Amino acid dipepetide frequency for Paracoccus phage vB_PmaS-R3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.334AlaAla: 13.334 ± 2.092
0.843AlaCys: 0.843 ± 0.253
7.357AlaAsp: 7.357 ± 0.854
6.667AlaGlu: 6.667 ± 0.96
4.215AlaPhe: 4.215 ± 0.492
6.897AlaGly: 6.897 ± 0.744
2.146AlaHis: 2.146 ± 0.545
5.364AlaIle: 5.364 ± 0.533
6.514AlaLys: 6.514 ± 1.28
8.583AlaLeu: 8.583 ± 1.064
2.682AlaMet: 2.682 ± 0.541
2.989AlaAsn: 2.989 ± 0.486
4.675AlaPro: 4.675 ± 0.82
4.138AlaGln: 4.138 ± 0.576
5.901AlaArg: 5.901 ± 0.993
6.82AlaSer: 6.82 ± 1.123
7.28AlaThr: 7.28 ± 0.983
6.361AlaVal: 6.361 ± 0.742
1.992AlaTrp: 1.992 ± 0.386
4.828AlaTyr: 4.828 ± 0.635
0.0AlaXaa: 0.0 ± 0.0
Cys
0.69CysAla: 0.69 ± 0.21
0.077CysCys: 0.077 ± 0.061
0.996CysAsp: 0.996 ± 0.274
0.46CysGlu: 0.46 ± 0.188
0.23CysPhe: 0.23 ± 0.134
0.766CysGly: 0.766 ± 0.216
0.613CysHis: 0.613 ± 0.221
0.383CysIle: 0.383 ± 0.17
0.843CysLys: 0.843 ± 0.248
0.536CysLeu: 0.536 ± 0.171
0.153CysMet: 0.153 ± 0.112
0.307CysAsn: 0.307 ± 0.169
0.307CysPro: 0.307 ± 0.16
0.153CysGln: 0.153 ± 0.116
0.536CysArg: 0.536 ± 0.205
0.46CysSer: 0.46 ± 0.146
0.077CysThr: 0.077 ± 0.067
0.613CysVal: 0.613 ± 0.268
0.077CysTrp: 0.077 ± 0.083
0.383CysTyr: 0.383 ± 0.168
0.0CysXaa: 0.0 ± 0.0
Asp
8.506AspAla: 8.506 ± 0.938
0.383AspCys: 0.383 ± 0.157
5.671AspAsp: 5.671 ± 0.749
5.211AspGlu: 5.211 ± 0.596
1.992AspPhe: 1.992 ± 0.354
6.744AspGly: 6.744 ± 0.8
0.92AspHis: 0.92 ± 0.287
2.069AspIle: 2.069 ± 0.397
3.219AspLys: 3.219 ± 0.452
5.134AspLeu: 5.134 ± 0.611
2.069AspMet: 2.069 ± 0.387
3.449AspAsn: 3.449 ± 0.594
3.525AspPro: 3.525 ± 0.621
1.456AspGln: 1.456 ± 0.267
3.832AspArg: 3.832 ± 0.719
1.456AspSer: 1.456 ± 0.38
4.828AspThr: 4.828 ± 0.728
6.131AspVal: 6.131 ± 0.546
1.686AspTrp: 1.686 ± 0.311
2.529AspTyr: 2.529 ± 0.477
0.0AspXaa: 0.0 ± 0.0
Glu
8.047GluAla: 8.047 ± 1.013
0.383GluCys: 0.383 ± 0.172
3.525GluAsp: 3.525 ± 0.676
4.138GluGlu: 4.138 ± 0.493
2.452GluPhe: 2.452 ± 0.433
3.985GluGly: 3.985 ± 0.551
1.379GluHis: 1.379 ± 0.312
2.682GluIle: 2.682 ± 0.446
2.606GluLys: 2.606 ± 0.506
4.751GluLeu: 4.751 ± 0.502
1.686GluMet: 1.686 ± 0.384
1.533GluAsn: 1.533 ± 0.382
2.835GluPro: 2.835 ± 0.559
1.763GluGln: 1.763 ± 0.381
3.219GluArg: 3.219 ± 0.545
1.763GluSer: 1.763 ± 0.364
3.372GluThr: 3.372 ± 0.587
3.525GluVal: 3.525 ± 0.663
1.303GluTrp: 1.303 ± 0.289
2.146GluTyr: 2.146 ± 0.44
0.0GluXaa: 0.0 ± 0.0
Phe
3.678PheAla: 3.678 ± 0.57
0.307PheCys: 0.307 ± 0.125
3.602PheAsp: 3.602 ± 0.414
1.839PheGlu: 1.839 ± 0.404
1.15PhePhe: 1.15 ± 0.298
3.372PheGly: 3.372 ± 0.412
0.613PheHis: 0.613 ± 0.186
2.222PheIle: 2.222 ± 0.398
1.226PheLys: 1.226 ± 0.327
1.839PheLeu: 1.839 ± 0.369
0.46PheMet: 0.46 ± 0.174
1.15PheAsn: 1.15 ± 0.325
1.379PhePro: 1.379 ± 0.28
1.226PheGln: 1.226 ± 0.297
1.916PheArg: 1.916 ± 0.32
1.686PheSer: 1.686 ± 0.366
2.682PheThr: 2.682 ± 0.569
2.989PheVal: 2.989 ± 0.411
0.46PheTrp: 0.46 ± 0.193
1.379PheTyr: 1.379 ± 0.289
0.0PheXaa: 0.0 ± 0.0
Gly
6.897GlyAla: 6.897 ± 0.751
0.153GlyCys: 0.153 ± 0.099
5.594GlyAsp: 5.594 ± 0.715
5.058GlyGlu: 5.058 ± 0.512
3.678GlyPhe: 3.678 ± 0.582
7.05GlyGly: 7.05 ± 1.046
2.146GlyHis: 2.146 ± 0.46
3.142GlyIle: 3.142 ± 0.522
3.678GlyLys: 3.678 ± 0.569
5.977GlyLeu: 5.977 ± 0.675
1.456GlyMet: 1.456 ± 0.305
3.908GlyAsn: 3.908 ± 0.521
3.525GlyPro: 3.525 ± 0.513
4.138GlyGln: 4.138 ± 1.262
3.985GlyArg: 3.985 ± 0.558
4.905GlySer: 4.905 ± 0.755
6.284GlyThr: 6.284 ± 0.666
6.437GlyVal: 6.437 ± 0.915
1.839GlyTrp: 1.839 ± 0.488
3.295GlyTyr: 3.295 ± 0.602
0.0GlyXaa: 0.0 ± 0.0
His
1.916HisAla: 1.916 ± 0.377
0.23HisCys: 0.23 ± 0.137
1.609HisAsp: 1.609 ± 0.38
1.379HisGlu: 1.379 ± 0.318
0.69HisPhe: 0.69 ± 0.272
1.609HisGly: 1.609 ± 0.455
0.153HisHis: 0.153 ± 0.108
0.996HisIle: 0.996 ± 0.265
1.226HisLys: 1.226 ± 0.291
1.073HisLeu: 1.073 ± 0.28
0.23HisMet: 0.23 ± 0.142
0.843HisAsn: 0.843 ± 0.22
0.536HisPro: 0.536 ± 0.215
0.69HisGln: 0.69 ± 0.223
0.996HisArg: 0.996 ± 0.337
0.996HisSer: 0.996 ± 0.271
1.379HisThr: 1.379 ± 0.217
1.533HisVal: 1.533 ± 0.396
0.23HisTrp: 0.23 ± 0.147
0.92HisTyr: 0.92 ± 0.258
0.0HisXaa: 0.0 ± 0.0
Ile
4.751IleAla: 4.751 ± 0.636
0.69IleCys: 0.69 ± 0.248
4.675IleAsp: 4.675 ± 0.529
2.682IleGlu: 2.682 ± 0.447
1.15IlePhe: 1.15 ± 0.272
3.065IleGly: 3.065 ± 0.493
0.46IleHis: 0.46 ± 0.185
1.456IleIle: 1.456 ± 0.318
1.763IleLys: 1.763 ± 0.309
2.376IleLeu: 2.376 ± 0.537
0.46IleMet: 0.46 ± 0.204
1.686IleAsn: 1.686 ± 0.376
2.912IlePro: 2.912 ± 0.517
1.15IleGln: 1.15 ± 0.35
2.835IleArg: 2.835 ± 0.514
1.916IleSer: 1.916 ± 0.328
2.835IleThr: 2.835 ± 0.413
1.992IleVal: 1.992 ± 0.34
0.307IleTrp: 0.307 ± 0.2
1.379IleTyr: 1.379 ± 0.32
0.0IleXaa: 0.0 ± 0.0
Lys
6.207LysAla: 6.207 ± 1.293
0.383LysCys: 0.383 ± 0.189
2.452LysAsp: 2.452 ± 0.514
2.682LysGlu: 2.682 ± 0.596
1.533LysPhe: 1.533 ± 0.244
3.985LysGly: 3.985 ± 0.471
0.92LysHis: 0.92 ± 0.311
0.996LysIle: 0.996 ± 0.29
2.299LysLys: 2.299 ± 0.548
4.675LysLeu: 4.675 ± 0.704
0.843LysMet: 0.843 ± 0.288
2.299LysAsn: 2.299 ± 0.396
2.222LysPro: 2.222 ± 0.379
1.303LysGln: 1.303 ± 0.303
4.062LysArg: 4.062 ± 0.553
2.299LysSer: 2.299 ± 0.354
3.832LysThr: 3.832 ± 0.639
3.678LysVal: 3.678 ± 0.536
0.46LysTrp: 0.46 ± 0.164
0.92LysTyr: 0.92 ± 0.268
0.0LysXaa: 0.0 ± 0.0
Leu
8.813LeuAla: 8.813 ± 0.847
0.996LeuCys: 0.996 ± 0.312
5.364LeuAsp: 5.364 ± 0.823
3.755LeuGlu: 3.755 ± 0.608
1.686LeuPhe: 1.686 ± 0.325
4.905LeuGly: 4.905 ± 0.7
1.763LeuHis: 1.763 ± 0.362
3.449LeuIle: 3.449 ± 0.485
2.989LeuLys: 2.989 ± 0.498
4.138LeuLeu: 4.138 ± 0.435
1.533LeuMet: 1.533 ± 0.256
3.908LeuAsn: 3.908 ± 0.562
4.215LeuPro: 4.215 ± 0.513
2.989LeuGln: 2.989 ± 0.42
6.054LeuArg: 6.054 ± 0.715
4.215LeuSer: 4.215 ± 0.585
6.667LeuThr: 6.667 ± 0.621
4.828LeuVal: 4.828 ± 0.473
1.609LeuTrp: 1.609 ± 0.323
2.069LeuTyr: 2.069 ± 0.454
0.0LeuXaa: 0.0 ± 0.0
Met
2.376MetAla: 2.376 ± 0.514
0.23MetCys: 0.23 ± 0.126
0.536MetAsp: 0.536 ± 0.209
1.073MetGlu: 1.073 ± 0.238
0.383MetPhe: 0.383 ± 0.134
1.533MetGly: 1.533 ± 0.338
0.383MetHis: 0.383 ± 0.264
0.69MetIle: 0.69 ± 0.25
1.456MetLys: 1.456 ± 0.336
2.069MetLeu: 2.069 ± 0.327
0.077MetMet: 0.077 ± 0.071
0.69MetAsn: 0.69 ± 0.304
1.456MetPro: 1.456 ± 0.258
1.226MetGln: 1.226 ± 0.269
0.996MetArg: 0.996 ± 0.275
1.916MetSer: 1.916 ± 0.451
1.839MetThr: 1.839 ± 0.543
1.839MetVal: 1.839 ± 0.506
0.153MetTrp: 0.153 ± 0.092
0.46MetTyr: 0.46 ± 0.163
0.0MetXaa: 0.0 ± 0.0
Asn
5.441AsnAla: 5.441 ± 0.628
0.383AsnCys: 0.383 ± 0.161
2.606AsnAsp: 2.606 ± 0.478
2.452AsnGlu: 2.452 ± 0.494
0.92AsnPhe: 0.92 ± 0.266
4.675AsnGly: 4.675 ± 0.67
0.536AsnHis: 0.536 ± 0.18
1.686AsnIle: 1.686 ± 0.287
1.839AsnLys: 1.839 ± 0.306
2.989AsnLeu: 2.989 ± 0.478
0.843AsnMet: 0.843 ± 0.235
1.992AsnAsn: 1.992 ± 0.464
1.839AsnPro: 1.839 ± 0.299
1.609AsnGln: 1.609 ± 0.313
2.146AsnArg: 2.146 ± 0.434
1.839AsnSer: 1.839 ± 0.451
2.759AsnThr: 2.759 ± 0.405
3.678AsnVal: 3.678 ± 0.428
0.613AsnTrp: 0.613 ± 0.186
0.996AsnTyr: 0.996 ± 0.271
0.0AsnXaa: 0.0 ± 0.0
Pro
4.598ProAla: 4.598 ± 0.569
0.383ProCys: 0.383 ± 0.18
3.142ProAsp: 3.142 ± 0.605
2.299ProGlu: 2.299 ± 0.429
1.839ProPhe: 1.839 ± 0.312
4.062ProGly: 4.062 ± 0.617
0.766ProHis: 0.766 ± 0.265
2.146ProIle: 2.146 ± 0.426
2.835ProLys: 2.835 ± 0.487
3.985ProLeu: 3.985 ± 0.663
0.766ProMet: 0.766 ± 0.231
2.529ProAsn: 2.529 ± 0.438
2.146ProPro: 2.146 ± 0.419
2.759ProGln: 2.759 ± 0.739
2.529ProArg: 2.529 ± 0.438
2.069ProSer: 2.069 ± 0.409
3.832ProThr: 3.832 ± 0.595
4.062ProVal: 4.062 ± 0.538
0.843ProTrp: 0.843 ± 0.28
1.303ProTyr: 1.303 ± 0.343
0.0ProXaa: 0.0 ± 0.0
Gln
4.062GlnAla: 4.062 ± 0.987
0.0GlnCys: 0.0 ± 0.0
1.533GlnAsp: 1.533 ± 0.306
1.15GlnGlu: 1.15 ± 0.289
1.073GlnPhe: 1.073 ± 0.275
3.372GlnGly: 3.372 ± 1.189
1.073GlnHis: 1.073 ± 0.307
1.839GlnIle: 1.839 ± 0.292
0.69GlnLys: 0.69 ± 0.206
3.755GlnLeu: 3.755 ± 0.528
1.303GlnMet: 1.303 ± 0.337
1.686GlnAsn: 1.686 ± 0.289
3.065GlnPro: 3.065 ± 1.018
2.146GlnGln: 2.146 ± 0.402
3.602GlnArg: 3.602 ± 0.598
2.222GlnSer: 2.222 ± 0.265
1.456GlnThr: 1.456 ± 0.333
2.069GlnVal: 2.069 ± 0.367
0.23GlnTrp: 0.23 ± 0.139
1.533GlnTyr: 1.533 ± 0.366
0.0GlnXaa: 0.0 ± 0.0
Arg
5.518ArgAla: 5.518 ± 0.726
0.843ArgCys: 0.843 ± 0.244
4.675ArgAsp: 4.675 ± 0.695
3.372ArgGlu: 3.372 ± 0.622
2.146ArgPhe: 2.146 ± 0.455
4.521ArgGly: 4.521 ± 0.636
1.226ArgHis: 1.226 ± 0.361
3.142ArgIle: 3.142 ± 0.551
3.449ArgLys: 3.449 ± 0.615
6.591ArgLeu: 6.591 ± 0.632
1.379ArgMet: 1.379 ± 0.344
2.835ArgAsn: 2.835 ± 0.568
2.222ArgPro: 2.222 ± 0.572
2.376ArgGln: 2.376 ± 0.486
3.678ArgArg: 3.678 ± 0.656
3.525ArgSer: 3.525 ± 0.591
3.219ArgThr: 3.219 ± 0.452
3.449ArgVal: 3.449 ± 0.442
0.843ArgTrp: 0.843 ± 0.222
2.069ArgTyr: 2.069 ± 0.359
0.0ArgXaa: 0.0 ± 0.0
Ser
5.824SerAla: 5.824 ± 0.582
0.46SerCys: 0.46 ± 0.205
3.295SerAsp: 3.295 ± 0.481
2.222SerGlu: 2.222 ± 0.475
1.073SerPhe: 1.073 ± 0.221
6.207SerGly: 6.207 ± 0.983
0.843SerHis: 0.843 ± 0.214
2.376SerIle: 2.376 ± 0.607
1.916SerLys: 1.916 ± 0.353
4.981SerLeu: 4.981 ± 0.507
1.226SerMet: 1.226 ± 0.253
1.992SerAsn: 1.992 ± 0.364
2.835SerPro: 2.835 ± 0.513
2.069SerGln: 2.069 ± 0.365
2.759SerArg: 2.759 ± 0.445
2.912SerSer: 2.912 ± 0.638
2.912SerThr: 2.912 ± 0.511
3.908SerVal: 3.908 ± 0.485
0.843SerTrp: 0.843 ± 0.251
1.609SerTyr: 1.609 ± 0.312
0.0SerXaa: 0.0 ± 0.0
Thr
7.204ThrAla: 7.204 ± 1.179
0.23ThrCys: 0.23 ± 0.115
5.441ThrAsp: 5.441 ± 0.63
4.138ThrGlu: 4.138 ± 0.504
3.065ThrPhe: 3.065 ± 0.498
5.594ThrGly: 5.594 ± 0.688
0.843ThrHis: 0.843 ± 0.241
2.222ThrIle: 2.222 ± 0.439
3.372ThrLys: 3.372 ± 0.427
3.832ThrLeu: 3.832 ± 0.649
1.686ThrMet: 1.686 ± 0.387
2.606ThrAsn: 2.606 ± 0.535
3.832ThrPro: 3.832 ± 0.463
2.835ThrGln: 2.835 ± 0.443
3.908ThrArg: 3.908 ± 0.581
2.835ThrSer: 2.835 ± 0.373
3.602ThrThr: 3.602 ± 0.689
5.824ThrVal: 5.824 ± 0.781
0.536ThrTrp: 0.536 ± 0.183
2.529ThrTyr: 2.529 ± 0.629
0.0ThrXaa: 0.0 ± 0.0
Val
7.51ValAla: 7.51 ± 0.718
0.69ValCys: 0.69 ± 0.199
5.134ValAsp: 5.134 ± 0.486
3.832ValGlu: 3.832 ± 0.537
3.602ValPhe: 3.602 ± 0.423
6.131ValGly: 6.131 ± 0.752
1.073ValHis: 1.073 ± 0.249
2.299ValIle: 2.299 ± 0.527
3.678ValLys: 3.678 ± 0.532
4.751ValLeu: 4.751 ± 0.639
1.686ValMet: 1.686 ± 0.253
2.835ValAsn: 2.835 ± 0.478
3.065ValPro: 3.065 ± 0.486
2.682ValGln: 2.682 ± 0.328
4.062ValArg: 4.062 ± 0.481
4.751ValSer: 4.751 ± 0.607
4.675ValThr: 4.675 ± 0.755
5.594ValVal: 5.594 ± 0.69
1.15ValTrp: 1.15 ± 0.259
2.529ValTyr: 2.529 ± 0.52
0.0ValXaa: 0.0 ± 0.0
Trp
1.226TrpAla: 1.226 ± 0.282
0.307TrpCys: 0.307 ± 0.14
0.613TrpAsp: 0.613 ± 0.216
0.613TrpGlu: 0.613 ± 0.203
0.92TrpPhe: 0.92 ± 0.374
1.15TrpGly: 1.15 ± 0.375
0.383TrpHis: 0.383 ± 0.159
0.307TrpIle: 0.307 ± 0.134
1.073TrpLys: 1.073 ± 0.279
1.226TrpLeu: 1.226 ± 0.277
0.153TrpMet: 0.153 ± 0.107
0.613TrpAsn: 0.613 ± 0.202
0.69TrpPro: 0.69 ± 0.232
0.46TrpGln: 0.46 ± 0.187
1.456TrpArg: 1.456 ± 0.256
1.379TrpSer: 1.379 ± 0.348
0.843TrpThr: 0.843 ± 0.2
1.15TrpVal: 1.15 ± 0.273
0.153TrpTrp: 0.153 ± 0.092
1.15TrpTyr: 1.15 ± 0.255
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.989TyrAla: 2.989 ± 0.386
0.69TyrCys: 0.69 ± 0.248
2.989TyrAsp: 2.989 ± 0.463
2.069TyrGlu: 2.069 ± 0.402
1.379TyrPhe: 1.379 ± 0.366
3.525TyrGly: 3.525 ± 0.673
0.996TyrHis: 0.996 ± 0.225
1.073TyrIle: 1.073 ± 0.284
1.379TyrLys: 1.379 ± 0.269
2.682TyrLeu: 2.682 ± 0.432
0.613TyrMet: 0.613 ± 0.208
1.992TyrAsn: 1.992 ± 0.372
1.686TyrPro: 1.686 ± 0.389
0.69TyrGln: 0.69 ± 0.222
2.606TyrArg: 2.606 ± 0.422
2.299TyrSer: 2.299 ± 0.395
1.763TyrThr: 1.763 ± 0.292
2.069TyrVal: 2.069 ± 0.33
0.536TyrTrp: 0.536 ± 0.201
0.69TyrTyr: 0.69 ± 0.209
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (13050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski