Amino acid dipepetide frequency for Streptomyces sp. Ncost-T10-10d

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.521AlaAla: 20.521 ± 0.118	1.051AlaCys: 1.051 ± 0.022	8.233AlaAsp: 8.233 ± 0.063	8.433AlaGlu: 8.433 ± 0.069	3.483AlaPhe: 3.483 ± 0.035	12.682AlaGly: 12.682 ± 0.079	2.798AlaHis: 2.798 ± 0.031	3.61AlaIle: 3.61 ± 0.042	2.906AlaLys: 2.906 ± 0.042	13.986AlaLeu: 13.986 ± 0.091	2.573AlaMet: 2.573 ± 0.035	1.978AlaAsn: 1.978 ± 0.029	6.878AlaPro: 6.878 ± 0.065	3.875AlaGln: 3.875 ± 0.043	9.785AlaArg: 9.785 ± 0.076	5.99AlaSer: 5.99 ± 0.056	7.12AlaThr: 7.12 ± 0.061	12.125AlaVal: 12.125 ± 0.08	1.822AlaTrp: 1.822 ± 0.03	2.735AlaTyr: 2.735 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.092CysAla: 1.092 ± 0.023	0.111CysCys: 0.111 ± 0.006	0.475CysAsp: 0.475 ± 0.013	0.392CysGlu: 0.392 ± 0.014	0.231CysPhe: 0.231 ± 0.011	0.976CysGly: 0.976 ± 0.022	0.208CysHis: 0.208 ± 0.008	0.204CysIle: 0.204 ± 0.01	0.132CysLys: 0.132 ± 0.008	0.743CysLeu: 0.743 ± 0.019	0.134CysMet: 0.134 ± 0.007	0.142CysAsn: 0.142 ± 0.007	0.519CysPro: 0.519 ± 0.014	0.186CysGln: 0.186 ± 0.009	0.659CysArg: 0.659 ± 0.018	0.479CysSer: 0.479 ± 0.013	0.569CysThr: 0.569 ± 0.016	0.674CysVal: 0.674 ± 0.015	0.135CysTrp: 0.135 ± 0.008	0.155CysTyr: 0.155 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.422AspAla: 7.422 ± 0.061	0.457AspCys: 0.457 ± 0.014	3.514AspAsp: 3.514 ± 0.044	3.848AspGlu: 3.848 ± 0.043	1.629AspPhe: 1.629 ± 0.026	6.32AspGly: 6.32 ± 0.056	1.469AspHis: 1.469 ± 0.023	2.057AspIle: 2.057 ± 0.03	1.276AspLys: 1.276 ± 0.026	5.944AspLeu: 5.944 ± 0.05	0.873AspMet: 0.873 ± 0.018	1.061AspAsn: 1.061 ± 0.02	4.349AspPro: 4.349 ± 0.042	1.556AspGln: 1.556 ± 0.025	5.049AspArg: 5.049 ± 0.054	2.75AspSer: 2.75 ± 0.03	3.286AspThr: 3.286 ± 0.039	4.468AspVal: 4.468 ± 0.044	0.992AspTrp: 0.992 ± 0.021	1.122AspTyr: 1.122 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.093GluAla: 7.093 ± 0.066	0.378GluCys: 0.378 ± 0.012	2.627GluAsp: 2.627 ± 0.031	3.256GluGlu: 3.256 ± 0.045	1.437GluPhe: 1.437 ± 0.022	4.205GluGly: 4.205 ± 0.04	1.508GluHis: 1.508 ± 0.025	2.269GluIle: 2.269 ± 0.03	1.496GluLys: 1.496 ± 0.028	6.706GluLeu: 6.706 ± 0.061	0.888GluMet: 0.888 ± 0.017	1.077GluAsn: 1.077 ± 0.02	3.28GluPro: 3.28 ± 0.044	2.307GluGln: 2.307 ± 0.036	5.23GluArg: 5.23 ± 0.052	2.699GluSer: 2.699 ± 0.038	2.865GluThr: 2.865 ± 0.033	4.256GluVal: 4.256 ± 0.043	0.786GluTrp: 0.786 ± 0.019	1.103GluTyr: 1.103 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.634PheAla: 3.634 ± 0.038	0.279PheCys: 0.279 ± 0.011	1.992PheAsp: 1.992 ± 0.032	1.421PheGlu: 1.421 ± 0.023	0.891PhePhe: 0.891 ± 0.019	3.017PheGly: 3.017 ± 0.037	0.618PheHis: 0.618 ± 0.015	0.822PheIle: 0.822 ± 0.016	0.536PheLys: 0.536 ± 0.015	2.538PheLeu: 2.538 ± 0.036	0.411PheMet: 0.411 ± 0.013	0.588PheAsn: 0.588 ± 0.015	1.421PhePro: 1.421 ± 0.023	0.682PheGln: 0.682 ± 0.016	1.853PheArg: 1.853 ± 0.027	1.504PheSer: 1.504 ± 0.022	2.057PheThr: 2.057 ± 0.031	2.163PheVal: 2.163 ± 0.032	0.435PheTrp: 0.435 ± 0.013	0.601PheTyr: 0.601 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.854GlyAla: 10.854 ± 0.074	0.861GlyCys: 0.861 ± 0.02	5.043GlyAsp: 5.043 ± 0.042	4.967GlyGlu: 4.967 ± 0.051	2.853GlyPhe: 2.853 ± 0.036	8.605GlyGly: 8.605 ± 0.086	2.395GlyHis: 2.395 ± 0.03	3.715GlyIle: 3.715 ± 0.037	2.573GlyLys: 2.573 ± 0.034	9.32GlyLeu: 9.32 ± 0.058	2.029GlyMet: 2.029 ± 0.033	1.95GlyAsn: 1.95 ± 0.033	5.244GlyPro: 5.244 ± 0.051	2.692GlyGln: 2.692 ± 0.034	7.769GlyArg: 7.769 ± 0.07	5.664GlySer: 5.664 ± 0.053	6.395GlyThr: 6.395 ± 0.064	7.198GlyVal: 7.198 ± 0.055	1.703GlyTrp: 1.703 ± 0.03	2.262GlyTyr: 2.262 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.642HisAla: 2.642 ± 0.033	0.225HisCys: 0.225 ± 0.011	1.403HisAsp: 1.403 ± 0.024	1.211HisGlu: 1.211 ± 0.023	0.644HisPhe: 0.644 ± 0.016	2.405HisGly: 2.405 ± 0.03	0.757HisHis: 0.757 ± 0.021	0.796HisIle: 0.796 ± 0.018	0.371HisLys: 0.371 ± 0.012	2.43HisLeu: 2.43 ± 0.032	0.383HisMet: 0.383 ± 0.012	0.402HisAsn: 0.402 ± 0.014	1.851HisPro: 1.851 ± 0.027	0.673HisGln: 0.673 ± 0.015	2.205HisArg: 2.205 ± 0.027	1.099HisSer: 1.099 ± 0.021	1.38HisThr: 1.38 ± 0.026	1.657HisVal: 1.657 ± 0.023	0.409HisTrp: 0.409 ± 0.012	0.487HisTyr: 0.487 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	5.093IleAla: 5.093 ± 0.05	0.342IleCys: 0.342 ± 0.012	2.436IleAsp: 2.436 ± 0.033	2.129IleGlu: 2.129 ± 0.032	0.748IlePhe: 0.748 ± 0.017	3.871IleGly: 3.871 ± 0.046	0.697IleHis: 0.697 ± 0.017	0.927IleIle: 0.927 ± 0.021	0.851IleLys: 0.851 ± 0.018	2.491IleLeu: 2.491 ± 0.033	0.467IleMet: 0.467 ± 0.014	0.763IleAsn: 0.763 ± 0.018	1.901IlePro: 1.901 ± 0.029	0.783IleGln: 0.783 ± 0.018	2.379IleArg: 2.379 ± 0.031	1.924IleSer: 1.924 ± 0.028	2.377IleThr: 2.377 ± 0.028	2.817IleVal: 2.817 ± 0.038	0.435IleTrp: 0.435 ± 0.013	0.564IleTyr: 0.564 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.004LysAla: 3.004 ± 0.044	0.124LysCys: 0.124 ± 0.008	1.439LysAsp: 1.439 ± 0.027	1.249LysGlu: 1.249 ± 0.026	0.513LysPhe: 0.513 ± 0.014	1.968LysGly: 1.968 ± 0.032	0.458LysHis: 0.458 ± 0.013	0.895LysIle: 0.895 ± 0.02	0.977LysLys: 0.977 ± 0.027	2.144LysLeu: 2.144 ± 0.031	0.421LysMet: 0.421 ± 0.015	0.626LysAsn: 0.626 ± 0.017	1.433LysPro: 1.433 ± 0.028	0.786LysGln: 0.786 ± 0.019	1.52LysArg: 1.52 ± 0.029	1.272LysSer: 1.272 ± 0.028	1.371LysThr: 1.371 ± 0.027	1.938LysVal: 1.938 ± 0.03	0.297LysTrp: 0.297 ± 0.012	0.481LysTyr: 0.481 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.454LeuAla: 14.454 ± 0.091	0.848LeuCys: 0.848 ± 0.019	6.637LeuAsp: 6.637 ± 0.057	4.466LeuGlu: 4.466 ± 0.043	2.647LeuPhe: 2.647 ± 0.034	9.09LeuGly: 9.09 ± 0.061	2.324LeuHis: 2.324 ± 0.03	3.591LeuIle: 3.591 ± 0.04	2.111LeuLys: 2.111 ± 0.03	11.058LeuLeu: 11.058 ± 0.078	1.7LeuMet: 1.7 ± 0.025	1.777LeuAsn: 1.777 ± 0.027	6.419LeuPro: 6.419 ± 0.052	2.31LeuGln: 2.31 ± 0.033	8.35LeuArg: 8.35 ± 0.069	5.472LeuSer: 5.472 ± 0.051	6.86LeuThr: 6.86 ± 0.06	8.468LeuVal: 8.468 ± 0.061	1.275LeuTrp: 1.275 ± 0.026	1.856LeuTyr: 1.856 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.285MetAla: 2.285 ± 0.034	0.143MetCys: 0.143 ± 0.008	0.923MetAsp: 0.923 ± 0.02	0.785MetGlu: 0.785 ± 0.017	0.473MetPhe: 0.473 ± 0.013	1.356MetGly: 1.356 ± 0.025	0.375MetHis: 0.375 ± 0.012	0.675MetIle: 0.675 ± 0.016	0.462MetLys: 0.462 ± 0.014	1.806MetLeu: 1.806 ± 0.03	0.335MetMet: 0.335 ± 0.012	0.476MetAsn: 0.476 ± 0.014	1.174MetPro: 1.174 ± 0.023	0.504MetGln: 0.504 ± 0.014	1.45MetArg: 1.45 ± 0.025	1.392MetSer: 1.392 ± 0.023	1.578MetThr: 1.578 ± 0.025	1.396MetVal: 1.396 ± 0.024	0.222MetTrp: 0.222 ± 0.01	0.35MetTyr: 0.35 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.249AsnAla: 2.249 ± 0.028	0.183AsnCys: 0.183 ± 0.008	1.022AsnAsp: 1.022 ± 0.02	0.879AsnGlu: 0.879 ± 0.019	0.512AsnPhe: 0.512 ± 0.014	2.036AsnGly: 2.036 ± 0.031	0.451AsnHis: 0.451 ± 0.013	0.667AsnIle: 0.667 ± 0.017	0.459AsnLys: 0.459 ± 0.016	1.683AsnLeu: 1.683 ± 0.027	0.329AsnMet: 0.329 ± 0.012	0.48AsnAsn: 0.48 ± 0.015	1.41AsnPro: 1.41 ± 0.024	0.534AsnGln: 0.534 ± 0.014	1.399AsnArg: 1.399 ± 0.026	1.054AsnSer: 1.054 ± 0.022	1.271AsnThr: 1.271 ± 0.022	1.397AsnVal: 1.397 ± 0.025	0.315AsnTrp: 0.315 ± 0.011	0.443AsnTyr: 0.443 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.319ProAla: 8.319 ± 0.062	0.385ProCys: 0.385 ± 0.012	4.401ProAsp: 4.401 ± 0.042	4.141ProGlu: 4.141 ± 0.044	1.561ProPhe: 1.561 ± 0.024	6.589ProGly: 6.589 ± 0.05	1.432ProHis: 1.432 ± 0.025	1.355ProIle: 1.355 ± 0.024	1.284ProLys: 1.284 ± 0.025	5.352ProLeu: 5.352 ± 0.049	1.042ProMet: 1.042 ± 0.019	0.91ProAsn: 0.91 ± 0.021	3.355ProPro: 3.355 ± 0.052	1.893ProGln: 1.893 ± 0.035	3.806ProArg: 3.806 ± 0.038	3.352ProSer: 3.352 ± 0.041	3.238ProThr: 3.238 ± 0.037	5.622ProVal: 5.622 ± 0.045	0.884ProTrp: 0.884 ± 0.019	1.463ProTyr: 1.463 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.672GlnAla: 3.672 ± 0.041	0.175GlnCys: 0.175 ± 0.009	1.45GlnAsp: 1.45 ± 0.023	1.498GlnGlu: 1.498 ± 0.023	0.727GlnPhe: 0.727 ± 0.017	2.342GlnGly: 2.342 ± 0.03	0.713GlnHis: 0.713 ± 0.015	1.195GlnIle: 1.195 ± 0.022	0.665GlnLys: 0.665 ± 0.018	3.225GlnLeu: 3.225 ± 0.033	0.495GlnMet: 0.495 ± 0.014	0.555GlnAsn: 0.555 ± 0.016	1.771GlnPro: 1.771 ± 0.034	1.381GlnGln: 1.381 ± 0.032	2.437GlnArg: 2.437 ± 0.029	1.387GlnSer: 1.387 ± 0.024	1.38GlnThr: 1.38 ± 0.024	2.394GlnVal: 2.394 ± 0.031	0.501GlnTrp: 0.501 ± 0.014	0.63GlnTyr: 0.63 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.428ArgAla: 9.428 ± 0.076	0.661ArgCys: 0.661 ± 0.018	4.099ArgAsp: 4.099 ± 0.048	4.46ArgGlu: 4.46 ± 0.05	2.275ArgPhe: 2.275 ± 0.033	5.695ArgGly: 5.695 ± 0.052	2.113ArgHis: 2.113 ± 0.032	3.605ArgIle: 3.605 ± 0.041	1.753ArgLys: 1.753 ± 0.029	8.418ArgLeu: 8.418 ± 0.068	1.793ArgMet: 1.793 ± 0.023	1.495ArgAsn: 1.495 ± 0.024	4.949ArgPro: 4.949 ± 0.049	2.294ArgGln: 2.294 ± 0.031	7.517ArgArg: 7.517 ± 0.076	4.376ArgSer: 4.376 ± 0.043	5.745ArgThr: 5.745 ± 0.05	5.428ArgVal: 5.428 ± 0.053	1.331ArgTrp: 1.331 ± 0.023	1.77ArgTyr: 1.77 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.985SerAla: 6.985 ± 0.058	0.462SerCys: 0.462 ± 0.015	2.862SerAsp: 2.862 ± 0.035	2.534SerGlu: 2.534 ± 0.036	1.624SerPhe: 1.624 ± 0.025	6.278SerGly: 6.278 ± 0.059	1.093SerHis: 1.093 ± 0.021	1.612SerIle: 1.612 ± 0.026	1.164SerLys: 1.164 ± 0.027	4.934SerLeu: 4.934 ± 0.042	1.175SerMet: 1.175 ± 0.021	0.952SerAsn: 0.952 ± 0.022	3.28SerPro: 3.28 ± 0.035	1.306SerGln: 1.306 ± 0.021	3.864SerArg: 3.864 ± 0.038	3.087SerSer: 3.087 ± 0.042	3.342SerThr: 3.342 ± 0.044	4.515SerVal: 4.515 ± 0.043	0.955SerTrp: 0.955 ± 0.019	1.281SerTyr: 1.281 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	9.0ThrAla: 9.0 ± 0.061	0.459ThrCys: 0.459 ± 0.013	3.763ThrAsp: 3.763 ± 0.04	3.295ThrGlu: 3.295 ± 0.036	1.66ThrPhe: 1.66 ± 0.029	6.941ThrGly: 6.941 ± 0.057	1.284ThrHis: 1.284 ± 0.02	1.854ThrIle: 1.854 ± 0.029	1.266ThrLys: 1.266 ± 0.029	5.736ThrLeu: 5.736 ± 0.048	1.023ThrMet: 1.023 ± 0.02	1.042ThrAsn: 1.042 ± 0.023	4.14ThrPro: 4.14 ± 0.041	1.398ThrGln: 1.398 ± 0.026	3.866ThrArg: 3.866 ± 0.035	3.383ThrSer: 3.383 ± 0.04	4.093ThrThr: 4.093 ± 0.055	6.311ThrVal: 6.311 ± 0.05	0.921ThrTrp: 0.921 ± 0.019	1.403ThrTyr: 1.403 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.392ValAla: 10.392 ± 0.077	0.745ValCys: 0.745 ± 0.018	4.793ValAsp: 4.793 ± 0.048	4.524ValGlu: 4.524 ± 0.044	2.39ValPhe: 2.39 ± 0.033	6.386ValGly: 6.386 ± 0.058	1.987ValHis: 1.987 ± 0.026	3.025ValIle: 3.025 ± 0.036	1.82ValLys: 1.82 ± 0.028	9.339ValLeu: 9.339 ± 0.072	1.496ValMet: 1.496 ± 0.025	1.627ValAsn: 1.627 ± 0.025	5.121ValPro: 5.121 ± 0.053	2.199ValGln: 2.199 ± 0.029	6.91ValArg: 6.91 ± 0.064	4.424ValSer: 4.424 ± 0.048	5.597ValThr: 5.597 ± 0.052	7.724ValVal: 7.724 ± 0.075	1.102ValTrp: 1.102 ± 0.021	1.547ValTyr: 1.547 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.672TrpAla: 1.672 ± 0.026	0.157TrpCys: 0.157 ± 0.008	0.835TrpAsp: 0.835 ± 0.021	0.72TrpGlu: 0.72 ± 0.017	0.514TrpPhe: 0.514 ± 0.014	1.049TrpGly: 1.049 ± 0.023	0.356TrpHis: 0.356 ± 0.011	0.575TrpIle: 0.575 ± 0.015	0.392TrpLys: 0.392 ± 0.013	1.777TrpLeu: 1.777 ± 0.03	0.31TrpMet: 0.31 ± 0.011	0.428TrpAsn: 0.428 ± 0.013	0.798TrpPro: 0.798 ± 0.018	0.652TrpGln: 0.652 ± 0.015	1.277TrpArg: 1.277 ± 0.022	0.984TrpSer: 0.984 ± 0.02	1.047TrpThr: 1.047 ± 0.019	0.981TrpVal: 0.981 ± 0.022	0.338TrpTrp: 0.338 ± 0.012	0.357TrpTyr: 0.357 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.771TyrAla: 2.771 ± 0.035	0.171TyrCys: 0.171 ± 0.009	1.497TyrAsp: 1.497 ± 0.03	1.262TyrGlu: 1.262 ± 0.023	0.65TyrPhe: 0.65 ± 0.015	2.281TyrGly: 2.281 ± 0.028	0.394TyrHis: 0.394 ± 0.013	0.546TyrIle: 0.546 ± 0.016	0.421TyrLys: 0.421 ± 0.014	2.081TyrLeu: 2.081 ± 0.026	0.282TyrMet: 0.282 ± 0.012	0.446TyrAsn: 0.446 ± 0.012	1.094TyrPro: 1.094 ± 0.019	0.584TyrGln: 0.584 ± 0.015	1.879TyrArg: 1.879 ± 0.029	1.012TyrSer: 1.012 ± 0.02	1.264TyrThr: 1.264 ± 0.024	1.615TyrVal: 1.615 ± 0.023	0.362TyrTrp: 0.362 ± 0.012	0.442TyrTyr: 0.442 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8519 proteins (2687042 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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