Amino acid dipepetide frequency for Streptococcus satellite phage Javan408

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
1.19AlaCys: 1.19 ± 0.604
1.586AlaAsp: 1.586 ± 0.738
3.569AlaGlu: 3.569 ± 1.161
2.379AlaPhe: 2.379 ± 0.748
3.965AlaGly: 3.965 ± 0.858
0.397AlaHis: 0.397 ± 0.417
7.137AlaIle: 7.137 ± 0.904
1.983AlaLys: 1.983 ± 0.713
6.741AlaLeu: 6.741 ± 1.23
1.983AlaMet: 1.983 ± 0.648
3.172AlaAsn: 3.172 ± 0.709
2.379AlaPro: 2.379 ± 1.22
2.776AlaGln: 2.776 ± 1.187
1.586AlaArg: 1.586 ± 0.682
0.793AlaSer: 0.793 ± 0.383
4.362AlaThr: 4.362 ± 1.524
1.983AlaVal: 1.983 ± 1.071
0.0AlaTrp: 0.0 ± 0.0
2.776AlaTyr: 2.776 ± 0.863
0.0AlaXaa: 0.0 ± 0.0
Cys
1.19CysAla: 1.19 ± 0.885
0.0CysCys: 0.0 ± 0.0
0.793CysAsp: 0.793 ± 0.49
0.397CysGlu: 0.397 ± 0.298
0.0CysPhe: 0.0 ± 0.0
0.397CysGly: 0.397 ± 0.46
0.0CysHis: 0.0 ± 0.0
1.19CysIle: 1.19 ± 0.594
0.397CysLys: 0.397 ± 0.406
0.793CysLeu: 0.793 ± 0.572
0.0CysMet: 0.0 ± 0.0
0.397CysAsn: 0.397 ± 0.298
0.397CysPro: 0.397 ± 0.373
0.0CysGln: 0.0 ± 0.0
0.397CysArg: 0.397 ± 0.373
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.397CysVal: 0.397 ± 0.298
0.0CysTrp: 0.0 ± 0.0
0.397CysTyr: 0.397 ± 0.511
0.0CysXaa: 0.0 ± 0.0
Asp
0.397AspAla: 0.397 ± 0.298
0.793AspCys: 0.793 ± 0.778
3.965AspAsp: 3.965 ± 1.624
1.983AspGlu: 1.983 ± 0.945
3.172AspPhe: 3.172 ± 0.685
2.379AspGly: 2.379 ± 0.832
0.397AspHis: 0.397 ± 0.298
8.723AspIle: 8.723 ± 1.377
3.965AspLys: 3.965 ± 0.988
6.741AspLeu: 6.741 ± 1.241
3.172AspMet: 3.172 ± 1.567
4.362AspAsn: 4.362 ± 1.669
0.793AspPro: 0.793 ± 0.452
1.586AspGln: 1.586 ± 0.765
1.586AspArg: 1.586 ± 0.686
1.983AspSer: 1.983 ± 0.56
4.758AspThr: 4.758 ± 1.79
1.983AspVal: 1.983 ± 0.622
0.0AspTrp: 0.0 ± 0.0
8.723AspTyr: 8.723 ± 1.716
0.0AspXaa: 0.0 ± 0.0
Glu
7.137GluAla: 7.137 ± 1.48
1.19GluCys: 1.19 ± 0.885
5.551GluAsp: 5.551 ± 2.506
2.776GluGlu: 2.776 ± 1.126
3.965GluPhe: 3.965 ± 0.843
1.19GluGly: 1.19 ± 0.728
1.586GluHis: 1.586 ± 0.749
5.155GluIle: 5.155 ± 1.736
5.155GluLys: 5.155 ± 1.495
11.499GluLeu: 11.499 ± 2.057
2.379GluMet: 2.379 ± 0.734
6.344GluAsn: 6.344 ± 1.654
3.569GluPro: 3.569 ± 1.135
2.379GluGln: 2.379 ± 1.345
3.172GluArg: 3.172 ± 1.034
1.586GluSer: 1.586 ± 0.578
3.172GluThr: 3.172 ± 1.028
2.776GluVal: 2.776 ± 1.548
0.397GluTrp: 0.397 ± 0.465
1.983GluTyr: 1.983 ± 1.112
0.0GluXaa: 0.0 ± 0.0
Phe
0.793PheAla: 0.793 ± 0.502
0.0PheCys: 0.0 ± 0.0
1.983PheAsp: 1.983 ± 0.663
4.758PheGlu: 4.758 ± 1.606
1.586PhePhe: 1.586 ± 0.756
1.983PheGly: 1.983 ± 1.02
0.397PheHis: 0.397 ± 0.373
4.758PheIle: 4.758 ± 1.285
5.155PheLys: 5.155 ± 1.426
1.19PheLeu: 1.19 ± 0.855
0.397PheMet: 0.397 ± 0.437
1.586PheAsn: 1.586 ± 0.497
0.793PhePro: 0.793 ± 0.764
0.793PheGln: 0.793 ± 0.512
1.19PheArg: 1.19 ± 0.603
2.379PheSer: 2.379 ± 0.822
3.965PheThr: 3.965 ± 1.086
0.793PheVal: 0.793 ± 0.486
0.397PheTrp: 0.397 ± 0.298
1.983PheTyr: 1.983 ± 0.958
0.0PheXaa: 0.0 ± 0.0
Gly
2.776GlyAla: 2.776 ± 1.146
0.793GlyCys: 0.793 ± 0.746
3.172GlyAsp: 3.172 ± 0.926
0.793GlyGlu: 0.793 ± 0.49
1.586GlyPhe: 1.586 ± 0.558
1.983GlyGly: 1.983 ± 1.0
0.397GlyHis: 0.397 ± 0.373
2.776GlyIle: 2.776 ± 0.714
4.362GlyLys: 4.362 ± 0.917
3.569GlyLeu: 3.569 ± 1.352
1.19GlyMet: 1.19 ± 0.568
4.362GlyAsn: 4.362 ± 1.36
0.0GlyPro: 0.0 ± 0.0
2.379GlyGln: 2.379 ± 0.655
1.983GlyArg: 1.983 ± 0.798
2.776GlySer: 2.776 ± 0.827
4.362GlyThr: 4.362 ± 1.125
1.983GlyVal: 1.983 ± 1.022
0.397GlyTrp: 0.397 ± 0.298
3.172GlyTyr: 3.172 ± 0.759
0.0GlyXaa: 0.0 ± 0.0
His
1.586HisAla: 1.586 ± 1.048
0.0HisCys: 0.0 ± 0.0
1.586HisAsp: 1.586 ± 0.841
1.19HisGlu: 1.19 ± 0.778
1.19HisPhe: 1.19 ± 0.617
0.793HisGly: 0.793 ± 0.5
0.397HisHis: 0.397 ± 0.298
0.793HisIle: 0.793 ± 0.498
0.397HisLys: 0.397 ± 0.389
0.793HisLeu: 0.793 ± 0.746
0.397HisMet: 0.397 ± 0.425
0.793HisAsn: 0.793 ± 0.746
0.0HisPro: 0.0 ± 0.0
0.793HisGln: 0.793 ± 0.601
0.793HisArg: 0.793 ± 0.487
0.793HisSer: 0.793 ± 0.486
1.586HisThr: 1.586 ± 0.417
0.793HisVal: 0.793 ± 0.487
0.397HisTrp: 0.397 ± 0.417
0.397HisTyr: 0.397 ± 0.298
0.0HisXaa: 0.0 ± 0.0
Ile
4.758IleAla: 4.758 ± 1.407
1.19IleCys: 1.19 ± 0.9
5.948IleAsp: 5.948 ± 1.517
7.93IleGlu: 7.93 ± 1.624
1.983IlePhe: 1.983 ± 0.753
3.172IleGly: 3.172 ± 1.357
0.397IleHis: 0.397 ± 0.386
7.137IleIle: 7.137 ± 1.698
9.12IleLys: 9.12 ± 1.858
6.344IleLeu: 6.344 ± 1.457
2.379IleMet: 2.379 ± 0.986
8.327IleAsn: 8.327 ± 1.835
3.569IlePro: 3.569 ± 1.174
2.776IleGln: 2.776 ± 0.826
3.569IleArg: 3.569 ± 0.859
3.965IleSer: 3.965 ± 1.292
6.344IleThr: 6.344 ± 1.404
1.586IleVal: 1.586 ± 0.66
0.793IleTrp: 0.793 ± 0.452
3.965IleTyr: 3.965 ± 0.966
0.0IleXaa: 0.0 ± 0.0
Lys
7.534LysAla: 7.534 ± 1.813
0.397LysCys: 0.397 ± 0.406
6.741LysAsp: 6.741 ± 1.65
11.895LysGlu: 11.895 ± 2.44
1.19LysPhe: 1.19 ± 0.439
3.965LysGly: 3.965 ± 1.574
1.586LysHis: 1.586 ± 0.745
3.569LysIle: 3.569 ± 1.104
8.327LysLys: 8.327 ± 1.785
3.965LysLeu: 3.965 ± 1.407
1.983LysMet: 1.983 ± 0.814
7.534LysAsn: 7.534 ± 1.627
4.758LysPro: 4.758 ± 1.719
2.776LysGln: 2.776 ± 1.344
5.551LysArg: 5.551 ± 1.999
5.551LysSer: 5.551 ± 1.348
5.948LysThr: 5.948 ± 1.264
3.569LysVal: 3.569 ± 1.098
0.793LysTrp: 0.793 ± 0.474
3.569LysTyr: 3.569 ± 0.864
0.0LysXaa: 0.0 ± 0.0
Leu
3.965LeuAla: 3.965 ± 1.022
0.0LeuCys: 0.0 ± 0.0
5.551LeuAsp: 5.551 ± 1.638
7.137LeuGlu: 7.137 ± 1.655
1.586LeuPhe: 1.586 ± 0.571
4.758LeuGly: 4.758 ± 1.282
1.19LeuHis: 1.19 ± 0.555
8.723LeuIle: 8.723 ± 2.154
7.534LeuLys: 7.534 ± 1.336
9.913LeuLeu: 9.913 ± 1.564
2.776LeuMet: 2.776 ± 0.979
6.741LeuAsn: 6.741 ± 2.265
4.362LeuPro: 4.362 ± 1.038
5.948LeuGln: 5.948 ± 0.845
3.569LeuArg: 3.569 ± 0.909
7.534LeuSer: 7.534 ± 1.272
6.344LeuThr: 6.344 ± 1.354
3.569LeuVal: 3.569 ± 0.905
0.397LeuTrp: 0.397 ± 0.373
4.758LeuTyr: 4.758 ± 1.172
0.0LeuXaa: 0.0 ± 0.0
Met
1.983MetAla: 1.983 ± 0.969
0.0MetCys: 0.0 ± 0.0
1.19MetAsp: 1.19 ± 0.527
1.19MetGlu: 1.19 ± 0.62
0.793MetPhe: 0.793 ± 0.452
0.397MetGly: 0.397 ± 0.417
0.0MetHis: 0.0 ± 0.0
1.983MetIle: 1.983 ± 0.837
3.965MetLys: 3.965 ± 0.749
0.397MetLeu: 0.397 ± 0.373
0.397MetMet: 0.397 ± 0.298
1.19MetAsn: 1.19 ± 0.583
0.793MetPro: 0.793 ± 0.556
0.397MetGln: 0.397 ± 0.298
1.586MetArg: 1.586 ± 0.785
0.793MetSer: 0.793 ± 0.516
4.362MetThr: 4.362 ± 0.887
1.586MetVal: 1.586 ± 0.889
0.0MetTrp: 0.0 ± 0.0
0.793MetTyr: 0.793 ± 0.468
0.0MetXaa: 0.0 ± 0.0
Asn
3.569AsnAla: 3.569 ± 0.87
1.19AsnCys: 1.19 ± 0.631
4.362AsnAsp: 4.362 ± 1.47
6.344AsnGlu: 6.344 ± 1.789
2.379AsnPhe: 2.379 ± 0.699
4.362AsnGly: 4.362 ± 0.858
1.19AsnHis: 1.19 ± 0.644
3.172AsnIle: 3.172 ± 1.071
6.344AsnLys: 6.344 ± 1.216
6.344AsnLeu: 6.344 ± 1.415
1.586AsnMet: 1.586 ± 0.842
2.776AsnAsn: 2.776 ± 1.365
2.776AsnPro: 2.776 ± 1.182
1.983AsnGln: 1.983 ± 0.719
3.172AsnArg: 3.172 ± 1.281
3.965AsnSer: 3.965 ± 1.067
3.172AsnThr: 3.172 ± 0.848
1.983AsnVal: 1.983 ± 0.903
0.0AsnTrp: 0.0 ± 0.0
5.948AsnTyr: 5.948 ± 1.49
0.0AsnXaa: 0.0 ± 0.0
Pro
1.19ProAla: 1.19 ± 0.504
0.0ProCys: 0.0 ± 0.0
2.776ProAsp: 2.776 ± 0.987
2.776ProGlu: 2.776 ± 0.776
1.586ProPhe: 1.586 ± 0.728
0.0ProGly: 0.0 ± 0.0
0.397ProHis: 0.397 ± 0.298
1.19ProIle: 1.19 ± 0.624
5.948ProLys: 5.948 ± 1.302
3.172ProLeu: 3.172 ± 1.002
0.397ProMet: 0.397 ± 0.382
1.983ProAsn: 1.983 ± 0.941
1.586ProPro: 1.586 ± 0.877
1.19ProGln: 1.19 ± 0.65
1.983ProArg: 1.983 ± 0.879
0.793ProSer: 0.793 ± 0.486
3.172ProThr: 3.172 ± 0.979
2.379ProVal: 2.379 ± 0.877
0.0ProTrp: 0.0 ± 0.0
1.983ProTyr: 1.983 ± 0.853
0.0ProXaa: 0.0 ± 0.0
Gln
3.569GlnAla: 3.569 ± 1.009
0.0GlnCys: 0.0 ± 0.0
1.19GlnAsp: 1.19 ± 0.612
3.569GlnGlu: 3.569 ± 1.598
2.379GlnPhe: 2.379 ± 0.821
3.172GlnGly: 3.172 ± 1.091
1.19GlnHis: 1.19 ± 0.527
0.793GlnIle: 0.793 ± 0.572
2.379GlnLys: 2.379 ± 0.94
4.758GlnLeu: 4.758 ± 1.33
0.793GlnMet: 0.793 ± 0.596
1.983GlnAsn: 1.983 ± 0.681
0.793GlnPro: 0.793 ± 0.601
3.569GlnGln: 3.569 ± 1.651
2.379GlnArg: 2.379 ± 0.695
2.379GlnSer: 2.379 ± 0.92
2.776GlnThr: 2.776 ± 1.133
1.19GlnVal: 1.19 ± 0.877
0.397GlnTrp: 0.397 ± 0.511
1.586GlnTyr: 1.586 ± 0.704
0.0GlnXaa: 0.0 ± 0.0
Arg
1.983ArgAla: 1.983 ± 0.793
0.0ArgCys: 0.0 ± 0.0
3.172ArgAsp: 3.172 ± 0.929
2.379ArgGlu: 2.379 ± 1.019
1.983ArgPhe: 1.983 ± 0.762
2.379ArgGly: 2.379 ± 0.918
0.793ArgHis: 0.793 ± 0.434
4.362ArgIle: 4.362 ± 0.963
4.362ArgLys: 4.362 ± 1.393
6.344ArgLeu: 6.344 ± 1.361
1.19ArgMet: 1.19 ± 0.625
0.793ArgAsn: 0.793 ± 0.764
0.0ArgPro: 0.0 ± 0.0
3.569ArgGln: 3.569 ± 1.536
1.983ArgArg: 1.983 ± 0.551
0.793ArgSer: 0.793 ± 0.596
2.379ArgThr: 2.379 ± 0.986
3.569ArgVal: 3.569 ± 1.147
0.397ArgTrp: 0.397 ± 0.417
1.586ArgTyr: 1.586 ± 0.695
0.0ArgXaa: 0.0 ± 0.0
Ser
1.983SerAla: 1.983 ± 0.877
0.0SerCys: 0.0 ± 0.0
4.362SerAsp: 4.362 ± 1.52
2.379SerGlu: 2.379 ± 0.722
1.586SerPhe: 1.586 ± 0.869
1.586SerGly: 1.586 ± 0.901
1.586SerHis: 1.586 ± 0.998
5.948SerIle: 5.948 ± 1.412
4.758SerLys: 4.758 ± 1.242
5.551SerLeu: 5.551 ± 1.344
0.0SerMet: 0.0 ± 0.0
1.983SerAsn: 1.983 ± 0.736
1.983SerPro: 1.983 ± 0.941
1.983SerGln: 1.983 ± 0.787
2.379SerArg: 2.379 ± 0.963
3.569SerSer: 3.569 ± 1.155
1.586SerThr: 1.586 ± 0.734
3.965SerVal: 3.965 ± 1.293
0.397SerTrp: 0.397 ± 0.417
3.965SerTyr: 3.965 ± 2.064
0.0SerXaa: 0.0 ± 0.0
Thr
1.983ThrAla: 1.983 ± 0.578
0.0ThrCys: 0.0 ± 0.0
3.569ThrAsp: 3.569 ± 1.101
5.551ThrGlu: 5.551 ± 1.696
4.758ThrPhe: 4.758 ± 1.506
4.758ThrGly: 4.758 ± 1.304
0.397ThrHis: 0.397 ± 0.373
6.741ThrIle: 6.741 ± 1.801
6.344ThrLys: 6.344 ± 1.223
8.327ThrLeu: 8.327 ± 2.217
0.793ThrMet: 0.793 ± 0.486
3.172ThrAsn: 3.172 ± 1.445
2.776ThrPro: 2.776 ± 0.523
1.19ThrGln: 1.19 ± 0.595
2.776ThrArg: 2.776 ± 0.908
3.569ThrSer: 3.569 ± 0.971
4.758ThrThr: 4.758 ± 0.782
5.948ThrVal: 5.948 ± 1.403
1.19ThrTrp: 1.19 ± 0.615
2.379ThrTyr: 2.379 ± 1.268
0.0ThrXaa: 0.0 ± 0.0
Val
3.569ValAla: 3.569 ± 1.15
0.0ValCys: 0.0 ± 0.0
1.19ValAsp: 1.19 ± 0.778
0.793ValGlu: 0.793 ± 0.383
1.983ValPhe: 1.983 ± 1.0
1.586ValGly: 1.586 ± 0.728
2.379ValHis: 2.379 ± 0.61
4.758ValIle: 4.758 ± 1.127
5.551ValLys: 5.551 ± 1.6
3.965ValLeu: 3.965 ± 1.255
0.397ValMet: 0.397 ± 0.437
2.379ValAsn: 2.379 ± 1.297
0.793ValPro: 0.793 ± 0.746
0.793ValGln: 0.793 ± 0.643
1.586ValArg: 1.586 ± 1.05
3.965ValSer: 3.965 ± 1.599
3.569ValThr: 3.569 ± 1.013
1.983ValVal: 1.983 ± 0.926
0.397ValTrp: 0.397 ± 0.298
1.983ValTyr: 1.983 ± 0.808
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.397TrpAsp: 0.397 ± 0.349
0.793TrpGlu: 0.793 ± 0.581
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.397TrpHis: 0.397 ± 0.298
0.397TrpIle: 0.397 ± 0.511
0.397TrpLys: 0.397 ± 0.298
2.379TrpLeu: 2.379 ± 0.698
0.0TrpMet: 0.0 ± 0.0
0.397TrpAsn: 0.397 ± 0.298
0.0TrpPro: 0.0 ± 0.0
0.397TrpGln: 0.397 ± 0.417
0.0TrpArg: 0.0 ± 0.0
0.793TrpSer: 0.793 ± 0.383
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.397TrpTyr: 0.397 ± 0.417
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.19TyrAla: 1.19 ± 0.637
0.397TyrCys: 0.397 ± 0.382
2.379TyrAsp: 2.379 ± 1.146
4.758TyrGlu: 4.758 ± 2.269
0.793TyrPhe: 0.793 ± 0.383
1.983TyrGly: 1.983 ± 0.675
0.397TyrHis: 0.397 ± 0.386
5.948TyrIle: 5.948 ± 1.052
4.758TyrLys: 4.758 ± 1.472
3.569TyrLeu: 3.569 ± 0.884
1.19TyrMet: 1.19 ± 0.446
6.344TyrAsn: 6.344 ± 1.439
2.379TyrPro: 2.379 ± 0.918
3.569TyrGln: 3.569 ± 1.297
2.776TyrArg: 2.776 ± 1.265
3.569TyrSer: 3.569 ± 1.015
4.362TyrThr: 4.362 ± 1.59
1.586TyrVal: 1.586 ± 0.771
0.397TyrTrp: 0.397 ± 0.298
2.776TyrTyr: 2.776 ± 0.854
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 14 proteins (2523 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski