Amino acid dipepetide frequency for Beggiatoa alba B18LD

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.239AlaAla: 5.239 ± 0.093
1.069AlaCys: 1.069 ± 0.035
4.611AlaAsp: 4.611 ± 0.08
5.828AlaGlu: 5.828 ± 0.083
3.223AlaPhe: 3.223 ± 0.059
5.9AlaGly: 5.9 ± 0.137
1.863AlaHis: 1.863 ± 0.047
5.879AlaIle: 5.879 ± 0.065
4.221AlaLys: 4.221 ± 0.074
9.838AlaLeu: 9.838 ± 0.11
2.092AlaMet: 2.092 ± 0.044
3.675AlaAsn: 3.675 ± 0.071
2.754AlaPro: 2.754 ± 0.052
4.618AlaGln: 4.618 ± 0.076
3.978AlaArg: 3.978 ± 0.057
4.562AlaSer: 4.562 ± 0.073
5.32AlaThr: 5.32 ± 0.097
5.7AlaVal: 5.7 ± 0.088
1.068AlaTrp: 1.068 ± 0.035
2.65AlaTyr: 2.65 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.736CysAla: 0.736 ± 0.025
0.139CysCys: 0.139 ± 0.011
0.461CysAsp: 0.461 ± 0.019
0.559CysGlu: 0.559 ± 0.025
0.436CysPhe: 0.436 ± 0.02
0.805CysGly: 0.805 ± 0.035
0.349CysHis: 0.349 ± 0.019
0.565CysIle: 0.565 ± 0.021
0.352CysLys: 0.352 ± 0.019
1.272CysLeu: 1.272 ± 0.036
0.181CysMet: 0.181 ± 0.01
0.356CysAsn: 0.356 ± 0.017
0.549CysPro: 0.549 ± 0.024
0.619CysGln: 0.619 ± 0.024
0.499CysArg: 0.499 ± 0.02
0.574CysSer: 0.574 ± 0.022
0.507CysThr: 0.507 ± 0.025
0.635CysVal: 0.635 ± 0.023
0.136CysTrp: 0.136 ± 0.016
0.372CysTyr: 0.372 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.131AspAla: 4.131 ± 0.085
0.494AspCys: 0.494 ± 0.02
2.598AspAsp: 2.598 ± 0.049
3.276AspGlu: 3.276 ± 0.073
2.355AspPhe: 2.355 ± 0.053
3.185AspGly: 3.185 ± 0.085
0.698AspHis: 0.698 ± 0.026
4.122AspIle: 4.122 ± 0.064
3.255AspLys: 3.255 ± 0.068
5.061AspLeu: 5.061 ± 0.07
1.223AspMet: 1.223 ± 0.034
2.573AspAsn: 2.573 ± 0.055
1.94AspPro: 1.94 ± 0.052
1.181AspGln: 1.181 ± 0.032
1.884AspArg: 1.884 ± 0.042
2.768AspSer: 2.768 ± 0.074
3.033AspThr: 3.033 ± 0.098
3.424AspVal: 3.424 ± 0.057
0.741AspTrp: 0.741 ± 0.025
2.1AspTyr: 2.1 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.003GluAla: 5.003 ± 0.072
0.374GluCys: 0.374 ± 0.021
2.37GluAsp: 2.37 ± 0.055
3.758GluGlu: 3.758 ± 0.082
2.143GluPhe: 2.143 ± 0.051
3.244GluGly: 3.244 ± 0.061
1.411GluHis: 1.411 ± 0.041
4.23GluIle: 4.23 ± 0.065
4.265GluLys: 4.265 ± 0.081
6.423GluLeu: 6.423 ± 0.107
1.505GluMet: 1.505 ± 0.038
2.936GluAsn: 2.936 ± 0.055
1.979GluPro: 1.979 ± 0.05
4.03GluGln: 4.03 ± 0.072
3.435GluArg: 3.435 ± 0.066
3.041GluSer: 3.041 ± 0.052
3.937GluThr: 3.937 ± 0.077
3.442GluVal: 3.442 ± 0.065
0.733GluTrp: 0.733 ± 0.025
1.679GluTyr: 1.679 ± 0.04
0.0GluXaa: 0.0 ± 0.0
Phe
3.295PheAla: 3.295 ± 0.05
0.53PheCys: 0.53 ± 0.021
2.159PheAsp: 2.159 ± 0.044
2.114PheGlu: 2.114 ± 0.046
2.047PhePhe: 2.047 ± 0.05
2.6PheGly: 2.6 ± 0.056
0.848PheHis: 0.848 ± 0.026
3.218PheIle: 3.218 ± 0.059
1.963PheLys: 1.963 ± 0.042
4.319PheLeu: 4.319 ± 0.073
0.964PheMet: 0.964 ± 0.029
2.054PheAsn: 2.054 ± 0.045
1.617PhePro: 1.617 ± 0.041
1.565PheGln: 1.565 ± 0.039
1.545PheArg: 1.545 ± 0.037
2.958PheSer: 2.958 ± 0.055
2.62PheThr: 2.62 ± 0.061
2.333PheVal: 2.333 ± 0.045
0.588PheTrp: 0.588 ± 0.026
1.528PheTyr: 1.528 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.332GlyAla: 4.332 ± 0.083
0.773GlyCys: 0.773 ± 0.029
3.209GlyAsp: 3.209 ± 0.093
3.813GlyGlu: 3.813 ± 0.057
2.919GlyPhe: 2.919 ± 0.045
4.231GlyGly: 4.231 ± 0.081
1.402GlyHis: 1.402 ± 0.043
4.863GlyIle: 4.863 ± 0.074
3.714GlyLys: 3.714 ± 0.051
6.888GlyLeu: 6.888 ± 0.08
1.635GlyMet: 1.635 ± 0.041
2.602GlyAsn: 2.602 ± 0.08
0.713GlyPro: 0.713 ± 0.029
2.99GlyGln: 2.99 ± 0.051
2.761GlyArg: 2.761 ± 0.051
3.282GlySer: 3.282 ± 0.084
3.697GlyThr: 3.697 ± 0.117
4.612GlyVal: 4.612 ± 0.094
0.869GlyTrp: 0.869 ± 0.029
2.389GlyTyr: 2.389 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.925HisAla: 1.925 ± 0.043
0.345HisCys: 0.345 ± 0.018
1.109HisAsp: 1.109 ± 0.032
1.312HisGlu: 1.312 ± 0.037
1.154HisPhe: 1.154 ± 0.035
1.322HisGly: 1.322 ± 0.031
0.791HisHis: 0.791 ± 0.026
1.616HisIle: 1.616 ± 0.038
0.962HisLys: 0.962 ± 0.034
2.857HisLeu: 2.857 ± 0.056
0.324HisMet: 0.324 ± 0.017
0.873HisAsn: 0.873 ± 0.03
1.397HisPro: 1.397 ± 0.041
1.308HisGln: 1.308 ± 0.037
1.087HisArg: 1.087 ± 0.031
1.201HisSer: 1.201 ± 0.027
1.278HisThr: 1.278 ± 0.033
1.425HisVal: 1.425 ± 0.034
0.383HisTrp: 0.383 ± 0.018
1.076HisTyr: 1.076 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.376IleAla: 6.376 ± 0.086
0.678IleCys: 0.678 ± 0.027
4.02IleAsp: 4.02 ± 0.065
4.489IleGlu: 4.489 ± 0.071
2.645IlePhe: 2.645 ± 0.056
4.466IleGly: 4.466 ± 0.067
1.559IleHis: 1.559 ± 0.036
4.366IleIle: 4.366 ± 0.074
3.211IleLys: 3.211 ± 0.065
6.577IleLeu: 6.577 ± 0.09
1.252IleMet: 1.252 ± 0.038
3.29IleAsn: 3.29 ± 0.057
3.231IlePro: 3.231 ± 0.052
3.31IleGln: 3.31 ± 0.055
3.102IleArg: 3.102 ± 0.058
4.129IleSer: 4.129 ± 0.066
4.301IleThr: 4.301 ± 0.073
4.321IleVal: 4.321 ± 0.065
0.706IleTrp: 0.706 ± 0.026
2.208IleTyr: 2.208 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.135LysAla: 4.135 ± 0.068
0.277LysCys: 0.277 ± 0.016
2.292LysAsp: 2.292 ± 0.056
2.901LysGlu: 2.901 ± 0.072
1.401LysPhe: 1.401 ± 0.036
2.834LysGly: 2.834 ± 0.048
1.154LysHis: 1.154 ± 0.03
3.397LysIle: 3.397 ± 0.062
2.781LysLys: 2.781 ± 0.064
4.698LysLeu: 4.698 ± 0.078
1.125LysMet: 1.125 ± 0.03
2.487LysAsn: 2.487 ± 0.051
2.359LysPro: 2.359 ± 0.056
3.214LysGln: 3.214 ± 0.069
2.627LysArg: 2.627 ± 0.054
2.465LysSer: 2.465 ± 0.047
3.63LysThr: 3.63 ± 0.062
3.158LysVal: 3.158 ± 0.052
0.463LysTrp: 0.463 ± 0.024
1.308LysTyr: 1.308 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
10.087LeuAla: 10.087 ± 0.112
1.18LeuCys: 1.18 ± 0.035
5.312LeuAsp: 5.312 ± 0.077
6.497LeuGlu: 6.497 ± 0.103
4.623LeuPhe: 4.623 ± 0.087
6.65LeuGly: 6.65 ± 0.091
2.601LeuHis: 2.601 ± 0.049
7.199LeuIle: 7.199 ± 0.112
5.62LeuLys: 5.62 ± 0.089
12.772LeuLeu: 12.772 ± 0.185
2.373LeuMet: 2.373 ± 0.048
5.32LeuAsn: 5.32 ± 0.075
5.453LeuPro: 5.453 ± 0.072
6.183LeuGln: 6.183 ± 0.109
5.385LeuArg: 5.385 ± 0.084
7.641LeuSer: 7.641 ± 0.097
7.084LeuThr: 7.084 ± 0.097
6.357LeuVal: 6.357 ± 0.082
1.289LeuTrp: 1.289 ± 0.039
3.302LeuTyr: 3.302 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.755MetAla: 1.755 ± 0.044
0.142MetCys: 0.142 ± 0.011
1.076MetAsp: 1.076 ± 0.037
1.071MetGlu: 1.071 ± 0.034
0.711MetPhe: 0.711 ± 0.025
1.538MetGly: 1.538 ± 0.043
0.458MetHis: 0.458 ± 0.021
1.254MetIle: 1.254 ± 0.037
0.951MetLys: 0.951 ± 0.028
2.461MetLeu: 2.461 ± 0.05
0.673MetMet: 0.673 ± 0.03
1.005MetAsn: 1.005 ± 0.029
1.233MetPro: 1.233 ± 0.037
1.334MetGln: 1.334 ± 0.036
1.207MetArg: 1.207 ± 0.034
1.608MetSer: 1.608 ± 0.035
1.447MetThr: 1.447 ± 0.037
1.34MetVal: 1.34 ± 0.039
0.163MetTrp: 0.163 ± 0.011
0.437MetTyr: 0.437 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.987AsnAla: 3.987 ± 0.072
0.439AsnCys: 0.439 ± 0.022
2.027AsnAsp: 2.027 ± 0.055
2.256AsnGlu: 2.256 ± 0.046
1.603AsnPhe: 1.603 ± 0.038
2.649AsnGly: 2.649 ± 0.087
0.986AsnHis: 0.986 ± 0.033
3.089AsnIle: 3.089 ± 0.055
1.955AsnLys: 1.955 ± 0.049
4.651AsnLeu: 4.651 ± 0.084
0.941AsnMet: 0.941 ± 0.029
2.282AsnAsn: 2.282 ± 0.076
2.709AsnPro: 2.709 ± 0.049
2.35AsnGln: 2.35 ± 0.055
2.122AsnArg: 2.122 ± 0.049
2.473AsnSer: 2.473 ± 0.06
3.008AsnThr: 3.008 ± 0.069
2.501AsnVal: 2.501 ± 0.043
0.517AsnTrp: 0.517 ± 0.023
1.573AsnTyr: 1.573 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
3.759ProAla: 3.759 ± 0.066
0.355ProCys: 0.355 ± 0.018
2.587ProAsp: 2.587 ± 0.05
3.008ProGlu: 3.008 ± 0.062
1.81ProPhe: 1.81 ± 0.041
0.963ProGly: 0.963 ± 0.04
1.134ProHis: 1.134 ± 0.032
3.036ProIle: 3.036 ± 0.061
1.704ProLys: 1.704 ± 0.039
4.895ProLeu: 4.895 ± 0.071
0.852ProMet: 0.852 ± 0.028
1.99ProAsn: 1.99 ± 0.042
1.959ProPro: 1.959 ± 0.049
2.003ProGln: 2.003 ± 0.036
1.608ProArg: 1.608 ± 0.042
2.497ProSer: 2.497 ± 0.049
2.936ProThr: 2.936 ± 0.063
3.103ProVal: 3.103 ± 0.061
0.386ProTrp: 0.386 ± 0.018
1.521ProTyr: 1.521 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
6.035GlnAla: 6.035 ± 0.1
0.404GlnCys: 0.404 ± 0.02
2.052GlnAsp: 2.052 ± 0.052
2.856GlnGlu: 2.856 ± 0.057
1.841GlnPhe: 1.841 ± 0.044
3.358GlnGly: 3.358 ± 0.068
1.571GlnHis: 1.571 ± 0.042
3.205GlnIle: 3.205 ± 0.055
2.367GlnLys: 2.367 ± 0.059
6.546GlnLeu: 6.546 ± 0.102
0.974GlnMet: 0.974 ± 0.032
1.82GlnAsn: 1.82 ± 0.04
1.939GlnPro: 1.939 ± 0.045
4.493GlnGln: 4.493 ± 0.103
3.145GlnArg: 3.145 ± 0.069
2.516GlnSer: 2.516 ± 0.05
3.562GlnThr: 3.562 ± 0.07
3.383GlnVal: 3.383 ± 0.051
0.771GlnTrp: 0.771 ± 0.028
1.509GlnTyr: 1.509 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.655ArgAla: 3.655 ± 0.066
0.517ArgCys: 0.517 ± 0.022
2.395ArgAsp: 2.395 ± 0.05
3.08ArgGlu: 3.08 ± 0.059
2.417ArgPhe: 2.417 ± 0.046
2.492ArgGly: 2.492 ± 0.053
1.308ArgHis: 1.308 ± 0.04
3.1ArgIle: 3.1 ± 0.051
2.013ArgLys: 2.013 ± 0.044
6.202ArgLeu: 6.202 ± 0.091
1.082ArgMet: 1.082 ± 0.033
1.737ArgAsn: 1.737 ± 0.043
1.706ArgPro: 1.706 ± 0.041
2.96ArgGln: 2.96 ± 0.054
2.461ArgArg: 2.461 ± 0.056
2.025ArgSer: 2.025 ± 0.044
2.406ArgThr: 2.406 ± 0.054
3.11ArgVal: 3.11 ± 0.06
0.737ArgTrp: 0.737 ± 0.025
2.165ArgTyr: 2.165 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.768SerAla: 4.768 ± 0.073
0.583SerCys: 0.583 ± 0.025
2.698SerAsp: 2.698 ± 0.058
3.03SerGlu: 3.03 ± 0.061
2.574SerPhe: 2.574 ± 0.051
3.836SerGly: 3.836 ± 0.086
1.46SerHis: 1.46 ± 0.037
3.768SerIle: 3.768 ± 0.06
2.235SerLys: 2.235 ± 0.05
6.76SerLeu: 6.76 ± 0.078
1.211SerMet: 1.211 ± 0.033
2.362SerAsn: 2.362 ± 0.066
2.779SerPro: 2.779 ± 0.053
2.622SerGln: 2.622 ± 0.054
2.557SerArg: 2.557 ± 0.056
3.539SerSer: 3.539 ± 0.083
3.49SerThr: 3.49 ± 0.073
3.9SerVal: 3.9 ± 0.075
0.653SerTrp: 0.653 ± 0.025
1.887SerTyr: 1.887 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
5.772ThrAla: 5.772 ± 0.11
0.575ThrCys: 0.575 ± 0.023
3.457ThrAsp: 3.457 ± 0.103
3.734ThrGlu: 3.734 ± 0.061
2.218ThrPhe: 2.218 ± 0.043
4.77ThrGly: 4.77 ± 0.143
1.564ThrHis: 1.564 ± 0.035
3.956ThrIle: 3.956 ± 0.075
2.104ThrLys: 2.104 ± 0.047
7.654ThrLeu: 7.654 ± 0.102
1.067ThrMet: 1.067 ± 0.033
2.35ThrAsn: 2.35 ± 0.069
3.563ThrPro: 3.563 ± 0.071
3.435ThrGln: 3.435 ± 0.064
2.578ThrArg: 2.578 ± 0.046
2.972ThrSer: 2.972 ± 0.079
4.423ThrThr: 4.423 ± 0.16
4.502ThrVal: 4.502 ± 0.111
0.754ThrTrp: 0.754 ± 0.025
1.757ThrTyr: 1.757 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.579ValAla: 5.579 ± 0.081
0.686ValCys: 0.686 ± 0.025
3.436ValAsp: 3.436 ± 0.061
3.909ValGlu: 3.909 ± 0.065
2.657ValPhe: 2.657 ± 0.055
4.103ValGly: 4.103 ± 0.071
1.316ValHis: 1.316 ± 0.031
4.683ValIle: 4.683 ± 0.07
3.219ValLys: 3.219 ± 0.06
7.277ValLeu: 7.277 ± 0.093
1.545ValMet: 1.545 ± 0.036
2.776ValAsn: 2.776 ± 0.06
2.43ValPro: 2.43 ± 0.048
2.65ValGln: 2.65 ± 0.045
2.945ValArg: 2.945 ± 0.056
3.95ValSer: 3.95 ± 0.072
4.123ValThr: 4.123 ± 0.122
4.34ValVal: 4.34 ± 0.089
0.824ValTrp: 0.824 ± 0.031
1.881ValTyr: 1.881 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.87TrpAla: 0.87 ± 0.028
0.127TrpCys: 0.127 ± 0.011
0.589TrpAsp: 0.589 ± 0.021
0.695TrpGlu: 0.695 ± 0.025
0.625TrpPhe: 0.625 ± 0.025
0.758TrpGly: 0.758 ± 0.027
0.356TrpHis: 0.356 ± 0.018
0.781TrpIle: 0.781 ± 0.027
0.466TrpLys: 0.466 ± 0.021
1.849TrpLeu: 1.849 ± 0.048
0.267TrpMet: 0.267 ± 0.015
0.403TrpAsn: 0.403 ± 0.019
0.124TrpPro: 0.124 ± 0.01
1.156TrpGln: 1.156 ± 0.037
0.731TrpArg: 0.731 ± 0.029
0.645TrpSer: 0.645 ± 0.026
0.578TrpThr: 0.578 ± 0.026
0.896TrpVal: 0.896 ± 0.03
0.192TrpTrp: 0.192 ± 0.015
0.348TrpTyr: 0.348 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.65TyrAla: 2.65 ± 0.05
0.417TyrCys: 0.417 ± 0.017
1.582TyrAsp: 1.582 ± 0.033
1.751TyrGlu: 1.751 ± 0.046
1.464TyrPhe: 1.464 ± 0.032
1.993TyrGly: 1.993 ± 0.05
0.913TyrHis: 0.913 ± 0.026
1.91TyrIle: 1.91 ± 0.04
1.349TyrLys: 1.349 ± 0.034
3.927TyrLeu: 3.927 ± 0.061
0.575TyrMet: 0.575 ± 0.023
1.228TyrAsn: 1.228 ± 0.034
1.669TyrPro: 1.669 ± 0.04
2.323TyrGln: 2.323 ± 0.047
1.914TyrArg: 1.914 ± 0.038
1.868TyrSer: 1.868 ± 0.042
1.828TyrThr: 1.828 ± 0.049
1.846TyrVal: 1.846 ± 0.045
0.482TyrTrp: 0.482 ± 0.021
1.253TyrTyr: 1.253 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3440 proteins (1223585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski