Amino acid dipepetide frequency for Psychrobacillus psychrotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.461AlaAla: 5.461 ± 0.097	0.504AlaCys: 0.504 ± 0.025	3.375AlaAsp: 3.375 ± 0.06	4.412AlaGlu: 4.412 ± 0.081	3.351AlaPhe: 3.351 ± 0.06	5.028AlaGly: 5.028 ± 0.085	1.242AlaHis: 1.242 ± 0.03	6.481AlaIle: 6.481 ± 0.084	4.645AlaLys: 4.645 ± 0.069	7.054AlaLeu: 7.054 ± 0.097	1.938AlaMet: 1.938 ± 0.048	3.002AlaAsn: 3.002 ± 0.064	1.975AlaPro: 1.975 ± 0.048	2.215AlaGln: 2.215 ± 0.044	2.408AlaArg: 2.408 ± 0.058	4.242AlaSer: 4.242 ± 0.072	3.928AlaThr: 3.928 ± 0.072	5.195AlaVal: 5.195 ± 0.078	0.576AlaTrp: 0.576 ± 0.022	2.316AlaTyr: 2.316 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.411CysAla: 0.411 ± 0.022	0.078CysCys: 0.078 ± 0.01	0.33CysAsp: 0.33 ± 0.02	0.389CysGlu: 0.389 ± 0.02	0.264CysPhe: 0.264 ± 0.017	0.568CysGly: 0.568 ± 0.024	0.152CysHis: 0.152 ± 0.014	0.554CysIle: 0.554 ± 0.021	0.29CysLys: 0.29 ± 0.015	0.57CysLeu: 0.57 ± 0.022	0.139CysMet: 0.139 ± 0.011	0.281CysAsn: 0.281 ± 0.019	0.286CysPro: 0.286 ± 0.018	0.172CysGln: 0.172 ± 0.013	0.23CysArg: 0.23 ± 0.015	0.463CysSer: 0.463 ± 0.02	0.355CysThr: 0.355 ± 0.019	0.336CysVal: 0.336 ± 0.02	0.062CysTrp: 0.062 ± 0.008	0.191CysTyr: 0.191 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.533AspAla: 3.533 ± 0.063	0.298AspCys: 0.298 ± 0.017	2.399AspAsp: 2.399 ± 0.053	4.415AspGlu: 4.415 ± 0.071	2.535AspPhe: 2.535 ± 0.053	3.371AspGly: 3.371 ± 0.053	1.001AspHis: 1.001 ± 0.033	4.331AspIle: 4.331 ± 0.063	3.096AspLys: 3.096 ± 0.065	4.871AspLeu: 4.871 ± 0.069	1.346AspMet: 1.346 ± 0.04	1.982AspAsn: 1.982 ± 0.043	1.738AspPro: 1.738 ± 0.039	1.779AspGln: 1.779 ± 0.042	1.911AspArg: 1.911 ± 0.044	2.722AspSer: 2.722 ± 0.053	2.596AspThr: 2.596 ± 0.05	3.671AspVal: 3.671 ± 0.073	0.555AspTrp: 0.555 ± 0.025	2.105AspTyr: 2.105 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.324GluAla: 5.324 ± 0.073	0.329GluCys: 0.329 ± 0.019	3.855GluAsp: 3.855 ± 0.068	7.166GluGlu: 7.166 ± 0.098	2.643GluPhe: 2.643 ± 0.051	4.174GluGly: 4.174 ± 0.074	1.423GluHis: 1.423 ± 0.045	5.892GluIle: 5.892 ± 0.083	6.41GluLys: 6.41 ± 0.095	7.322GluLeu: 7.322 ± 0.09	2.36GluMet: 2.36 ± 0.049	3.708GluAsn: 3.708 ± 0.062	1.879GluPro: 1.879 ± 0.044	3.601GluGln: 3.601 ± 0.073	3.04GluArg: 3.04 ± 0.064	3.825GluSer: 3.825 ± 0.068	4.086GluThr: 4.086 ± 0.068	5.541GluVal: 5.541 ± 0.068	0.894GluTrp: 0.894 ± 0.03	2.205GluTyr: 2.205 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.059PheAla: 3.059 ± 0.057	0.3PheCys: 0.3 ± 0.018	2.312PheAsp: 2.312 ± 0.049	3.167PheGlu: 3.167 ± 0.061	2.358PhePhe: 2.358 ± 0.063	3.376PheGly: 3.376 ± 0.064	0.973PheHis: 0.973 ± 0.033	3.999PheIle: 3.999 ± 0.074	2.36PheLys: 2.36 ± 0.049	4.593PheLeu: 4.593 ± 0.086	1.211PheMet: 1.211 ± 0.042	2.004PheAsn: 2.004 ± 0.043	1.709PhePro: 1.709 ± 0.044	1.672PheGln: 1.672 ± 0.041	1.43PheArg: 1.43 ± 0.035	3.331PheSer: 3.331 ± 0.068	2.82PheThr: 2.82 ± 0.056	3.356PheVal: 3.356 ± 0.063	0.466PheTrp: 0.466 ± 0.024	1.763PheTyr: 1.763 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.755GlyAla: 4.755 ± 0.076	0.549GlyCys: 0.549 ± 0.022	3.214GlyAsp: 3.214 ± 0.066	4.395GlyGlu: 4.395 ± 0.071	3.357GlyPhe: 3.357 ± 0.062	4.532GlyGly: 4.532 ± 0.09	1.301GlyHis: 1.301 ± 0.038	6.186GlyIle: 6.186 ± 0.078	4.807GlyLys: 4.807 ± 0.076	6.248GlyLeu: 6.248 ± 0.09	2.046GlyMet: 2.046 ± 0.043	2.792GlyAsn: 2.792 ± 0.056	1.667GlyPro: 1.667 ± 0.04	2.149GlyGln: 2.149 ± 0.053	2.407GlyArg: 2.407 ± 0.05	3.94GlySer: 3.94 ± 0.059	4.036GlyThr: 4.036 ± 0.075	4.903GlyVal: 4.903 ± 0.073	0.724GlyTrp: 0.724 ± 0.028	2.729GlyTyr: 2.729 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.284HisAla: 1.284 ± 0.037	0.155HisCys: 0.155 ± 0.013	0.898HisAsp: 0.898 ± 0.03	1.346HisGlu: 1.346 ± 0.037	1.002HisPhe: 1.002 ± 0.037	1.289HisGly: 1.289 ± 0.037	0.578HisHis: 0.578 ± 0.025	1.58HisIle: 1.58 ± 0.039	0.998HisLys: 0.998 ± 0.029	2.01HisLeu: 2.01 ± 0.039	0.521HisMet: 0.521 ± 0.021	0.731HisAsn: 0.731 ± 0.026	1.07HisPro: 1.07 ± 0.034	0.787HisGln: 0.787 ± 0.027	0.735HisArg: 0.735 ± 0.026	1.173HisSer: 1.173 ± 0.029	1.082HisThr: 1.082 ± 0.034	1.317HisVal: 1.317 ± 0.034	0.175HisTrp: 0.175 ± 0.012	0.818HisTyr: 0.818 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.447IleAla: 6.447 ± 0.088	0.599IleCys: 0.599 ± 0.024	4.478IleAsp: 4.478 ± 0.065	6.175IleGlu: 6.175 ± 0.079	3.613IlePhe: 3.613 ± 0.078	6.206IleGly: 6.206 ± 0.083	1.728IleHis: 1.728 ± 0.043	6.902IleIle: 6.902 ± 0.098	4.475IleLys: 4.475 ± 0.082	7.766IleLeu: 7.766 ± 0.11	2.019IleMet: 2.019 ± 0.043	3.325IleAsn: 3.325 ± 0.059	3.493IlePro: 3.493 ± 0.065	3.269IleGln: 3.269 ± 0.058	2.986IleArg: 2.986 ± 0.052	5.53IleSer: 5.53 ± 0.079	4.724IleThr: 4.724 ± 0.075	6.101IleVal: 6.101 ± 0.064	0.697IleTrp: 0.697 ± 0.028	2.607IleTyr: 2.607 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.286LysAla: 4.286 ± 0.083	0.288LysCys: 0.288 ± 0.019	3.647LysAsp: 3.647 ± 0.068	6.711LysGlu: 6.711 ± 0.092	2.165LysPhe: 2.165 ± 0.047	4.216LysGly: 4.216 ± 0.069	1.198LysHis: 1.198 ± 0.032	4.672LysIle: 4.672 ± 0.068	5.581LysLys: 5.581 ± 0.086	5.987LysLeu: 5.987 ± 0.079	2.299LysMet: 2.299 ± 0.046	3.387LysAsn: 3.387 ± 0.061	2.073LysPro: 2.073 ± 0.05	2.989LysGln: 2.989 ± 0.06	2.906LysArg: 2.906 ± 0.058	3.782LysSer: 3.782 ± 0.063	3.652LysThr: 3.652 ± 0.06	4.854LysVal: 4.854 ± 0.066	0.866LysTrp: 0.866 ± 0.031	2.285LysTyr: 2.285 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	7.248LeuAla: 7.248 ± 0.096	0.595LeuCys: 0.595 ± 0.022	4.765LeuAsp: 4.765 ± 0.068	7.019LeuGlu: 7.019 ± 0.095	4.964LeuPhe: 4.964 ± 0.104	6.256LeuGly: 6.256 ± 0.084	1.93LeuHis: 1.93 ± 0.043	7.426LeuIle: 7.426 ± 0.108	6.463LeuLys: 6.463 ± 0.081	10.537LeuLeu: 10.537 ± 0.125	2.621LeuMet: 2.621 ± 0.053	4.33LeuAsn: 4.33 ± 0.074	3.838LeuPro: 3.838 ± 0.062	3.762LeuGln: 3.762 ± 0.072	3.345LeuArg: 3.345 ± 0.06	6.715LeuSer: 6.715 ± 0.093	5.622LeuThr: 5.622 ± 0.077	6.721LeuVal: 6.721 ± 0.094	0.818LeuTrp: 0.818 ± 0.033	3.081LeuTyr: 3.081 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.842MetAla: 1.842 ± 0.041	0.133MetCys: 0.133 ± 0.011	1.632MetAsp: 1.632 ± 0.044	2.153MetGlu: 2.153 ± 0.046	1.056MetPhe: 1.056 ± 0.036	1.729MetGly: 1.729 ± 0.041	0.453MetHis: 0.453 ± 0.02	2.111MetIle: 2.111 ± 0.046	2.532MetLys: 2.532 ± 0.051	2.562MetLeu: 2.562 ± 0.05	0.831MetMet: 0.831 ± 0.032	1.579MetAsn: 1.579 ± 0.038	0.97MetPro: 0.97 ± 0.032	1.047MetGln: 1.047 ± 0.033	1.062MetArg: 1.062 ± 0.035	1.778MetSer: 1.778 ± 0.037	1.87MetThr: 1.87 ± 0.043	1.714MetVal: 1.714 ± 0.038	0.223MetTrp: 0.223 ± 0.016	0.81MetTyr: 0.81 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.983AsnAla: 2.983 ± 0.057	0.27AsnCys: 0.27 ± 0.017	2.333AsnAsp: 2.333 ± 0.043	3.613AsnGlu: 3.613 ± 0.06	1.865AsnPhe: 1.865 ± 0.046	3.311AsnGly: 3.311 ± 0.068	0.941AsnHis: 0.941 ± 0.032	3.65AsnIle: 3.65 ± 0.059	2.989AsnLys: 2.989 ± 0.064	4.021AsnLeu: 4.021 ± 0.07	1.239AsnMet: 1.239 ± 0.034	2.312AsnAsn: 2.312 ± 0.055	2.108AsnPro: 2.108 ± 0.042	1.541AsnGln: 1.541 ± 0.044	1.928AsnArg: 1.928 ± 0.052	2.712AsnSer: 2.712 ± 0.055	2.447AsnThr: 2.447 ± 0.05	3.077AsnVal: 3.077 ± 0.057	0.521AsnTrp: 0.521 ± 0.023	1.657AsnTyr: 1.657 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	2.099ProAla: 2.099 ± 0.044	0.185ProCys: 0.185 ± 0.015	1.681ProAsp: 1.681 ± 0.042	2.651ProGlu: 2.651 ± 0.055	2.003ProPhe: 2.003 ± 0.047	2.096ProGly: 2.096 ± 0.054	0.734ProHis: 0.734 ± 0.027	3.055ProIle: 3.055 ± 0.06	2.125ProLys: 2.125 ± 0.047	3.423ProLeu: 3.423 ± 0.059	0.867ProMet: 0.867 ± 0.029	1.755ProAsn: 1.755 ± 0.042	0.927ProPro: 0.927 ± 0.034	1.066ProGln: 1.066 ± 0.032	0.939ProArg: 0.939 ± 0.033	2.307ProSer: 2.307 ± 0.046	2.179ProThr: 2.179 ± 0.052	2.752ProVal: 2.752 ± 0.059	0.331ProTrp: 0.331 ± 0.019	1.339ProTyr: 1.339 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.7GlnAla: 2.7 ± 0.053	0.144GlnCys: 0.144 ± 0.012	1.64GlnAsp: 1.64 ± 0.038	2.663GlnGlu: 2.663 ± 0.057	1.603GlnPhe: 1.603 ± 0.043	2.051GlnGly: 2.051 ± 0.051	0.737GlnHis: 0.737 ± 0.029	2.746GlnIle: 2.746 ± 0.062	2.616GlnLys: 2.616 ± 0.05	4.165GlnLeu: 4.165 ± 0.071	1.138GlnMet: 1.138 ± 0.034	1.635GlnAsn: 1.635 ± 0.045	1.079GlnPro: 1.079 ± 0.036	1.974GlnGln: 1.974 ± 0.058	1.348GlnArg: 1.348 ± 0.04	2.261GlnSer: 2.261 ± 0.049	2.119GlnThr: 2.119 ± 0.049	2.618GlnVal: 2.618 ± 0.05	0.357GlnTrp: 0.357 ± 0.019	1.248GlnTyr: 1.248 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.304ArgAla: 2.304 ± 0.044	0.203ArgCys: 0.203 ± 0.014	1.891ArgAsp: 1.891 ± 0.047	2.799ArgGlu: 2.799 ± 0.059	1.697ArgPhe: 1.697 ± 0.042	2.125ArgGly: 2.125 ± 0.043	0.672ArgHis: 0.672 ± 0.026	3.011ArgIle: 3.011 ± 0.058	2.938ArgLys: 2.938 ± 0.053	3.786ArgLeu: 3.786 ± 0.069	1.157ArgMet: 1.157 ± 0.032	1.722ArgAsn: 1.722 ± 0.047	1.178ArgPro: 1.178 ± 0.037	1.372ArgGln: 1.372 ± 0.039	1.515ArgArg: 1.515 ± 0.04	2.015ArgSer: 2.015 ± 0.042	1.984ArgThr: 1.984 ± 0.047	2.538ArgVal: 2.538 ± 0.055	0.314ArgTrp: 0.314 ± 0.016	1.321ArgTyr: 1.321 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.799SerAla: 3.799 ± 0.063	0.336SerCys: 0.336 ± 0.019	2.845SerAsp: 2.845 ± 0.056	4.102SerGlu: 4.102 ± 0.072	3.462SerPhe: 3.462 ± 0.065	4.267SerGly: 4.267 ± 0.071	1.161SerHis: 1.161 ± 0.037	5.848SerIle: 5.848 ± 0.082	4.189SerLys: 4.189 ± 0.069	6.285SerLeu: 6.285 ± 0.094	1.807SerMet: 1.807 ± 0.044	2.829SerAsn: 2.829 ± 0.06	2.172SerPro: 2.172 ± 0.047	1.888SerGln: 1.888 ± 0.043	2.15SerArg: 2.15 ± 0.044	4.311SerSer: 4.311 ± 0.08	3.578SerThr: 3.578 ± 0.059	4.351SerVal: 4.351 ± 0.062	0.575SerTrp: 0.575 ± 0.027	2.26SerTyr: 2.26 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.042ThrAla: 4.042 ± 0.08	0.31ThrCys: 0.31 ± 0.016	2.91ThrAsp: 2.91 ± 0.056	3.957ThrGlu: 3.957 ± 0.068	2.714ThrPhe: 2.714 ± 0.05	4.237ThrGly: 4.237 ± 0.071	1.116ThrHis: 1.116 ± 0.035	5.029ThrIle: 5.029 ± 0.074	3.816ThrLys: 3.816 ± 0.055	5.46ThrLeu: 5.46 ± 0.078	1.401ThrMet: 1.401 ± 0.042	2.807ThrAsn: 2.807 ± 0.052	2.26ThrPro: 2.26 ± 0.048	1.558ThrGln: 1.558 ± 0.036	1.777ThrArg: 1.777 ± 0.037	3.577ThrSer: 3.577 ± 0.056	3.419ThrThr: 3.419 ± 0.062	4.242ThrVal: 4.242 ± 0.067	0.526ThrTrp: 0.526 ± 0.024	2.1ThrTyr: 2.1 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.962ValAla: 4.962 ± 0.086	0.519ValCys: 0.519 ± 0.024	3.676ValAsp: 3.676 ± 0.062	5.322ValGlu: 5.322 ± 0.08	3.247ValPhe: 3.247 ± 0.056	4.861ValGly: 4.861 ± 0.067	1.326ValHis: 1.326 ± 0.038	6.01ValIle: 6.01 ± 0.073	4.58ValLys: 4.58 ± 0.077	7.037ValLeu: 7.037 ± 0.084	1.862ValMet: 1.862 ± 0.042	3.191ValAsn: 3.191 ± 0.062	2.558ValPro: 2.558 ± 0.053	2.448ValGln: 2.448 ± 0.052	2.605ValArg: 2.605 ± 0.052	4.745ValSer: 4.745 ± 0.071	4.313ValThr: 4.313 ± 0.081	5.377ValVal: 5.377 ± 0.075	0.594ValTrp: 0.594 ± 0.026	2.218ValTyr: 2.218 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.529TrpAla: 0.529 ± 0.023	0.064TrpCys: 0.064 ± 0.009	0.515TrpAsp: 0.515 ± 0.023	0.657TrpGlu: 0.657 ± 0.025	0.5TrpPhe: 0.5 ± 0.025	0.624TrpGly: 0.624 ± 0.028	0.223TrpHis: 0.223 ± 0.017	0.893TrpIle: 0.893 ± 0.033	0.729TrpLys: 0.729 ± 0.03	1.005TrpLeu: 1.005 ± 0.034	0.353TrpMet: 0.353 ± 0.018	0.535TrpAsn: 0.535 ± 0.02	0.256TrpPro: 0.256 ± 0.018	0.325TrpGln: 0.325 ± 0.019	0.365TrpArg: 0.365 ± 0.018	0.62TrpSer: 0.62 ± 0.024	0.568TrpThr: 0.568 ± 0.027	0.592TrpVal: 0.592 ± 0.024	0.135TrpTrp: 0.135 ± 0.011	0.319TrpTyr: 0.319 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.281TyrAla: 2.281 ± 0.048	0.26TyrCys: 0.26 ± 0.016	1.859TyrAsp: 1.859 ± 0.047	2.566TyrGlu: 2.566 ± 0.05	1.862TyrPhe: 1.862 ± 0.045	2.418TyrGly: 2.418 ± 0.049	0.666TyrHis: 0.666 ± 0.025	2.763TyrIle: 2.763 ± 0.051	2.207TyrLys: 2.207 ± 0.047	3.352TyrLeu: 3.352 ± 0.06	0.93TyrMet: 0.93 ± 0.033	1.613TyrAsn: 1.613 ± 0.039	1.277TyrPro: 1.277 ± 0.037	1.226TyrGln: 1.226 ± 0.039	1.454TyrArg: 1.454 ± 0.04	2.166TyrSer: 2.166 ± 0.047	1.882TyrThr: 1.882 ± 0.041	2.193TyrVal: 2.193 ± 0.045	0.396TyrTrp: 0.396 ± 0.018	1.409TyrTyr: 1.409 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3550 proteins (1022668 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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