Amino acid dipepetide frequency for Streptococcus satellite phage Javan265

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.452AlaAla: 0.452 ± 0.367
0.0AlaCys: 0.0 ± 0.0
1.807AlaAsp: 1.807 ± 1.054
5.872AlaGlu: 5.872 ± 2.067
3.162AlaPhe: 3.162 ± 0.911
3.613AlaGly: 3.613 ± 1.644
0.903AlaHis: 0.903 ± 0.407
5.872AlaIle: 5.872 ± 2.336
3.613AlaLys: 3.613 ± 1.097
4.968AlaLeu: 4.968 ± 2.141
1.355AlaMet: 1.355 ± 0.732
1.807AlaAsn: 1.807 ± 0.81
2.71AlaPro: 2.71 ± 0.751
1.807AlaGln: 1.807 ± 0.859
2.258AlaArg: 2.258 ± 0.826
4.065AlaSer: 4.065 ± 1.284
4.968AlaThr: 4.968 ± 1.371
1.355AlaVal: 1.355 ± 0.695
0.0AlaTrp: 0.0 ± 0.0
4.065AlaTyr: 4.065 ± 1.149
0.0AlaXaa: 0.0 ± 0.0
Cys
0.452CysAla: 0.452 ± 0.491
0.0CysCys: 0.0 ± 0.0
0.452CysAsp: 0.452 ± 0.483
0.452CysGlu: 0.452 ± 0.488
0.903CysPhe: 0.903 ± 0.792
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.452CysLys: 0.452 ± 0.367
0.903CysLeu: 0.903 ± 0.705
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.452CysArg: 0.452 ± 0.367
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.452CysTrp: 0.452 ± 0.342
0.452CysTyr: 0.452 ± 0.601
0.0CysXaa: 0.0 ± 0.0
Asp
1.355AspAla: 1.355 ± 0.57
1.355AspCys: 1.355 ± 1.324
2.71AspAsp: 2.71 ± 1.381
4.968AspGlu: 4.968 ± 1.694
3.162AspPhe: 3.162 ± 1.01
2.71AspGly: 2.71 ± 0.546
0.0AspHis: 0.0 ± 0.0
4.065AspIle: 4.065 ± 1.363
6.775AspLys: 6.775 ± 1.813
4.968AspLeu: 4.968 ± 1.099
3.613AspMet: 3.613 ± 1.344
4.517AspAsn: 4.517 ± 0.932
0.0AspPro: 0.0 ± 0.0
0.452AspGln: 0.452 ± 0.505
1.355AspArg: 1.355 ± 0.805
2.258AspSer: 2.258 ± 0.984
2.71AspThr: 2.71 ± 0.934
2.71AspVal: 2.71 ± 1.095
0.903AspTrp: 0.903 ± 0.505
3.613AspTyr: 3.613 ± 0.865
0.0AspXaa: 0.0 ± 0.0
Glu
3.162GluAla: 3.162 ± 1.207
0.903GluCys: 0.903 ± 0.667
6.775GluAsp: 6.775 ± 1.811
7.227GluGlu: 7.227 ± 2.944
3.162GluPhe: 3.162 ± 1.206
1.807GluGly: 1.807 ± 0.794
1.355GluHis: 1.355 ± 0.735
3.162GluIle: 3.162 ± 1.23
8.582GluLys: 8.582 ± 1.7
12.195GluLeu: 12.195 ± 3.448
1.355GluMet: 1.355 ± 0.831
5.42GluAsn: 5.42 ± 1.589
1.807GluPro: 1.807 ± 0.748
4.968GluGln: 4.968 ± 1.192
4.968GluArg: 4.968 ± 1.077
3.613GluSer: 3.613 ± 1.506
2.71GluThr: 2.71 ± 0.953
6.323GluVal: 6.323 ± 1.197
0.903GluTrp: 0.903 ± 0.546
3.613GluTyr: 3.613 ± 1.555
0.0GluXaa: 0.0 ± 0.0
Phe
0.0PheAla: 0.0 ± 0.0
0.0PheCys: 0.0 ± 0.0
3.162PheAsp: 3.162 ± 1.661
2.71PheGlu: 2.71 ± 1.187
1.355PhePhe: 1.355 ± 0.729
2.71PheGly: 2.71 ± 1.136
1.807PheHis: 1.807 ± 0.961
2.71PheIle: 2.71 ± 0.704
3.613PheLys: 3.613 ± 0.882
4.968PheLeu: 4.968 ± 1.631
0.452PheMet: 0.452 ± 0.367
2.71PheAsn: 2.71 ± 0.783
0.903PhePro: 0.903 ± 0.579
0.903PheGln: 0.903 ± 0.446
2.258PheArg: 2.258 ± 0.599
4.065PheSer: 4.065 ± 1.146
1.807PheThr: 1.807 ± 0.61
0.903PheVal: 0.903 ± 0.505
0.452PheTrp: 0.452 ± 0.342
4.968PheTyr: 4.968 ± 1.854
0.0PheXaa: 0.0 ± 0.0
Gly
4.517GlyAla: 4.517 ± 1.913
0.452GlyCys: 0.452 ± 0.367
2.71GlyAsp: 2.71 ± 1.282
3.613GlyGlu: 3.613 ± 0.836
3.613GlyPhe: 3.613 ± 1.112
1.355GlyGly: 1.355 ± 0.958
0.903GlyHis: 0.903 ± 0.626
4.968GlyIle: 4.968 ± 1.489
4.968GlyLys: 4.968 ± 1.562
4.065GlyLeu: 4.065 ± 1.423
0.452GlyMet: 0.452 ± 0.444
1.807GlyAsn: 1.807 ± 1.44
0.0GlyPro: 0.0 ± 0.0
1.355GlyGln: 1.355 ± 0.821
2.258GlyArg: 2.258 ± 0.577
2.258GlySer: 2.258 ± 0.911
3.613GlyThr: 3.613 ± 1.325
3.162GlyVal: 3.162 ± 1.26
0.903GlyTrp: 0.903 ± 0.505
2.71GlyTyr: 2.71 ± 0.805
0.0GlyXaa: 0.0 ± 0.0
His
1.355HisAla: 1.355 ± 1.1
0.0HisCys: 0.0 ± 0.0
0.903HisAsp: 0.903 ± 0.569
1.807HisGlu: 1.807 ± 0.775
0.903HisPhe: 0.903 ± 0.446
0.903HisGly: 0.903 ± 0.622
0.0HisHis: 0.0 ± 0.0
2.258HisIle: 2.258 ± 1.242
0.903HisLys: 0.903 ± 0.525
1.807HisLeu: 1.807 ± 0.658
0.0HisMet: 0.0 ± 0.0
0.903HisAsn: 0.903 ± 0.69
0.452HisPro: 0.452 ± 0.342
1.355HisGln: 1.355 ± 1.025
1.355HisArg: 1.355 ± 0.695
0.0HisSer: 0.0 ± 0.0
0.452HisThr: 0.452 ± 0.367
0.452HisVal: 0.452 ± 0.452
0.0HisTrp: 0.0 ± 0.0
0.903HisTyr: 0.903 ± 0.675
0.0HisXaa: 0.0 ± 0.0
Ile
5.872IleAla: 5.872 ± 1.778
0.452IleCys: 0.452 ± 0.452
4.968IleAsp: 4.968 ± 1.459
3.613IleGlu: 3.613 ± 1.139
3.162IlePhe: 3.162 ± 1.218
2.71IleGly: 2.71 ± 0.905
1.807IleHis: 1.807 ± 0.641
3.162IleIle: 3.162 ± 1.386
11.292IleLys: 11.292 ± 2.037
6.323IleLeu: 6.323 ± 1.745
1.355IleMet: 1.355 ± 0.821
5.872IleAsn: 5.872 ± 1.518
4.065IlePro: 4.065 ± 1.179
3.162IleGln: 3.162 ± 1.181
2.71IleArg: 2.71 ± 1.339
2.71IleSer: 2.71 ± 1.534
4.517IleThr: 4.517 ± 1.041
3.162IleVal: 3.162 ± 0.961
0.452IleTrp: 0.452 ± 0.342
0.903IleTyr: 0.903 ± 0.525
0.0IleXaa: 0.0 ± 0.0
Lys
4.968LysAla: 4.968 ± 1.732
0.0LysCys: 0.0 ± 0.0
4.517LysAsp: 4.517 ± 1.451
14.905LysGlu: 14.905 ± 2.549
1.807LysPhe: 1.807 ± 1.16
4.968LysGly: 4.968 ± 1.243
0.452LysHis: 0.452 ± 0.491
9.033LysIle: 9.033 ± 1.425
7.227LysLys: 7.227 ± 1.72
4.968LysLeu: 4.968 ± 1.263
2.258LysMet: 2.258 ± 0.852
1.355LysAsn: 1.355 ± 0.657
5.42LysPro: 5.42 ± 1.619
6.775LysGln: 6.775 ± 1.302
5.872LysArg: 5.872 ± 1.489
4.968LysSer: 4.968 ± 0.908
6.323LysThr: 6.323 ± 1.6
4.517LysVal: 4.517 ± 0.892
0.0LysTrp: 0.0 ± 0.0
3.162LysTyr: 3.162 ± 1.514
0.0LysXaa: 0.0 ± 0.0
Leu
7.678LeuAla: 7.678 ± 1.331
0.0LeuCys: 0.0 ± 0.0
6.775LeuAsp: 6.775 ± 1.459
10.388LeuGlu: 10.388 ± 2.134
3.162LeuPhe: 3.162 ± 1.12
6.323LeuGly: 6.323 ± 1.427
1.355LeuHis: 1.355 ± 0.756
7.227LeuIle: 7.227 ± 1.758
7.678LeuLys: 7.678 ± 1.312
8.13LeuLeu: 8.13 ± 1.797
3.613LeuMet: 3.613 ± 1.287
9.033LeuAsn: 9.033 ± 2.553
4.968LeuPro: 4.968 ± 0.983
4.517LeuGln: 4.517 ± 1.19
2.258LeuArg: 2.258 ± 0.783
4.517LeuSer: 4.517 ± 1.712
4.968LeuThr: 4.968 ± 1.282
4.968LeuVal: 4.968 ± 1.115
0.452LeuTrp: 0.452 ± 0.367
4.065LeuTyr: 4.065 ± 1.501
0.0LeuXaa: 0.0 ± 0.0
Met
2.258MetAla: 2.258 ± 1.242
0.0MetCys: 0.0 ± 0.0
0.452MetAsp: 0.452 ± 0.367
2.71MetGlu: 2.71 ± 1.089
0.452MetPhe: 0.452 ± 0.342
0.903MetGly: 0.903 ± 0.69
0.0MetHis: 0.0 ± 0.0
1.355MetIle: 1.355 ± 0.841
0.903MetLys: 0.903 ± 0.687
2.71MetLeu: 2.71 ± 0.788
0.903MetMet: 0.903 ± 0.685
2.258MetAsn: 2.258 ± 0.649
0.452MetPro: 0.452 ± 0.536
1.355MetGln: 1.355 ± 0.768
0.452MetArg: 0.452 ± 0.491
0.903MetSer: 0.903 ± 0.579
4.517MetThr: 4.517 ± 1.186
0.452MetVal: 0.452 ± 0.491
0.452MetTrp: 0.452 ± 0.601
0.452MetTyr: 0.452 ± 0.452
0.0MetXaa: 0.0 ± 0.0
Asn
3.162AsnAla: 3.162 ± 0.927
0.452AsnCys: 0.452 ± 0.488
1.807AsnAsp: 1.807 ± 1.003
2.71AsnGlu: 2.71 ± 1.004
1.355AsnPhe: 1.355 ± 0.67
2.71AsnGly: 2.71 ± 1.255
2.258AsnHis: 2.258 ± 0.697
2.71AsnIle: 2.71 ± 0.79
7.227AsnLys: 7.227 ± 1.878
7.678AsnLeu: 7.678 ± 2.408
1.355AsnMet: 1.355 ± 0.825
3.162AsnAsn: 3.162 ± 1.252
3.613AsnPro: 3.613 ± 1.54
2.258AsnGln: 2.258 ± 1.095
4.065AsnArg: 4.065 ± 0.835
3.162AsnSer: 3.162 ± 1.261
3.613AsnThr: 3.613 ± 0.904
2.71AsnVal: 2.71 ± 1.198
0.452AsnTrp: 0.452 ± 0.443
2.258AsnTyr: 2.258 ± 1.174
0.0AsnXaa: 0.0 ± 0.0
Pro
2.258ProAla: 2.258 ± 1.077
