Amino acid dipepetide frequency for Paracoccus sp. BM15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.346AlaAla: 17.346 ± 0.199	0.972AlaCys: 0.972 ± 0.033	7.902AlaAsp: 7.902 ± 0.088	8.287AlaGlu: 8.287 ± 0.1	4.01AlaPhe: 4.01 ± 0.068	11.297AlaGly: 11.297 ± 0.106	2.286AlaHis: 2.286 ± 0.049	6.249AlaIle: 6.249 ± 0.095	3.314AlaLys: 3.314 ± 0.081	13.522AlaLeu: 13.522 ± 0.146	4.063AlaMet: 4.063 ± 0.066	2.736AlaAsn: 2.736 ± 0.048	5.661AlaPro: 5.661 ± 0.083	4.789AlaGln: 4.789 ± 0.066	9.115AlaArg: 9.115 ± 0.107	5.743AlaSer: 5.743 ± 0.07	6.166AlaThr: 6.166 ± 0.074	8.296AlaVal: 8.296 ± 0.098	1.443AlaTrp: 1.443 ± 0.036	2.319AlaTyr: 2.319 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.985CysAla: 0.985 ± 0.031	0.099CysCys: 0.099 ± 0.008	0.585CysAsp: 0.585 ± 0.023	0.412CysGlu: 0.412 ± 0.02	0.32CysPhe: 0.32 ± 0.016	0.905CysGly: 0.905 ± 0.032	0.26CysHis: 0.26 ± 0.017	0.389CysIle: 0.389 ± 0.021	0.165CysLys: 0.165 ± 0.014	0.772CysLeu: 0.772 ± 0.027	0.18CysMet: 0.18 ± 0.011	0.206CysAsn: 0.206 ± 0.013	0.475CysPro: 0.475 ± 0.02	0.243CysGln: 0.243 ± 0.013	0.549CysArg: 0.549 ± 0.023	0.435CysSer: 0.435 ± 0.019	0.392CysThr: 0.392 ± 0.018	0.539CysVal: 0.539 ± 0.021	0.132CysTrp: 0.132 ± 0.012	0.19CysTyr: 0.19 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.883AspAla: 7.883 ± 0.091	0.528AspCys: 0.528 ± 0.021	4.116AspAsp: 4.116 ± 0.075	3.872AspGlu: 3.872 ± 0.062	2.423AspPhe: 2.423 ± 0.043	6.164AspGly: 6.164 ± 0.087	1.534AspHis: 1.534 ± 0.04	2.97AspIle: 2.97 ± 0.051	1.678AspLys: 1.678 ± 0.043	6.781AspLeu: 6.781 ± 0.08	1.718AspMet: 1.718 ± 0.037	1.397AspAsn: 1.397 ± 0.038	3.895AspPro: 3.895 ± 0.069	2.63AspGln: 2.63 ± 0.046	4.772AspArg: 4.772 ± 0.076	2.56AspSer: 2.56 ± 0.049	2.775AspThr: 2.775 ± 0.056	3.835AspVal: 3.835 ± 0.064	1.348AspTrp: 1.348 ± 0.034	1.661AspTyr: 1.661 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.644GluAla: 7.644 ± 0.106	0.332GluCys: 0.332 ± 0.02	3.097GluAsp: 3.097 ± 0.065	2.931GluGlu: 2.931 ± 0.059	1.853GluPhe: 1.853 ± 0.04	4.661GluGly: 4.661 ± 0.064	1.069GluHis: 1.069 ± 0.034	3.389GluIle: 3.389 ± 0.059	1.923GluLys: 1.923 ± 0.048	5.005GluLeu: 5.005 ± 0.076	1.723GluMet: 1.723 ± 0.039	1.712GluAsn: 1.712 ± 0.04	2.586GluPro: 2.586 ± 0.049	2.123GluGln: 2.123 ± 0.046	4.037GluArg: 4.037 ± 0.068	2.123GluSer: 2.123 ± 0.044	3.451GluThr: 3.451 ± 0.064	3.929GluVal: 3.929 ± 0.054	0.822GluTrp: 0.822 ± 0.027	1.063GluTyr: 1.063 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.304PheAla: 4.304 ± 0.059	0.377PheCys: 0.377 ± 0.019	2.842PheAsp: 2.842 ± 0.053	1.913PheGlu: 1.913 ± 0.044	1.321PhePhe: 1.321 ± 0.038	3.632PheGly: 3.632 ± 0.058	0.727PheHis: 0.727 ± 0.026	1.76PheIle: 1.76 ± 0.043	0.795PheLys: 0.795 ± 0.027	3.306PheLeu: 3.306 ± 0.062	0.886PheMet: 0.886 ± 0.027	0.952PheAsn: 0.952 ± 0.029	1.588PhePro: 1.588 ± 0.041	1.113PheGln: 1.113 ± 0.029	2.159PheArg: 2.159 ± 0.05	2.032PheSer: 2.032 ± 0.042	1.945PheThr: 1.945 ± 0.043	2.569PheVal: 2.569 ± 0.049	0.604PheTrp: 0.604 ± 0.023	0.87PheTyr: 0.87 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	9.774GlyAla: 9.774 ± 0.104	0.826GlyCys: 0.826 ± 0.026	5.306GlyAsp: 5.306 ± 0.078	4.676GlyGlu: 4.676 ± 0.072	3.662GlyPhe: 3.662 ± 0.066	7.895GlyGly: 7.895 ± 0.115	1.955GlyHis: 1.955 ± 0.042	4.56GlyIle: 4.56 ± 0.068	3.013GlyLys: 3.013 ± 0.052	9.432GlyLeu: 9.432 ± 0.094	2.779GlyMet: 2.779 ± 0.053	2.331GlyAsn: 2.331 ± 0.051	3.836GlyPro: 3.836 ± 0.063	3.687GlyGln: 3.687 ± 0.058	6.087GlyArg: 6.087 ± 0.084	4.476GlySer: 4.476 ± 0.078	4.544GlyThr: 4.544 ± 0.077	6.04GlyVal: 6.04 ± 0.08	1.655GlyTrp: 1.655 ± 0.039	2.164GlyTyr: 2.164 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.238HisAla: 2.238 ± 0.051	0.233HisCys: 0.233 ± 0.016	1.411HisAsp: 1.411 ± 0.038	1.011HisGlu: 1.011 ± 0.03	0.796HisPhe: 0.796 ± 0.025	1.901HisGly: 1.901 ± 0.037	0.558HisHis: 0.558 ± 0.028	0.98HisIle: 0.98 ± 0.03	0.45HisLys: 0.45 ± 0.021	2.091HisLeu: 2.091 ± 0.047	0.554HisMet: 0.554 ± 0.02	0.429HisAsn: 0.429 ± 0.019	1.357HisPro: 1.357 ± 0.035	0.663HisGln: 0.663 ± 0.025	1.409HisArg: 1.409 ± 0.036	0.94HisSer: 0.94 ± 0.035	0.732HisThr: 0.732 ± 0.025	1.4HisVal: 1.4 ± 0.035	0.348HisTrp: 0.348 ± 0.016	0.496HisTyr: 0.496 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.371IleAla: 7.371 ± 0.088	0.597IleCys: 0.597 ± 0.024	3.669IleAsp: 3.669 ± 0.054	3.542IleGlu: 3.542 ± 0.062	1.858IlePhe: 1.858 ± 0.047	5.167IleGly: 5.167 ± 0.068	0.905IleHis: 0.905 ± 0.027	2.454IleIle: 2.454 ± 0.056	1.308IleLys: 1.308 ± 0.038	4.744IleLeu: 4.744 ± 0.062	1.216IleMet: 1.216 ± 0.031	1.392IleAsn: 1.392 ± 0.038	2.445IlePro: 2.445 ± 0.047	1.234IleGln: 1.234 ± 0.034	3.553IleArg: 3.553 ± 0.056	3.061IleSer: 3.061 ± 0.058	2.968IleThr: 2.968 ± 0.054	3.781IleVal: 3.781 ± 0.064	0.858IleTrp: 0.858 ± 0.034	1.134IleTyr: 1.134 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.373LysAla: 3.373 ± 0.072	0.148LysCys: 0.148 ± 0.011	1.652LysAsp: 1.652 ± 0.041	1.237LysGlu: 1.237 ± 0.04	0.805LysPhe: 0.805 ± 0.029	2.454LysGly: 2.454 ± 0.056	0.518LysHis: 0.518 ± 0.023	1.498LysIle: 1.498 ± 0.043	1.018LysLys: 1.018 ± 0.034	2.744LysLeu: 2.744 ± 0.052	0.793LysMet: 0.793 ± 0.027	0.764LysAsn: 0.764 ± 0.032	1.751LysPro: 1.751 ± 0.041	0.87LysGln: 0.87 ± 0.029	1.924LysArg: 1.924 ± 0.043	1.655LysSer: 1.655 ± 0.041	1.712LysThr: 1.712 ± 0.044	1.918LysVal: 1.918 ± 0.047	0.361LysTrp: 0.361 ± 0.016	0.6LysTyr: 0.6 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.303LeuAla: 13.303 ± 0.132	0.856LeuCys: 0.856 ± 0.028	6.2LeuAsp: 6.2 ± 0.079	4.519LeuGlu: 4.519 ± 0.065	3.359LeuPhe: 3.359 ± 0.069	8.168LeuGly: 8.168 ± 0.095	1.745LeuHis: 1.745 ± 0.04	5.92LeuIle: 5.92 ± 0.079	2.695LeuLys: 2.695 ± 0.055	8.95LeuLeu: 8.95 ± 0.129	2.752LeuMet: 2.752 ± 0.05	2.697LeuAsn: 2.697 ± 0.045	5.936LeuPro: 5.936 ± 0.081	3.037LeuGln: 3.037 ± 0.052	7.264LeuArg: 7.264 ± 0.089	6.39LeuSer: 6.39 ± 0.084	6.251LeuThr: 6.251 ± 0.078	6.389LeuVal: 6.389 ± 0.083	1.347LeuTrp: 1.347 ± 0.035	1.9LeuTyr: 1.9 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.763MetAla: 3.763 ± 0.056	0.175MetCys: 0.175 ± 0.012	1.52MetAsp: 1.52 ± 0.038	1.156MetGlu: 1.156 ± 0.032	0.84MetPhe: 0.84 ± 0.025	2.376MetGly: 2.376 ± 0.053	0.442MetHis: 0.442 ± 0.021	1.728MetIle: 1.728 ± 0.048	0.961MetLys: 0.961 ± 0.031	2.769MetLeu: 2.769 ± 0.052	0.833MetMet: 0.833 ± 0.026	0.954MetAsn: 0.954 ± 0.027	1.631MetPro: 1.631 ± 0.037	1.134MetGln: 1.134 ± 0.033	2.044MetArg: 2.044 ± 0.047	1.762MetSer: 1.762 ± 0.039	2.153MetThr: 2.153 ± 0.04	1.907MetVal: 1.907 ± 0.04	0.279MetTrp: 0.279 ± 0.015	0.33MetTyr: 0.33 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.127AsnAla: 3.127 ± 0.061	0.27AsnCys: 0.27 ± 0.017	1.611AsnAsp: 1.611 ± 0.049	1.208AsnGlu: 1.208 ± 0.033	0.892AsnPhe: 0.892 ± 0.026	2.323AsnGly: 2.323 ± 0.049	0.563AsnHis: 0.563 ± 0.022	1.411AsnIle: 1.411 ± 0.036	0.658AsnLys: 0.658 ± 0.027	2.466AsnLeu: 2.466 ± 0.054	0.749AsnMet: 0.749 ± 0.027	0.694AsnAsn: 0.694 ± 0.03	1.854AsnPro: 1.854 ± 0.043	0.81AsnGln: 0.81 ± 0.023	1.838AsnArg: 1.838 ± 0.038	1.337AsnSer: 1.337 ± 0.037	1.212AsnThr: 1.212 ± 0.036	1.75AsnVal: 1.75 ± 0.044	0.502AsnTrp: 0.502 ± 0.021	0.627AsnTyr: 0.627 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.579ProAla: 6.579 ± 0.101	0.35ProCys: 0.35 ± 0.019	4.506ProAsp: 4.506 ± 0.071	3.879ProGlu: 3.879 ± 0.059	1.878ProPhe: 1.878 ± 0.041	4.65ProGly: 4.65 ± 0.062	1.009ProHis: 1.009 ± 0.03	2.365ProIle: 2.365 ± 0.039	1.394ProLys: 1.394 ± 0.038	4.606ProLeu: 4.606 ± 0.07	1.401ProMet: 1.401 ± 0.036	1.285ProAsn: 1.285 ± 0.03	2.421ProPro: 2.421 ± 0.063	1.877ProGln: 1.877 ± 0.039	3.081ProArg: 3.081 ± 0.053	2.472ProSer: 2.472 ± 0.048	2.385ProThr: 2.385 ± 0.042	4.322ProVal: 4.322 ± 0.066	0.694ProTrp: 0.694 ± 0.024	1.123ProTyr: 1.123 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.689GlnAla: 4.689 ± 0.081	0.213GlnCys: 0.213 ± 0.012	1.989GlnAsp: 1.989 ± 0.042	1.559GlnGlu: 1.559 ± 0.039	1.114GlnPhe: 1.114 ± 0.033	3.056GlnGly: 3.056 ± 0.055	0.684GlnHis: 0.684 ± 0.025	2.381GlnIle: 2.381 ± 0.046	1.045GlnLys: 1.045 ± 0.035	3.177GlnLeu: 3.177 ± 0.054	1.269GlnMet: 1.269 ± 0.034	0.968GlnAsn: 0.968 ± 0.031	2.171GlnPro: 2.171 ± 0.046	1.492GlnGln: 1.492 ± 0.043	2.508GlnArg: 2.508 ± 0.05	1.782GlnSer: 1.782 ± 0.04	1.944GlnThr: 1.944 ± 0.042	2.58GlnVal: 2.58 ± 0.046	0.418GlnTrp: 0.418 ± 0.022	0.629GlnTyr: 0.629 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.285ArgAla: 8.285 ± 0.116	0.498ArgCys: 0.498 ± 0.024	4.707ArgAsp: 4.707 ± 0.069	3.847ArgGlu: 3.847 ± 0.064	2.688ArgPhe: 2.688 ± 0.05	4.902ArgGly: 4.902 ± 0.06	1.632ArgHis: 1.632 ± 0.04	4.046ArgIle: 4.046 ± 0.06	2.106ArgLys: 2.106 ± 0.047	7.829ArgLeu: 7.829 ± 0.103	2.161ArgMet: 2.161 ± 0.046	1.858ArgAsn: 1.858 ± 0.043	3.559ArgPro: 3.559 ± 0.069	2.722ArgGln: 2.722 ± 0.056	5.44ArgArg: 5.44 ± 0.089	3.343ArgSer: 3.343 ± 0.061	2.796ArgThr: 2.796 ± 0.053	4.581ArgVal: 4.581 ± 0.065	1.011ArgTrp: 1.011 ± 0.029	1.548ArgTyr: 1.548 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.93SerAla: 5.93 ± 0.072	0.395SerCys: 0.395 ± 0.021	3.513SerAsp: 3.513 ± 0.059	2.75SerGlu: 2.75 ± 0.055	2.141SerPhe: 2.141 ± 0.049	5.449SerGly: 5.449 ± 0.065	1.046SerHis: 1.046 ± 0.029	2.477SerIle: 2.477 ± 0.047	1.298SerLys: 1.298 ± 0.039	4.867SerLeu: 4.867 ± 0.069	1.339SerMet: 1.339 ± 0.033	1.337SerAsn: 1.337 ± 0.037	2.591SerPro: 2.591 ± 0.058	1.767SerGln: 1.767 ± 0.041	3.492SerArg: 3.492 ± 0.071	2.497SerSer: 2.497 ± 0.056	2.467SerThr: 2.467 ± 0.052	3.679SerVal: 3.679 ± 0.061	0.759SerTrp: 0.759 ± 0.027	1.233SerTyr: 1.233 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.472ThrAla: 6.472 ± 0.075	0.454ThrCys: 0.454 ± 0.018	3.403ThrAsp: 3.403 ± 0.06	3.034ThrGlu: 3.034 ± 0.053	1.685ThrPhe: 1.685 ± 0.038	5.459ThrGly: 5.459 ± 0.088	1.034ThrHis: 1.034 ± 0.028	2.778ThrIle: 2.778 ± 0.05	1.258ThrLys: 1.258 ± 0.034	5.393ThrLeu: 5.393 ± 0.063	1.291ThrMet: 1.291 ± 0.035	1.237ThrAsn: 1.237 ± 0.033	3.295ThrPro: 3.295 ± 0.058	1.635ThrGln: 1.635 ± 0.038	3.577ThrArg: 3.577 ± 0.053	2.51ThrSer: 2.51 ± 0.046	2.758ThrThr: 2.758 ± 0.057	4.032ThrVal: 4.032 ± 0.067	0.584ThrTrp: 0.584 ± 0.023	1.105ThrTyr: 1.105 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.612ValAla: 8.612 ± 0.095	0.554ValCys: 0.554 ± 0.021	4.043ValAsp: 4.043 ± 0.065	3.99ValGlu: 3.99 ± 0.058	2.632ValPhe: 2.632 ± 0.049	5.137ValGly: 5.137 ± 0.079	1.199ValHis: 1.199 ± 0.034	4.297ValIle: 4.297 ± 0.068	1.824ValLys: 1.824 ± 0.044	7.157ValLeu: 7.157 ± 0.084	2.204ValMet: 2.204 ± 0.046	1.945ValAsn: 1.945 ± 0.047	3.364ValPro: 3.364 ± 0.056	2.28ValGln: 2.28 ± 0.044	3.871ValArg: 3.871 ± 0.062	3.933ValSer: 3.933 ± 0.067	4.55ValThr: 4.55 ± 0.064	5.082ValVal: 5.082 ± 0.08	1.013ValTrp: 1.013 ± 0.031	1.322ValTyr: 1.322 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.469TrpAla: 1.469 ± 0.038	0.12TrpCys: 0.12 ± 0.01	0.862TrpAsp: 0.862 ± 0.026	0.542TrpGlu: 0.542 ± 0.022	0.587TrpPhe: 0.587 ± 0.024	1.056TrpGly: 1.056 ± 0.033	0.347TrpHis: 0.347 ± 0.015	0.708TrpIle: 0.708 ± 0.028	0.402TrpLys: 0.402 ± 0.017	1.892TrpLeu: 1.892 ± 0.039	0.406TrpMet: 0.406 ± 0.019	0.428TrpAsn: 0.428 ± 0.018	0.766TrpPro: 0.766 ± 0.028	0.826TrpGln: 0.826 ± 0.027	1.249TrpArg: 1.249 ± 0.036	0.878TrpSer: 0.878 ± 0.03	0.781TrpThr: 0.781 ± 0.028	0.913TrpVal: 0.913 ± 0.031	0.243TrpTrp: 0.243 ± 0.015	0.291TrpTyr: 0.291 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.37TyrAla: 2.37 ± 0.043	0.237TyrCys: 0.237 ± 0.015	1.607TyrAsp: 1.607 ± 0.041	1.108TyrGlu: 1.108 ± 0.029	0.829TyrPhe: 0.829 ± 0.024	2.043TyrGly: 2.043 ± 0.046	0.484TyrHis: 0.484 ± 0.021	0.902TyrIle: 0.902 ± 0.032	0.487TyrLys: 0.487 ± 0.019	2.174TyrLeu: 2.174 ± 0.043	0.44TyrMet: 0.44 ± 0.023	0.581TyrAsn: 0.581 ± 0.023	1.097TyrPro: 1.097 ± 0.035	0.736TyrGln: 0.736 ± 0.026	1.589TyrArg: 1.589 ± 0.036	1.096TyrSer: 1.096 ± 0.032	1.01TyrThr: 1.01 ± 0.03	1.469TyrVal: 1.469 ± 0.039	0.346TyrTrp: 0.346 ± 0.017	0.55TyrTyr: 0.55 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3740 proteins (1166477 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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