Amino acid dipepetide frequency for Mucilaginibacter pedocola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.07AlaAla: 8.07 ± 0.101
0.713AlaCys: 0.713 ± 0.02
5.273AlaAsp: 5.273 ± 0.06
5.033AlaGlu: 5.033 ± 0.067
3.856AlaPhe: 3.856 ± 0.05
6.718AlaGly: 6.718 ± 0.1
1.326AlaHis: 1.326 ± 0.029
5.782AlaIle: 5.782 ± 0.06
5.221AlaLys: 5.221 ± 0.063
7.878AlaLeu: 7.878 ± 0.079
1.998AlaMet: 1.998 ± 0.031
4.258AlaAsn: 4.258 ± 0.055
2.875AlaPro: 2.875 ± 0.044
3.339AlaGln: 3.339 ± 0.043
2.826AlaArg: 2.826 ± 0.038
4.899AlaSer: 4.899 ± 0.079
4.947AlaThr: 4.947 ± 0.096
5.453AlaVal: 5.453 ± 0.057
0.913AlaTrp: 0.913 ± 0.026
3.21AlaTyr: 3.21 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.557CysAla: 0.557 ± 0.02
0.14CysCys: 0.14 ± 0.009
0.386CysAsp: 0.386 ± 0.013
0.353CysGlu: 0.353 ± 0.013
0.451CysPhe: 0.451 ± 0.015
0.628CysGly: 0.628 ± 0.021
0.182CysHis: 0.182 ± 0.011
0.561CysIle: 0.561 ± 0.018
0.462CysLys: 0.462 ± 0.016
0.774CysLeu: 0.774 ± 0.021
0.179CysMet: 0.179 ± 0.01
0.344CysAsn: 0.344 ± 0.013
0.305CysPro: 0.305 ± 0.012
0.202CysGln: 0.202 ± 0.01
0.342CysArg: 0.342 ± 0.013
0.475CysSer: 0.475 ± 0.015
0.442CysThr: 0.442 ± 0.018
0.469CysVal: 0.469 ± 0.016
0.088CysTrp: 0.088 ± 0.007
0.336CysTyr: 0.336 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.687AspAla: 4.687 ± 0.059
0.356AspCys: 0.356 ± 0.013
2.728AspAsp: 2.728 ± 0.048
3.371AspGlu: 3.371 ± 0.046
2.799AspPhe: 2.799 ± 0.043
4.243AspGly: 4.243 ± 0.061
0.91AspHis: 0.91 ± 0.02
3.904AspIle: 3.904 ± 0.051
3.979AspLys: 3.979 ± 0.046
4.42AspLeu: 4.42 ± 0.054
1.277AspMet: 1.277 ± 0.025
2.798AspAsn: 2.798 ± 0.044
1.984AspPro: 1.984 ± 0.034
1.427AspGln: 1.427 ± 0.028
2.041AspArg: 2.041 ± 0.03
2.884AspSer: 2.884 ± 0.045
2.886AspThr: 2.886 ± 0.042
3.544AspVal: 3.544 ± 0.045
0.772AspTrp: 0.772 ± 0.019
2.404AspTyr: 2.404 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.542GluAla: 4.542 ± 0.061
0.314GluCys: 0.314 ± 0.012
2.624GluAsp: 2.624 ± 0.039
3.297GluGlu: 3.297 ± 0.06
2.287GluPhe: 2.287 ± 0.034
3.368GluGly: 3.368 ± 0.046
1.158GluHis: 1.158 ± 0.028
3.57GluIle: 3.57 ± 0.05
4.099GluLys: 4.099 ± 0.052
5.592GluLeu: 5.592 ± 0.073
1.38GluMet: 1.38 ± 0.029
2.807GluAsn: 2.807 ± 0.042
1.778GluPro: 1.778 ± 0.036
2.47GluGln: 2.47 ± 0.044
2.514GluArg: 2.514 ± 0.041
2.567GluSer: 2.567 ± 0.038
2.775GluThr: 2.775 ± 0.041
3.718GluVal: 3.718 ± 0.045
0.624GluTrp: 0.624 ± 0.017
2.112GluTyr: 2.112 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.838PheAla: 3.838 ± 0.047
0.493PheCys: 0.493 ± 0.016
2.909PheAsp: 2.909 ± 0.047
2.541PheGlu: 2.541 ± 0.038
2.3PhePhe: 2.3 ± 0.048
3.523PheGly: 3.523 ± 0.051
0.778PheHis: 0.778 ± 0.021
3.246PheIle: 3.246 ± 0.05
3.267PheLys: 3.267 ± 0.048
3.976PheLeu: 3.976 ± 0.059
1.106PheMet: 1.106 ± 0.025
2.892PheAsn: 2.892 ± 0.047
1.685PhePro: 1.685 ± 0.026
1.222PheGln: 1.222 ± 0.024
1.847PheArg: 1.847 ± 0.033
3.373PheSer: 3.373 ± 0.044
3.221PheThr: 3.221 ± 0.048
2.911PheVal: 2.911 ± 0.044
0.561PheTrp: 0.561 ± 0.019
2.151PheTyr: 2.151 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.178GlyAla: 5.178 ± 0.07
0.604GlyCys: 0.604 ± 0.021
3.593GlyAsp: 3.593 ± 0.046
3.362GlyGlu: 3.362 ± 0.038
3.66GlyPhe: 3.66 ± 0.049
5.249GlyGly: 5.249 ± 0.078
1.33GlyHis: 1.33 ± 0.027
5.197GlyIle: 5.197 ± 0.061
5.305GlyLys: 5.305 ± 0.058
6.597GlyLeu: 6.597 ± 0.069
1.728GlyMet: 1.728 ± 0.031
3.89GlyAsn: 3.89 ± 0.068
1.786GlyPro: 1.786 ± 0.033
2.528GlyGln: 2.528 ± 0.036
2.799GlyArg: 2.799 ± 0.039
4.428GlySer: 4.428 ± 0.069
4.69GlyThr: 4.69 ± 0.096
4.624GlyVal: 4.624 ± 0.051
1.046GlyTrp: 1.046 ± 0.028
3.348GlyTyr: 3.348 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.232HisAla: 1.232 ± 0.026
0.18HisCys: 0.18 ± 0.009
0.928HisAsp: 0.928 ± 0.023
0.989HisGlu: 0.989 ± 0.024
1.084HisPhe: 1.084 ± 0.025
1.186HisGly: 1.186 ± 0.027
0.512HisHis: 0.512 ± 0.019
1.377HisIle: 1.377 ± 0.03
0.979HisLys: 0.979 ± 0.026
1.829HisLeu: 1.829 ± 0.033
0.383HisMet: 0.383 ± 0.014
0.969HisAsn: 0.969 ± 0.024
1.025HisPro: 1.025 ± 0.024
0.762HisGln: 0.762 ± 0.019
0.807HisArg: 0.807 ± 0.023
1.028HisSer: 1.028 ± 0.023
1.04HisThr: 1.04 ± 0.024
1.007HisVal: 1.007 ± 0.023
0.261HisTrp: 0.261 ± 0.012
0.873HisTyr: 0.873 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.176IleAla: 6.176 ± 0.06
0.619IleCys: 0.619 ± 0.017
3.881IleAsp: 3.881 ± 0.046
3.625IleGlu: 3.625 ± 0.048
2.838IlePhe: 2.838 ± 0.049
4.68IleGly: 4.68 ± 0.057
1.148IleHis: 1.148 ± 0.024
4.531IleIle: 4.531 ± 0.062
4.562IleLys: 4.562 ± 0.052
5.507IleLeu: 5.507 ± 0.068
1.269IleMet: 1.269 ± 0.03
3.963IleAsn: 3.963 ± 0.045
2.848IlePro: 2.848 ± 0.038
2.022IleGln: 2.022 ± 0.031
2.769IleArg: 2.769 ± 0.042
4.744IleSer: 4.744 ± 0.051
4.827IleThr: 4.827 ± 0.074
4.037IleVal: 4.037 ± 0.046
0.684IleTrp: 0.684 ± 0.019
2.503IleTyr: 2.503 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
5.771LysAla: 5.771 ± 0.075
0.291LysCys: 0.291 ± 0.012
3.636LysAsp: 3.636 ± 0.051
3.876LysGlu: 3.876 ± 0.056
2.597LysPhe: 2.597 ± 0.04
4.406LysGly: 4.406 ± 0.05
1.342LysHis: 1.342 ± 0.026
4.299LysIle: 4.299 ± 0.044
4.779LysLys: 4.779 ± 0.052
6.437LysLeu: 6.437 ± 0.073
1.772LysMet: 1.772 ± 0.031
3.824LysAsn: 3.824 ± 0.046
3.087LysPro: 3.087 ± 0.047
2.946LysGln: 2.946 ± 0.045
2.753LysArg: 2.753 ± 0.041
3.265LysSer: 3.265 ± 0.044
4.173LysThr: 4.173 ± 0.044
4.386LysVal: 4.386 ± 0.049
0.781LysTrp: 0.781 ± 0.02
2.86LysTyr: 2.86 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
7.83LeuAla: 7.83 ± 0.082
0.823LeuCys: 0.823 ± 0.022
4.601LeuAsp: 4.601 ± 0.051
4.499LeuGlu: 4.499 ± 0.069
4.573LeuPhe: 4.573 ± 0.056
5.814LeuGly: 5.814 ± 0.065
1.734LeuHis: 1.734 ± 0.034
5.897LeuIle: 5.897 ± 0.071
6.905LeuLys: 6.905 ± 0.068
9.38LeuLeu: 9.38 ± 0.12
2.204LeuMet: 2.204 ± 0.037
5.437LeuAsn: 5.437 ± 0.059
4.276LeuPro: 4.276 ± 0.049
3.763LeuGln: 3.763 ± 0.053
3.796LeuArg: 3.796 ± 0.047
6.737LeuSer: 6.737 ± 0.065
5.575LeuThr: 5.575 ± 0.067
5.65LeuVal: 5.65 ± 0.059
0.991LeuTrp: 0.991 ± 0.027
3.375LeuTyr: 3.375 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.186MetAla: 2.186 ± 0.032
0.15MetCys: 0.15 ± 0.008
1.198MetAsp: 1.198 ± 0.025
1.269MetGlu: 1.269 ± 0.027
0.858MetPhe: 0.858 ± 0.022
1.586MetGly: 1.586 ± 0.03
0.452MetHis: 0.452 ± 0.016
1.273MetIle: 1.273 ± 0.027
1.847MetLys: 1.847 ± 0.029
2.301MetLeu: 2.301 ± 0.041
0.61MetMet: 0.61 ± 0.02
1.147MetAsn: 1.147 ± 0.027
1.193MetPro: 1.193 ± 0.028
1.05MetGln: 1.05 ± 0.026
1.035MetArg: 1.035 ± 0.022
1.258MetSer: 1.258 ± 0.027
0.942MetThr: 0.942 ± 0.022
1.619MetVal: 1.619 ± 0.031
0.191MetTrp: 0.191 ± 0.009
0.692MetTyr: 0.692 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
4.342AsnAla: 4.342 ± 0.055
0.388AsnCys: 0.388 ± 0.014
2.702AsnAsp: 2.702 ± 0.043
2.714AsnGlu: 2.714 ± 0.04
2.597AsnPhe: 2.597 ± 0.043
4.351AsnGly: 4.351 ± 0.071
0.965AsnHis: 0.965 ± 0.023
3.948AsnIle: 3.948 ± 0.049
3.47AsnLys: 3.47 ± 0.047
4.841AsnLeu: 4.841 ± 0.062
1.153AsnMet: 1.153 ± 0.027
3.257AsnAsn: 3.257 ± 0.061
2.582AsnPro: 2.582 ± 0.04
1.878AsnGln: 1.878 ± 0.034
2.276AsnArg: 2.276 ± 0.033
3.228AsnSer: 3.228 ± 0.053
3.435AsnThr: 3.435 ± 0.056
3.176AsnVal: 3.176 ± 0.05
0.759AsnTrp: 0.759 ± 0.021
2.759AsnTyr: 2.759 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
4.023ProAla: 4.023 ± 0.067
0.218ProCys: 0.218 ± 0.011
2.577ProAsp: 2.577 ± 0.04
2.83ProGlu: 2.83 ± 0.043
1.913ProPhe: 1.913 ± 0.035
3.174ProGly: 3.174 ± 0.04
0.714ProHis: 0.714 ± 0.021
2.314ProIle: 2.314 ± 0.034
2.274ProLys: 2.274 ± 0.033
3.438ProLeu: 3.438 ± 0.043
0.832ProMet: 0.832 ± 0.021
1.995ProAsn: 1.995 ± 0.036
1.262ProPro: 1.262 ± 0.033
1.583ProGln: 1.583 ± 0.031
1.137ProArg: 1.137 ± 0.029
2.124ProSer: 2.124 ± 0.033
2.141ProThr: 2.141 ± 0.038
3.427ProVal: 3.427 ± 0.051
0.428ProTrp: 0.428 ± 0.015
1.608ProTyr: 1.608 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.007GlnAla: 3.007 ± 0.043
0.214GlnCys: 0.214 ± 0.01
1.538GlnAsp: 1.538 ± 0.029
1.785GlnGlu: 1.785 ± 0.034
1.641GlnPhe: 1.641 ± 0.033
2.102GlnGly: 2.102 ± 0.041
0.821GlnHis: 0.821 ± 0.025
2.252GlnIle: 2.252 ± 0.033
2.522GlnLys: 2.522 ± 0.046
3.938GlnLeu: 3.938 ± 0.052
0.953GlnMet: 0.953 ± 0.025
2.05GlnAsn: 2.05 ± 0.038
1.666GlnPro: 1.666 ± 0.031
2.213GlnGln: 2.213 ± 0.068
1.687GlnArg: 1.687 ± 0.035
2.118GlnSer: 2.118 ± 0.034
2.259GlnThr: 2.259 ± 0.032
2.428GlnVal: 2.428 ± 0.041
0.469GlnTrp: 0.469 ± 0.016
1.599GlnTyr: 1.599 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.777ArgAla: 2.777 ± 0.046
0.241ArgCys: 0.241 ± 0.009
2.121ArgAsp: 2.121 ± 0.037
2.308ArgGlu: 2.308 ± 0.042
2.101ArgPhe: 2.101 ± 0.036
2.266ArgGly: 2.266 ± 0.041
0.779ArgHis: 0.779 ± 0.022
2.897ArgIle: 2.897 ± 0.036
2.796ArgLys: 2.796 ± 0.044
3.983ArgLeu: 3.983 ± 0.045
1.059ArgMet: 1.059 ± 0.02
2.244ArgAsn: 2.244 ± 0.037
1.5ArgPro: 1.5 ± 0.029
1.609ArgGln: 1.609 ± 0.033
1.79ArgArg: 1.79 ± 0.034
2.423ArgSer: 2.423 ± 0.038
2.093ArgThr: 2.093 ± 0.037
2.58ArgVal: 2.58 ± 0.037
0.512ArgTrp: 0.512 ± 0.016
1.895ArgTyr: 1.895 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
5.324SerAla: 5.324 ± 0.062
0.498SerCys: 0.498 ± 0.018
2.762SerAsp: 2.762 ± 0.042
2.781SerGlu: 2.781 ± 0.04
3.327SerPhe: 3.327 ± 0.046
4.889SerGly: 4.889 ± 0.081
1.055SerHis: 1.055 ± 0.024
4.158SerIle: 4.158 ± 0.049
3.614SerLys: 3.614 ± 0.05
5.859SerLeu: 5.859 ± 0.069
1.219SerMet: 1.219 ± 0.026
2.981SerAsn: 2.981 ± 0.047
2.564SerPro: 2.564 ± 0.046
1.912SerGln: 1.912 ± 0.038
2.416SerArg: 2.416 ± 0.039
3.638SerSer: 3.638 ± 0.057
3.599SerThr: 3.599 ± 0.061
4.249SerVal: 4.249 ± 0.053
0.706SerTrp: 0.706 ± 0.018
2.653SerTyr: 2.653 ± 0.046
0.0SerXaa: 0.0 ± 0.0
Thr
5.46ThrAla: 5.46 ± 0.102
0.382ThrCys: 0.382 ± 0.015
3.588ThrAsp: 3.588 ± 0.044
3.111ThrGlu: 3.111 ± 0.04
2.837ThrPhe: 2.837 ± 0.044
5.183ThrGly: 5.183 ± 0.083
1.034ThrHis: 1.034 ± 0.023
4.308ThrIle: 4.308 ± 0.064
3.174ThrLys: 3.174 ± 0.042
5.68ThrLeu: 5.68 ± 0.067
1.052ThrMet: 1.052 ± 0.022
2.943ThrAsn: 2.943 ± 0.045
2.939ThrPro: 2.939 ± 0.061
1.986ThrGln: 1.986 ± 0.031
2.128ThrArg: 2.128 ± 0.035
3.372ThrSer: 3.372 ± 0.057
3.777ThrThr: 3.777 ± 0.079
4.348ThrVal: 4.348 ± 0.102
0.681ThrTrp: 0.681 ± 0.017
2.591ThrTyr: 2.591 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
5.6ValAla: 5.6 ± 0.074
0.594ValCys: 0.594 ± 0.019
3.383ValAsp: 3.383 ± 0.05
3.266ValGlu: 3.266 ± 0.044
3.21ValPhe: 3.21 ± 0.041
3.932ValGly: 3.932 ± 0.049
1.031ValHis: 1.031 ± 0.023
4.498ValIle: 4.498 ± 0.054
4.507ValLys: 4.507 ± 0.049
6.119ValLeu: 6.119 ± 0.058
1.527ValMet: 1.527 ± 0.028
3.813ValAsn: 3.813 ± 0.056
2.544ValPro: 2.544 ± 0.037
2.036ValGln: 2.036 ± 0.032
2.447ValArg: 2.447 ± 0.038
4.368ValSer: 4.368 ± 0.063
4.43ValThr: 4.43 ± 0.104
4.602ValVal: 4.602 ± 0.052
0.729ValTrp: 0.729 ± 0.02
2.674ValTyr: 2.674 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.894TrpAla: 0.894 ± 0.022
0.111TrpCys: 0.111 ± 0.009
0.685TrpAsp: 0.685 ± 0.019
0.658TrpGlu: 0.658 ± 0.018
0.629TrpPhe: 0.629 ± 0.018
0.85TrpGly: 0.85 ± 0.02
0.289TrpHis: 0.289 ± 0.012
0.644TrpIle: 0.644 ± 0.023
0.778TrpLys: 0.778 ± 0.022
1.278TrpLeu: 1.278 ± 0.027
0.352TrpMet: 0.352 ± 0.013
0.611TrpAsn: 0.611 ± 0.018
0.381TrpPro: 0.381 ± 0.012
0.598TrpGln: 0.598 ± 0.019
0.521TrpArg: 0.521 ± 0.015
0.614TrpSer: 0.614 ± 0.02
0.564TrpThr: 0.564 ± 0.016
0.799TrpVal: 0.799 ± 0.023
0.213TrpTrp: 0.213 ± 0.011
0.49TrpTyr: 0.49 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.09TyrAla: 3.09 ± 0.04
0.348TyrCys: 0.348 ± 0.015
2.3TyrAsp: 2.3 ± 0.039
1.928TyrGlu: 1.928 ± 0.031
2.284TyrPhe: 2.284 ± 0.038
2.793TyrGly: 2.793 ± 0.048
0.895TyrHis: 0.895 ± 0.021
2.576TyrIle: 2.576 ± 0.035
2.74TyrLys: 2.74 ± 0.04
4.032TyrLeu: 4.032 ± 0.053
0.803TyrMet: 0.803 ± 0.021
2.6TyrAsn: 2.6 ± 0.047
1.733TyrPro: 1.733 ± 0.034
1.717TyrGln: 1.717 ± 0.031
2.042TyrArg: 2.042 ± 0.033
2.66TyrSer: 2.66 ± 0.039
2.759TyrThr: 2.759 ± 0.059
2.284TyrVal: 2.284 ± 0.047
0.548TyrTrp: 0.548 ± 0.018
2.019TyrTyr: 2.019 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5893 proteins (2023964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski