyMet: 2.869 ± 0.628
2.231GlyAsn: 2.231 ± 0.633
2.072GlyPro: 2.072 ± 0.551
1.275GlyGln: 1.275 ± 0.578
3.985GlyArg: 3.985 ± 0.854
3.985GlySer: 3.985 ± 0.806
3.666GlyThr: 3.666 ± 0.997
6.694GlyVal: 6.694 ± 1.157
1.275GlyTrp: 1.275 ± 0.67
1.913GlyTyr: 1.913 ± 0.703
0.0GlyXaa: 0.0 ± 0.0
His
1.434HisAla: 1.434 ± 0.387
0.0HisCys: 0.0 ± 0.0
1.434HisAsp: 1.434 ± 0.588
1.753HisGlu: 1.753 ± 0.446
0.319HisPhe: 0.319 ± 0.302
1.594HisGly: 1.594 ± 0.361
1.275HisHis: 1.275 ± 0.582
0.797HisIle: 0.797 ± 0.423
0.956HisLys: 0.956 ± 0.286
3.985HisLeu: 3.985 ± 0.791
0.797HisMet: 0.797 ± 0.347
0.478HisAsn: 0.478 ± 0.25
1.116HisPro: 1.116 ± 0.33
0.319HisGln: 0.319 ± 0.226
1.913HisArg: 1.913 ± 0.675
0.956HisSer: 0.956 ± 0.277
0.956HisThr: 0.956 ± 0.275
1.594HisVal: 1.594 ± 0.359
0.159HisTrp: 0.159 ± 0.164
1.434HisTyr: 1.434 ± 0.515
0.0HisXaa: 0.0 ± 0.0
Ile
4.782IleAla: 4.782 ± 0.831
0.797IleCys: 0.797 ± 0.384
3.507IleAsp: 3.507 ± 0.627
3.666IleGlu: 3.666 ± 0.873
2.55IlePhe: 2.55 ± 0.737
2.869IleGly: 2.869 ± 0.685
0.797IleHis: 0.797 ± 0.388
2.71IleIle: 2.71 ± 0.371
4.303IleLys: 4.303 ± 0.78
4.463IleLeu: 4.463 ± 0.743
1.753IleMet: 1.753 ± 0.457
2.869IleAsn: 2.869 ± 0.793
3.028IlePro: 3.028 ± 0.712
2.231IleGln: 2.231 ± 0.639
4.941IleArg: 4.941 ± 0.473
3.666IleSer: 3.666 ± 0.697
3.347IleThr: 3.347 ± 0.834
3.188IleVal: 3.188 ± 0.394
0.319IleTrp: 0.319 ± 0.196
2.55IleTyr: 2.55 ± 0.734
0.0IleXaa: 0.0 ± 0.0
Lys
4.144LysAla: 4.144 ± 1.017
0.638LysCys: 0.638 ± 0.307
2.869LysAsp: 2.869 ± 0.861
4.463LysGlu: 4.463 ± 1.269
2.231LysPhe: 2.231 ± 0.634
2.71LysGly: 2.71 ± 0.617
1.594LysHis: 1.594 ± 0.33
4.463LysIle: 4.463 ± 1.028
4.463LysLys: 4.463 ± 1.362
4.463LysLeu: 4.463 ± 1.3
1.594LysMet: 1.594 ± 0.368
1.434LysAsn: 1.434 ± 0.35
1.594LysPro: 1.594 ± 0.606
1.594LysGln: 1.594 ± 0.58
4.303LysArg: 4.303 ± 0.73
3.347LysSer: 3.347 ± 0.872
3.507LysThr: 3.507 ± 0.578
3.347LysVal: 3.347 ± 0.72
0.638LysTrp: 0.638 ± 0.283
2.072LysTyr: 2.072 ± 0.438
0.0LysXaa: 0.0 ± 0.0
Leu
5.579LeuAla: 5.579 ± 1.072
1.116LeuCys: 1.116 ± 0.373
7.172LeuAsp: 7.172 ± 0.78
6.376LeuGlu: 6.376 ± 1.085
3.507LeuPhe: 3.507 ± 0.646
5.26LeuGly: 5.26 ± 0.692
2.71LeuHis: 2.71 ± 0.936
4.144LeuIle: 4.144 ± 0.673
4.144LeuLys: 4.144 ± 0.685
7.172LeuLeu: 7.172 ± 1.177
3.188LeuMet: 3.188 ± 0.67
3.666LeuAsn: 3.666 ± 0.793
5.26LeuPro: 5.26 ± 0.902
3.507LeuGln: 3.507 ± 1.201
8.448LeuArg: 8.448 ± 1.514
7.491LeuSer: 7.491 ± 1.093
4.622LeuThr: 4.622 ± 0.721
3.825LeuVal: 3.825 ± 0.708
1.116LeuTrp: 1.116 ± 0.42
1.753LeuTyr: 1.753 ± 0.489
0.0LeuXaa: 0.0 ± 0.0
Met
2.71MetAla: 2.71 ± 0.465
0.319MetCys: 0.319 ± 0.197
1.116MetAsp: 1.116 ± 0.613
2.072MetGlu: 2.072 ± 0.375
1.116MetPhe: 1.116 ± 0.381
0.638MetGly: 0.638 ± 0.249
0.797MetHis: 0.797 ± 0.269
2.55MetIle: 2.55 ± 0.423
1.275MetLys: 1.275 ± 0.339
5.738MetLeu: 5.738 ± 0.77
1.594MetMet: 1.594 ± 0.611
1.753MetAsn: 1.753 ± 0.555
0.638MetPro: 0.638 ± 0.33
1.594MetGln: 1.594 ± 0.538
3.188MetArg: 3.188 ± 1.075
2.869MetSer: 2.869 ± 0.513
1.594MetThr: 1.594 ± 0.553
2.231MetVal: 2.231 ± 0.393
0.159MetTrp: 0.159 ± 0.147
0.797MetTyr: 0.797 ± 0.305
0.0MetXaa: 0.0 ± 0.0
Asn
3.188AsnAla: 3.188 ± 0.818
0.159AsnCys: 0.159 ± 0.164
1.913AsnAsp: 1.913 ± 0.465
1.753AsnGlu: 1.753 ± 0.3
1.116AsnPhe: 1.116 ± 0.613
2.391AsnGly: 2.391 ± 0.783
0.478AsnHis: 0.478 ± 0.212
2.072AsnIle: 2.072 ± 0.475
1.594AsnLys: 1.594 ± 0.49
3.825AsnLeu: 3.825 ± 0.651
1.434AsnMet: 1.434 ± 0.628
0.956AsnAsn: 0.956 ± 0.585
1.913AsnPro: 1.913 ± 0.894
1.913AsnGln: 1.913 ± 0.431
2.55AsnArg: 2.55 ± 0.795
2.072AsnSer: 2.072 ± 0.797
1.913AsnThr: 1.913 ± 0.62
3.507AsnVal: 3.507 ± 0.771
0.319AsnTrp: 0.319 ± 0.285
1.116AsnTyr: 1.116 ± 0.323
0.0AsnXaa: 0.0 ± 0.0
Pro
1.594ProAla: 1.594 ± 0.852
0.319ProCys: 0.319 ± 0.201
2.55ProAsp: 2.55 ± 0.568
2.072ProGlu: 2.072 ± 0.433
1.753ProPhe: 1.753 ± 0.471
3.028ProGly: 3.028 ± 1.026
1.116ProHis: 1.116 ± 0.23
4.303ProIle: 4.303 ± 0.663
2.71ProLys: 2.71 ± 0.329
2.869ProLeu: 2.869 ± 0.381
0.797ProMet: 0.797 ± 0.423
1.753ProAsn: 1.753 ± 0.535
2.072ProPro: 2.072 ± 0.63
1.753ProGln: 1.753 ± 0.33
3.985ProArg: 3.985 ± 0.697
1.434ProSer: 1.434 ± 0.432
3.347ProThr: 3.347 ± 0.747
2.71ProVal: 2.71 ± 0.408
0.478ProTrp: 0.478 ± 0.303
2.71ProTyr: 2.71 ± 0.615
0.0ProXaa: 0.0 ± 0.0
Gln
2.55GlnAla: 2.55 ± 0.561
0.159GlnCys: 0.159 ± 0.151
2.072GlnAsp: 2.072 ± 0.918
2.072GlnGlu: 2.072 ± 1.07
2.072GlnPhe: 2.072 ± 0.626
3.028GlnGly: 3.028 ± 0.783
0.478GlnHis: 0.478 ± 0.268
2.391GlnIle: 2.391 ± 0.761
0.797GlnLys: 0.797 ± 0.246
2.072GlnLeu: 2.072 ± 0.524
1.275GlnMet: 1.275 ± 0.368
1.434GlnAsn: 1.434 ± 0.439
1.275GlnPro: 1.275 ± 0.403
1.434GlnGln: 1.434 ± 0.658
2.391GlnArg: 2.391 ± 0.69
2.231GlnSer: 2.231 ± 0.693
2.072GlnThr: 2.072 ± 0.493
2.231GlnVal: 2.231 ± 0.905
0.478GlnTrp: 0.478 ± 0.245
0.319GlnTyr: 0.319 ± 0.167
0.0GlnXaa: 0.0 ± 0.0
Arg
4.941ArgAla: 4.941 ± 0.898
0.797ArgCys: 0.797 ± 0.34
4.144ArgAsp: 4.144 ± 0.775
6.535ArgGlu: 6.535 ± 0.883
3.985ArgPhe: 3.985 ± 0.615
5.1ArgGly: 5.1 ± 0.817
0.797ArgHis: 0.797 ± 0.318
3.666ArgIle: 3.666 ± 0.889
4.144ArgLys: 4.144 ± 0.669
7.332ArgLeu: 7.332 ± 1.055
2.869ArgMet: 2.869 ± 0.618
3.347ArgAsn: 3.347 ± 0.879
1.434ArgPro: 1.434 ± 0.404
1.753ArgGln: 1.753 ± 0.308
4.941ArgArg: 4.941 ± 1.104
2.869ArgSer: 2.869 ± 0.604
4.622ArgThr: 4.622 ± 0.653
7.81ArgVal: 7.81 ± 1.34
0.478ArgTrp: 0.478 ± 0.335
2.072ArgTyr: 2.072 ± 0.444
0.0ArgXaa: 0.0 ± 0.0
Ser
5.26SerAla: 5.26 ± 0.849
0.478SerCys: 0.478 ± 0.345
3.825SerAsp: 3.825 ± 0.497
4.463SerGlu: 4.463 ± 0.769
2.391SerPhe: 2.391 ± 0.396
3.825SerGly: 3.825 ± 0.699
2.231SerHis: 2.231 ± 0.706
4.303SerIle: 4.303 ± 0.509
4.463SerLys: 4.463 ± 0.645
6.535SerLeu: 6.535 ± 1.07
1.594SerMet: 1.594 ± 0.53
1.913SerAsn: 1.913 ± 0.492
2.55SerPro: 2.55 ± 0.691
1.275SerGln: 1.275 ± 0.385
3.347SerArg: 3.347 ± 1.085
5.1SerSer: 5.1 ± 1.071
3.985SerThr: 3.985 ± 1.107
3.985SerVal: 3.985 ± 0.755
0.797SerTrp: 0.797 ± 0.249
1.753SerTyr: 1.753 ± 0.474
0.0SerXaa: 0.0 ± 0.0
Thr
3.666ThrAla: 3.666 ± 1.048
0.159ThrCys: 0.159 ± 0.151
2.072ThrAsp: 2.072 ± 0.711
2.869ThrGlu: 2.869 ± 0.775
2.55ThrPhe: 2.55 ± 0.728
3.985ThrGly: 3.985 ± 0.876
1.116ThrHis: 1.116 ± 0.453
3.666ThrIle: 3.666 ± 1.223
2.072ThrLys: 2.072 ± 0.888
5.419ThrLeu: 5.419 ± 1.075
1.594ThrMet: 1.594 ± 0.618
2.231ThrAsn: 2.231 ± 0.578
2.71ThrPro: 2.71 ± 0.83
3.028ThrGln: 3.028 ± 0.912
3.347ThrArg: 3.347 ± 0.518
4.463ThrSer: 4.463 ± 0.632
1.753ThrThr: 1.753 ± 0.6
3.347ThrVal: 3.347 ± 1.041
1.116ThrTrp: 1.116 ± 0.42
1.116ThrTyr: 1.116 ± 0.565
0.0ThrXaa: 0.0 ± 0.0
Val
7.172ValAla: 7.172 ± 0.848
0.638ValCys: 0.638 ± 0.317
3.985ValAsp: 3.985 ± 1.113
3.507ValGlu: 3.507 ± 0.812
2.072ValPhe: 2.072 ± 0.475
3.028ValGly: 3.028 ± 0.671
2.391ValHis: 2.391 ± 0.498
6.057ValIle: 6.057 ± 0.804
4.622ValLys: 4.622 ± 0.766
5.26ValLeu: 5.26 ± 0.982
1.434ValMet: 1.434 ± 0.618
3.825ValAsn: 3.825 ± 0.38
4.622ValPro: 4.622 ± 1.148
2.231ValGln: 2.231 ± 0.508
4.463ValArg: 4.463 ± 1.081
5.419ValSer: 5.419 ± 0.786
1.594ValThr: 1.594 ± 0.441
5.1ValVal: 5.1 ± 0.842
1.594ValTrp: 1.594 ± 0.509
3.507ValTyr: 3.507 ± 0.727
0.0ValXaa: 0.0 ± 0.0
Trp
1.116TrpAla: 1.116 ± 0.396
0.478TrpCys: 0.478 ± 0.362
1.434TrpAsp: 1.434 ± 0.277
1.275TrpGlu: 1.275 ± 0.49
0.478TrpPhe: 0.478 ± 0.203
1.275TrpGly: 1.275 ± 0.507
0.638TrpHis: 0.638 ± 0.452
0.159TrpIle: 0.159 ± 0.151
0.638TrpLys: 0.638 ± 0.36
1.275TrpLeu: 1.275 ± 0.426
0.797TrpMet: 0.797 ± 0.669
0.478TrpAsn: 0.478 ± 0.235
0.159TrpPro: 0.159 ± 0.237
0.0TrpGln: 0.0 ± 0.0
1.275TrpArg: 1.275 ± 0.563
0.319TrpSer: 0.319 ± 0.192
0.797TrpThr: 0.797 ± 0.436
0.638TrpVal: 0.638 ± 0.273
0.159TrpTrp: 0.159 ± 0.147
0.478TrpTyr: 0.478 ± 0.303
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.71TyrAla: 2.71 ± 0.468
0.797TyrCys: 0.797 ± 0.318
2.231TyrAsp: 2.231 ± 0.688
1.434TyrGlu: 1.434 ± 0.433
0.956TyrPhe: 0.956 ± 0.253
3.507TyrGly: 3.507 ± 0.913
0.956TyrHis: 0.956 ± 0.305
3.028TyrIle: 3.028 ± 0.435
1.116TyrLys: 1.116 ± 0.295
2.55TyrLeu: 2.55 ± 0.584
1.594TyrMet: 1.594 ± 0.369
1.116TyrAsn: 1.116 ± 0.285
0.956TyrPro: 0.956 ± 0.163
0.956TyrGln: 0.956 ± 0.375
2.231TyrArg: 2.231 ± 0.57
2.71TyrSer: 2.71 ± 0.818
1.913TyrThr: 1.913 ± 0.516
2.072TyrVal: 2.072 ± 0.486
0.478TyrTrp: 0.478 ± 0.345
1.594TyrTyr: 1.594 ± 0.468
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (6275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski