Amino acid dipepetide frequency for Vulcanibacillus modesticaldus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.1AlaAla: 4.1 ± 0.121	0.327AlaCys: 0.327 ± 0.024	2.942AlaAsp: 2.942 ± 0.074	4.085AlaGlu: 4.085 ± 0.094	2.416AlaPhe: 2.416 ± 0.072	4.203AlaGly: 4.203 ± 0.098	0.988AlaHis: 0.988 ± 0.043	6.318AlaIle: 6.318 ± 0.11	5.227AlaLys: 5.227 ± 0.097	6.129AlaLeu: 6.129 ± 0.11	1.611AlaMet: 1.611 ± 0.066	2.909AlaAsn: 2.909 ± 0.084	1.658AlaPro: 1.658 ± 0.044	1.693AlaGln: 1.693 ± 0.057	2.415AlaArg: 2.415 ± 0.063	3.07AlaSer: 3.07 ± 0.072	3.097AlaThr: 3.097 ± 0.086	4.1AlaVal: 4.1 ± 0.073	0.4AlaTrp: 0.4 ± 0.026	2.05AlaTyr: 2.05 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.255CysAla: 0.255 ± 0.023	0.057CysCys: 0.057 ± 0.01	0.271CysAsp: 0.271 ± 0.02	0.29CysGlu: 0.29 ± 0.023	0.14CysPhe: 0.14 ± 0.015	0.497CysGly: 0.497 ± 0.034	0.148CysHis: 0.148 ± 0.017	0.344CysIle: 0.344 ± 0.027	0.336CysLys: 0.336 ± 0.025	0.365CysLeu: 0.365 ± 0.024	0.1CysMet: 0.1 ± 0.014	0.273CysAsn: 0.273 ± 0.019	0.324CysPro: 0.324 ± 0.029	0.159CysGln: 0.159 ± 0.019	0.222CysArg: 0.222 ± 0.018	0.363CysSer: 0.363 ± 0.022	0.25CysThr: 0.25 ± 0.022	0.271CysVal: 0.271 ± 0.024	0.048CysTrp: 0.048 ± 0.01	0.185CysTyr: 0.185 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.646AspAla: 2.646 ± 0.066	0.226AspCys: 0.226 ± 0.02	2.834AspAsp: 2.834 ± 0.099	4.439AspGlu: 4.439 ± 0.092	2.512AspPhe: 2.512 ± 0.064	3.393AspGly: 3.393 ± 0.078	0.907AspHis: 0.907 ± 0.039	5.244AspIle: 5.244 ± 0.09	4.208AspLys: 4.208 ± 0.089	5.466AspLeu: 5.466 ± 0.104	1.283AspMet: 1.283 ± 0.05	2.477AspAsn: 2.477 ± 0.078	1.997AspPro: 1.997 ± 0.061	2.05AspGln: 2.05 ± 0.072	2.114AspArg: 2.114 ± 0.058	2.718AspSer: 2.718 ± 0.074	2.171AspThr: 2.171 ± 0.055	3.644AspVal: 3.644 ± 0.078	0.603AspTrp: 0.603 ± 0.035	2.348AspTyr: 2.348 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.465GluAla: 4.465 ± 0.107	0.23GluCys: 0.23 ± 0.02	3.741GluAsp: 3.741 ± 0.071	6.715GluGlu: 6.715 ± 0.139	2.568GluPhe: 2.568 ± 0.067	3.918GluGly: 3.918 ± 0.083	1.246GluHis: 1.246 ± 0.042	7.621GluIle: 7.621 ± 0.122	7.205GluLys: 7.205 ± 0.112	7.476GluLeu: 7.476 ± 0.136	2.149GluMet: 2.149 ± 0.063	3.886GluAsn: 3.886 ± 0.076	1.776GluPro: 1.776 ± 0.057	3.154GluGln: 3.154 ± 0.073	3.307GluArg: 3.307 ± 0.079	3.15GluSer: 3.15 ± 0.07	3.06GluThr: 3.06 ± 0.08	5.502GluVal: 5.502 ± 0.104	0.655GluTrp: 0.655 ± 0.036	2.617GluTyr: 2.617 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	2.584PheAla: 2.584 ± 0.078	0.223PheCys: 0.223 ± 0.017	2.346PheAsp: 2.346 ± 0.066	2.855PheGlu: 2.855 ± 0.056	2.204PhePhe: 2.204 ± 0.07	3.067PheGly: 3.067 ± 0.082	0.711PheHis: 0.711 ± 0.034	4.093PheIle: 4.093 ± 0.104	2.786PheLys: 2.786 ± 0.063	4.139PheLeu: 4.139 ± 0.11	0.923PheMet: 0.923 ± 0.04	2.415PheAsn: 2.415 ± 0.072	1.519PhePro: 1.519 ± 0.05	1.345PheGln: 1.345 ± 0.044	1.524PheArg: 1.524 ± 0.055	3.135PheSer: 3.135 ± 0.067	2.252PheThr: 2.252 ± 0.072	2.832PheVal: 2.832 ± 0.072	0.432PheTrp: 0.432 ± 0.029	1.72PheTyr: 1.72 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.031GlyAla: 4.031 ± 0.106	0.459GlyCys: 0.459 ± 0.03	3.129GlyAsp: 3.129 ± 0.071	4.254GlyGlu: 4.254 ± 0.087	3.146GlyPhe: 3.146 ± 0.078	4.316GlyGly: 4.316 ± 0.111	1.205GlyHis: 1.205 ± 0.052	6.787GlyIle: 6.787 ± 0.118	5.451GlyLys: 5.451 ± 0.101	6.406GlyLeu: 6.406 ± 0.126	1.757GlyMet: 1.757 ± 0.053	2.748GlyAsn: 2.748 ± 0.07	1.586GlyPro: 1.586 ± 0.057	1.925GlyGln: 1.925 ± 0.054	2.577GlyArg: 2.577 ± 0.074	3.59GlySer: 3.59 ± 0.071	3.712GlyThr: 3.712 ± 0.087	4.927GlyVal: 4.927 ± 0.102	0.622GlyTrp: 0.622 ± 0.037	2.888GlyTyr: 2.888 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	0.866HisAla: 0.866 ± 0.038	0.108HisCys: 0.108 ± 0.014	0.845HisAsp: 0.845 ± 0.037	1.011HisGlu: 1.011 ± 0.036	0.913HisPhe: 0.913 ± 0.043	1.16HisGly: 1.16 ± 0.042	0.512HisHis: 0.512 ± 0.041	1.39HisIle: 1.39 ± 0.044	1.116HisLys: 1.116 ± 0.046	1.898HisLeu: 1.898 ± 0.062	0.349HisMet: 0.349 ± 0.022	0.771HisAsn: 0.771 ± 0.035	0.971HisPro: 0.971 ± 0.037	0.797HisGln: 0.797 ± 0.036	0.778HisArg: 0.778 ± 0.035	1.034HisSer: 1.034 ± 0.033	0.778HisThr: 0.778 ± 0.039	0.979HisVal: 0.979 ± 0.04	0.15HisTrp: 0.15 ± 0.017	0.676HisTyr: 0.676 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.422IleAla: 6.422 ± 0.107	0.456IleCys: 0.456 ± 0.027	5.834IleAsp: 5.834 ± 0.104	7.361IleGlu: 7.361 ± 0.12	4.218IlePhe: 4.218 ± 0.113	6.615IleGly: 6.615 ± 0.151	1.607IleHis: 1.607 ± 0.059	9.184IleIle: 9.184 ± 0.146	7.613IleLys: 7.613 ± 0.126	8.827IleLeu: 8.827 ± 0.152	1.949IleMet: 1.949 ± 0.063	5.23IleAsn: 5.23 ± 0.109	3.876IlePro: 3.876 ± 0.087	2.914IleGln: 2.914 ± 0.071	3.668IleArg: 3.668 ± 0.082	6.207IleSer: 6.207 ± 0.114	5.074IleThr: 5.074 ± 0.09	6.294IleVal: 6.294 ± 0.092	0.735IleTrp: 0.735 ± 0.039	3.371IleTyr: 3.371 ± 0.079	0.0IleXaa: 0.0 ± 0.0
Lys	4.479LysAla: 4.479 ± 0.09	0.343LysCys: 0.343 ± 0.029	4.388LysAsp: 4.388 ± 0.084	7.637LysGlu: 7.637 ± 0.132	2.436LysPhe: 2.436 ± 0.064	4.651LysGly: 4.651 ± 0.088	1.258LysHis: 1.258 ± 0.042	7.86LysIle: 7.86 ± 0.112	7.442LysLys: 7.442 ± 0.139	7.004LysLeu: 7.004 ± 0.12	2.294LysMet: 2.294 ± 0.062	4.563LysAsn: 4.563 ± 0.086	2.448LysPro: 2.448 ± 0.066	3.107LysGln: 3.107 ± 0.076	3.644LysArg: 3.644 ± 0.08	3.738LysSer: 3.738 ± 0.078	3.723LysThr: 3.723 ± 0.086	5.464LysVal: 5.464 ± 0.112	0.81LysTrp: 0.81 ± 0.041	3.213LysTyr: 3.213 ± 0.084	0.0LysXaa: 0.0 ± 0.0
Leu	6.62LeuAla: 6.62 ± 0.107	0.309LeuCys: 0.309 ± 0.023	5.324LeuAsp: 5.324 ± 0.089	7.036LeuGlu: 7.036 ± 0.115	4.235LeuPhe: 4.235 ± 0.099	6.652LeuGly: 6.652 ± 0.122	1.519LeuHis: 1.519 ± 0.056	9.178LeuIle: 9.178 ± 0.156	7.66LeuLys: 7.66 ± 0.116	9.506LeuLeu: 9.506 ± 0.179	2.33LeuMet: 2.33 ± 0.067	5.287LeuAsn: 5.287 ± 0.1	3.604LeuPro: 3.604 ± 0.08	3.103LeuGln: 3.103 ± 0.074	3.741LeuArg: 3.741 ± 0.088	6.61LeuSer: 6.61 ± 0.101	5.335LeuThr: 5.335 ± 0.096	6.318LeuVal: 6.318 ± 0.113	0.711LeuTrp: 0.711 ± 0.033	3.223LeuTyr: 3.223 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.819MetAla: 1.819 ± 0.056	0.096MetCys: 0.096 ± 0.014	1.336MetAsp: 1.336 ± 0.043	1.787MetGlu: 1.787 ± 0.049	0.928MetPhe: 0.928 ± 0.041	1.825MetGly: 1.825 ± 0.05	0.304MetHis: 0.304 ± 0.024	2.268MetIle: 2.268 ± 0.066	2.107MetLys: 2.107 ± 0.06	2.214MetLeu: 2.214 ± 0.063	0.724MetMet: 0.724 ± 0.039	1.315MetAsn: 1.315 ± 0.046	0.797MetPro: 0.797 ± 0.04	0.603MetGln: 0.603 ± 0.031	1.009MetArg: 1.009 ± 0.039	1.417MetSer: 1.417 ± 0.048	1.288MetThr: 1.288 ± 0.047	1.815MetVal: 1.815 ± 0.055	0.139MetTrp: 0.139 ± 0.016	0.647MetTyr: 0.647 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.493AsnAla: 2.493 ± 0.061	0.29AsnCys: 0.29 ± 0.022	2.668AsnAsp: 2.668 ± 0.068	3.676AsnGlu: 3.676 ± 0.085	2.153AsnPhe: 2.153 ± 0.054	3.274AsnGly: 3.274 ± 0.08	0.937AsnHis: 0.937 ± 0.033	4.922AsnIle: 4.922 ± 0.093	4.182AsnLys: 4.182 ± 0.084	5.008AsnLeu: 5.008 ± 0.081	1.149AsnMet: 1.149 ± 0.045	3.068AsnAsn: 3.068 ± 0.076	2.232AsnPro: 2.232 ± 0.064	2.319AsnGln: 2.319 ± 0.059	2.31AsnArg: 2.31 ± 0.06	2.893AsnSer: 2.893 ± 0.075	2.369AsnThr: 2.369 ± 0.067	3.177AsnVal: 3.177 ± 0.079	0.5AsnTrp: 0.5 ± 0.031	2.05AsnTyr: 2.05 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.726ProAla: 1.726 ± 0.053	0.159ProCys: 0.159 ± 0.016	1.922ProAsp: 1.922 ± 0.059	2.713ProGlu: 2.713 ± 0.063	1.686ProPhe: 1.686 ± 0.052	2.181ProGly: 2.181 ± 0.066	0.654ProHis: 0.654 ± 0.038	3.433ProIle: 3.433 ± 0.072	2.614ProLys: 2.614 ± 0.082	3.221ProLeu: 3.221 ± 0.074	0.687ProMet: 0.687 ± 0.03	1.954ProAsn: 1.954 ± 0.06	0.952ProPro: 0.952 ± 0.043	0.99ProGln: 0.99 ± 0.036	1.211ProArg: 1.211 ± 0.042	1.992ProSer: 1.992 ± 0.064	1.849ProThr: 1.849 ± 0.054	2.349ProVal: 2.349 ± 0.071	0.324ProTrp: 0.324 ± 0.024	1.468ProTyr: 1.468 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.157GlnAla: 2.157 ± 0.064	0.142GlnCys: 0.142 ± 0.016	1.524GlnAsp: 1.524 ± 0.052	2.641GlnGlu: 2.641 ± 0.07	1.38GlnPhe: 1.38 ± 0.041	1.93GlnGly: 1.93 ± 0.054	0.542GlnHis: 0.542 ± 0.031	3.419GlnIle: 3.419 ± 0.077	2.708GlnLys: 2.708 ± 0.074	3.95GlnLeu: 3.95 ± 0.086	1.007GlnMet: 1.007 ± 0.04	1.61GlnAsn: 1.61 ± 0.056	0.956GlnPro: 0.956 ± 0.038	1.352GlnGln: 1.352 ± 0.06	1.361GlnArg: 1.361 ± 0.049	1.82GlnSer: 1.82 ± 0.06	1.565GlnThr: 1.565 ± 0.054	2.295GlnVal: 2.295 ± 0.056	0.26GlnTrp: 0.26 ± 0.02	1.304GlnTyr: 1.304 ± 0.049	0.0GlnXaa: 0.0 ± 0.0
Arg	2.198ArgAla: 2.198 ± 0.06	0.21ArgCys: 0.21 ± 0.021	2.01ArgAsp: 2.01 ± 0.049	3.24ArgGlu: 3.24 ± 0.077	1.825ArgPhe: 1.825 ± 0.059	2.546ArgGly: 2.546 ± 0.064	0.706ArgHis: 0.706 ± 0.037	3.888ArgIle: 3.888 ± 0.079	3.419ArgLys: 3.419 ± 0.077	4.127ArgLeu: 4.127 ± 0.082	1.05ArgMet: 1.05 ± 0.037	2.061ArgAsn: 2.061 ± 0.057	1.286ArgPro: 1.286 ± 0.042	1.387ArgGln: 1.387 ± 0.051	1.873ArgArg: 1.873 ± 0.068	1.986ArgSer: 1.986 ± 0.07	1.83ArgThr: 1.83 ± 0.052	2.844ArgVal: 2.844 ± 0.071	0.394ArgTrp: 0.394 ± 0.024	1.613ArgTyr: 1.613 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.035SerAla: 3.035 ± 0.082	0.314SerCys: 0.314 ± 0.026	2.863SerAsp: 2.863 ± 0.071	3.741SerGlu: 3.741 ± 0.083	2.883SerPhe: 2.883 ± 0.07	3.929SerGly: 3.929 ± 0.08	1.012SerHis: 1.012 ± 0.04	5.643SerIle: 5.643 ± 0.108	4.447SerLys: 4.447 ± 0.081	6.059SerLeu: 6.059 ± 0.099	1.46SerMet: 1.46 ± 0.046	2.907SerAsn: 2.907 ± 0.069	1.938SerPro: 1.938 ± 0.057	1.859SerGln: 1.859 ± 0.053	2.247SerArg: 2.247 ± 0.057	3.566SerSer: 3.566 ± 0.076	2.92SerThr: 2.92 ± 0.061	3.481SerVal: 3.481 ± 0.081	0.54SerTrp: 0.54 ± 0.033	2.208SerTyr: 2.208 ± 0.069	0.0SerXaa: 0.0 ± 0.0
Thr	3.094ThrAla: 3.094 ± 0.077	0.285ThrCys: 0.285 ± 0.024	2.62ThrAsp: 2.62 ± 0.053	3.207ThrGlu: 3.207 ± 0.074	2.276ThrPhe: 2.276 ± 0.064	3.888ThrGly: 3.888 ± 0.084	0.842ThrHis: 0.842 ± 0.038	5.046ThrIle: 5.046 ± 0.083	3.59ThrLys: 3.59 ± 0.081	4.962ThrLeu: 4.962 ± 0.103	1.087ThrMet: 1.087 ± 0.047	2.426ThrAsn: 2.426 ± 0.071	1.992ThrPro: 1.992 ± 0.064	1.235ThrGln: 1.235 ± 0.049	1.733ThrArg: 1.733 ± 0.047	2.957ThrSer: 2.957 ± 0.076	2.813ThrThr: 2.813 ± 0.077	3.456ThrVal: 3.456 ± 0.076	0.427ThrTrp: 0.427 ± 0.03	1.863ThrTyr: 1.863 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.485ValAla: 4.485 ± 0.085	0.381ValCys: 0.381 ± 0.026	4.087ValAsp: 4.087 ± 0.095	4.818ValGlu: 4.818 ± 0.089	2.895ValPhe: 2.895 ± 0.069	4.489ValGly: 4.489 ± 0.094	1.028ValHis: 1.028 ± 0.043	6.75ValIle: 6.75 ± 0.115	5.23ValLys: 5.23 ± 0.095	6.323ValLeu: 6.323 ± 0.105	1.541ValMet: 1.541 ± 0.04	3.419ValAsn: 3.419 ± 0.074	2.385ValPro: 2.385 ± 0.064	1.736ValGln: 1.736 ± 0.047	2.633ValArg: 2.633 ± 0.075	4.045ValSer: 4.045 ± 0.088	3.644ValThr: 3.644 ± 0.073	5.029ValVal: 5.029 ± 0.107	0.494ValTrp: 0.494 ± 0.032	2.284ValTyr: 2.284 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.449TrpAla: 0.449 ± 0.029	0.038TrpCys: 0.038 ± 0.008	0.516TrpAsp: 0.516 ± 0.029	0.61TrpGlu: 0.61 ± 0.035	0.432TrpPhe: 0.432 ± 0.03	0.532TrpGly: 0.532 ± 0.035	0.134TrpHis: 0.134 ± 0.018	0.846TrpIle: 0.846 ± 0.042	0.646TrpLys: 0.646 ± 0.032	1.012TrpLeu: 1.012 ± 0.043	0.236TrpMet: 0.236 ± 0.018	0.496TrpAsn: 0.496 ± 0.031	0.225TrpPro: 0.225 ± 0.018	0.319TrpGln: 0.319 ± 0.021	0.344TrpArg: 0.344 ± 0.024	0.454TrpSer: 0.454 ± 0.026	0.434TrpThr: 0.434 ± 0.028	0.559TrpVal: 0.559 ± 0.033	0.115TrpTrp: 0.115 ± 0.015	0.32TrpTyr: 0.32 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.815TyrAla: 1.815 ± 0.056	0.245TyrCys: 0.245 ± 0.019	2.08TyrAsp: 2.08 ± 0.063	2.324TyrGlu: 2.324 ± 0.066	1.859TyrPhe: 1.859 ± 0.062	2.451TyrGly: 2.451 ± 0.064	0.842TyrHis: 0.842 ± 0.033	3.218TyrIle: 3.218 ± 0.068	2.514TyrLys: 2.514 ± 0.075	4.21TyrLeu: 4.21 ± 0.087	0.748TyrMet: 0.748 ± 0.034	1.855TyrAsn: 1.855 ± 0.064	1.565TyrPro: 1.565 ± 0.054	1.878TyrGln: 1.878 ± 0.061	1.782TyrArg: 1.782 ± 0.05	2.306TyrSer: 2.306 ± 0.061	1.635TyrThr: 1.635 ± 0.054	2.359TyrVal: 2.359 ± 0.064	0.362TyrTrp: 0.362 ± 0.027	1.737TyrTyr: 1.737 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2107 proteins (627377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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