Amino acid dipepetide frequency for Phaeodactylibacter xiamenensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.298AlaAla: 7.298 ± 0.095	0.899AlaCys: 0.899 ± 0.035	4.725AlaAsp: 4.725 ± 0.061	5.397AlaGlu: 5.397 ± 0.066	4.049AlaPhe: 4.049 ± 0.044	6.398AlaGly: 6.398 ± 0.071	1.49AlaHis: 1.49 ± 0.035	4.893AlaIle: 4.893 ± 0.06	3.213AlaLys: 3.213 ± 0.056	8.392AlaLeu: 8.392 ± 0.095	1.873AlaMet: 1.873 ± 0.034	3.322AlaAsn: 3.322 ± 0.048	3.687AlaPro: 3.687 ± 0.067	3.638AlaGln: 3.638 ± 0.049	3.743AlaArg: 3.743 ± 0.061	4.512AlaSer: 4.512 ± 0.06	4.547AlaThr: 4.547 ± 0.067	5.307AlaVal: 5.307 ± 0.061	1.048AlaTrp: 1.048 ± 0.03	3.213AlaTyr: 3.213 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.746CysAla: 0.746 ± 0.029	0.133CysCys: 0.133 ± 0.009	0.748CysAsp: 0.748 ± 0.049	0.647CysGlu: 0.647 ± 0.027	0.475CysPhe: 0.475 ± 0.02	0.921CysGly: 0.921 ± 0.038	0.232CysHis: 0.232 ± 0.042	0.497CysIle: 0.497 ± 0.018	0.333CysLys: 0.333 ± 0.014	0.851CysLeu: 0.851 ± 0.021	0.175CysMet: 0.175 ± 0.009	0.494CysAsn: 0.494 ± 0.023	0.61CysPro: 0.61 ± 0.026	0.461CysGln: 0.461 ± 0.025	0.438CysArg: 0.438 ± 0.015	0.707CysSer: 0.707 ± 0.028	0.72CysThr: 0.72 ± 0.035	0.485CysVal: 0.485 ± 0.018	0.128CysTrp: 0.128 ± 0.008	0.329CysTyr: 0.329 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.595AspAla: 4.595 ± 0.066	0.795AspCys: 0.795 ± 0.046	2.878AspAsp: 2.878 ± 0.053	3.885AspGlu: 3.885 ± 0.05	3.285AspPhe: 3.285 ± 0.057	5.114AspGly: 5.114 ± 0.107	1.061AspHis: 1.061 ± 0.027	3.694AspIle: 3.694 ± 0.049	2.342AspLys: 2.342 ± 0.039	5.518AspLeu: 5.518 ± 0.069	1.172AspMet: 1.172 ± 0.027	2.74AspAsn: 2.74 ± 0.061	2.696AspPro: 2.696 ± 0.06	2.254AspGln: 2.254 ± 0.036	2.808AspArg: 2.808 ± 0.046	3.189AspSer: 3.189 ± 0.061	3.383AspThr: 3.383 ± 0.07	3.266AspVal: 3.266 ± 0.068	1.038AspTrp: 1.038 ± 0.025	2.694AspTyr: 2.694 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.527GluAla: 6.527 ± 0.075	0.438GluCys: 0.438 ± 0.019	4.018GluAsp: 4.018 ± 0.052	5.355GluGlu: 5.355 ± 0.079	2.303GluPhe: 2.303 ± 0.042	5.122GluGly: 5.122 ± 0.053	1.275GluHis: 1.275 ± 0.031	3.907GluIle: 3.907 ± 0.048	3.443GluLys: 3.443 ± 0.066	6.564GluLeu: 6.564 ± 0.066	1.551GluMet: 1.551 ± 0.028	2.785GluAsn: 2.785 ± 0.037	2.509GluPro: 2.509 ± 0.04	3.502GluGln: 3.502 ± 0.055	3.617GluArg: 3.617 ± 0.062	3.115GluSer: 3.115 ± 0.042	3.278GluThr: 3.278 ± 0.042	5.239GluVal: 5.239 ± 0.055	0.923GluTrp: 0.923 ± 0.023	2.207GluTyr: 2.207 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.255PheAla: 3.255 ± 0.046	0.521PheCys: 0.521 ± 0.02	3.106PheAsp: 3.106 ± 0.048	3.396PheGlu: 3.396 ± 0.05	2.455PhePhe: 2.455 ± 0.043	3.607PheGly: 3.607 ± 0.052	0.823PheHis: 0.823 ± 0.021	2.555PheIle: 2.555 ± 0.041	1.853PheLys: 1.853 ± 0.033	4.37PheLeu: 4.37 ± 0.058	0.941PheMet: 0.941 ± 0.021	2.265PheAsn: 2.265 ± 0.042	2.047PhePro: 2.047 ± 0.034	1.832PheGln: 1.832 ± 0.032	2.458PheArg: 2.458 ± 0.04	3.53PheSer: 3.53 ± 0.048	2.978PheThr: 2.978 ± 0.052	2.605PheVal: 2.605 ± 0.041	0.677PheTrp: 0.677 ± 0.021	1.81PheTyr: 1.81 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.821GlyAla: 5.821 ± 0.064	1.091GlyCys: 1.091 ± 0.048	4.194GlyAsp: 4.194 ± 0.076	4.488GlyGlu: 4.488 ± 0.055	3.648GlyPhe: 3.648 ± 0.044	5.898GlyGly: 5.898 ± 0.106	1.391GlyHis: 1.391 ± 0.032	4.647GlyIle: 4.647 ± 0.054	3.569GlyLys: 3.569 ± 0.063	7.387GlyLeu: 7.387 ± 0.087	1.807GlyMet: 1.807 ± 0.034	3.611GlyAsn: 3.611 ± 0.075	2.262GlyPro: 2.262 ± 0.043	3.855GlyGln: 3.855 ± 0.058	3.31GlyArg: 3.31 ± 0.05	4.72GlySer: 4.72 ± 0.078	4.848GlyThr: 4.848 ± 0.085	4.69GlyVal: 4.69 ± 0.056	1.091GlyTrp: 1.091 ± 0.027	3.016GlyTyr: 3.016 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.259HisAla: 1.259 ± 0.03	0.21HisCys: 0.21 ± 0.012	0.849HisAsp: 0.849 ± 0.026	1.04HisGlu: 1.04 ± 0.025	1.211HisPhe: 1.211 ± 0.027	1.144HisGly: 1.144 ± 0.027	0.546HisHis: 0.546 ± 0.019	1.186HisIle: 1.186 ± 0.027	0.77HisLys: 0.77 ± 0.024	2.177HisLeu: 2.177 ± 0.045	0.341HisMet: 0.341 ± 0.014	0.797HisAsn: 0.797 ± 0.025	1.194HisPro: 1.194 ± 0.028	0.898HisGln: 0.898 ± 0.027	1.053HisArg: 1.053 ± 0.027	1.035HisSer: 1.035 ± 0.027	1.098HisThr: 1.098 ± 0.028	0.855HisVal: 0.855 ± 0.024	0.314HisTrp: 0.314 ± 0.013	0.949HisTyr: 0.949 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.922IleAla: 4.922 ± 0.056	0.638IleCys: 0.638 ± 0.024	3.906IleAsp: 3.906 ± 0.052	4.097IleGlu: 4.097 ± 0.053	2.439IlePhe: 2.439 ± 0.04	4.466IleGly: 4.466 ± 0.049	1.054IleHis: 1.054 ± 0.028	3.432IleIle: 3.432 ± 0.05	2.621IleLys: 2.621 ± 0.045	5.133IleLeu: 5.133 ± 0.062	1.045IleMet: 1.045 ± 0.025	2.851IleAsn: 2.851 ± 0.049	2.793IlePro: 2.793 ± 0.043	2.298IleGln: 2.298 ± 0.037	3.126IleArg: 3.126 ± 0.044	3.737IleSer: 3.737 ± 0.049	3.592IleThr: 3.592 ± 0.058	3.517IleVal: 3.517 ± 0.052	0.734IleTrp: 0.734 ± 0.025	2.076IleTyr: 2.076 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.363LysAla: 4.363 ± 0.07	0.232LysCys: 0.232 ± 0.012	2.532LysAsp: 2.532 ± 0.042	3.196LysGlu: 3.196 ± 0.059	1.363LysPhe: 1.363 ± 0.03	3.251LysGly: 3.251 ± 0.06	0.883LysHis: 0.883 ± 0.024	2.701LysIle: 2.701 ± 0.05	2.723LysLys: 2.723 ± 0.057	3.995LysLeu: 3.995 ± 0.062	1.122LysMet: 1.122 ± 0.028	1.786LysAsn: 1.786 ± 0.032	1.978LysPro: 1.978 ± 0.038	1.849LysGln: 1.849 ± 0.04	2.414LysArg: 2.414 ± 0.046	2.425LysSer: 2.425 ± 0.042	2.398LysThr: 2.398 ± 0.047	3.277LysVal: 3.277 ± 0.052	0.545LysTrp: 0.545 ± 0.017	1.546LysTyr: 1.546 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	7.144LeuAla: 7.144 ± 0.08	0.898LeuCys: 0.898 ± 0.032	5.549LeuAsp: 5.549 ± 0.068	6.962LeuGlu: 6.962 ± 0.084	4.611LeuPhe: 4.611 ± 0.072	6.542LeuGly: 6.542 ± 0.072	1.916LeuHis: 1.916 ± 0.035	5.444LeuIle: 5.444 ± 0.059	4.924LeuLys: 4.924 ± 0.075	10.566LeuLeu: 10.566 ± 0.122	2.148LeuMet: 2.148 ± 0.039	4.49LeuAsn: 4.49 ± 0.056	5.275LeuPro: 5.275 ± 0.06	4.662LeuGln: 4.662 ± 0.064	5.143LeuArg: 5.143 ± 0.077	7.665LeuSer: 7.665 ± 0.083	5.448LeuThr: 5.448 ± 0.057	5.296LeuVal: 5.296 ± 0.069	1.129LeuTrp: 1.129 ± 0.026	3.449LeuTyr: 3.449 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	1.931MetAla: 1.931 ± 0.036	0.108MetCys: 0.108 ± 0.007	1.3MetAsp: 1.3 ± 0.032	1.639MetGlu: 1.639 ± 0.035	0.583MetPhe: 0.583 ± 0.021	1.544MetGly: 1.544 ± 0.034	0.415MetHis: 0.415 ± 0.016	1.133MetIle: 1.133 ± 0.022	1.357MetLys: 1.357 ± 0.03	2.047MetLeu: 2.047 ± 0.039	0.491MetMet: 0.491 ± 0.018	0.926MetAsn: 0.926 ± 0.022	1.202MetPro: 1.202 ± 0.024	0.956MetGln: 0.956 ± 0.023	1.107MetArg: 1.107 ± 0.027	1.259MetSer: 1.259 ± 0.028	1.086MetThr: 1.086 ± 0.028	1.442MetVal: 1.442 ± 0.03	0.158MetTrp: 0.158 ± 0.01	0.54MetTyr: 0.54 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.583AsnAla: 3.583 ± 0.05	0.582AsnCys: 0.582 ± 0.03	2.379AsnAsp: 2.379 ± 0.049	2.428AsnGlu: 2.428 ± 0.041	2.108AsnPhe: 2.108 ± 0.042	4.174AsnGly: 4.174 ± 0.096	0.792AsnHis: 0.792 ± 0.021	2.806AsnIle: 2.806 ± 0.044	1.66AsnLys: 1.66 ± 0.036	4.427AsnLeu: 4.427 ± 0.06	0.868AsnMet: 0.868 ± 0.019	2.187AsnAsn: 2.187 ± 0.049	2.735AsnPro: 2.735 ± 0.048	1.793AsnGln: 1.793 ± 0.035	2.265AsnArg: 2.265 ± 0.041	2.525AsnSer: 2.525 ± 0.051	2.794AsnThr: 2.794 ± 0.057	2.377AsnVal: 2.377 ± 0.046	0.75AsnTrp: 0.75 ± 0.023	1.794AsnTyr: 1.794 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.091ProAla: 4.091 ± 0.06	0.417ProCys: 0.417 ± 0.023	3.431ProAsp: 3.431 ± 0.052	4.007ProGlu: 4.007 ± 0.061	2.276ProPhe: 2.276 ± 0.043	3.935ProGly: 3.935 ± 0.071	0.745ProHis: 0.745 ± 0.022	2.388ProIle: 2.388 ± 0.034	1.84ProLys: 1.84 ± 0.038	3.935ProLeu: 3.935 ± 0.051	0.913ProMet: 0.913 ± 0.024	2.409ProAsn: 2.409 ± 0.05	2.011ProPro: 2.011 ± 0.051	1.67ProGln: 1.67 ± 0.029	1.495ProArg: 1.495 ± 0.031	2.441ProSer: 2.441 ± 0.041	2.325ProThr: 2.325 ± 0.046	3.674ProVal: 3.674 ± 0.045	0.478ProTrp: 0.478 ± 0.016	1.74ProTyr: 1.74 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.729GlnAla: 3.729 ± 0.053	0.277GlnCys: 0.277 ± 0.013	2.237GlnAsp: 2.237 ± 0.039	3.03GlnGlu: 3.03 ± 0.05	1.837GlnPhe: 1.837 ± 0.029	2.66GlnGly: 2.66 ± 0.04	0.922GlnHis: 0.922 ± 0.023	2.341GlnIle: 2.341 ± 0.035	2.019GlnLys: 2.019 ± 0.045	5.061GlnLeu: 5.061 ± 0.074	1.015GlnMet: 1.015 ± 0.027	1.721GlnAsn: 1.721 ± 0.034	2.272GlnPro: 2.272 ± 0.042	2.617GlnGln: 2.617 ± 0.051	2.272GlnArg: 2.272 ± 0.047	2.481GlnSer: 2.481 ± 0.038	2.14GlnThr: 2.14 ± 0.038	2.944GlnVal: 2.944 ± 0.043	0.596GlnTrp: 0.596 ± 0.018	1.681GlnTyr: 1.681 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.523ArgAla: 3.523 ± 0.057	0.382ArgCys: 0.382 ± 0.014	2.431ArgAsp: 2.431 ± 0.052	3.293ArgGlu: 3.293 ± 0.062	2.629ArgPhe: 2.629 ± 0.046	2.777ArgGly: 2.777 ± 0.046	1.102ArgHis: 1.102 ± 0.026	3.253ArgIle: 3.253 ± 0.048	2.644ArgLys: 2.644 ± 0.05	5.269ArgLeu: 5.269 ± 0.069	1.33ArgMet: 1.33 ± 0.027	2.134ArgAsn: 2.134 ± 0.044	1.975ArgPro: 1.975 ± 0.033	2.422ArgGln: 2.422 ± 0.052	2.712ArgArg: 2.712 ± 0.05	2.78ArgSer: 2.78 ± 0.053	2.371ArgThr: 2.371 ± 0.041	2.906ArgVal: 2.906 ± 0.044	0.739ArgTrp: 0.739 ± 0.021	2.259ArgTyr: 2.259 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.856SerAla: 4.856 ± 0.065	0.806SerCys: 0.806 ± 0.032	3.367SerAsp: 3.367 ± 0.051	3.404SerGlu: 3.404 ± 0.048	3.156SerPhe: 3.156 ± 0.052	5.371SerGly: 5.371 ± 0.064	0.968SerHis: 0.968 ± 0.023	3.814SerIle: 3.814 ± 0.053	2.397SerLys: 2.397 ± 0.045	5.906SerLeu: 5.906 ± 0.071	1.199SerMet: 1.199 ± 0.026	2.847SerAsn: 2.847 ± 0.053	2.933SerPro: 2.933 ± 0.052	2.0SerGln: 2.0 ± 0.036	2.709SerArg: 2.709 ± 0.048	3.771SerSer: 3.771 ± 0.064	3.637SerThr: 3.637 ± 0.066	3.907SerVal: 3.907 ± 0.052	0.935SerTrp: 0.935 ± 0.025	2.389SerTyr: 2.389 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.04ThrAla: 5.04 ± 0.07	0.56ThrCys: 0.56 ± 0.031	3.722ThrAsp: 3.722 ± 0.074	3.288ThrGlu: 3.288 ± 0.042	2.908ThrPhe: 2.908 ± 0.051	4.856ThrGly: 4.856 ± 0.072	0.945ThrHis: 0.945 ± 0.028	3.603ThrIle: 3.603 ± 0.053	1.859ThrLys: 1.859 ± 0.033	6.038ThrLeu: 6.038 ± 0.075	0.915ThrMet: 0.915 ± 0.023	2.315ThrAsn: 2.315 ± 0.047	3.071ThrPro: 3.071 ± 0.052	1.849ThrGln: 1.849 ± 0.032	2.022ThrArg: 2.022 ± 0.033	3.007ThrSer: 3.007 ± 0.053	3.371ThrThr: 3.371 ± 0.065	4.565ThrVal: 4.565 ± 0.107	0.711ThrTrp: 0.711 ± 0.021	2.377ThrTyr: 2.377 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	5.039ValAla: 5.039 ± 0.059	0.634ValCys: 0.634 ± 0.024	3.793ValAsp: 3.793 ± 0.054	4.525ValGlu: 4.525 ± 0.058	3.121ValPhe: 3.121 ± 0.04	4.083ValGly: 4.083 ± 0.058	1.178ValHis: 1.178 ± 0.027	3.555ValIle: 3.555 ± 0.05	2.829ValLys: 2.829 ± 0.045	6.241ValLeu: 6.241 ± 0.069	1.314ValMet: 1.314 ± 0.024	2.948ValAsn: 2.948 ± 0.049	2.827ValPro: 2.827 ± 0.036	2.626ValGln: 2.626 ± 0.038	3.234ValArg: 3.234 ± 0.043	4.165ValSer: 4.165 ± 0.064	3.954ValThr: 3.954 ± 0.1	4.372ValVal: 4.372 ± 0.06	0.774ValTrp: 0.774 ± 0.021	2.39ValTyr: 2.39 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.084TrpAla: 1.084 ± 0.026	0.125TrpCys: 0.125 ± 0.009	0.795TrpAsp: 0.795 ± 0.02	0.933TrpGlu: 0.933 ± 0.026	0.53TrpPhe: 0.53 ± 0.015	0.949TrpGly: 0.949 ± 0.027	0.301TrpHis: 0.301 ± 0.013	0.714TrpIle: 0.714 ± 0.022	0.64TrpLys: 0.64 ± 0.019	1.418TrpLeu: 1.418 ± 0.035	0.374TrpMet: 0.374 ± 0.016	0.587TrpAsn: 0.587 ± 0.017	0.408TrpPro: 0.408 ± 0.016	0.685TrpGln: 0.685 ± 0.018	0.691TrpArg: 0.691 ± 0.021	1.025TrpSer: 1.025 ± 0.033	0.648TrpThr: 0.648 ± 0.02	0.902TrpVal: 0.902 ± 0.026	0.228TrpTrp: 0.228 ± 0.013	0.501TrpTyr: 0.501 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.835TyrAla: 2.835 ± 0.042	0.383TyrCys: 0.383 ± 0.016	2.448TyrAsp: 2.448 ± 0.039	2.671TyrGlu: 2.671 ± 0.037	2.096TyrPhe: 2.096 ± 0.036	2.532TyrGly: 2.532 ± 0.039	0.885TyrHis: 0.885 ± 0.023	1.914TyrIle: 1.914 ± 0.034	1.543TyrLys: 1.543 ± 0.035	3.962TyrLeu: 3.962 ± 0.062	0.631TyrMet: 0.631 ± 0.019	1.812TyrAsn: 1.812 ± 0.036	1.738TyrPro: 1.738 ± 0.034	1.988TyrGln: 1.988 ± 0.035	2.315TyrArg: 2.315 ± 0.035	2.282TyrSer: 2.282 ± 0.034	2.409TyrThr: 2.409 ± 0.048	1.975TyrVal: 1.975 ± 0.034	0.542TyrTrp: 0.542 ± 0.019	1.712TyrTyr: 1.712 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5064 proteins (1899700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---