0.0ProCys: 0.0 ± 0.0
2.258ProAsp: 2.258 ± 1.106
1.807ProGlu: 1.807 ± 0.723
1.355ProPhe: 1.355 ± 0.718
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
2.71ProIle: 2.71 ± 0.868
4.517ProLys: 4.517 ± 1.473
4.065ProLeu: 4.065 ± 1.35
0.452ProMet: 0.452 ± 0.488
2.71ProAsn: 2.71 ± 1.172
0.903ProPro: 0.903 ± 0.536
2.258ProGln: 2.258 ± 1.036
1.355ProArg: 1.355 ± 0.5
1.807ProSer: 1.807 ± 0.686
2.258ProThr: 2.258 ± 0.606
2.71ProVal: 2.71 ± 1.074
0.0ProTrp: 0.0 ± 0.0
2.258ProTyr: 2.258 ± 0.927
0.0ProXaa: 0.0 ± 0.0
Gln
3.162GlnAla: 3.162 ± 1.038
0.0GlnCys: 0.0 ± 0.0
2.258GlnAsp: 2.258 ± 0.831
3.613GlnGlu: 3.613 ± 1.648
1.355GlnPhe: 1.355 ± 0.826
2.258GlnGly: 2.258 ± 0.834
0.452GlnHis: 0.452 ± 0.367
4.517GlnIle: 4.517 ± 1.404
2.71GlnLys: 2.71 ± 0.958
8.13GlnLeu: 8.13 ± 1.519
1.355GlnMet: 1.355 ± 0.73
1.807GlnAsn: 1.807 ± 0.641
0.903GlnPro: 0.903 ± 0.685
1.807GlnGln: 1.807 ± 0.636
0.903GlnArg: 0.903 ± 0.56
4.968GlnSer: 4.968 ± 1.594
2.258GlnThr: 2.258 ± 0.716
1.807GlnVal: 1.807 ± 0.894
0.0GlnTrp: 0.0 ± 0.0
3.162GlnTyr: 3.162 ± 0.986
0.0GlnXaa: 0.0 ± 0.0
Arg
2.258ArgAla: 2.258 ± 0.894
0.452ArgCys: 0.452 ± 0.367
2.258ArgAsp: 2.258 ± 0.587
2.258ArgGlu: 2.258 ± 0.599
1.807ArgPhe: 1.807 ± 0.952
2.258ArgGly: 2.258 ± 0.885
1.807ArgHis: 1.807 ± 0.767
4.517ArgIle: 4.517 ± 1.082
2.71ArgLys: 2.71 ± 1.476
3.613ArgLeu: 3.613 ± 0.926
0.452ArgMet: 0.452 ± 0.342
2.258ArgAsn: 2.258 ± 1.0
0.903ArgPro: 0.903 ± 0.548
3.162ArgGln: 3.162 ± 1.017
0.903ArgArg: 0.903 ± 0.564
0.452ArgSer: 0.452 ± 0.367
4.517ArgThr: 4.517 ± 1.235
2.258ArgVal: 2.258 ± 1.027
0.903ArgTrp: 0.903 ± 0.685
1.355ArgTyr: 1.355 ± 0.869
0.0ArgXaa: 0.0 ± 0.0
Ser
1.807SerAla: 1.807 ± 0.641
0.0SerCys: 0.0 ± 0.0
4.517SerAsp: 4.517 ± 1.257
4.517SerGlu: 4.517 ± 1.746
3.162SerPhe: 3.162 ± 1.156
0.903SerGly: 0.903 ± 0.536
0.452SerHis: 0.452 ± 0.367
4.065SerIle: 4.065 ± 1.345
3.613SerLys: 3.613 ± 0.885
6.775SerLeu: 6.775 ± 1.047
1.355SerMet: 1.355 ± 0.712
2.258SerAsn: 2.258 ± 0.826
2.71SerPro: 2.71 ± 0.838
2.71SerGln: 2.71 ± 1.05
1.355SerArg: 1.355 ± 0.735
1.355SerSer: 1.355 ± 0.797
2.258SerThr: 2.258 ± 0.918
3.613SerVal: 3.613 ± 0.954
0.452SerTrp: 0.452 ± 0.367
3.162SerTyr: 3.162 ± 1.547
0.0SerXaa: 0.0 ± 0.0
Thr
4.517ThrAla: 4.517 ± 0.838
0.452ThrCys: 0.452 ± 0.488
3.162ThrAsp: 3.162 ± 1.424
4.065ThrGlu: 4.065 ± 1.493
2.258ThrPhe: 2.258 ± 0.814
4.968ThrGly: 4.968 ± 1.587
0.452ThrHis: 0.452 ± 0.367
4.968ThrIle: 4.968 ± 1.201
5.42ThrLys: 5.42 ± 1.681
4.968ThrLeu: 4.968 ± 0.74
0.903ThrMet: 0.903 ± 0.548
1.355ThrAsn: 1.355 ± 0.967
3.613ThrPro: 3.613 ± 1.604
1.807ThrGln: 1.807 ± 0.882
2.258ThrArg: 2.258 ± 0.736
3.613ThrSer: 3.613 ± 1.061
3.613ThrThr: 3.613 ± 0.967
5.872ThrVal: 5.872 ± 1.681
0.0ThrTrp: 0.0 ± 0.0
3.162ThrTyr: 3.162 ± 1.084
0.0ThrXaa: 0.0 ± 0.0
Val
3.613ValAla: 3.613 ± 0.564
0.0ValCys: 0.0 ± 0.0
1.355ValAsp: 1.355 ± 0.734
3.613ValGlu: 3.613 ± 0.999
4.968ValPhe: 4.968 ± 1.885
3.162ValGly: 3.162 ± 1.302
0.452ValHis: 0.452 ± 0.452
1.355ValIle: 1.355 ± 0.695
4.968ValLys: 4.968 ± 1.455
5.42ValLeu: 5.42 ± 1.443
0.903ValMet: 0.903 ± 0.688
4.065ValAsn: 4.065 ± 1.848
0.903ValPro: 0.903 ± 0.505
1.807ValGln: 1.807 ± 0.686
2.258ValArg: 2.258 ± 0.965
3.162ValSer: 3.162 ± 1.326
3.613ValThr: 3.613 ± 0.999
0.903ValVal: 0.903 ± 0.446
0.0ValTrp: 0.0 ± 0.0
2.258ValTyr: 2.258 ± 1.125
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.452TrpAsp: 0.452 ± 0.601
1.355TrpGlu: 1.355 ± 0.843
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.452TrpIle: 0.452 ± 0.452
0.903TrpLys: 0.903 ± 0.683
1.355TrpLeu: 1.355 ± 0.656
0.0TrpMet: 0.0 ± 0.0
0.452TrpAsn: 0.452 ± 0.342
0.0TrpPro: 0.0 ± 0.0
0.452TrpGln: 0.452 ± 0.452
0.0TrpArg: 0.0 ± 0.0
0.452TrpSer: 0.452 ± 0.367
0.0TrpThr: 0.0 ± 0.0
0.903TrpVal: 0.903 ± 0.546
0.0TrpTrp: 0.0 ± 0.0
0.452TrpTyr: 0.452 ± 0.342
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.258TyrAla: 2.258 ± 1.059
0.452TyrCys: 0.452 ± 0.342
0.903TyrAsp: 0.903 ± 0.559
1.807TyrGlu: 1.807 ± 0.777
1.355TyrPhe: 1.355 ± 0.749
5.42TyrGly: 5.42 ± 1.51
2.258TyrHis: 2.258 ± 0.795
3.162TyrIle: 3.162 ± 1.035
5.42TyrLys: 5.42 ± 1.503
4.065TyrLeu: 4.065 ± 1.285
1.355TyrMet: 1.355 ± 0.57
4.968TyrAsn: 4.968 ± 1.013
1.355TyrPro: 1.355 ± 0.5
4.517TyrGln: 4.517 ± 1.065
1.807TyrArg: 1.807 ± 0.997
2.71TyrSer: 2.71 ± 0.719
2.71TyrThr: 2.71 ± 0.98
0.0TyrVal: 0.0 ± 0.0
0.452TyrTrp: 0.452 ± 0.342
3.162TyrTyr: 3.162 ± 1.342
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2215 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski