Amino acid dipepetide frequency for Bole Tick Virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.052AlaAla: 4.052 ± 0.809
0.27AlaCys: 0.27 ± 0.14
2.971AlaAsp: 2.971 ± 0.848
3.782AlaGlu: 3.782 ± 0.58
2.431AlaPhe: 2.431 ± 0.8
4.862AlaGly: 4.862 ± 0.824
2.431AlaHis: 2.431 ± 1.244
4.862AlaIle: 4.862 ± 0.841
1.621AlaLys: 1.621 ± 0.369
6.213AlaLeu: 6.213 ± 0.23
1.08AlaMet: 1.08 ± 0.56
1.08AlaAsn: 1.08 ± 0.306
4.052AlaPro: 4.052 ± 1.872
1.621AlaGln: 1.621 ± 0.493
2.971AlaArg: 2.971 ± 0.826
4.052AlaSer: 4.052 ± 0.994
4.862AlaThr: 4.862 ± 1.552
3.512AlaVal: 3.512 ± 0.914
1.891AlaTrp: 1.891 ± 0.795
2.161AlaTyr: 2.161 ± 0.658
0.0AlaXaa: 0.0 ± 0.0
Cys
0.81CysAla: 0.81 ± 0.813
0.81CysCys: 0.81 ± 0.94
0.27CysAsp: 0.27 ± 0.14
0.54CysGlu: 0.54 ± 0.28
0.54CysPhe: 0.54 ± 0.28
1.08CysGly: 1.08 ± 1.054
0.0CysHis: 0.0 ± 0.0
1.621CysIle: 1.621 ± 0.437
0.54CysLys: 0.54 ± 0.266
1.08CysLeu: 1.08 ± 0.593
0.0CysMet: 0.0 ± 0.0
1.08CysAsn: 1.08 ± 0.365
0.81CysPro: 0.81 ± 0.94
0.0CysGln: 0.0 ± 0.0
1.351CysArg: 1.351 ± 0.901
0.54CysSer: 0.54 ± 0.266
1.351CysThr: 1.351 ± 0.7
0.81CysVal: 0.81 ± 0.325
0.81CysTrp: 0.81 ± 0.287
1.08CysTyr: 1.08 ± 0.365
0.0CysXaa: 0.0 ± 0.0
Asp
1.351AspAla: 1.351 ± 0.546
1.08AspCys: 1.08 ± 0.593
2.161AspAsp: 2.161 ± 0.555
1.351AspGlu: 1.351 ± 0.546
3.512AspPhe: 3.512 ± 1.115
2.971AspGly: 2.971 ± 0.943
1.351AspHis: 1.351 ± 0.603
1.891AspIle: 1.891 ± 0.942
2.161AspLys: 2.161 ± 0.631
8.374AspLeu: 8.374 ± 0.779
0.54AspMet: 0.54 ± 0.296
1.351AspAsn: 1.351 ± 0.349
5.673AspPro: 5.673 ± 1.169
2.161AspGln: 2.161 ± 0.573
2.971AspArg: 2.971 ± 1.26
0.54AspSer: 0.54 ± 0.28
2.431AspThr: 2.431 ± 0.827
2.701AspVal: 2.701 ± 0.803
1.891AspTrp: 1.891 ± 0.556
1.621AspTyr: 1.621 ± 0.594
0.0AspXaa: 0.0 ± 0.0
Glu
6.213GluAla: 6.213 ± 1.207
0.81GluCys: 0.81 ± 0.351
2.701GluAsp: 2.701 ± 0.361
6.753GluGlu: 6.753 ± 1.717
3.782GluPhe: 3.782 ± 0.918
4.052GluGly: 4.052 ± 0.489
1.891GluHis: 1.891 ± 0.705
4.592GluIle: 4.592 ± 0.72
2.701GluLys: 2.701 ± 0.591
3.782GluLeu: 3.782 ± 0.587
1.08GluMet: 1.08 ± 0.321
1.08GluAsn: 1.08 ± 0.677
4.052GluPro: 4.052 ± 0.478
1.351GluGln: 1.351 ± 0.655
3.512GluArg: 3.512 ± 0.55
3.512GluSer: 3.512 ± 1.534
2.701GluThr: 2.701 ± 0.705
7.023GluVal: 7.023 ± 0.753
0.81GluTrp: 0.81 ± 0.425
1.891GluTyr: 1.891 ± 0.854
0.0GluXaa: 0.0 ± 0.0
Phe
2.161PheAla: 2.161 ± 0.807
0.54PheCys: 0.54 ± 0.266
1.621PheAsp: 1.621 ± 0.84
2.701PheGlu: 2.701 ± 0.715
2.971PhePhe: 2.971 ± 0.282
2.161PheGly: 2.161 ± 0.573
1.08PheHis: 1.08 ± 0.306
3.241PheIle: 3.241 ± 0.616
2.431PheLys: 2.431 ± 0.613
4.592PheLeu: 4.592 ± 0.601
0.54PheMet: 0.54 ± 0.28
0.81PheAsn: 0.81 ± 0.329
2.701PhePro: 2.701 ± 0.787
1.891PheGln: 1.891 ± 0.629
3.241PheArg: 3.241 ± 0.91
4.862PheSer: 4.862 ± 0.541
2.161PheThr: 2.161 ± 0.91
2.701PheVal: 2.701 ± 0.818
1.351PheTrp: 1.351 ± 0.591
1.621PheTyr: 1.621 ± 0.506
0.0PheXaa: 0.0 ± 0.0
Gly
3.241GlyAla: 3.241 ± 0.409
1.351GlyCys: 1.351 ± 0.472
2.701GlyAsp: 2.701 ± 0.543
2.971GlyGlu: 2.971 ± 0.36
1.891GlyPhe: 1.891 ± 0.561
3.512GlyGly: 3.512 ± 0.911
0.54GlyHis: 0.54 ± 0.28
3.512GlyIle: 3.512 ± 0.923
2.431GlyLys: 2.431 ± 0.42
12.696GlyLeu: 12.696 ± 3.132
1.08GlyMet: 1.08 ± 0.306
0.81GlyAsn: 0.81 ± 0.42
3.512GlyPro: 3.512 ± 1.401
4.052GlyGln: 4.052 ± 0.974
4.052GlyArg: 4.052 ± 0.843
5.402GlySer: 5.402 ± 0.879
4.322GlyThr: 4.322 ± 1.205
4.052GlyVal: 4.052 ± 1.087
1.621GlyTrp: 1.621 ± 0.557
1.891GlyTyr: 1.891 ± 0.532
0.0GlyXaa: 0.0 ± 0.0
His
1.351HisAla: 1.351 ± 0.35
0.54HisCys: 0.54 ± 0.28
0.81HisAsp: 0.81 ± 0.431
1.351HisGlu: 1.351 ± 0.526
1.351HisPhe: 1.351 ± 0.506
0.54HisGly: 0.54 ± 0.266
0.27HisHis: 0.27 ± 0.14
1.351HisIle: 1.351 ± 0.644
0.81HisLys: 0.81 ± 0.267
3.512HisLeu: 3.512 ± 0.863
0.27HisMet: 0.27 ± 0.14
0.27HisAsn: 0.27 ± 0.313
3.782HisPro: 3.782 ± 1.163
1.891HisGln: 1.891 ± 0.729
1.08HisArg: 1.08 ± 0.56
1.621HisSer: 1.621 ± 0.242
1.351HisThr: 1.351 ± 0.513
1.621HisVal: 1.621 ± 0.83
1.351HisTrp: 1.351 ± 0.535
0.54HisTyr: 0.54 ± 0.331
0.0HisXaa: 0.0 ± 0.0
Ile
3.241IleAla: 3.241 ± 1.006
1.621IleCys: 1.621 ± 0.797
1.351IleAsp: 1.351 ± 0.546
2.161IleGlu: 2.161 ± 0.927
2.971IlePhe: 2.971 ± 0.926
4.322IleGly: 4.322 ± 0.8
2.431IleHis: 2.431 ± 0.716
1.891IleIle: 1.891 ± 0.932
4.592IleLys: 4.592 ± 0.773
6.213IleLeu: 6.213 ± 0.661
1.08IleMet: 1.08 ± 0.416
1.891IleAsn: 1.891 ± 0.538
5.673IlePro: 5.673 ± 1.092
1.351IleGln: 1.351 ± 0.358
4.592IleArg: 4.592 ± 1.262
5.132IleSer: 5.132 ± 0.615
2.431IleThr: 2.431 ± 1.111
2.161IleVal: 2.161 ± 0.453
1.351IleTrp: 1.351 ± 0.513
1.08IleTyr: 1.08 ± 0.397
0.0IleXaa: 0.0 ± 0.0
Lys
3.241LysAla: 3.241 ± 0.327
1.08LysCys: 1.08 ± 0.566
2.971LysAsp: 2.971 ± 0.65
2.971LysGlu: 2.971 ± 0.615
0.54LysPhe: 0.54 ± 0.296
6.753LysGly: 6.753 ± 1.313
1.08LysHis: 1.08 ± 0.532
1.621LysIle: 1.621 ± 0.992
1.891LysLys: 1.891 ± 0.629
4.862LysLeu: 4.862 ± 0.635
1.621LysMet: 1.621 ± 0.594
1.891LysAsn: 1.891 ± 0.778
2.161LysPro: 2.161 ± 0.607
1.08LysGln: 1.08 ± 0.56
1.891LysArg: 1.891 ± 0.722
3.241LysSer: 3.241 ± 0.474
3.241LysThr: 3.241 ± 1.023
3.241LysVal: 3.241 ± 0.459
1.351LysTrp: 1.351 ± 0.7
1.891LysTyr: 1.891 ± 0.619
0.0LysXaa: 0.0 ± 0.0
Leu
7.293LeuAla: 7.293 ± 0.75
0.0LeuCys: 0.0 ± 0.0
5.943LeuAsp: 5.943 ± 0.571
6.483LeuGlu: 6.483 ± 1.475
5.943LeuPhe: 5.943 ± 0.859
5.402LeuGly: 5.402 ± 0.831
2.701LeuHis: 2.701 ± 1.053
8.374LeuIle: 8.374 ± 1.624
4.862LeuLys: 4.862 ± 0.888
10.535LeuLeu: 10.535 ± 1.304
4.052LeuMet: 4.052 ± 0.455
3.241LeuAsn: 3.241 ± 0.286
5.943LeuPro: 5.943 ± 1.051
4.322LeuGln: 4.322 ± 1.049
8.374LeuArg: 8.374 ± 1.847
7.563LeuSer: 7.563 ± 0.799
7.023LeuThr: 7.023 ± 0.744
6.753LeuVal: 6.753 ± 1.068
2.161LeuTrp: 2.161 ± 0.758
1.891LeuTyr: 1.891 ± 0.335
0.0LeuXaa: 0.0 ± 0.0
Met
2.161MetAla: 2.161 ± 0.399
0.27MetCys: 0.27 ± 0.313
0.54MetAsp: 0.54 ± 0.331
1.351MetGlu: 1.351 ± 0.701
1.08MetPhe: 1.08 ± 0.363
0.81MetGly: 0.81 ± 0.287
0.27MetHis: 0.27 ± 0.379
1.621MetIle: 1.621 ± 0.84
0.81MetLys: 0.81 ± 0.425
1.351MetLeu: 1.351 ± 0.644
0.54MetMet: 0.54 ± 0.32
0.81MetAsn: 0.81 ± 0.287
1.08MetPro: 1.08 ± 0.414
1.08MetGln: 1.08 ± 0.414
1.351MetArg: 1.351 ± 0.758
1.351MetSer: 1.351 ± 0.526
2.701MetThr: 2.701 ± 0.368
1.08MetVal: 1.08 ± 0.382
0.54MetTrp: 0.54 ± 0.281
1.08MetTyr: 1.08 ± 0.56
0.0MetXaa: 0.0 ± 0.0
Asn
0.81AsnAla: 0.81 ± 0.329
0.27AsnCys: 0.27 ± 0.313
1.351AsnAsp: 1.351 ± 0.472
2.161AsnGlu: 2.161 ± 0.437
1.351AsnPhe: 1.351 ± 0.545
1.621AsnGly: 1.621 ± 1.128
1.08AsnHis: 1.08 ± 0.262
1.08AsnIle: 1.08 ± 0.416
1.621AsnLys: 1.621 ± 0.574
3.241AsnLeu: 3.241 ± 0.399
0.27AsnMet: 0.27 ± 0.14
1.621AsnAsn: 1.621 ± 0.397
1.621AsnPro: 1.621 ± 0.39
1.891AsnGln: 1.891 ± 0.221
0.81AsnArg: 0.81 ± 0.325
2.701AsnSer: 2.701 ± 0.818
1.891AsnThr: 1.891 ± 0.705
1.891AsnVal: 1.891 ± 0.421
0.27AsnTrp: 0.27 ± 0.313
1.08AsnTyr: 1.08 ± 0.371
0.0AsnXaa: 0.0 ± 0.0
Pro
4.052ProAla: 4.052 ± 1.187
0.54ProCys: 0.54 ± 0.28
5.402ProAsp: 5.402 ± 0.708
5.402ProGlu: 5.402 ± 0.863
1.351ProPhe: 1.351 ± 0.394
4.052ProGly: 4.052 ± 1.296
1.891ProHis: 1.891 ± 0.394
2.701ProIle: 2.701 ± 1.101
2.971ProLys: 2.971 ± 0.401
8.644ProLeu: 8.644 ± 1.744
0.81ProMet: 0.81 ± 0.724
2.161ProAsn: 2.161 ± 0.958
5.673ProPro: 5.673 ± 1.327
2.161ProGln: 2.161 ± 0.705
3.241ProArg: 3.241 ± 0.887
6.753ProSer: 6.753 ± 1.181
3.782ProThr: 3.782 ± 0.547
2.971ProVal: 2.971 ± 0.837
0.54ProTrp: 0.54 ± 0.28
1.351ProTyr: 1.351 ± 0.535
0.0ProXaa: 0.0 ± 0.0
Gln
1.351GlnAla: 1.351 ± 1.181
0.0GlnCys: 0.0 ± 0.0
2.701GlnAsp: 2.701 ± 1.564
2.971GlnGlu: 2.971 ± 0.684
1.08GlnPhe: 1.08 ± 0.56
3.512GlnGly: 3.512 ± 0.459
0.0GlnHis: 0.0 ± 0.0
2.971GlnIle: 2.971 ± 1.242
3.241GlnLys: 3.241 ± 0.82
2.431GlnLeu: 2.431 ± 0.691
1.08GlnMet: 1.08 ± 0.408
1.08GlnAsn: 1.08 ± 0.593
1.351GlnPro: 1.351 ± 0.526
0.54GlnGln: 0.54 ± 0.281
1.891GlnArg: 1.891 ± 0.476
3.512GlnSer: 3.512 ± 1.004
1.891GlnThr: 1.891 ± 0.565
3.241GlnVal: 3.241 ± 0.699
0.27GlnTrp: 0.27 ± 0.379
1.351GlnTyr: 1.351 ± 0.591
0.0GlnXaa: 0.0 ± 0.0
Arg
4.052ArgAla: 4.052 ± 1.133
1.08ArgCys: 1.08 ± 0.365
2.971ArgAsp: 2.971 ± 0.857
5.402ArgGlu: 5.402 ± 1.621
2.701ArgPhe: 2.701 ± 0.748
2.431ArgGly: 2.431 ± 0.459
1.08ArgHis: 1.08 ± 0.56
2.701ArgIle: 2.701 ± 1.026
3.512ArgLys: 3.512 ± 0.542
7.293ArgLeu: 7.293 ± 0.953
1.891ArgMet: 1.891 ± 0.626
1.621ArgAsn: 1.621 ± 0.506
4.052ArgPro: 4.052 ± 2.138
2.701ArgGln: 2.701 ± 0.42
4.322ArgArg: 4.322 ± 0.793
4.592ArgSer: 4.592 ± 1.061
2.701ArgThr: 2.701 ± 0.8
4.592ArgVal: 4.592 ± 1.264
0.54ArgTrp: 0.54 ± 0.266
1.621ArgTyr: 1.621 ± 0.39
0.0ArgXaa: 0.0 ± 0.0
Ser
5.402SerAla: 5.402 ± 1.32
1.891SerCys: 1.891 ± 0.731
2.971SerAsp: 2.971 ± 0.363
4.052SerGlu: 4.052 ± 1.237
3.241SerPhe: 3.241 ± 0.889
4.322SerGly: 4.322 ± 0.818
1.891SerHis: 1.891 ± 0.795
6.483SerIle: 6.483 ± 0.461
4.052SerLys: 4.052 ± 0.925
7.023SerLeu: 7.023 ± 1.469
0.81SerMet: 0.81 ± 0.706
2.161SerAsn: 2.161 ± 0.574
4.052SerPro: 4.052 ± 0.595
2.701SerGln: 2.701 ± 1.025
5.402SerArg: 5.402 ± 1.179
6.483SerSer: 6.483 ± 2.373
4.052SerThr: 4.052 ± 0.953
3.512SerVal: 3.512 ± 0.704
2.161SerTrp: 2.161 ± 0.573
1.621SerTyr: 1.621 ± 0.369
0.0SerXaa: 0.0 ± 0.0
Thr
2.971ThrAla: 2.971 ± 1.132
1.351ThrCys: 1.351 ± 0.901
3.512ThrAsp: 3.512 ± 1.673
2.971ThrGlu: 2.971 ± 0.964
1.351ThrPhe: 1.351 ± 0.535
5.673ThrGly: 5.673 ± 0.759
2.161ThrHis: 2.161 ± 0.55
2.431ThrIle: 2.431 ± 0.37
2.971ThrLys: 2.971 ± 1.011
7.834ThrLeu: 7.834 ± 2.039
2.431ThrMet: 2.431 ± 0.768
1.621ThrAsn: 1.621 ± 0.397
2.971ThrPro: 2.971 ± 1.752
1.08ThrGln: 1.08 ± 0.416
4.322ThrArg: 4.322 ± 0.996
4.052ThrSer: 4.052 ± 1.25
2.161ThrThr: 2.161 ± 1.226
2.701ThrVal: 2.701 ± 0.439
1.08ThrTrp: 1.08 ± 0.414
2.431ThrTyr: 2.431 ± 1.224
0.0ThrXaa: 0.0 ± 0.0
Val
3.241ValAla: 3.241 ± 1.397
1.08ValCys: 1.08 ± 0.262
2.971ValAsp: 2.971 ± 0.658
4.052ValGlu: 4.052 ± 0.607
4.052ValPhe: 4.052 ± 0.909
3.782ValGly: 3.782 ± 0.931
1.621ValHis: 1.621 ± 0.431
2.971ValIle: 2.971 ± 0.253
2.431ValLys: 2.431 ± 0.76
5.132ValLeu: 5.132 ± 0.853
1.891ValMet: 1.891 ± 0.613
2.431ValAsn: 2.431 ± 0.723
4.862ValPro: 4.862 ± 0.536
1.891ValGln: 1.891 ± 0.421
2.971ValArg: 2.971 ± 0.508
5.132ValSer: 5.132 ± 1.429
4.052ValThr: 4.052 ± 0.679
4.592ValVal: 4.592 ± 0.93
0.0ValTrp: 0.0 ± 0.0
1.891ValTyr: 1.891 ± 0.335
0.0ValXaa: 0.0 ± 0.0
Trp
2.161TrpAla: 2.161 ± 0.658
0.54TrpCys: 0.54 ± 0.28
1.08TrpAsp: 1.08 ± 0.306
2.971TrpGlu: 2.971 ± 1.101
1.621TrpPhe: 1.621 ± 0.594
1.621TrpGly: 1.621 ± 0.574
0.81TrpHis: 0.81 ± 0.364
1.08TrpIle: 1.08 ± 0.262
1.621TrpLys: 1.621 ± 0.424
0.81TrpLeu: 0.81 ± 0.267
0.0TrpMet: 0.0 ± 0.0
0.54TrpAsn: 0.54 ± 0.266
0.54TrpPro: 0.54 ± 0.28
0.27TrpGln: 0.27 ± 0.14
1.351TrpArg: 1.351 ± 1.162
0.81TrpSer: 0.81 ± 0.364
1.08TrpThr: 1.08 ± 0.598
1.08TrpVal: 1.08 ± 0.262
0.27TrpTrp: 0.27 ± 0.313
0.54TrpTyr: 0.54 ± 0.28
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.621TyrAla: 1.621 ± 0.437
0.0TyrCys: 0.0 ± 0.0
1.08TyrAsp: 1.08 ± 0.532
1.891TyrGlu: 1.891 ± 0.561
1.621TyrPhe: 1.621 ± 0.951
2.161TyrGly: 2.161 ± 1.12
1.08TyrHis: 1.08 ± 0.382
0.54TyrIle: 0.54 ± 0.28
1.351TyrLys: 1.351 ± 0.351
3.241TyrLeu: 3.241 ± 0.399
0.54TyrMet: 0.54 ± 0.296
1.08TyrAsn: 1.08 ± 0.416
2.161TyrPro: 2.161 ± 0.507
2.431TyrGln: 2.431 ± 0.666
2.161TyrArg: 2.161 ± 0.406
2.431TyrSer: 2.431 ± 0.459
1.891TyrThr: 1.891 ± 1.114
0.81TyrVal: 0.81 ± 0.431
0.54TyrTrp: 0.54 ± 0.486
1.891TyrTyr: 1.891 ± 0.581
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3703 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski