Amino acid dipepetide frequency for Lachnoclostridium sp. An131

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.026AlaAla: 10.026 ± 0.16	1.368AlaCys: 1.368 ± 0.038	4.933AlaAsp: 4.933 ± 0.073	7.19AlaGlu: 7.19 ± 0.115	3.41AlaPhe: 3.41 ± 0.066	7.7AlaGly: 7.7 ± 0.098	1.116AlaHis: 1.116 ± 0.034	4.129AlaIle: 4.129 ± 0.071	3.962AlaLys: 3.962 ± 0.074	8.36AlaLeu: 8.36 ± 0.121	2.349AlaMet: 2.349 ± 0.051	2.133AlaAsn: 2.133 ± 0.05	2.366AlaPro: 2.366 ± 0.06	2.601AlaGln: 2.601 ± 0.054	4.048AlaArg: 4.048 ± 0.066	4.435AlaSer: 4.435 ± 0.072	2.487AlaThr: 2.487 ± 0.052	7.548AlaVal: 7.548 ± 0.099	0.863AlaTrp: 0.863 ± 0.031	2.9AlaTyr: 2.9 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.232CysAla: 1.232 ± 0.032	0.299CysCys: 0.299 ± 0.019	0.772CysAsp: 0.772 ± 0.026	0.949CysGlu: 0.949 ± 0.032	0.666CysPhe: 0.666 ± 0.025	1.744CysGly: 1.744 ± 0.044	0.293CysHis: 0.293 ± 0.018	1.05CysIle: 1.05 ± 0.035	0.544CysLys: 0.544 ± 0.024	1.357CysLeu: 1.357 ± 0.039	0.465CysMet: 0.465 ± 0.022	0.415CysAsn: 0.415 ± 0.018	0.737CysPro: 0.737 ± 0.034	0.409CysGln: 0.409 ± 0.021	1.057CysArg: 1.057 ± 0.036	0.957CysSer: 0.957 ± 0.03	0.759CysThr: 0.759 ± 0.03	1.091CysVal: 1.091 ± 0.032	0.143CysTrp: 0.143 ± 0.012	0.524CysTyr: 0.524 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.332AspAla: 4.332 ± 0.066	0.788AspCys: 0.788 ± 0.028	2.423AspAsp: 2.423 ± 0.062	4.383AspGlu: 4.383 ± 0.069	2.46AspPhe: 2.46 ± 0.052	4.6AspGly: 4.6 ± 0.094	0.801AspHis: 0.801 ± 0.03	3.705AspIle: 3.705 ± 0.059	2.558AspLys: 2.558 ± 0.056	4.591AspLeu: 4.591 ± 0.071	1.694AspMet: 1.694 ± 0.037	1.608AspAsn: 1.608 ± 0.043	2.008AspPro: 2.008 ± 0.052	1.338AspGln: 1.338 ± 0.04	2.873AspArg: 2.873 ± 0.061	3.014AspSer: 3.014 ± 0.058	3.113AspThr: 3.113 ± 0.063	3.598AspVal: 3.598 ± 0.058	0.581AspTrp: 0.581 ± 0.023	2.598AspTyr: 2.598 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	7.277GluAla: 7.277 ± 0.091	0.878GluCys: 0.878 ± 0.032	4.283GluAsp: 4.283 ± 0.064	9.1GluGlu: 9.1 ± 0.144	2.52GluPhe: 2.52 ± 0.056	5.421GluGly: 5.421 ± 0.089	1.447GluHis: 1.447 ± 0.042	5.445GluIle: 5.445 ± 0.078	6.454GluLys: 6.454 ± 0.096	8.311GluLeu: 8.311 ± 0.118	2.38GluMet: 2.38 ± 0.047	3.87GluAsn: 3.87 ± 0.07	2.237GluPro: 2.237 ± 0.043	3.423GluGln: 3.423 ± 0.071	4.62GluArg: 4.62 ± 0.076	3.455GluSer: 3.455 ± 0.056	4.172GluThr: 4.172 ± 0.077	4.183GluVal: 4.183 ± 0.076	0.695GluTrp: 0.695 ± 0.027	3.097GluTyr: 3.097 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.068PheAla: 3.068 ± 0.059	0.799PheCys: 0.799 ± 0.024	2.39PheAsp: 2.39 ± 0.05	2.643PheGlu: 2.643 ± 0.054	1.814PhePhe: 1.814 ± 0.048	3.122PheGly: 3.122 ± 0.055	0.804PheHis: 0.804 ± 0.024	2.217PheIle: 2.217 ± 0.047	1.399PheLys: 1.399 ± 0.041	4.382PheLeu: 4.382 ± 0.082	0.989PheMet: 0.989 ± 0.033	1.2PheAsn: 1.2 ± 0.037	1.512PhePro: 1.512 ± 0.043	1.492PheGln: 1.492 ± 0.039	2.152PheArg: 2.152 ± 0.046	2.799PheSer: 2.799 ± 0.047	2.251PheThr: 2.251 ± 0.071	2.701PheVal: 2.701 ± 0.056	0.487PheTrp: 0.487 ± 0.025	1.693PheTyr: 1.693 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	5.882GlyAla: 5.882 ± 0.093	1.413GlyCys: 1.413 ± 0.042	3.603GlyAsp: 3.603 ± 0.068	5.535GlyGlu: 5.535 ± 0.089	3.232GlyPhe: 3.232 ± 0.057	5.711GlyGly: 5.711 ± 0.093	1.265GlyHis: 1.265 ± 0.037	6.085GlyIle: 6.085 ± 0.091	4.906GlyLys: 4.906 ± 0.075	6.66GlyLeu: 6.66 ± 0.092	2.489GlyMet: 2.489 ± 0.054	2.792GlyAsn: 2.792 ± 0.057	1.483GlyPro: 1.483 ± 0.042	2.428GlyGln: 2.428 ± 0.05	4.332GlyArg: 4.332 ± 0.066	4.623GlySer: 4.623 ± 0.083	4.52GlyThr: 4.52 ± 0.089	5.25GlyVal: 5.25 ± 0.087	0.828GlyTrp: 0.828 ± 0.032	3.117GlyTyr: 3.117 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.199HisAla: 1.199 ± 0.029	0.291HisCys: 0.291 ± 0.015	0.782HisAsp: 0.782 ± 0.03	1.055HisGlu: 1.055 ± 0.032	0.792HisPhe: 0.792 ± 0.026	1.32HisGly: 1.32 ± 0.038	0.367HisHis: 0.367 ± 0.027	1.277HisIle: 1.277 ± 0.038	0.757HisLys: 0.757 ± 0.027	1.512HisLeu: 1.512 ± 0.039	0.507HisMet: 0.507 ± 0.023	0.583HisAsn: 0.583 ± 0.025	0.876HisPro: 0.876 ± 0.033	0.536HisGln: 0.536 ± 0.023	0.881HisArg: 0.881 ± 0.029	0.932HisSer: 0.932 ± 0.033	0.962HisThr: 0.962 ± 0.033	1.155HisVal: 1.155 ± 0.036	0.158HisTrp: 0.158 ± 0.013	0.724HisTyr: 0.724 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.205IleAla: 5.205 ± 0.083	1.25IleCys: 1.25 ± 0.035	3.442IleAsp: 3.442 ± 0.061	4.279IleGlu: 4.279 ± 0.065	2.551IlePhe: 2.551 ± 0.052	4.652IleGly: 4.652 ± 0.075	1.217IleHis: 1.217 ± 0.032	3.757IleIle: 3.757 ± 0.064	2.761IleLys: 2.761 ± 0.068	6.903IleLeu: 6.903 ± 0.085	1.562IleMet: 1.562 ± 0.043	2.096IleAsn: 2.096 ± 0.046	2.905IlePro: 2.905 ± 0.057	2.24IleGln: 2.24 ± 0.04	4.204IleArg: 4.204 ± 0.072	4.152IleSer: 4.152 ± 0.061	3.482IleThr: 3.482 ± 0.067	4.254IleVal: 4.254 ± 0.073	0.648IleTrp: 0.648 ± 0.027	2.434IleTyr: 2.434 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.94LysAla: 4.94 ± 0.08	0.573LysCys: 0.573 ± 0.026	2.962LysAsp: 2.962 ± 0.054	5.837LysGlu: 5.837 ± 0.088	1.472LysPhe: 1.472 ± 0.033	3.97LysGly: 3.97 ± 0.072	0.862LysHis: 0.862 ± 0.029	3.538LysIle: 3.538 ± 0.062	4.807LysLys: 4.807 ± 0.088	4.841LysLeu: 4.841 ± 0.071	1.631LysMet: 1.631 ± 0.04	2.632LysAsn: 2.632 ± 0.052	1.843LysPro: 1.843 ± 0.044	1.869LysGln: 1.869 ± 0.049	3.241LysArg: 3.241 ± 0.064	2.734LysSer: 2.734 ± 0.05	3.035LysThr: 3.035 ± 0.058	3.34LysVal: 3.34 ± 0.063	0.485LysTrp: 0.485 ± 0.021	2.257LysTyr: 2.257 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.456LeuAla: 8.456 ± 0.11	1.764LeuCys: 1.764 ± 0.046	5.233LeuAsp: 5.233 ± 0.061	7.536LeuGlu: 7.536 ± 0.099	4.036LeuPhe: 4.036 ± 0.079	6.725LeuGly: 6.725 ± 0.094	1.627LeuHis: 1.627 ± 0.038	5.912LeuIle: 5.912 ± 0.088	5.904LeuLys: 5.904 ± 0.088	10.539LeuLeu: 10.539 ± 0.159	2.73LeuMet: 2.73 ± 0.054	3.486LeuAsn: 3.486 ± 0.062	4.013LeuPro: 4.013 ± 0.072	3.087LeuGln: 3.087 ± 0.058	4.713LeuArg: 4.713 ± 0.076	6.525LeuSer: 6.525 ± 0.08	5.254LeuThr: 5.254 ± 0.075	5.858LeuVal: 5.858 ± 0.09	0.935LeuTrp: 0.935 ± 0.034	3.695LeuTyr: 3.695 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.444MetAla: 2.444 ± 0.045	0.273MetCys: 0.273 ± 0.017	1.602MetAsp: 1.602 ± 0.041	2.657MetGlu: 2.657 ± 0.053	0.837MetPhe: 0.837 ± 0.025	2.001MetGly: 2.001 ± 0.05	0.379MetHis: 0.379 ± 0.018	1.805MetIle: 1.805 ± 0.039	2.326MetLys: 2.326 ± 0.049	2.731MetLeu: 2.731 ± 0.049	0.84MetMet: 0.84 ± 0.033	1.307MetAsn: 1.307 ± 0.036	1.135MetPro: 1.135 ± 0.034	1.001MetGln: 1.001 ± 0.033	1.402MetArg: 1.402 ± 0.036	1.626MetSer: 1.626 ± 0.039	1.719MetThr: 1.719 ± 0.043	1.64MetVal: 1.64 ± 0.04	0.202MetTrp: 0.202 ± 0.013	0.805MetTyr: 0.805 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.783AsnAla: 2.783 ± 0.056	0.519AsnCys: 0.519 ± 0.023	1.603AsnAsp: 1.603 ± 0.047	2.291AsnGlu: 2.291 ± 0.049	1.33AsnPhe: 1.33 ± 0.039	3.039AsnGly: 3.039 ± 0.064	0.666AsnHis: 0.666 ± 0.029	2.556AsnIle: 2.556 ± 0.054	1.594AsnLys: 1.594 ± 0.044	3.321AsnLeu: 3.321 ± 0.063	1.108AsnMet: 1.108 ± 0.03	1.206AsnAsn: 1.206 ± 0.039	1.87AsnPro: 1.87 ± 0.043	1.316AsnGln: 1.316 ± 0.032	2.103AsnArg: 2.103 ± 0.049	1.935AsnSer: 1.935 ± 0.043	1.995AsnThr: 1.995 ± 0.052	2.369AsnVal: 2.369 ± 0.046	0.393AsnTrp: 0.393 ± 0.017	1.513AsnTyr: 1.513 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	3.137ProAla: 3.137 ± 0.066	0.48ProCys: 0.48 ± 0.022	2.491ProAsp: 2.491 ± 0.054	4.198ProGlu: 4.198 ± 0.066	1.652ProPhe: 1.652 ± 0.042	2.913ProGly: 2.913 ± 0.062	0.595ProHis: 0.595 ± 0.027	1.662ProIle: 1.662 ± 0.044	1.619ProLys: 1.619 ± 0.04	3.109ProLeu: 3.109 ± 0.065	0.829ProMet: 0.829 ± 0.028	1.077ProAsn: 1.077 ± 0.031	0.854ProPro: 0.854 ± 0.033	1.045ProGln: 1.045 ± 0.033	1.269ProArg: 1.269 ± 0.035	1.87ProSer: 1.87 ± 0.041	1.325ProThr: 1.325 ± 0.041	3.276ProVal: 3.276 ± 0.063	0.333ProTrp: 0.333 ± 0.019	1.516ProTyr: 1.516 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.047GlnAla: 3.047 ± 0.063	0.331GlnCys: 0.331 ± 0.018	1.594GlnAsp: 1.594 ± 0.041	3.368GlnGlu: 3.368 ± 0.061	1.053GlnPhe: 1.053 ± 0.03	2.179GlnGly: 2.179 ± 0.046	0.44GlnHis: 0.44 ± 0.018	2.521GlnIle: 2.521 ± 0.051	2.549GlnLys: 2.549 ± 0.054	2.996GlnLeu: 2.996 ± 0.056	1.097GlnMet: 1.097 ± 0.034	1.468GlnAsn: 1.468 ± 0.038	1.021GlnPro: 1.021 ± 0.035	1.12GlnGln: 1.12 ± 0.036	1.564GlnArg: 1.564 ± 0.044	1.661GlnSer: 1.661 ± 0.041	1.748GlnThr: 1.748 ± 0.043	2.118GlnVal: 2.118 ± 0.052	0.295GlnTrp: 0.295 ± 0.017	1.331GlnTyr: 1.331 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.636ArgAla: 3.636 ± 0.059	0.753ArgCys: 0.753 ± 0.032	2.559ArgAsp: 2.559 ± 0.048	5.128ArgGlu: 5.128 ± 0.093	2.193ArgPhe: 2.193 ± 0.05	3.051ArgGly: 3.051 ± 0.054	0.898ArgHis: 0.898 ± 0.027	3.993ArgIle: 3.993 ± 0.061	3.782ArgLys: 3.782 ± 0.065	5.615ArgLeu: 5.615 ± 0.087	1.799ArgMet: 1.799 ± 0.038	2.054ArgAsn: 2.054 ± 0.047	1.71ArgPro: 1.71 ± 0.053	2.153ArgGln: 2.153 ± 0.057	3.582ArgArg: 3.582 ± 0.068	2.728ArgSer: 2.728 ± 0.05	2.724ArgThr: 2.724 ± 0.053	3.146ArgVal: 3.146 ± 0.055	0.504ArgTrp: 0.504 ± 0.023	2.217ArgTyr: 2.217 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.452SerAla: 4.452 ± 0.079	0.953SerCys: 0.953 ± 0.035	2.932SerAsp: 2.932 ± 0.064	4.017SerGlu: 4.017 ± 0.077	2.739SerPhe: 2.739 ± 0.058	5.465SerGly: 5.465 ± 0.09	0.975SerHis: 0.975 ± 0.032	3.358SerIle: 3.358 ± 0.054	2.319SerLys: 2.319 ± 0.052	5.615SerLeu: 5.615 ± 0.086	1.811SerMet: 1.811 ± 0.045	1.632SerAsn: 1.632 ± 0.039	1.913SerPro: 1.913 ± 0.045	1.859SerGln: 1.859 ± 0.044	3.427SerArg: 3.427 ± 0.056	3.569SerSer: 3.569 ± 0.074	2.497SerThr: 2.497 ± 0.052	4.233SerVal: 4.233 ± 0.071	0.744SerTrp: 0.744 ± 0.029	2.428SerTyr: 2.428 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.944ThrAla: 4.944 ± 0.086	0.642ThrCys: 0.642 ± 0.026	3.145ThrAsp: 3.145 ± 0.066	4.428ThrGlu: 4.428 ± 0.072	1.948ThrPhe: 1.948 ± 0.055	4.853ThrGly: 4.853 ± 0.087	0.841ThrHis: 0.841 ± 0.028	3.15ThrIle: 3.15 ± 0.057	2.381ThrLys: 2.381 ± 0.05	4.751ThrLeu: 4.751 ± 0.075	1.187ThrMet: 1.187 ± 0.042	1.589ThrAsn: 1.589 ± 0.044	2.171ThrPro: 2.171 ± 0.046	1.349ThrGln: 1.349 ± 0.036	2.174ThrArg: 2.174 ± 0.049	2.593ThrSer: 2.593 ± 0.061	2.344ThrThr: 2.344 ± 0.06	4.41ThrVal: 4.41 ± 0.089	0.497ThrTrp: 0.497 ± 0.022	1.843ThrTyr: 1.843 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	4.31ValAla: 4.31 ± 0.075	1.286ValCys: 1.286 ± 0.034	3.477ValAsp: 3.477 ± 0.067	4.707ValGlu: 4.707 ± 0.072	3.033ValPhe: 3.033 ± 0.059	3.985ValGly: 3.985 ± 0.069	1.103ValHis: 1.103 ± 0.033	4.796ValIle: 4.796 ± 0.073	3.825ValLys: 3.825 ± 0.066	7.274ValLeu: 7.274 ± 0.095	1.981ValMet: 1.981 ± 0.048	2.495ValAsn: 2.495 ± 0.053	2.77ValPro: 2.77 ± 0.052	2.209ValGln: 2.209 ± 0.041	3.696ValArg: 3.696 ± 0.073	4.632ValSer: 4.632 ± 0.064	4.066ValThr: 4.066 ± 0.087	4.308ValVal: 4.308 ± 0.068	0.778ValTrp: 0.778 ± 0.031	2.738ValTyr: 2.738 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.64TrpAla: 0.64 ± 0.028	0.172TrpCys: 0.172 ± 0.013	0.576TrpAsp: 0.576 ± 0.021	0.816TrpGlu: 0.816 ± 0.03	0.425TrpPhe: 0.425 ± 0.021	0.682TrpGly: 0.682 ± 0.028	0.185TrpHis: 0.185 ± 0.016	0.661TrpIle: 0.661 ± 0.032	0.749TrpLys: 0.749 ± 0.03	1.112TrpLeu: 1.112 ± 0.038	0.3TrpMet: 0.3 ± 0.018	0.528TrpAsn: 0.528 ± 0.025	0.262TrpPro: 0.262 ± 0.016	0.41TrpGln: 0.41 ± 0.02	0.507TrpArg: 0.507 ± 0.022	0.501TrpSer: 0.501 ± 0.024	0.497TrpThr: 0.497 ± 0.023	0.518TrpVal: 0.518 ± 0.027	0.1TrpTrp: 0.1 ± 0.01	0.429TrpTyr: 0.429 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.916TyrAla: 2.916 ± 0.058	0.634TyrCys: 0.634 ± 0.026	2.264TyrAsp: 2.264 ± 0.052	3.151TyrGlu: 3.151 ± 0.064	1.753TyrPhe: 1.753 ± 0.038	3.02TyrGly: 3.02 ± 0.054	0.788TyrHis: 0.788 ± 0.027	2.378TyrIle: 2.378 ± 0.046	1.671TyrLys: 1.671 ± 0.046	4.047TyrLeu: 4.047 ± 0.062	0.979TyrMet: 0.979 ± 0.029	1.338TyrAsn: 1.338 ± 0.035	1.561TyrPro: 1.561 ± 0.041	1.62TyrGln: 1.62 ± 0.041	2.38TyrArg: 2.38 ± 0.048	2.197TyrSer: 2.197 ± 0.046	2.29TyrThr: 2.29 ± 0.058	2.473TyrVal: 2.473 ± 0.048	0.4TyrTrp: 0.4 ± 0.022	1.852TyrTyr: 1.852 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3214 proteins (1029157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---