Amino acid dipepetide frequency for Malassezia pachydermatis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.208AlaAla: 11.208 ± 0.142	1.248AlaCys: 1.248 ± 0.028	4.731AlaAsp: 4.731 ± 0.048	5.772AlaGlu: 5.772 ± 0.079	3.052AlaPhe: 3.052 ± 0.037	5.255AlaGly: 5.255 ± 0.054	2.904AlaHis: 2.904 ± 0.041	3.646AlaIle: 3.646 ± 0.042	4.347AlaLys: 4.347 ± 0.068	10.604AlaLeu: 10.604 ± 0.122	3.305AlaMet: 3.305 ± 0.042	2.481AlaAsn: 2.481 ± 0.037	7.11AlaPro: 7.11 ± 0.095	4.982AlaGln: 4.982 ± 0.072	6.486AlaArg: 6.486 ± 0.065	9.33AlaSer: 9.33 ± 0.09	6.485AlaThr: 6.485 ± 0.072	5.636AlaVal: 5.636 ± 0.068	1.873AlaTrp: 1.873 ± 0.037	2.649AlaTyr: 2.649 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.122CysAla: 1.122 ± 0.027	0.163CysCys: 0.163 ± 0.009	0.635CysAsp: 0.635 ± 0.018	0.622CysGlu: 0.622 ± 0.016	0.412CysPhe: 0.412 ± 0.014	0.798CysGly: 0.798 ± 0.019	0.318CysHis: 0.318 ± 0.012	0.607CysIle: 0.607 ± 0.019	0.383CysLys: 0.383 ± 0.013	1.191CysLeu: 1.191 ± 0.025	0.333CysMet: 0.333 ± 0.013	0.269CysAsn: 0.269 ± 0.011	0.53CysPro: 0.53 ± 0.017	0.393CysGln: 0.393 ± 0.013	0.658CysArg: 0.658 ± 0.018	0.641CysSer: 0.641 ± 0.019	0.768CysThr: 0.768 ± 0.018	0.926CysVal: 0.926 ± 0.02	0.17CysTrp: 0.17 ± 0.009	0.31CysTyr: 0.31 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.635AspAla: 6.635 ± 0.073	0.44AspCys: 0.44 ± 0.014	4.734AspAsp: 4.734 ± 0.087	5.21AspGlu: 5.21 ± 0.075	1.596AspPhe: 1.596 ± 0.03	3.443AspGly: 3.443 ± 0.041	1.25AspHis: 1.25 ± 0.026	2.328AspIle: 2.328 ± 0.032	2.058AspLys: 2.058 ± 0.036	4.861AspLeu: 4.861 ± 0.051	1.827AspMet: 1.827 ± 0.027	1.356AspAsn: 1.356 ± 0.026	3.15AspPro: 3.15 ± 0.045	1.81AspGln: 1.81 ± 0.03	2.891AspArg: 2.891 ± 0.044	3.026AspSer: 3.026 ± 0.051	3.82AspThr: 3.82 ± 0.044	4.872AspVal: 4.872 ± 0.053	0.791AspTrp: 0.791 ± 0.018	1.316AspTyr: 1.316 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.385GluAla: 7.385 ± 0.093	0.56GluCys: 0.56 ± 0.018	3.769GluAsp: 3.769 ± 0.069	5.288GluGlu: 5.288 ± 0.087	1.538GluPhe: 1.538 ± 0.029	3.129GluGly: 3.129 ± 0.043	1.815GluHis: 1.815 ± 0.03	2.099GluIle: 2.099 ± 0.035	3.006GluLys: 3.006 ± 0.048	5.305GluLeu: 5.305 ± 0.061	1.608GluMet: 1.608 ± 0.031	1.678GluAsn: 1.678 ± 0.03	3.09GluPro: 3.09 ± 0.041	2.935GluGln: 2.935 ± 0.049	4.665GluArg: 4.665 ± 0.054	3.927GluSer: 3.927 ± 0.053	3.306GluThr: 3.306 ± 0.046	3.216GluVal: 3.216 ± 0.036	0.836GluTrp: 0.836 ± 0.023	1.581GluTyr: 1.581 ± 0.032	0.001GluXaa: 0.001 ± 0.001
Phe	2.898PheAla: 2.898 ± 0.042	0.445PheCys: 0.445 ± 0.015	1.92PheAsp: 1.92 ± 0.029	1.768PheGlu: 1.768 ± 0.028	1.289PhePhe: 1.289 ± 0.032	2.376PheGly: 2.376 ± 0.05	0.932PheHis: 0.932 ± 0.024	1.15PheIle: 1.15 ± 0.032	1.022PheLys: 1.022 ± 0.026	3.183PheLeu: 3.183 ± 0.047	0.758PheMet: 0.758 ± 0.023	0.846PheAsn: 0.846 ± 0.02	1.544PhePro: 1.544 ± 0.028	1.261PheGln: 1.261 ± 0.025	1.832PheArg: 1.832 ± 0.032	2.402PheSer: 2.402 ± 0.044	1.703PheThr: 1.703 ± 0.03	2.441PheVal: 2.441 ± 0.037	0.46PheTrp: 0.46 ± 0.016	0.923PheTyr: 0.923 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.536GlyAla: 5.536 ± 0.059	0.668GlyCys: 0.668 ± 0.019	3.047GlyAsp: 3.047 ± 0.044	3.087GlyGlu: 3.087 ± 0.041	2.07GlyPhe: 2.07 ± 0.036	4.292GlyGly: 4.292 ± 0.064	1.78GlyHis: 1.78 ± 0.036	2.532GlyIle: 2.532 ± 0.041	2.507GlyLys: 2.507 ± 0.042	5.442GlyLeu: 5.442 ± 0.057	1.799GlyMet: 1.799 ± 0.038	1.523GlyAsn: 1.523 ± 0.033	3.026GlyPro: 3.026 ± 0.04	2.27GlyGln: 2.27 ± 0.034	3.69GlyArg: 3.69 ± 0.043	4.376GlySer: 4.376 ± 0.055	3.996GlyThr: 3.996 ± 0.047	4.021GlyVal: 4.021 ± 0.052	0.973GlyTrp: 0.973 ± 0.024	1.643GlyTyr: 1.643 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	3.447HisAla: 3.447 ± 0.055	0.306HisCys: 0.306 ± 0.012	1.66HisAsp: 1.66 ± 0.03	1.623HisGlu: 1.623 ± 0.028	0.888HisPhe: 0.888 ± 0.021	2.003HisGly: 2.003 ± 0.028	0.902HisHis: 0.902 ± 0.031	1.385HisIle: 1.385 ± 0.029	0.936HisLys: 0.936 ± 0.022	2.582HisLeu: 2.582 ± 0.038	0.897HisMet: 0.897 ± 0.023	0.69HisAsn: 0.69 ± 0.021	1.701HisPro: 1.701 ± 0.031	0.942HisGln: 0.942 ± 0.022	1.822HisArg: 1.822 ± 0.034	1.68HisSer: 1.68 ± 0.03	2.094HisThr: 2.094 ± 0.037	2.501HisVal: 2.501 ± 0.037	0.413HisTrp: 0.413 ± 0.014	0.703HisTyr: 0.703 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.678IleAla: 3.678 ± 0.05	0.53IleCys: 0.53 ± 0.017	2.436IleAsp: 2.436 ± 0.033	2.341IleGlu: 2.341 ± 0.033	1.25IlePhe: 1.25 ± 0.028	2.435IleGly: 2.435 ± 0.043	1.113IleHis: 1.113 ± 0.023	1.462IleIle: 1.462 ± 0.031	1.562IleLys: 1.562 ± 0.033	3.843IleLeu: 3.843 ± 0.049	0.919IleMet: 0.919 ± 0.023	1.161IleAsn: 1.161 ± 0.027	2.456IlePro: 2.456 ± 0.042	1.754IleGln: 1.754 ± 0.03	2.458IleArg: 2.458 ± 0.037	2.616IleSer: 2.616 ± 0.034	2.054IleThr: 2.054 ± 0.034	3.1IleVal: 3.1 ± 0.043	0.502IleTrp: 0.502 ± 0.015	0.988IleTyr: 0.988 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.058LysAla: 4.058 ± 0.058	0.343LysCys: 0.343 ± 0.013	2.286LysAsp: 2.286 ± 0.039	2.913LysGlu: 2.913 ± 0.056	0.992LysPhe: 0.992 ± 0.024	2.116LysGly: 2.116 ± 0.038	1.078LysHis: 1.078 ± 0.026	1.536LysIle: 1.536 ± 0.029	2.518LysLys: 2.518 ± 0.06	3.318LysLeu: 3.318 ± 0.043	0.954LysMet: 0.954 ± 0.021	1.251LysAsn: 1.251 ± 0.025	2.346LysPro: 2.346 ± 0.052	1.738LysGln: 1.738 ± 0.035	3.035LysArg: 3.035 ± 0.041	2.539LysSer: 2.539 ± 0.036	2.211LysThr: 2.211 ± 0.032	2.351LysVal: 2.351 ± 0.041	0.436LysTrp: 0.436 ± 0.015	1.142LysTyr: 1.142 ± 0.026	0.0LysXaa: 0.0 ± 0.001
Leu	9.707LeuAla: 9.707 ± 0.094	1.444LeuCys: 1.444 ± 0.03	5.8LeuAsp: 5.8 ± 0.064	5.515LeuGlu: 5.515 ± 0.06	3.261LeuPhe: 3.261 ± 0.049	5.674LeuGly: 5.674 ± 0.069	3.089LeuHis: 3.089 ± 0.046	3.226LeuIle: 3.226 ± 0.045	3.024LeuLys: 3.024 ± 0.04	9.681LeuLeu: 9.681 ± 0.104	2.043LeuMet: 2.043 ± 0.033	2.388LeuAsn: 2.388 ± 0.035	6.095LeuPro: 6.095 ± 0.057	4.779LeuGln: 4.779 ± 0.062	6.988LeuArg: 6.988 ± 0.075	7.439LeuSer: 7.439 ± 0.073	5.051LeuThr: 5.051 ± 0.055	6.26LeuVal: 6.26 ± 0.061	1.319LeuTrp: 1.319 ± 0.029	2.609LeuTyr: 2.609 ± 0.04	0.001LeuXaa: 0.001 ± 0.001
Met	3.008MetAla: 3.008 ± 0.038	0.247MetCys: 0.247 ± 0.011	1.838MetAsp: 1.838 ± 0.03	1.687MetGlu: 1.687 ± 0.028	0.745MetPhe: 0.745 ± 0.019	1.533MetGly: 1.533 ± 0.031	0.88MetHis: 0.88 ± 0.023	0.986MetIle: 0.986 ± 0.025	0.817MetLys: 0.817 ± 0.022	2.619MetLeu: 2.619 ± 0.037	0.757MetMet: 0.757 ± 0.02	0.789MetAsn: 0.789 ± 0.02	2.217MetPro: 2.217 ± 0.05	1.373MetGln: 1.373 ± 0.026	1.793MetArg: 1.793 ± 0.032	2.342MetSer: 2.342 ± 0.036	1.617MetThr: 1.617 ± 0.03	1.608MetVal: 1.608 ± 0.031	0.333MetTrp: 0.333 ± 0.011	0.826MetTyr: 0.826 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.859AsnAla: 2.859 ± 0.037	0.225AsnCys: 0.225 ± 0.011	1.691AsnAsp: 1.691 ± 0.029	1.827AsnGlu: 1.827 ± 0.035	0.833AsnPhe: 0.833 ± 0.022	1.717AsnGly: 1.717 ± 0.033	0.574AsnHis: 0.574 ± 0.016	1.235AsnIle: 1.235 ± 0.029	1.195AsnLys: 1.195 ± 0.025	2.22AsnLeu: 2.22 ± 0.039	0.836AsnMet: 0.836 ± 0.019	0.852AsnAsn: 0.852 ± 0.025	1.573AsnPro: 1.573 ± 0.031	0.944AsnGln: 0.944 ± 0.021	1.322AsnArg: 1.322 ± 0.028	1.482AsnSer: 1.482 ± 0.028	1.623AsnThr: 1.623 ± 0.033	2.175AsnVal: 2.175 ± 0.035	0.343AsnTrp: 0.343 ± 0.013	0.74AsnTyr: 0.74 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	6.477ProAla: 6.477 ± 0.088	0.529ProCys: 0.529 ± 0.016	3.061ProAsp: 3.061 ± 0.039	3.308ProGlu: 3.308 ± 0.044	1.834ProPhe: 1.834 ± 0.036	3.508ProGly: 3.508 ± 0.062	1.611ProHis: 1.611 ± 0.03	2.248ProIle: 2.248 ± 0.031	2.254ProLys: 2.254 ± 0.037	5.335ProLeu: 5.335 ± 0.065	1.899ProMet: 1.899 ± 0.04	1.623ProAsn: 1.623 ± 0.037	5.75ProPro: 5.75 ± 0.122	2.025ProGln: 2.025 ± 0.038	3.801ProArg: 3.801 ± 0.06	6.866ProSer: 6.866 ± 0.101	5.14ProThr: 5.14 ± 0.076	4.018ProVal: 4.018 ± 0.056	0.909ProTrp: 0.909 ± 0.024	1.481ProTyr: 1.481 ± 0.028	0.001ProXaa: 0.001 ± 0.001
Gln	5.22GlnAla: 5.22 ± 0.079	0.519GlnCys: 0.519 ± 0.016	2.191GlnAsp: 2.191 ± 0.033	2.419GlnGlu: 2.419 ± 0.043	1.183GlnPhe: 1.183 ± 0.024	2.67GlnGly: 2.67 ± 0.043	1.318GlnHis: 1.318 ± 0.03	1.519GlnIle: 1.519 ± 0.025	1.58GlnLys: 1.58 ± 0.032	4.068GlnLeu: 4.068 ± 0.053	1.01GlnMet: 1.01 ± 0.022	1.087GlnAsn: 1.087 ± 0.026	2.476GlnPro: 2.476 ± 0.045	2.336GlnGln: 2.336 ± 0.05	3.572GlnArg: 3.572 ± 0.043	2.799GlnSer: 2.799 ± 0.039	2.372GlnThr: 2.372 ± 0.037	2.735GlnVal: 2.735 ± 0.037	0.699GlnTrp: 0.699 ± 0.019	1.096GlnTyr: 1.096 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.753ArgAla: 6.753 ± 0.067	0.69ArgCys: 0.69 ± 0.019	3.459ArgAsp: 3.459 ± 0.044	4.004ArgGlu: 4.004 ± 0.058	2.061ArgPhe: 2.061 ± 0.031	3.662ArgGly: 3.662 ± 0.049	1.979ArgHis: 1.979 ± 0.028	2.896ArgIle: 2.896 ± 0.036	2.695ArgLys: 2.695 ± 0.042	6.247ArgLeu: 6.247 ± 0.062	1.902ArgMet: 1.902 ± 0.034	1.566ArgAsn: 1.566 ± 0.029	3.77ArgPro: 3.77 ± 0.06	2.721ArgGln: 2.721 ± 0.035	5.715ArgArg: 5.715 ± 0.066	4.686ArgSer: 4.686 ± 0.059	4.264ArgThr: 4.264 ± 0.054	4.386ArgVal: 4.386 ± 0.056	0.988ArgTrp: 0.988 ± 0.025	1.622ArgTyr: 1.622 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.433SerAla: 7.433 ± 0.078	0.682SerCys: 0.682 ± 0.021	4.265SerAsp: 4.265 ± 0.05	3.942SerGlu: 3.942 ± 0.048	2.504SerPhe: 2.504 ± 0.039	4.107SerGly: 4.107 ± 0.049	2.332SerHis: 2.332 ± 0.036	3.032SerIle: 3.032 ± 0.04	3.056SerLys: 3.056 ± 0.049	7.597SerLeu: 7.597 ± 0.064	2.625SerMet: 2.625 ± 0.04	2.045SerAsn: 2.045 ± 0.036	4.762SerPro: 4.762 ± 0.094	3.121SerGln: 3.121 ± 0.045	4.422SerArg: 4.422 ± 0.058	8.393SerSer: 8.393 ± 0.131	6.087SerThr: 6.087 ± 0.073	4.991SerVal: 4.991 ± 0.048	0.988SerTrp: 0.988 ± 0.022	1.845SerTyr: 1.845 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	5.627ThrAla: 5.627 ± 0.058	0.733ThrCys: 0.733 ± 0.017	3.047ThrAsp: 3.047 ± 0.039	3.354ThrGlu: 3.354 ± 0.046	1.951ThrPhe: 1.951 ± 0.034	3.504ThrGly: 3.504 ± 0.05	1.833ThrHis: 1.833 ± 0.032	2.463ThrIle: 2.463 ± 0.038	2.427ThrLys: 2.427 ± 0.035	6.312ThrLeu: 6.312 ± 0.065	1.818ThrMet: 1.818 ± 0.034	1.684ThrAsn: 1.684 ± 0.029	5.171ThrPro: 5.171 ± 0.077	2.679ThrGln: 2.679 ± 0.04	3.561ThrArg: 3.561 ± 0.045	6.228ThrSer: 6.228 ± 0.068	4.578ThrThr: 4.578 ± 0.075	3.53ThrVal: 3.53 ± 0.04	1.06ThrTrp: 1.06 ± 0.024	1.742ThrTyr: 1.742 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	6.053ValAla: 6.053 ± 0.054	0.932ValCys: 0.932 ± 0.021	4.008ValAsp: 4.008 ± 0.051	3.611ValGlu: 3.611 ± 0.043	2.24ValPhe: 2.24 ± 0.035	3.529ValGly: 3.529 ± 0.045	2.198ValHis: 2.198 ± 0.033	2.471ValIle: 2.471 ± 0.043	2.264ValLys: 2.264 ± 0.039	6.882ValLeu: 6.882 ± 0.069	1.572ValMet: 1.572 ± 0.027	1.656ValAsn: 1.656 ± 0.027	4.946ValPro: 4.946 ± 0.053	3.116ValGln: 3.116 ± 0.043	4.663ValArg: 4.663 ± 0.052	4.886ValSer: 4.886 ± 0.05	3.506ValThr: 3.506 ± 0.046	4.421ValVal: 4.421 ± 0.053	1.106ValTrp: 1.106 ± 0.027	1.945ValTyr: 1.945 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.269TrpAla: 1.269 ± 0.027	0.214TrpCys: 0.214 ± 0.01	1.099TrpAsp: 1.099 ± 0.026	0.758TrpGlu: 0.758 ± 0.021	0.436TrpPhe: 0.436 ± 0.017	0.754TrpGly: 0.754 ± 0.02	0.564TrpHis: 0.564 ± 0.019	0.689TrpIle: 0.689 ± 0.02	0.557TrpLys: 0.557 ± 0.016	1.524TrpLeu: 1.524 ± 0.034	0.396TrpMet: 0.396 ± 0.015	0.512TrpAsn: 0.512 ± 0.017	0.732TrpPro: 0.732 ± 0.02	0.672TrpGln: 0.672 ± 0.019	1.119TrpArg: 1.119 ± 0.025	1.078TrpSer: 1.078 ± 0.023	0.956TrpThr: 0.956 ± 0.021	0.811TrpVal: 0.811 ± 0.022	0.242TrpTrp: 0.242 ± 0.011	0.423TrpTyr: 0.423 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.732TyrAla: 2.732 ± 0.042	0.329TyrCys: 0.329 ± 0.013	1.736TyrAsp: 1.736 ± 0.036	1.687TyrGlu: 1.687 ± 0.032	1.02TyrPhe: 1.02 ± 0.026	1.771TyrGly: 1.771 ± 0.029	0.707TyrHis: 0.707 ± 0.018	1.15TyrIle: 1.15 ± 0.024	0.953TyrLys: 0.953 ± 0.023	2.579TyrLeu: 2.579 ± 0.035	0.758TyrMet: 0.758 ± 0.02	0.811TyrAsn: 0.811 ± 0.023	1.231TyrPro: 1.231 ± 0.026	1.018TyrGln: 1.018 ± 0.022	1.572TyrArg: 1.572 ± 0.027	1.493TyrSer: 1.493 ± 0.03	1.67TyrThr: 1.67 ± 0.029	2.003TyrVal: 2.003 ± 0.029	0.361TyrTrp: 0.361 ± 0.013	0.79TyrTyr: 0.79 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.064XaaXaa: 0.064 ± 0.021

Statistics based on 4201 proteins (2130625 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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