Amino acid dipepetide frequency for Lactobacillus phage Satyr

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.472AlaAla: 3.472 ± 0.761
0.264AlaCys: 0.264 ± 0.104
4.527AlaAsp: 4.527 ± 0.621
3.56AlaGlu: 3.56 ± 0.399
2.549AlaPhe: 2.549 ± 0.281
4.703AlaGly: 4.703 ± 0.654
0.659AlaHis: 0.659 ± 0.142
5.142AlaIle: 5.142 ± 0.538
5.89AlaLys: 5.89 ± 0.897
6.988AlaLeu: 6.988 ± 0.53
1.802AlaMet: 1.802 ± 0.303
3.648AlaAsn: 3.648 ± 0.565
1.714AlaPro: 1.714 ± 0.331
3.165AlaGln: 3.165 ± 0.566
2.505AlaArg: 2.505 ± 0.388
4.483AlaSer: 4.483 ± 0.888
4.439AlaThr: 4.439 ± 0.654
4.791AlaVal: 4.791 ± 0.556
1.143AlaTrp: 1.143 ± 0.222
3.209AlaTyr: 3.209 ± 0.392
0.0AlaXaa: 0.0 ± 0.0
Cys
0.352CysAla: 0.352 ± 0.139
0.0CysCys: 0.0 ± 0.0
0.615CysAsp: 0.615 ± 0.167
0.352CysGlu: 0.352 ± 0.123
0.22CysPhe: 0.22 ± 0.092
0.352CysGly: 0.352 ± 0.131
0.088CysHis: 0.088 ± 0.057
0.22CysIle: 0.22 ± 0.082
0.308CysLys: 0.308 ± 0.115
0.703CysLeu: 0.703 ± 0.153
0.088CysMet: 0.088 ± 0.063
0.264CysAsn: 0.264 ± 0.126
0.132CysPro: 0.132 ± 0.076
0.264CysGln: 0.264 ± 0.131
0.352CysArg: 0.352 ± 0.138
0.396CysSer: 0.396 ± 0.17
0.132CysThr: 0.132 ± 0.086
0.396CysVal: 0.396 ± 0.127
0.132CysTrp: 0.132 ± 0.063
0.659CysTyr: 0.659 ± 0.187
0.0CysXaa: 0.0 ± 0.0
Asp
2.637AspAla: 2.637 ± 0.301
0.747AspCys: 0.747 ± 0.192
6.505AspAsp: 6.505 ± 0.997
6.417AspGlu: 6.417 ± 0.679
3.34AspPhe: 3.34 ± 0.52
6.593AspGly: 6.593 ± 0.697
0.747AspHis: 0.747 ± 0.141
4.747AspIle: 4.747 ± 0.473
6.637AspLys: 6.637 ± 0.591
5.406AspLeu: 5.406 ± 0.709
2.066AspMet: 2.066 ± 0.311
4.175AspAsn: 4.175 ± 0.444
1.319AspPro: 1.319 ± 0.265
1.363AspGln: 1.363 ± 0.246
2.505AspArg: 2.505 ± 0.391
5.098AspSer: 5.098 ± 0.585
3.384AspThr: 3.384 ± 0.412
3.604AspVal: 3.604 ± 0.414
1.319AspTrp: 1.319 ± 0.242
4.044AspTyr: 4.044 ± 0.556
0.0AspXaa: 0.0 ± 0.0
Glu
5.098GluAla: 5.098 ± 0.506
0.44GluCys: 0.44 ± 0.169
4.527GluAsp: 4.527 ± 0.55
3.34GluGlu: 3.34 ± 0.477
2.461GluPhe: 2.461 ± 0.312
2.066GluGly: 2.066 ± 0.305
1.363GluHis: 1.363 ± 0.24
4.439GluIle: 4.439 ± 0.412
5.142GluLys: 5.142 ± 0.498
7.736GluLeu: 7.736 ± 0.777
2.461GluMet: 2.461 ± 0.351
2.505GluAsn: 2.505 ± 0.407
1.802GluPro: 1.802 ± 0.278
2.857GluGln: 2.857 ± 0.314
2.373GluArg: 2.373 ± 0.384
3.428GluSer: 3.428 ± 0.351
2.813GluThr: 2.813 ± 0.377
3.956GluVal: 3.956 ± 0.51
0.571GluTrp: 0.571 ± 0.164
2.329GluTyr: 2.329 ± 0.343
0.0GluXaa: 0.0 ± 0.0
Phe
2.461PheAla: 2.461 ± 0.283
0.527PheCys: 0.527 ± 0.162
3.34PheAsp: 3.34 ± 0.389
1.934PheGlu: 1.934 ± 0.335
1.626PhePhe: 1.626 ± 0.325
2.593PheGly: 2.593 ± 0.309
0.483PheHis: 0.483 ± 0.127
2.242PheIle: 2.242 ± 0.341
3.824PheLys: 3.824 ± 0.425
2.813PheLeu: 2.813 ± 0.443
1.011PheMet: 1.011 ± 0.216
2.637PheAsn: 2.637 ± 0.375
0.747PhePro: 0.747 ± 0.162
1.099PheGln: 1.099 ± 0.212
1.363PheArg: 1.363 ± 0.221
2.901PheSer: 2.901 ± 0.362
2.945PheThr: 2.945 ± 0.351
2.417PheVal: 2.417 ± 0.367
0.264PheTrp: 0.264 ± 0.121
1.67PheTyr: 1.67 ± 0.274
0.0PheXaa: 0.0 ± 0.0
Gly
4.703GlyAla: 4.703 ± 0.674
0.044GlyCys: 0.044 ± 0.047
4.132GlyAsp: 4.132 ± 0.455
3.824GlyGlu: 3.824 ± 0.445
3.077GlyPhe: 3.077 ± 0.419
4.483GlyGly: 4.483 ± 0.776
1.363GlyHis: 1.363 ± 0.23
4.571GlyIle: 4.571 ± 0.577
5.802GlyLys: 5.802 ± 0.828
6.197GlyLeu: 6.197 ± 0.564
1.319GlyMet: 1.319 ± 0.245
4.132GlyAsn: 4.132 ± 0.358
0.923GlyPro: 0.923 ± 0.202
2.242GlyGln: 2.242 ± 0.301
3.077GlyArg: 3.077 ± 0.345
4.0GlySer: 4.0 ± 0.468
4.747GlyThr: 4.747 ± 0.572
4.835GlyVal: 4.835 ± 0.459
1.055GlyTrp: 1.055 ± 0.197
3.516GlyTyr: 3.516 ± 0.308
0.0GlyXaa: 0.0 ± 0.0
His
1.011HisAla: 1.011 ± 0.2
0.132HisCys: 0.132 ± 0.09
1.231HisAsp: 1.231 ± 0.215
0.835HisGlu: 0.835 ± 0.205
0.923HisPhe: 0.923 ± 0.196
1.538HisGly: 1.538 ± 0.246
0.659HisHis: 0.659 ± 0.178
0.923HisIle: 0.923 ± 0.153
1.055HisLys: 1.055 ± 0.194
1.011HisLeu: 1.011 ± 0.221
0.396HisMet: 0.396 ± 0.123
1.099HisAsn: 1.099 ± 0.186
0.527HisPro: 0.527 ± 0.18
0.396HisGln: 0.396 ± 0.14
0.703HisArg: 0.703 ± 0.2
1.011HisSer: 1.011 ± 0.182
0.923HisThr: 0.923 ± 0.207
1.275HisVal: 1.275 ± 0.26
0.22HisTrp: 0.22 ± 0.102
1.011HisTyr: 1.011 ± 0.278
0.0HisXaa: 0.0 ± 0.0
Ile
4.967IleAla: 4.967 ± 0.514
0.483IleCys: 0.483 ± 0.155
4.747IleAsp: 4.747 ± 0.439
3.868IleGlu: 3.868 ± 0.496
2.373IlePhe: 2.373 ± 0.327
4.615IleGly: 4.615 ± 0.782
1.011IleHis: 1.011 ± 0.216
3.428IleIle: 3.428 ± 0.383
5.846IleLys: 5.846 ± 0.673
4.307IleLeu: 4.307 ± 0.442
1.45IleMet: 1.45 ± 0.282
4.879IleAsn: 4.879 ± 0.371
1.934IlePro: 1.934 ± 0.26
1.758IleGln: 1.758 ± 0.308
2.022IleArg: 2.022 ± 0.241
4.219IleSer: 4.219 ± 0.517
4.439IleThr: 4.439 ± 0.497
4.527IleVal: 4.527 ± 0.477
0.396IleTrp: 0.396 ± 0.12
2.066IleTyr: 2.066 ± 0.298
0.0IleXaa: 0.0 ± 0.0
Lys
6.065LysAla: 6.065 ± 0.717
0.22LysCys: 0.22 ± 0.111
4.835LysAsp: 4.835 ± 0.479
5.011LysGlu: 5.011 ± 0.608
2.945LysPhe: 2.945 ± 0.296
4.923LysGly: 4.923 ± 0.623
1.67LysHis: 1.67 ± 0.339
4.527LysIle: 4.527 ± 0.525
6.725LysLys: 6.725 ± 0.582
7.428LysLeu: 7.428 ± 0.532
3.209LysMet: 3.209 ± 0.466
3.736LysAsn: 3.736 ± 0.459
2.066LysPro: 2.066 ± 0.331
3.648LysGln: 3.648 ± 0.386
4.571LysArg: 4.571 ± 0.565
4.659LysSer: 4.659 ± 0.567
6.285LysThr: 6.285 ± 0.535
6.021LysVal: 6.021 ± 0.674
0.879LysTrp: 0.879 ± 0.275
3.868LysTyr: 3.868 ± 0.487
0.0LysXaa: 0.0 ± 0.0
Leu
5.494LeuAla: 5.494 ± 0.485
0.483LeuCys: 0.483 ± 0.164
6.857LeuAsp: 6.857 ± 0.684
5.89LeuGlu: 5.89 ± 0.667
2.945LeuPhe: 2.945 ± 0.409
5.67LeuGly: 5.67 ± 0.642
1.055LeuHis: 1.055 ± 0.243
4.879LeuIle: 4.879 ± 0.482
6.637LeuLys: 6.637 ± 0.567
6.857LeuLeu: 6.857 ± 0.549
2.329LeuMet: 2.329 ± 0.352
3.78LeuAsn: 3.78 ± 0.378
2.725LeuPro: 2.725 ± 0.331
2.329LeuGln: 2.329 ± 0.324
3.165LeuArg: 3.165 ± 0.371
5.977LeuSer: 5.977 ± 0.496
5.582LeuThr: 5.582 ± 0.487
4.967LeuVal: 4.967 ± 0.527
0.747LeuTrp: 0.747 ± 0.177
3.34LeuTyr: 3.34 ± 0.426
0.0LeuXaa: 0.0 ± 0.0
Met
1.978MetAla: 1.978 ± 0.278
0.132MetCys: 0.132 ± 0.069
1.275MetAsp: 1.275 ± 0.256
1.758MetGlu: 1.758 ± 0.328
0.703MetPhe: 0.703 ± 0.168
0.747MetGly: 0.747 ± 0.171
0.44MetHis: 0.44 ± 0.133
2.11MetIle: 2.11 ± 0.309
2.681MetLys: 2.681 ± 0.381
2.329MetLeu: 2.329 ± 0.36
0.527MetMet: 0.527 ± 0.145
1.582MetAsn: 1.582 ± 0.281
0.571MetPro: 0.571 ± 0.149
0.967MetGln: 0.967 ± 0.203
0.791MetArg: 0.791 ± 0.226
1.89MetSer: 1.89 ± 0.265
1.846MetThr: 1.846 ± 0.249
1.802MetVal: 1.802 ± 0.287
0.22MetTrp: 0.22 ± 0.089
0.615MetTyr: 0.615 ± 0.177
0.0MetXaa: 0.0 ± 0.0
Asn
3.252AsnAla: 3.252 ± 0.417
0.44AsnCys: 0.44 ± 0.128
4.307AsnAsp: 4.307 ± 0.394
3.428AsnGlu: 3.428 ± 0.331
1.846AsnPhe: 1.846 ± 0.261
6.197AsnGly: 6.197 ± 0.679
1.011AsnHis: 1.011 ± 0.196
3.516AsnIle: 3.516 ± 0.351
5.406AsnLys: 5.406 ± 0.687
3.428AsnLeu: 3.428 ± 0.377
1.363AsnMet: 1.363 ± 0.244
4.044AsnAsn: 4.044 ± 0.457
1.582AsnPro: 1.582 ± 0.269
2.373AsnGln: 2.373 ± 0.416
2.022AsnArg: 2.022 ± 0.397
3.692AsnSer: 3.692 ± 0.457
3.428AsnThr: 3.428 ± 0.331
3.604AsnVal: 3.604 ± 0.441
0.835AsnTrp: 0.835 ± 0.18
2.593AsnTyr: 2.593 ± 0.346
0.0AsnXaa: 0.0 ± 0.0
Pro
1.978ProAla: 1.978 ± 0.295
0.264ProCys: 0.264 ± 0.122
2.11ProAsp: 2.11 ± 0.299
2.11ProGlu: 2.11 ± 0.319
0.747ProPhe: 0.747 ± 0.206
1.011ProGly: 1.011 ± 0.213
0.308ProHis: 0.308 ± 0.122
1.363ProIle: 1.363 ± 0.266
1.846ProLys: 1.846 ± 0.279
1.714ProLeu: 1.714 ± 0.273
0.483ProMet: 0.483 ± 0.123
1.802ProAsn: 1.802 ± 0.222
0.264ProPro: 0.264 ± 0.116
0.835ProGln: 0.835 ± 0.205
0.835ProArg: 0.835 ± 0.205
2.022ProSer: 2.022 ± 0.296
1.319ProThr: 1.319 ± 0.26
2.725ProVal: 2.725 ± 0.369
0.264ProTrp: 0.264 ± 0.092
1.494ProTyr: 1.494 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
2.329GlnAla: 2.329 ± 0.385
0.132GlnCys: 0.132 ± 0.082
2.154GlnAsp: 2.154 ± 0.306
1.802GlnGlu: 1.802 ± 0.303
1.758GlnPhe: 1.758 ± 0.28
2.066GlnGly: 2.066 ± 0.336
0.703GlnHis: 0.703 ± 0.158
2.286GlnIle: 2.286 ± 0.34
2.329GlnLys: 2.329 ± 0.253
2.769GlnLeu: 2.769 ± 0.359
0.835GlnMet: 0.835 ± 0.199
2.637GlnAsn: 2.637 ± 0.503
1.231GlnPro: 1.231 ± 0.291
1.538GlnGln: 1.538 ± 0.368
1.934GlnArg: 1.934 ± 0.273
2.549GlnSer: 2.549 ± 0.525
3.165GlnThr: 3.165 ± 0.98
2.286GlnVal: 2.286 ± 0.385
0.264GlnTrp: 0.264 ± 0.088
1.89GlnTyr: 1.89 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
2.989ArgAla: 2.989 ± 0.358
0.176ArgCys: 0.176 ± 0.084
2.505ArgAsp: 2.505 ± 0.44
2.901ArgGlu: 2.901 ± 0.43
1.846ArgPhe: 1.846 ± 0.251
2.242ArgGly: 2.242 ± 0.271
0.835ArgHis: 0.835 ± 0.169
1.714ArgIle: 1.714 ± 0.292
3.077ArgLys: 3.077 ± 0.416
2.901ArgLeu: 2.901 ± 0.353
0.835ArgMet: 0.835 ± 0.22
2.373ArgAsn: 2.373 ± 0.334
1.099ArgPro: 1.099 ± 0.212
1.099ArgGln: 1.099 ± 0.222
1.582ArgArg: 1.582 ± 0.32
2.329ArgSer: 2.329 ± 0.334
2.329ArgThr: 2.329 ± 0.349
3.033ArgVal: 3.033 ± 0.408
0.659ArgTrp: 0.659 ± 0.171
1.758ArgTyr: 1.758 ± 0.278
0.0ArgXaa: 0.0 ± 0.0
Ser
6.241SerAla: 6.241 ± 0.998
0.22SerCys: 0.22 ± 0.091
5.142SerAsp: 5.142 ± 0.542
3.912SerGlu: 3.912 ± 0.396
2.329SerPhe: 2.329 ± 0.382
4.967SerGly: 4.967 ± 0.601
1.187SerHis: 1.187 ± 0.246
4.351SerIle: 4.351 ± 0.487
5.274SerLys: 5.274 ± 0.683
5.626SerLeu: 5.626 ± 0.32
1.319SerMet: 1.319 ± 0.237
3.956SerAsn: 3.956 ± 0.487
1.494SerPro: 1.494 ± 0.291
3.077SerGln: 3.077 ± 0.577
2.242SerArg: 2.242 ± 0.281
5.45SerSer: 5.45 ± 0.531
3.472SerThr: 3.472 ± 0.48
4.088SerVal: 4.088 ± 0.408
0.791SerTrp: 0.791 ± 0.174
2.417SerTyr: 2.417 ± 0.396
0.0SerXaa: 0.0 ± 0.0
Thr
5.274ThrAla: 5.274 ± 0.982
0.483ThrCys: 0.483 ± 0.156
4.351ThrAsp: 4.351 ± 0.444
3.56ThrGlu: 3.56 ± 0.408
2.286ThrPhe: 2.286 ± 0.323
4.351ThrGly: 4.351 ± 0.55
0.967ThrHis: 0.967 ± 0.223
4.835ThrIle: 4.835 ± 0.487
4.351ThrLys: 4.351 ± 0.4
4.571ThrLeu: 4.571 ± 0.391
0.967ThrMet: 0.967 ± 0.159
3.428ThrAsn: 3.428 ± 0.443
2.198ThrPro: 2.198 ± 0.356
2.637ThrGln: 2.637 ± 0.576
1.934ThrArg: 1.934 ± 0.352
4.132ThrSer: 4.132 ± 0.593
3.78ThrThr: 3.78 ± 0.484
5.098ThrVal: 5.098 ± 0.467
0.571ThrTrp: 0.571 ± 0.183
3.34ThrTyr: 3.34 ± 0.565
0.0ThrXaa: 0.0 ± 0.0
Val
4.967ValAla: 4.967 ± 0.445
0.352ValCys: 0.352 ± 0.13
5.055ValAsp: 5.055 ± 0.503
4.219ValGlu: 4.219 ± 0.5
2.373ValPhe: 2.373 ± 0.379
4.439ValGly: 4.439 ± 0.616
1.143ValHis: 1.143 ± 0.233
4.703ValIle: 4.703 ± 0.496
6.461ValLys: 6.461 ± 0.625
4.483ValLeu: 4.483 ± 0.467
1.363ValMet: 1.363 ± 0.277
4.483ValAsn: 4.483 ± 0.379
1.758ValPro: 1.758 ± 0.305
2.11ValGln: 2.11 ± 0.426
2.11ValArg: 2.11 ± 0.313
5.186ValSer: 5.186 ± 0.588
4.879ValThr: 4.879 ± 0.391
5.011ValVal: 5.011 ± 0.561
0.747ValTrp: 0.747 ± 0.183
2.066ValTyr: 2.066 ± 0.337
0.0ValXaa: 0.0 ± 0.0
Trp
0.615TrpAla: 0.615 ± 0.148
0.088TrpCys: 0.088 ± 0.065
0.747TrpAsp: 0.747 ± 0.197
0.527TrpGlu: 0.527 ± 0.136
0.879TrpPhe: 0.879 ± 0.268
0.835TrpGly: 0.835 ± 0.167
0.176TrpHis: 0.176 ± 0.08
0.967TrpIle: 0.967 ± 0.198
0.747TrpLys: 0.747 ± 0.161
1.363TrpLeu: 1.363 ± 0.261
0.044TrpMet: 0.044 ± 0.051
0.615TrpAsn: 0.615 ± 0.139
0.088TrpPro: 0.088 ± 0.067
0.571TrpGln: 0.571 ± 0.144
0.571TrpArg: 0.571 ± 0.132
1.011TrpSer: 1.011 ± 0.207
0.703TrpThr: 0.703 ± 0.165
0.615TrpVal: 0.615 ± 0.171
0.22TrpTrp: 0.22 ± 0.081
0.615TrpTyr: 0.615 ± 0.162
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.769TyrAla: 2.769 ± 0.374
0.396TyrCys: 0.396 ± 0.139
3.692TyrAsp: 3.692 ± 0.515
2.461TyrGlu: 2.461 ± 0.415
1.67TyrPhe: 1.67 ± 0.309
3.648TyrGly: 3.648 ± 0.388
1.011TyrHis: 1.011 ± 0.226
2.417TyrIle: 2.417 ± 0.324
3.252TyrLys: 3.252 ± 0.402
3.077TyrLeu: 3.077 ± 0.468
1.055TyrMet: 1.055 ± 0.228
2.593TyrAsn: 2.593 ± 0.353
1.319TyrPro: 1.319 ± 0.215
2.329TyrGln: 2.329 ± 0.559
1.626TyrArg: 1.626 ± 0.29
3.121TyrSer: 3.121 ± 0.422
2.505TyrThr: 2.505 ± 0.391
2.857TyrVal: 2.857 ± 0.438
0.703TyrTrp: 0.703 ± 0.135
1.978TyrTyr: 1.978 ± 0.274
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 111 proteins (22753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski