Amino acid dipepetide frequency for Yersinia phage Yep-phi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.395AlaAla: 8.395 ± 1.197
0.997AlaCys: 0.997 ± 0.2
5.403AlaAsp: 5.403 ± 1.105
5.985AlaGlu: 5.985 ± 0.837
3.408AlaPhe: 3.408 ± 0.395
6.733AlaGly: 6.733 ± 0.875
1.745AlaHis: 1.745 ± 0.305
4.572AlaIle: 4.572 ± 0.559
7.314AlaLys: 7.314 ± 0.914
6.816AlaLeu: 6.816 ± 0.904
2.992AlaMet: 2.992 ± 0.528
4.322AlaAsn: 4.322 ± 0.679
2.66AlaPro: 2.66 ± 0.361
3.823AlaGln: 3.823 ± 0.538
4.488AlaArg: 4.488 ± 0.546
4.156AlaSer: 4.156 ± 0.678
3.408AlaThr: 3.408 ± 0.624
5.652AlaVal: 5.652 ± 0.601
1.164AlaTrp: 1.164 ± 0.272
3.075AlaTyr: 3.075 ± 0.59
0.0AlaXaa: 0.0 ± 0.0
Cys
0.831CysAla: 0.831 ± 0.23
0.0CysCys: 0.0 ± 0.0
0.665CysAsp: 0.665 ± 0.308
0.831CysGlu: 0.831 ± 0.287
0.499CysPhe: 0.499 ± 0.207
0.499CysGly: 0.499 ± 0.212
0.416CysHis: 0.416 ± 0.16
0.416CysIle: 0.416 ± 0.178
0.332CysLys: 0.332 ± 0.183
1.247CysLeu: 1.247 ± 0.334
0.249CysMet: 0.249 ± 0.15
0.582CysAsn: 0.582 ± 0.236
0.332CysPro: 0.332 ± 0.159
0.332CysGln: 0.332 ± 0.166
0.997CysArg: 0.997 ± 0.342
0.831CysSer: 0.831 ± 0.236
0.166CysThr: 0.166 ± 0.122
0.499CysVal: 0.499 ± 0.243
0.166CysTrp: 0.166 ± 0.12
0.332CysTyr: 0.332 ± 0.198
0.0CysXaa: 0.0 ± 0.0
Asp
4.987AspAla: 4.987 ± 0.752
0.665AspCys: 0.665 ± 0.275
4.073AspAsp: 4.073 ± 0.93
3.99AspGlu: 3.99 ± 0.689
2.494AspPhe: 2.494 ± 0.452
6.733AspGly: 6.733 ± 0.811
1.081AspHis: 1.081 ± 0.302
2.909AspIle: 2.909 ± 0.418
3.823AspLys: 3.823 ± 0.539
3.491AspLeu: 3.491 ± 0.486
3.075AspMet: 3.075 ± 0.634
2.244AspAsn: 2.244 ± 0.457
3.075AspPro: 3.075 ± 0.701
2.494AspGln: 2.494 ± 0.444
3.242AspArg: 3.242 ± 0.844
4.322AspSer: 4.322 ± 0.59
3.823AspThr: 3.823 ± 0.442
4.322AspVal: 4.322 ± 0.483
0.831AspTrp: 0.831 ± 0.334
1.662AspTyr: 1.662 ± 0.34
0.0AspXaa: 0.0 ± 0.0
Glu
7.065GluAla: 7.065 ± 1.002
0.914GluCys: 0.914 ± 0.335
4.904GluAsp: 4.904 ± 0.608
5.652GluGlu: 5.652 ± 1.168
2.577GluPhe: 2.577 ± 0.49
5.486GluGly: 5.486 ± 0.667
1.912GluHis: 1.912 ± 0.462
2.992GluIle: 2.992 ± 0.399
2.992GluLys: 2.992 ± 0.573
5.486GluLeu: 5.486 ± 0.68
3.242GluMet: 3.242 ± 0.626
3.075GluAsn: 3.075 ± 0.509
2.41GluPro: 2.41 ± 0.432
2.743GluGln: 2.743 ± 0.396
4.073GluArg: 4.073 ± 0.572
3.325GluSer: 3.325 ± 0.669
3.574GluThr: 3.574 ± 0.525
4.572GluVal: 4.572 ± 0.544
1.164GluTrp: 1.164 ± 0.255
3.075GluTyr: 3.075 ± 0.383
0.0GluXaa: 0.0 ± 0.0
Phe
2.66PheAla: 2.66 ± 0.611
0.499PheCys: 0.499 ± 0.211
2.244PheAsp: 2.244 ± 0.522
1.829PheGlu: 1.829 ± 0.377
1.081PhePhe: 1.081 ± 0.26
3.159PheGly: 3.159 ± 0.539
0.499PheHis: 0.499 ± 0.194
1.579PheIle: 1.579 ± 0.437
2.327PheLys: 2.327 ± 0.463
2.743PheLeu: 2.743 ± 0.405
1.164PheMet: 1.164 ± 0.293
2.161PheAsn: 2.161 ± 0.493
1.912PhePro: 1.912 ± 0.424
0.914PheGln: 0.914 ± 0.329
1.745PheArg: 1.745 ± 0.343
2.078PheSer: 2.078 ± 0.501
2.992PheThr: 2.992 ± 0.539
1.995PheVal: 1.995 ± 0.367
0.166PheTrp: 0.166 ± 0.12
1.33PheTyr: 1.33 ± 0.208
0.0PheXaa: 0.0 ± 0.0
Gly
6.483GlyAla: 6.483 ± 1.016
0.831GlyCys: 0.831 ± 0.361
5.901GlyAsp: 5.901 ± 0.659
5.32GlyGlu: 5.32 ± 0.752
2.41GlyPhe: 2.41 ± 0.426
5.985GlyGly: 5.985 ± 0.658
0.831GlyHis: 0.831 ± 0.256
4.322GlyIle: 4.322 ± 0.659
6.068GlyLys: 6.068 ± 0.924
6.899GlyLeu: 6.899 ± 0.836
2.494GlyMet: 2.494 ± 0.431
3.408GlyAsn: 3.408 ± 0.569
0.416GlyPro: 0.416 ± 0.166
3.075GlyGln: 3.075 ± 0.48
4.405GlyArg: 4.405 ± 0.525
5.818GlySer: 5.818 ± 0.582
3.325GlyThr: 3.325 ± 0.569
5.32GlyVal: 5.32 ± 0.585
2.161GlyTrp: 2.161 ± 0.499
2.743GlyTyr: 2.743 ± 0.462
0.0GlyXaa: 0.0 ± 0.0
His
1.247HisAla: 1.247 ± 0.416
0.332HisCys: 0.332 ± 0.139
1.081HisAsp: 1.081 ± 0.275
0.997HisGlu: 0.997 ± 0.307
1.081HisPhe: 1.081 ± 0.302
1.496HisGly: 1.496 ± 0.269
0.582HisHis: 0.582 ± 0.201
1.164HisIle: 1.164 ± 0.324
1.662HisLys: 1.662 ± 0.456
1.912HisLeu: 1.912 ± 0.439
0.499HisMet: 0.499 ± 0.168
0.748HisAsn: 0.748 ± 0.283
0.166HisPro: 0.166 ± 0.12
0.166HisGln: 0.166 ± 0.104
0.499HisArg: 0.499 ± 0.193
1.247HisSer: 1.247 ± 0.33
0.914HisThr: 0.914 ± 0.235
1.745HisVal: 1.745 ± 0.331
0.332HisTrp: 0.332 ± 0.152
0.416HisTyr: 0.416 ± 0.159
0.0HisXaa: 0.0 ± 0.0
Ile
3.99IleAla: 3.99 ± 0.585
0.665IleCys: 0.665 ± 0.267
3.907IleAsp: 3.907 ± 0.502
3.657IleGlu: 3.657 ± 0.518
0.831IlePhe: 0.831 ± 0.252
3.325IleGly: 3.325 ± 0.547
0.914IleHis: 0.914 ± 0.315
2.161IleIle: 2.161 ± 0.405
3.823IleLys: 3.823 ± 0.554
3.74IleLeu: 3.74 ± 0.543
0.831IleMet: 0.831 ± 0.226
2.41IleAsn: 2.41 ± 0.625
1.995IlePro: 1.995 ± 0.443
1.995IleGln: 1.995 ± 0.421
3.491IleArg: 3.491 ± 0.444
2.909IleSer: 2.909 ± 0.652
2.41IleThr: 2.41 ± 0.417
2.992IleVal: 2.992 ± 0.585
0.831IleTrp: 0.831 ± 0.235
1.579IleTyr: 1.579 ± 0.344
0.0IleXaa: 0.0 ± 0.0
Lys
7.979LysAla: 7.979 ± 0.766
0.748LysCys: 0.748 ± 0.209
3.491LysAsp: 3.491 ± 0.581
5.818LysGlu: 5.818 ± 0.559
1.912LysPhe: 1.912 ± 0.448
5.652LysGly: 5.652 ± 0.591
1.579LysHis: 1.579 ± 0.415
2.161LysIle: 2.161 ± 0.334
4.904LysLys: 4.904 ± 0.736
5.735LysLeu: 5.735 ± 0.839
2.41LysMet: 2.41 ± 0.338
2.244LysAsn: 2.244 ± 0.235
2.909LysPro: 2.909 ± 0.574
2.327LysGln: 2.327 ± 0.409
3.823LysArg: 3.823 ± 0.602
4.156LysSer: 4.156 ± 0.663
3.075LysThr: 3.075 ± 0.469
4.987LysVal: 4.987 ± 0.581
0.665LysTrp: 0.665 ± 0.237
2.41LysTyr: 2.41 ± 0.421
0.0LysXaa: 0.0 ± 0.0
Leu
7.896LeuAla: 7.896 ± 0.747
0.416LeuCys: 0.416 ± 0.237
4.572LeuAsp: 4.572 ± 0.567
5.985LeuGlu: 5.985 ± 0.947
2.826LeuPhe: 2.826 ± 0.527
4.322LeuGly: 4.322 ± 0.553
1.081LeuHis: 1.081 ± 0.303
3.907LeuIle: 3.907 ± 0.578
7.398LeuLys: 7.398 ± 0.791
5.818LeuLeu: 5.818 ± 0.839
3.159LeuMet: 3.159 ± 0.547
4.572LeuAsn: 4.572 ± 0.78
2.992LeuPro: 2.992 ± 0.502
3.408LeuGln: 3.408 ± 0.545
5.153LeuArg: 5.153 ± 0.549
4.904LeuSer: 4.904 ± 0.678
4.572LeuThr: 4.572 ± 0.784
5.735LeuVal: 5.735 ± 0.686
1.081LeuTrp: 1.081 ± 0.34
2.577LeuTyr: 2.577 ± 0.472
0.0LeuXaa: 0.0 ± 0.0
Met
2.66MetAla: 2.66 ± 0.435
0.332MetCys: 0.332 ± 0.169
1.745MetAsp: 1.745 ± 0.347
2.327MetGlu: 2.327 ± 0.49
1.33MetPhe: 1.33 ± 0.323
2.992MetGly: 2.992 ± 0.614
0.416MetHis: 0.416 ± 0.192
1.081MetIle: 1.081 ± 0.294
1.579MetLys: 1.579 ± 0.334
3.99MetLeu: 3.99 ± 0.543
0.499MetMet: 0.499 ± 0.187
1.912MetAsn: 1.912 ± 0.608
1.33MetPro: 1.33 ± 0.314
1.33MetGln: 1.33 ± 0.422
0.831MetArg: 0.831 ± 0.302
2.078MetSer: 2.078 ± 0.279
1.912MetThr: 1.912 ± 0.471
2.66MetVal: 2.66 ± 0.543
0.249MetTrp: 0.249 ± 0.157
1.164MetTyr: 1.164 ± 0.302
0.0MetXaa: 0.0 ± 0.0
Asn
3.159AsnAla: 3.159 ± 0.54
0.665AsnCys: 0.665 ± 0.225
2.66AsnAsp: 2.66 ± 0.423
2.992AsnGlu: 2.992 ± 0.412
1.829AsnPhe: 1.829 ± 0.241
4.488AsnGly: 4.488 ± 0.603
0.831AsnHis: 0.831 ± 0.249
2.66AsnIle: 2.66 ± 0.401
3.242AsnLys: 3.242 ± 0.577
3.823AsnLeu: 3.823 ± 0.507
0.997AsnMet: 0.997 ± 0.3
1.745AsnAsn: 1.745 ± 0.396
2.244AsnPro: 2.244 ± 0.361
1.995AsnGln: 1.995 ± 0.26
2.909AsnArg: 2.909 ± 0.702
2.992AsnSer: 2.992 ± 0.653
2.494AsnThr: 2.494 ± 0.571
2.577AsnVal: 2.577 ± 0.427
0.665AsnTrp: 0.665 ± 0.234
2.327AsnTyr: 2.327 ± 0.445
0.0AsnXaa: 0.0 ± 0.0
Pro
2.244ProAla: 2.244 ± 0.361
0.332ProCys: 0.332 ± 0.162
2.909ProAsp: 2.909 ± 0.592
4.156ProGlu: 4.156 ± 0.771
1.164ProPhe: 1.164 ± 0.297
1.164ProGly: 1.164 ± 0.221
0.831ProHis: 0.831 ± 0.269
1.164ProIle: 1.164 ± 0.254
2.41ProLys: 2.41 ± 0.452
2.992ProLeu: 2.992 ± 0.462
1.164ProMet: 1.164 ± 0.396
2.327ProAsn: 2.327 ± 0.423
0.748ProPro: 0.748 ± 0.207
0.997ProGln: 0.997 ± 0.317
1.247ProArg: 1.247 ± 0.3
2.577ProSer: 2.577 ± 0.369
2.161ProThr: 2.161 ± 0.305
3.159ProVal: 3.159 ± 0.527
0.665ProTrp: 0.665 ± 0.192
1.164ProTyr: 1.164 ± 0.384
0.0ProXaa: 0.0 ± 0.0
Gln
4.488GlnAla: 4.488 ± 0.619
0.083GlnCys: 0.083 ± 0.086
2.41GlnAsp: 2.41 ± 0.466
2.494GlnGlu: 2.494 ± 0.501
1.829GlnPhe: 1.829 ± 0.314
2.577GlnGly: 2.577 ± 0.468
0.499GlnHis: 0.499 ± 0.17
2.327GlnIle: 2.327 ± 0.522
1.662GlnLys: 1.662 ± 0.459
4.073GlnLeu: 4.073 ± 0.546
1.247GlnMet: 1.247 ± 0.233
0.831GlnAsn: 0.831 ± 0.185
1.496GlnPro: 1.496 ± 0.385
1.829GlnGln: 1.829 ± 0.348
1.745GlnArg: 1.745 ± 0.391
1.995GlnSer: 1.995 ± 0.42
1.829GlnThr: 1.829 ± 0.481
2.078GlnVal: 2.078 ± 0.457
0.997GlnTrp: 0.997 ± 0.208
1.33GlnTyr: 1.33 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
4.821ArgAla: 4.821 ± 0.831
0.665ArgCys: 0.665 ± 0.264
3.159ArgAsp: 3.159 ± 0.468
3.907ArgGlu: 3.907 ± 0.797
1.829ArgPhe: 1.829 ± 0.358
3.907ArgGly: 3.907 ± 0.492
0.914ArgHis: 0.914 ± 0.32
2.244ArgIle: 2.244 ± 0.53
4.073ArgLys: 4.073 ± 0.714
4.655ArgLeu: 4.655 ± 0.573
1.413ArgMet: 1.413 ± 0.306
3.491ArgAsn: 3.491 ± 0.531
1.995ArgPro: 1.995 ± 0.351
1.912ArgGln: 1.912 ± 0.368
2.078ArgArg: 2.078 ± 0.373
3.823ArgSer: 3.823 ± 0.771
2.826ArgThr: 2.826 ± 0.418
3.491ArgVal: 3.491 ± 0.491
0.416ArgTrp: 0.416 ± 0.161
1.413ArgTyr: 1.413 ± 0.203
0.0ArgXaa: 0.0 ± 0.0
Ser
4.322SerAla: 4.322 ± 0.635
0.499SerCys: 0.499 ± 0.247
4.073SerAsp: 4.073 ± 0.592
3.325SerGlu: 3.325 ± 0.596
2.494SerPhe: 2.494 ± 0.379
6.068SerGly: 6.068 ± 0.766
1.829SerHis: 1.829 ± 0.489
3.325SerIle: 3.325 ± 0.5
3.823SerLys: 3.823 ± 0.697
4.904SerLeu: 4.904 ± 0.62
2.078SerMet: 2.078 ± 0.42
2.743SerAsn: 2.743 ± 0.428
1.829SerPro: 1.829 ± 0.25
2.494SerGln: 2.494 ± 0.481
3.657SerArg: 3.657 ± 0.606
3.159SerSer: 3.159 ± 0.59
2.992SerThr: 2.992 ± 0.394
4.322SerVal: 4.322 ± 0.476
0.748SerTrp: 0.748 ± 0.215
2.244SerTyr: 2.244 ± 0.691
0.0SerXaa: 0.0 ± 0.0
Thr
3.74ThrAla: 3.74 ± 0.833
0.665ThrCys: 0.665 ± 0.232
3.491ThrAsp: 3.491 ± 0.43
4.156ThrGlu: 4.156 ± 0.528
1.829ThrPhe: 1.829 ± 0.366
5.569ThrGly: 5.569 ± 0.657
0.665ThrHis: 0.665 ± 0.236
3.74ThrIle: 3.74 ± 0.559
4.322ThrLys: 4.322 ± 0.591
4.904ThrLeu: 4.904 ± 0.572
1.164ThrMet: 1.164 ± 0.326
1.912ThrAsn: 1.912 ± 0.356
2.41ThrPro: 2.41 ± 0.326
1.496ThrGln: 1.496 ± 0.409
1.995ThrArg: 1.995 ± 0.443
3.159ThrSer: 3.159 ± 0.463
3.159ThrThr: 3.159 ± 0.537
3.491ThrVal: 3.491 ± 0.643
0.582ThrTrp: 0.582 ± 0.243
1.496ThrTyr: 1.496 ± 0.304
0.0ThrXaa: 0.0 ± 0.0
Val
6.566ValAla: 6.566 ± 0.726
0.499ValCys: 0.499 ± 0.201
3.574ValAsp: 3.574 ± 0.481
4.738ValGlu: 4.738 ± 0.797
2.327ValPhe: 2.327 ± 0.527
4.239ValGly: 4.239 ± 0.6
1.081ValHis: 1.081 ± 0.317
3.574ValIle: 3.574 ± 0.501
4.821ValLys: 4.821 ± 0.877
4.904ValLeu: 4.904 ± 0.535
1.995ValMet: 1.995 ± 0.435
3.491ValAsn: 3.491 ± 0.645
2.992ValPro: 2.992 ± 0.428
2.327ValGln: 2.327 ± 0.581
4.405ValArg: 4.405 ± 0.641
4.322ValSer: 4.322 ± 0.68
4.987ValThr: 4.987 ± 0.614
4.239ValVal: 4.239 ± 0.903
0.997ValTrp: 0.997 ± 0.374
1.662ValTyr: 1.662 ± 0.495
0.0ValXaa: 0.0 ± 0.0
Trp
0.499TrpAla: 0.499 ± 0.174
0.166TrpCys: 0.166 ± 0.124
0.582TrpAsp: 0.582 ± 0.27
0.914TrpGlu: 0.914 ± 0.229
0.499TrpPhe: 0.499 ± 0.204
0.665TrpGly: 0.665 ± 0.19
0.332TrpHis: 0.332 ± 0.193
0.665TrpIle: 0.665 ± 0.291
1.496TrpLys: 1.496 ± 0.363
1.745TrpLeu: 1.745 ± 0.429
0.499TrpMet: 0.499 ± 0.17
1.081TrpAsn: 1.081 ± 0.339
0.332TrpPro: 0.332 ± 0.165
0.748TrpGln: 0.748 ± 0.232
0.582TrpArg: 0.582 ± 0.221
1.081TrpSer: 1.081 ± 0.354
1.164TrpThr: 1.164 ± 0.37
1.247TrpVal: 1.247 ± 0.311
0.166TrpTrp: 0.166 ± 0.101
0.332TrpTyr: 0.332 ± 0.159
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.159TyrAla: 3.159 ± 0.503
0.249TyrCys: 0.249 ± 0.144
2.494TyrAsp: 2.494 ± 0.393
2.161TyrGlu: 2.161 ± 0.374
0.831TyrPhe: 0.831 ± 0.225
3.159TyrGly: 3.159 ± 0.336
0.249TyrHis: 0.249 ± 0.127
1.496TyrIle: 1.496 ± 0.392
0.914TyrLys: 0.914 ± 0.249
2.494TyrLeu: 2.494 ± 0.486
1.164TyrMet: 1.164 ± 0.296
1.995TyrAsn: 1.995 ± 0.367
1.33TyrPro: 1.33 ± 0.307
1.413TyrGln: 1.413 ± 0.447
1.662TyrArg: 1.662 ± 0.285
1.995TyrSer: 1.995 ± 0.465
2.161TyrThr: 2.161 ± 0.514
2.66TyrVal: 2.66 ± 0.497
0.748TyrTrp: 0.748 ± 0.247
0.831TyrTyr: 0.831 ± 0.245
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 45 proteins (12032 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski