Amino acid dipepetide frequency for Ruminobacter amylophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.091AlaAla: 6.091 ± 0.126	1.157AlaCys: 1.157 ± 0.05	4.876AlaAsp: 4.876 ± 0.082	5.76AlaGlu: 5.76 ± 0.117	2.667AlaPhe: 2.667 ± 0.062	5.595AlaGly: 5.595 ± 0.1	1.274AlaHis: 1.274 ± 0.042	4.482AlaIle: 4.482 ± 0.086	4.483AlaLys: 4.483 ± 0.101	6.852AlaLeu: 6.852 ± 0.101	1.984AlaMet: 1.984 ± 0.052	2.709AlaAsn: 2.709 ± 0.062	2.221AlaPro: 2.221 ± 0.066	2.031AlaGln: 2.031 ± 0.059	3.549AlaArg: 3.549 ± 0.092	4.823AlaSer: 4.823 ± 0.093	3.205AlaThr: 3.205 ± 0.088	6.336AlaVal: 6.336 ± 0.099	0.575AlaTrp: 0.575 ± 0.029	2.446AlaTyr: 2.446 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	0.995CysAla: 0.995 ± 0.038	0.289CysCys: 0.289 ± 0.02	0.817CysAsp: 0.817 ± 0.034	0.795CysGlu: 0.795 ± 0.032	0.74CysPhe: 0.74 ± 0.037	1.375CysGly: 1.375 ± 0.049	0.353CysHis: 0.353 ± 0.022	1.002CysIle: 1.002 ± 0.041	0.633CysLys: 0.633 ± 0.033	1.285CysLeu: 1.285 ± 0.046	0.353CysMet: 0.353 ± 0.024	0.732CysAsn: 0.732 ± 0.034	0.592CysPro: 0.592 ± 0.031	0.41CysGln: 0.41 ± 0.025	0.87CysArg: 0.87 ± 0.033	1.191CysSer: 1.191 ± 0.041	0.753CysThr: 0.753 ± 0.031	0.879CysVal: 0.879 ± 0.04	0.096CysTrp: 0.096 ± 0.012	0.586CysTyr: 0.586 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.013AspAla: 4.013 ± 0.08	0.809AspCys: 0.809 ± 0.036	3.704AspAsp: 3.704 ± 0.086	4.663AspGlu: 4.663 ± 0.085	3.281AspPhe: 3.281 ± 0.067	4.092AspGly: 4.092 ± 0.084	0.984AspHis: 0.984 ± 0.039	4.655AspIle: 4.655 ± 0.1	3.588AspLys: 3.588 ± 0.076	5.203AspLeu: 5.203 ± 0.095	1.597AspMet: 1.597 ± 0.051	3.084AspAsn: 3.084 ± 0.069	2.06AspPro: 2.06 ± 0.058	1.177AspGln: 1.177 ± 0.041	2.999AspArg: 2.999 ± 0.067	4.135AspSer: 4.135 ± 0.097	2.896AspThr: 2.896 ± 0.068	3.983AspVal: 3.983 ± 0.078	0.555AspTrp: 0.555 ± 0.024	2.657AspTyr: 2.657 ± 0.068	0.0AspXaa: 0.0 ± 0.0
Glu	4.991GluAla: 4.991 ± 0.104	0.899GluCys: 0.899 ± 0.035	3.391GluAsp: 3.391 ± 0.074	4.89GluGlu: 4.89 ± 0.107	2.644GluPhe: 2.644 ± 0.063	3.411GluGly: 3.411 ± 0.075	1.427GluHis: 1.427 ± 0.046	5.23GluIle: 5.23 ± 0.086	5.643GluLys: 5.643 ± 0.091	6.791GluLeu: 6.791 ± 0.104	1.762GluMet: 1.762 ± 0.039	4.263GluAsn: 4.263 ± 0.076	1.837GluPro: 1.837 ± 0.053	2.607GluGln: 2.607 ± 0.057	2.938GluArg: 2.938 ± 0.078	3.887GluSer: 3.887 ± 0.073	3.091GluThr: 3.091 ± 0.065	4.018GluVal: 4.018 ± 0.085	0.603GluTrp: 0.603 ± 0.031	2.761GluTyr: 2.761 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.048PheAla: 3.048 ± 0.067	0.821PheCys: 0.821 ± 0.033	2.631PheAsp: 2.631 ± 0.058	2.408PheGlu: 2.408 ± 0.058	2.033PhePhe: 2.033 ± 0.064	3.019PheGly: 3.019 ± 0.071	0.705PheHis: 0.705 ± 0.028	3.278PheIle: 3.278 ± 0.078	2.598PheLys: 2.598 ± 0.059	3.708PheLeu: 3.708 ± 0.095	1.253PheMet: 1.253 ± 0.043	2.405PheAsn: 2.405 ± 0.056	1.304PhePro: 1.304 ± 0.042	0.865PheGln: 0.865 ± 0.035	2.18PheArg: 2.18 ± 0.051	3.464PheSer: 3.464 ± 0.08	2.558PheThr: 2.558 ± 0.063	2.744PheVal: 2.744 ± 0.063	0.391PheTrp: 0.391 ± 0.023	1.629PheTyr: 1.629 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.489GlyAla: 4.489 ± 0.098	1.201GlyCys: 1.201 ± 0.055	3.656GlyAsp: 3.656 ± 0.09	3.84GlyGlu: 3.84 ± 0.077	3.252GlyPhe: 3.252 ± 0.073	4.175GlyGly: 4.175 ± 0.095	1.329GlyHis: 1.329 ± 0.043	5.569GlyIle: 5.569 ± 0.097	4.657GlyLys: 4.657 ± 0.083	5.644GlyLeu: 5.644 ± 0.093	1.904GlyMet: 1.904 ± 0.05	3.431GlyAsn: 3.431 ± 0.072	1.341GlyPro: 1.341 ± 0.048	1.767GlyGln: 1.767 ± 0.056	3.359GlyArg: 3.359 ± 0.078	4.261GlySer: 4.261 ± 0.088	3.829GlyThr: 3.829 ± 0.072	4.593GlyVal: 4.593 ± 0.089	0.619GlyTrp: 0.619 ± 0.028	2.955GlyTyr: 2.955 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	1.263HisAla: 1.263 ± 0.039	0.279HisCys: 0.279 ± 0.019	1.22HisAsp: 1.22 ± 0.04	1.243HisGlu: 1.243 ± 0.046	0.777HisPhe: 0.777 ± 0.032	1.388HisGly: 1.388 ± 0.044	0.554HisHis: 0.554 ± 0.043	1.23HisIle: 1.23 ± 0.038	1.023HisLys: 1.023 ± 0.042	1.583HisLeu: 1.583 ± 0.044	0.489HisMet: 0.489 ± 0.024	0.932HisAsn: 0.932 ± 0.034	0.96HisPro: 0.96 ± 0.045	0.619HisGln: 0.619 ± 0.025	1.028HisArg: 1.028 ± 0.041	1.188HisSer: 1.188 ± 0.043	0.911HisThr: 0.911 ± 0.034	1.167HisVal: 1.167 ± 0.039	0.154HisTrp: 0.154 ± 0.015	0.743HisTyr: 0.743 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.256IleAla: 5.256 ± 0.09	1.183IleCys: 1.183 ± 0.045	4.128IleAsp: 4.128 ± 0.087	4.448IleGlu: 4.448 ± 0.073	2.81IlePhe: 2.81 ± 0.073	4.345IleGly: 4.345 ± 0.088	1.355IleHis: 1.355 ± 0.044	5.154IleIle: 5.154 ± 0.1	4.625IleLys: 4.625 ± 0.096	6.04IleLeu: 6.04 ± 0.101	1.728IleMet: 1.728 ± 0.048	3.846IleAsn: 3.846 ± 0.074	3.083IlePro: 3.083 ± 0.068	1.824IleGln: 1.824 ± 0.055	3.881IleArg: 3.881 ± 0.081	5.92IleSer: 5.92 ± 0.094	4.318IleThr: 4.318 ± 0.075	4.379IleVal: 4.379 ± 0.075	0.528IleTrp: 0.528 ± 0.029	2.559IleTyr: 2.559 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.088LysAla: 5.088 ± 0.116	0.779LysCys: 0.779 ± 0.041	3.987LysAsp: 3.987 ± 0.084	4.577LysGlu: 4.577 ± 0.09	2.47LysPhe: 2.47 ± 0.061	3.732LysGly: 3.732 ± 0.078	1.115LysHis: 1.115 ± 0.036	4.766LysIle: 4.766 ± 0.09	5.192LysLys: 5.192 ± 0.118	5.64LysLeu: 5.64 ± 0.085	1.706LysMet: 1.706 ± 0.048	4.147LysAsn: 4.147 ± 0.089	2.202LysPro: 2.202 ± 0.062	2.206LysGln: 2.206 ± 0.062	2.663LysArg: 2.663 ± 0.066	4.356LysSer: 4.356 ± 0.081	3.686LysThr: 3.686 ± 0.083	4.272LysVal: 4.272 ± 0.086	0.601LysTrp: 0.601 ± 0.026	2.674LysTyr: 2.674 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	6.578LeuAla: 6.578 ± 0.084	1.418LeuCys: 1.418 ± 0.056	5.126LeuAsp: 5.126 ± 0.087	5.166LeuGlu: 5.166 ± 0.104	3.703LeuPhe: 3.703 ± 0.09	5.722LeuGly: 5.722 ± 0.092	1.586LeuHis: 1.586 ± 0.048	6.012LeuIle: 6.012 ± 0.098	6.859LeuLys: 6.859 ± 0.1	7.769LeuLeu: 7.769 ± 0.123	2.288LeuMet: 2.288 ± 0.056	5.279LeuAsn: 5.279 ± 0.095	3.587LeuPro: 3.587 ± 0.081	2.468LeuGln: 2.468 ± 0.062	4.363LeuArg: 4.363 ± 0.095	7.389LeuSer: 7.389 ± 0.118	4.929LeuThr: 4.929 ± 0.078	5.519LeuVal: 5.519 ± 0.097	0.791LeuTrp: 0.791 ± 0.032	3.062LeuTyr: 3.062 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	2.047MetAla: 2.047 ± 0.052	0.306MetCys: 0.306 ± 0.022	1.448MetAsp: 1.448 ± 0.05	1.463MetGlu: 1.463 ± 0.045	1.078MetPhe: 1.078 ± 0.049	1.471MetGly: 1.471 ± 0.049	0.489MetHis: 0.489 ± 0.024	1.81MetIle: 1.81 ± 0.052	1.81MetLys: 1.81 ± 0.043	2.463MetLeu: 2.463 ± 0.065	0.702MetMet: 0.702 ± 0.032	1.634MetAsn: 1.634 ± 0.043	1.015MetPro: 1.015 ± 0.038	0.855MetGln: 0.855 ± 0.031	1.111MetArg: 1.111 ± 0.039	1.99MetSer: 1.99 ± 0.046	1.528MetThr: 1.528 ± 0.041	1.717MetVal: 1.717 ± 0.045	0.182MetTrp: 0.182 ± 0.015	0.883MetTyr: 0.883 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	3.54AsnAla: 3.54 ± 0.079	0.704AsnCys: 0.704 ± 0.031	2.981AsnAsp: 2.981 ± 0.07	3.298AsnGlu: 3.298 ± 0.076	2.212AsnPhe: 2.212 ± 0.053	3.891AsnGly: 3.891 ± 0.089	1.033AsnHis: 1.033 ± 0.033	3.909AsnIle: 3.909 ± 0.077	2.968AsnLys: 2.968 ± 0.069	4.586AsnLeu: 4.586 ± 0.084	1.253AsnMet: 1.253 ± 0.044	2.995AsnAsn: 2.995 ± 0.088	2.416AsnPro: 2.416 ± 0.058	1.679AsnGln: 1.679 ± 0.056	2.81AsnArg: 2.81 ± 0.059	3.954AsnSer: 3.954 ± 0.081	2.887AsnThr: 2.887 ± 0.062	3.201AsnVal: 3.201 ± 0.067	0.383AsnTrp: 0.383 ± 0.027	2.048AsnTyr: 2.048 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.754ProAla: 2.754 ± 0.074	0.461ProCys: 0.461 ± 0.028	2.658ProAsp: 2.658 ± 0.065	3.644ProGlu: 3.644 ± 0.071	1.6ProPhe: 1.6 ± 0.046	2.231ProGly: 2.231 ± 0.062	0.67ProHis: 0.67 ± 0.035	1.829ProIle: 1.829 ± 0.055	2.165ProLys: 2.165 ± 0.065	2.933ProLeu: 2.933 ± 0.063	0.707ProMet: 0.707 ± 0.028	1.586ProAsn: 1.586 ± 0.05	0.96ProPro: 0.96 ± 0.038	1.098ProGln: 1.098 ± 0.039	1.279ProArg: 1.279 ± 0.041	2.079ProSer: 2.079 ± 0.053	1.498ProThr: 1.498 ± 0.043	3.286ProVal: 3.286 ± 0.073	0.335ProTrp: 0.335 ± 0.019	1.335ProTyr: 1.335 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.181GlnAla: 2.181 ± 0.053	0.328GlnCys: 0.328 ± 0.02	1.457GlnAsp: 1.457 ± 0.044	1.911GlnGlu: 1.911 ± 0.057	1.068GlnPhe: 1.068 ± 0.033	1.644GlnGly: 1.644 ± 0.046	0.486GlnHis: 0.486 ± 0.024	2.281GlnIle: 2.281 ± 0.054	2.49GlnLys: 2.49 ± 0.069	2.547GlnLeu: 2.547 ± 0.058	0.868GlnMet: 0.868 ± 0.033	1.87GlnAsn: 1.87 ± 0.046	1.01GlnPro: 1.01 ± 0.044	1.164GlnGln: 1.164 ± 0.041	1.315GlnArg: 1.315 ± 0.043	1.814GlnSer: 1.814 ± 0.052	1.606GlnThr: 1.606 ± 0.055	1.828GlnVal: 1.828 ± 0.046	0.228GlnTrp: 0.228 ± 0.018	1.117GlnTyr: 1.117 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.077ArgAla: 3.077 ± 0.073	0.608ArgCys: 0.608 ± 0.028	2.898ArgAsp: 2.898 ± 0.057	3.54ArgGlu: 3.54 ± 0.091	2.145ArgPhe: 2.145 ± 0.057	2.568ArgGly: 2.568 ± 0.067	1.015ArgHis: 1.015 ± 0.041	3.949ArgIle: 3.949 ± 0.075	3.52ArgLys: 3.52 ± 0.074	4.542ArgLeu: 4.542 ± 0.082	1.468ArgMet: 1.468 ± 0.046	2.859ArgAsn: 2.859 ± 0.057	1.526ArgPro: 1.526 ± 0.05	1.683ArgGln: 1.683 ± 0.048	2.52ArgArg: 2.52 ± 0.071	2.705ArgSer: 2.705 ± 0.063	2.345ArgThr: 2.345 ± 0.061	3.031ArgVal: 3.031 ± 0.077	0.405ArgTrp: 0.405 ± 0.026	2.048ArgTyr: 2.048 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.279SerAla: 5.279 ± 0.106	0.997SerCys: 0.997 ± 0.038	4.535SerAsp: 4.535 ± 0.085	4.975SerGlu: 4.975 ± 0.089	3.395SerPhe: 3.395 ± 0.068	5.824SerGly: 5.824 ± 0.106	1.223SerHis: 1.223 ± 0.045	4.496SerIle: 4.496 ± 0.076	3.791SerLys: 3.791 ± 0.072	6.533SerLeu: 6.533 ± 0.096	1.825SerMet: 1.825 ± 0.042	3.087SerAsn: 3.087 ± 0.068	2.292SerPro: 2.292 ± 0.049	1.999SerGln: 1.999 ± 0.059	3.472SerArg: 3.472 ± 0.077	5.622SerSer: 5.622 ± 0.105	3.3SerThr: 3.3 ± 0.088	5.308SerVal: 5.308 ± 0.089	0.603SerTrp: 0.603 ± 0.031	2.679SerTyr: 2.679 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	4.418ThrAla: 4.418 ± 0.101	0.664ThrCys: 0.664 ± 0.033	3.754ThrAsp: 3.754 ± 0.085	3.677ThrGlu: 3.677 ± 0.075	1.978ThrPhe: 1.978 ± 0.052	4.552ThrGly: 4.552 ± 0.075	0.947ThrHis: 0.947 ± 0.031	3.291ThrIle: 3.291 ± 0.069	2.499ThrLys: 2.499 ± 0.062	4.705ThrLeu: 4.705 ± 0.066	1.139ThrMet: 1.139 ± 0.035	1.953ThrAsn: 1.953 ± 0.064	2.371ThrPro: 2.371 ± 0.057	1.333ThrGln: 1.333 ± 0.041	2.245ThrArg: 2.245 ± 0.057	3.648ThrSer: 3.648 ± 0.093	2.513ThrThr: 2.513 ± 0.062	4.52ThrVal: 4.52 ± 0.085	0.393ThrTrp: 0.393 ± 0.023	1.752ThrTyr: 1.752 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.782ValAla: 4.782 ± 0.09	1.096ValCys: 1.096 ± 0.039	3.842ValAsp: 3.842 ± 0.089	3.977ValGlu: 3.977 ± 0.077	3.076ValPhe: 3.076 ± 0.078	3.72ValGly: 3.72 ± 0.074	1.144ValHis: 1.144 ± 0.043	5.375ValIle: 5.375 ± 0.074	4.823ValLys: 4.823 ± 0.084	6.117ValLeu: 6.117 ± 0.1	1.818ValMet: 1.818 ± 0.051	3.596ValAsn: 3.596 ± 0.075	2.672ValPro: 2.672 ± 0.065	1.803ValGln: 1.803 ± 0.049	3.205ValArg: 3.205 ± 0.077	5.479ValSer: 5.479 ± 0.107	4.076ValThr: 4.076 ± 0.07	4.654ValVal: 4.654 ± 0.102	0.573ValTrp: 0.573 ± 0.032	2.524ValTyr: 2.524 ± 0.064	0.001ValXaa: 0.001 ± 0.001
Trp	0.464TrpAla: 0.464 ± 0.026	0.178TrpCys: 0.178 ± 0.015	0.543TrpAsp: 0.543 ± 0.031	0.443TrpGlu: 0.443 ± 0.024	0.429TrpPhe: 0.429 ± 0.023	0.502TrpGly: 0.502 ± 0.029	0.22TrpHis: 0.22 ± 0.015	0.55TrpIle: 0.55 ± 0.026	0.503TrpLys: 0.503 ± 0.024	0.908TrpLeu: 0.908 ± 0.033	0.253TrpMet: 0.253 ± 0.019	0.56TrpAsn: 0.56 ± 0.025	0.238TrpPro: 0.238 ± 0.019	0.35TrpGln: 0.35 ± 0.026	0.403TrpArg: 0.403 ± 0.022	0.55TrpSer: 0.55 ± 0.026	0.392TrpThr: 0.392 ± 0.023	0.513TrpVal: 0.513 ± 0.03	0.128TrpTrp: 0.128 ± 0.012	0.378TrpTyr: 0.378 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.762TyrAla: 2.762 ± 0.066	0.569TyrCys: 0.569 ± 0.028	2.486TyrAsp: 2.486 ± 0.063	2.365TyrGlu: 2.365 ± 0.051	1.683TyrPhe: 1.683 ± 0.052	2.612TyrGly: 2.612 ± 0.059	0.839TyrHis: 0.839 ± 0.031	2.543TyrIle: 2.543 ± 0.064	1.988TyrLys: 1.988 ± 0.051	3.764TyrLeu: 3.764 ± 0.069	0.903TyrMet: 0.903 ± 0.035	1.782TyrAsn: 1.782 ± 0.056	1.424TyrPro: 1.424 ± 0.044	1.274TyrGln: 1.274 ± 0.036	2.261TyrArg: 2.261 ± 0.056	2.782TyrSer: 2.782 ± 0.069	2.031TyrThr: 2.031 ± 0.055	2.403TyrVal: 2.403 ± 0.06	0.362TyrTrp: 0.362 ± 0.023	1.562TyrTyr: 1.562 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 2275 proteins (767510 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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