Amino acid dipepetide frequency for Taeniopygia guttata (Zebra finch) (Poephila guttata)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.06AlaAla: 8.06 ± 0.047	1.305AlaCys: 1.305 ± 0.01	2.997AlaAsp: 2.997 ± 0.016	5.245AlaGlu: 5.245 ± 0.025	2.444AlaPhe: 2.444 ± 0.012	5.285AlaGly: 5.285 ± 0.026	1.434AlaHis: 1.434 ± 0.011	2.728AlaIle: 2.728 ± 0.013	3.53AlaLys: 3.53 ± 0.018	7.151AlaLeu: 7.151 ± 0.03	1.521AlaMet: 1.521 ± 0.009	2.088AlaAsn: 2.088 ± 0.012	4.255AlaPro: 4.255 ± 0.025	3.143AlaGln: 3.143 ± 0.017	3.848AlaArg: 3.848 ± 0.018	5.31AlaSer: 5.31 ± 0.019	3.39AlaThr: 3.39 ± 0.02	5.102AlaVal: 5.102 ± 0.018	0.791AlaTrp: 0.791 ± 0.007	1.433AlaTyr: 1.433 ± 0.008	0.0AlaXaa: 0.0 ± 0.0
Cys	1.326CysAla: 1.326 ± 0.01	0.661CysCys: 0.661 ± 0.008	1.016CysAsp: 1.016 ± 0.01	1.263CysGlu: 1.263 ± 0.012	0.83CysPhe: 0.83 ± 0.006	1.58CysGly: 1.58 ± 0.015	0.72CysHis: 0.72 ± 0.009	0.999CysIle: 0.999 ± 0.01	1.15CysLys: 1.15 ± 0.009	2.092CysLeu: 2.092 ± 0.011	0.413CysMet: 0.413 ± 0.004	0.798CysAsn: 0.798 ± 0.007	1.652CysPro: 1.652 ± 0.018	1.111CysGln: 1.111 ± 0.01	1.37CysArg: 1.37 ± 0.011	2.074CysSer: 2.074 ± 0.013	1.12CysThr: 1.12 ± 0.009	1.304CysVal: 1.304 ± 0.011	0.304CysTrp: 0.304 ± 0.004	0.586CysTyr: 0.586 ± 0.005	0.0CysXaa: 0.0 ± 0.0
Asp	2.909AspAla: 2.909 ± 0.013	1.051AspCys: 1.051 ± 0.01	2.634AspAsp: 2.634 ± 0.016	3.553AspGlu: 3.553 ± 0.018	2.121AspPhe: 2.121 ± 0.013	3.403AspGly: 3.403 ± 0.019	1.084AspHis: 1.084 ± 0.008	2.682AspIle: 2.682 ± 0.016	2.617AspLys: 2.617 ± 0.013	4.782AspLeu: 4.782 ± 0.017	1.105AspMet: 1.105 ± 0.009	1.756AspAsn: 1.756 ± 0.012	2.808AspPro: 2.808 ± 0.015	1.726AspGln: 1.726 ± 0.011	2.381AspArg: 2.381 ± 0.014	4.155AspSer: 4.155 ± 0.018	2.549AspThr: 2.549 ± 0.014	3.105AspVal: 3.105 ± 0.018	0.623AspTrp: 0.623 ± 0.006	1.468AspTyr: 1.468 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.946GluAla: 4.946 ± 0.024	1.348GluCys: 1.348 ± 0.014	4.332GluAsp: 4.332 ± 0.02	8.179GluGlu: 8.179 ± 0.05	2.097GluPhe: 2.097 ± 0.013	4.195GluGly: 4.195 ± 0.02	1.561GluHis: 1.561 ± 0.01	3.278GluIle: 3.278 ± 0.016	5.413GluLys: 5.413 ± 0.034	6.647GluLeu: 6.647 ± 0.033	1.742GluMet: 1.742 ± 0.011	3.226GluAsn: 3.226 ± 0.018	3.145GluPro: 3.145 ± 0.018	3.366GluGln: 3.366 ± 0.022	4.194GluArg: 4.194 ± 0.024	4.444GluSer: 4.444 ± 0.019	3.387GluThr: 3.387 ± 0.018	4.118GluVal: 4.118 ± 0.019	0.719GluTrp: 0.719 ± 0.006	1.652GluTyr: 1.652 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.007PheAla: 2.007 ± 0.011	0.914PheCys: 0.914 ± 0.007	1.679PheAsp: 1.679 ± 0.01	1.969PheGlu: 1.969 ± 0.011	1.599PhePhe: 1.599 ± 0.014	2.332PheGly: 2.332 ± 0.015	1.021PheHis: 1.021 ± 0.008	1.775PheIle: 1.775 ± 0.013	1.744PheLys: 1.744 ± 0.011	3.914PheLeu: 3.914 ± 0.022	0.746PheMet: 0.746 ± 0.006	1.315PheAsn: 1.315 ± 0.008	2.206PhePro: 2.206 ± 0.024	1.76PheGln: 1.76 ± 0.009	1.862PheArg: 1.862 ± 0.01	3.272PheSer: 3.272 ± 0.019	1.963PheThr: 1.963 ± 0.012	2.145PheVal: 2.145 ± 0.012	0.535PheTrp: 0.535 ± 0.007	1.14PheTyr: 1.14 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	4.879GlyAla: 4.879 ± 0.025	1.396GlyCys: 1.396 ± 0.011	3.332GlyAsp: 3.332 ± 0.017	4.049GlyGlu: 4.049 ± 0.021	2.463GlyPhe: 2.463 ± 0.018	5.525GlyGly: 5.525 ± 0.042	1.817GlyHis: 1.817 ± 0.018	2.912GlyIle: 2.912 ± 0.019	3.797GlyLys: 3.797 ± 0.017	5.51GlyLeu: 5.51 ± 0.026	1.408GlyMet: 1.408 ± 0.011	2.479GlyAsn: 2.479 ± 0.016	3.711GlyPro: 3.711 ± 0.032	2.782GlyGln: 2.782 ± 0.018	4.084GlyArg: 4.084 ± 0.02	5.998GlySer: 5.998 ± 0.03	3.981GlyThr: 3.981 ± 0.023	3.745GlyVal: 3.745 ± 0.02	0.913GlyTrp: 0.913 ± 0.009	1.771GlyTyr: 1.771 ± 0.012	0.0GlyXaa: 0.0 ± 0.0
His	1.337HisAla: 1.337 ± 0.009	0.716HisCys: 0.716 ± 0.008	0.883HisAsp: 0.883 ± 0.007	1.344HisGlu: 1.344 ± 0.008	1.059HisPhe: 1.059 ± 0.01	1.674HisGly: 1.674 ± 0.012	0.879HisHis: 0.879 ± 0.01	1.241HisIle: 1.241 ± 0.008	1.273HisLys: 1.273 ± 0.009	2.764HisLeu: 2.764 ± 0.019	0.552HisMet: 0.552 ± 0.005	0.9HisAsn: 0.9 ± 0.008	1.742HisPro: 1.742 ± 0.02	1.198HisGln: 1.198 ± 0.011	1.617HisArg: 1.617 ± 0.012	2.263HisSer: 2.263 ± 0.018	1.321HisThr: 1.321 ± 0.012	1.46HisVal: 1.46 ± 0.01	0.359HisTrp: 0.359 ± 0.007	0.788HisTyr: 0.788 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	2.656IleAla: 2.656 ± 0.015	1.057IleCys: 1.057 ± 0.009	2.087IleAsp: 2.087 ± 0.013	2.61IleGlu: 2.61 ± 0.013	1.874IlePhe: 1.874 ± 0.015	2.239IleGly: 2.239 ± 0.014	1.267IleHis: 1.267 ± 0.019	2.326IleIle: 2.326 ± 0.017	2.668IleLys: 2.668 ± 0.015	4.414IleLeu: 4.414 ± 0.022	0.972IleMet: 0.972 ± 0.007	1.914IleAsn: 1.914 ± 0.011	2.878IlePro: 2.878 ± 0.02	2.282IleGln: 2.282 ± 0.013	2.368IleArg: 2.368 ± 0.012	3.73IleSer: 3.73 ± 0.017	2.552IleThr: 2.552 ± 0.014	2.525IleVal: 2.525 ± 0.016	0.518IleTrp: 0.518 ± 0.007	1.352IleTyr: 1.352 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	3.914LysAla: 3.914 ± 0.019	1.108LysCys: 1.108 ± 0.01	3.187LysAsp: 3.187 ± 0.017	5.177LysGlu: 5.177 ± 0.03	1.727LysPhe: 1.727 ± 0.013	3.228LysGly: 3.228 ± 0.021	1.403LysHis: 1.403 ± 0.01	2.865LysIle: 2.865 ± 0.017	4.801LysLys: 4.801 ± 0.031	5.225LysLeu: 5.225 ± 0.023	1.464LysMet: 1.464 ± 0.01	2.499LysAsn: 2.499 ± 0.014	2.942LysPro: 2.942 ± 0.016	2.767LysGln: 2.767 ± 0.017	3.293LysArg: 3.293 ± 0.016	4.045LysSer: 4.045 ± 0.02	3.057LysThr: 3.057 ± 0.016	3.445LysVal: 3.445 ± 0.016	0.627LysTrp: 0.627 ± 0.007	1.617LysTyr: 1.617 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	6.484LeuAla: 6.484 ± 0.025	2.251LeuCys: 2.251 ± 0.014	4.573LeuAsp: 4.573 ± 0.018	7.16LeuGlu: 7.16 ± 0.032	3.251LeuPhe: 3.251 ± 0.018	5.806LeuGly: 5.806 ± 0.027	2.65LeuHis: 2.65 ± 0.014	3.705LeuIle: 3.705 ± 0.019	5.801LeuLys: 5.801 ± 0.027	10.277LeuLeu: 10.277 ± 0.039	1.912LeuMet: 1.912 ± 0.011	3.488LeuAsn: 3.488 ± 0.015	5.921LeuPro: 5.921 ± 0.025	5.747LeuGln: 5.747 ± 0.024	5.887LeuArg: 5.887 ± 0.024	7.788LeuSer: 7.788 ± 0.024	4.607LeuThr: 4.607 ± 0.018	5.151LeuVal: 5.151 ± 0.02	1.119LeuTrp: 1.119 ± 0.009	2.491LeuTyr: 2.491 ± 0.015	0.0LeuXaa: 0.0 ± 0.0
Met	1.799MetAla: 1.799 ± 0.01	0.411MetCys: 0.411 ± 0.005	1.263MetAsp: 1.263 ± 0.009	1.891MetGlu: 1.891 ± 0.011	0.743MetPhe: 0.743 ± 0.006	1.318MetGly: 1.318 ± 0.01	0.472MetHis: 0.472 ± 0.005	0.827MetIle: 0.827 ± 0.007	1.477MetLys: 1.477 ± 0.009	1.881MetLeu: 1.881 ± 0.01	0.556MetMet: 0.556 ± 0.005	0.898MetAsn: 0.898 ± 0.007	1.013MetPro: 1.013 ± 0.01	0.985MetGln: 0.985 ± 0.009	1.041MetArg: 1.041 ± 0.007	1.611MetSer: 1.611 ± 0.014	1.058MetThr: 1.058 ± 0.008	1.331MetVal: 1.331 ± 0.008	0.248MetTrp: 0.248 ± 0.004	0.555MetTyr: 0.555 ± 0.005	0.0MetXaa: 0.0 ± 0.0
Asn	2.201AsnAla: 2.201 ± 0.011	0.864AsnCys: 0.864 ± 0.008	1.55AsnAsp: 1.55 ± 0.012	2.357AsnGlu: 2.357 ± 0.014	1.508AsnPhe: 1.508 ± 0.011	2.629AsnGly: 2.629 ± 0.016	0.899AsnHis: 0.899 ± 0.007	2.158AsnIle: 2.158 ± 0.013	2.264AsnLys: 2.264 ± 0.012	3.697AsnLeu: 3.697 ± 0.018	0.912AsnMet: 0.912 ± 0.006	1.62AsnAsn: 1.62 ± 0.01	2.248AsnPro: 2.248 ± 0.014	1.6AsnGln: 1.6 ± 0.011	1.826AsnArg: 1.826 ± 0.011	3.226AsnSer: 3.226 ± 0.017	2.038AsnThr: 2.038 ± 0.012	2.259AsnVal: 2.259 ± 0.012	0.456AsnTrp: 0.456 ± 0.006	1.122AsnTyr: 1.122 ± 0.008	0.0AsnXaa: 0.0 ± 0.0
Pro	5.309ProAla: 5.309 ± 0.028	1.314ProCys: 1.314 ± 0.014	2.645ProAsp: 2.645 ± 0.015	4.29ProGlu: 4.29 ± 0.022	1.981ProPhe: 1.981 ± 0.018	5.444ProGly: 5.444 ± 0.046	1.49ProHis: 1.49 ± 0.013	1.89ProIle: 1.89 ± 0.015	2.872ProLys: 2.872 ± 0.023	5.074ProLeu: 5.074 ± 0.025	0.988ProMet: 0.988 ± 0.011	1.903ProAsn: 1.903 ± 0.015	6.046ProPro: 6.046 ± 0.054	2.864ProGln: 2.864 ± 0.023	3.542ProArg: 3.542 ± 0.024	5.599ProSer: 5.599 ± 0.032	2.844ProThr: 2.844 ± 0.022	4.023ProVal: 4.023 ± 0.02	0.695ProTrp: 0.695 ± 0.007	1.36ProTyr: 1.36 ± 0.011	0.0ProXaa: 0.0 ± 0.0
Gln	3.233GlnAla: 3.233 ± 0.018	1.0GlnCys: 1.0 ± 0.01	2.244GlnAsp: 2.244 ± 0.011	3.81GlnGlu: 3.81 ± 0.025	1.412GlnPhe: 1.412 ± 0.01	2.766GlnGly: 2.766 ± 0.017	1.36GlnHis: 1.36 ± 0.011	2.052GlnIle: 2.052 ± 0.013	2.986GlnLys: 2.986 ± 0.018	4.716GlnLeu: 4.716 ± 0.019	1.096GlnMet: 1.096 ± 0.008	1.972GlnAsn: 1.972 ± 0.015	2.743GlnPro: 2.743 ± 0.02	3.183GlnGln: 3.183 ± 0.032	2.949GlnArg: 2.949 ± 0.016	3.219GlnSer: 3.219 ± 0.019	2.256GlnThr: 2.256 ± 0.013	2.74GlnVal: 2.74 ± 0.016	0.542GlnTrp: 0.542 ± 0.006	1.183GlnTyr: 1.183 ± 0.009	0.0GlnXaa: 0.0 ± 0.0
Arg	4.171ArgAla: 4.171 ± 0.021	1.371ArgCys: 1.371 ± 0.012	2.899ArgAsp: 2.899 ± 0.016	4.005ArgGlu: 4.005 ± 0.023	1.874ArgPhe: 1.874 ± 0.012	4.001ArgGly: 4.001 ± 0.025	1.537ArgHis: 1.537 ± 0.01	2.423ArgIle: 2.423 ± 0.012	3.551ArgLys: 3.551 ± 0.016	5.179ArgLeu: 5.179 ± 0.02	1.187ArgMet: 1.187 ± 0.008	2.137ArgAsn: 2.137 ± 0.011	3.144ArgPro: 3.144 ± 0.02	2.605ArgGln: 2.605 ± 0.014	4.649ArgArg: 4.649 ± 0.026	4.438ArgSer: 4.438 ± 0.024	2.732ArgThr: 2.732 ± 0.012	3.108ArgVal: 3.108 ± 0.014	0.727ArgTrp: 0.727 ± 0.007	1.474ArgTyr: 1.474 ± 0.009	0.0ArgXaa: 0.0 ± 0.0
Ser	5.597SerAla: 5.597 ± 0.021	1.93SerCys: 1.93 ± 0.012	3.871SerAsp: 3.871 ± 0.02	5.064SerGlu: 5.064 ± 0.021	2.953SerPhe: 2.953 ± 0.017	5.51SerGly: 5.51 ± 0.027	2.068SerHis: 2.068 ± 0.015	3.293SerIle: 3.293 ± 0.021	4.118SerLys: 4.118 ± 0.02	7.953SerLeu: 7.953 ± 0.027	1.581SerMet: 1.581 ± 0.011	2.745SerAsn: 2.745 ± 0.013	6.257SerPro: 6.257 ± 0.037	3.758SerGln: 3.758 ± 0.018	4.545SerArg: 4.545 ± 0.026	9.402SerSer: 9.402 ± 0.053	4.394SerThr: 4.394 ± 0.021	4.94SerVal: 4.94 ± 0.02	1.022SerTrp: 1.022 ± 0.009	2.028SerTyr: 2.028 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	3.974ThrAla: 3.974 ± 0.016	1.267ThrCys: 1.267 ± 0.012	2.544ThrAsp: 2.544 ± 0.012	3.649ThrGlu: 3.649 ± 0.018	1.98ThrPhe: 1.98 ± 0.011	3.62ThrGly: 3.62 ± 0.023	1.16ThrHis: 1.16 ± 0.011	2.316ThrIle: 2.316 ± 0.015	2.621ThrLys: 2.621 ± 0.015	4.9ThrLeu: 4.9 ± 0.019	1.055ThrMet: 1.055 ± 0.008	1.768ThrAsn: 1.768 ± 0.012	3.539ThrPro: 3.539 ± 0.031	2.088ThrGln: 2.088 ± 0.012	2.375ThrArg: 2.375 ± 0.013	4.423ThrSer: 4.423 ± 0.024	2.822ThrThr: 2.822 ± 0.028	3.836ThrVal: 3.836 ± 0.02	0.695ThrTrp: 0.695 ± 0.008	1.366ThrTyr: 1.366 ± 0.008	0.0ThrXaa: 0.0 ± 0.0
Val	4.132ValAla: 4.132 ± 0.017	1.49ValCys: 1.49 ± 0.011	2.781ValAsp: 2.781 ± 0.017	3.836ValGlu: 3.836 ± 0.017	2.364ValPhe: 2.364 ± 0.014	3.362ValGly: 3.362 ± 0.017	1.509ValHis: 1.509 ± 0.013	2.841ValIle: 2.841 ± 0.017	3.434ValLys: 3.434 ± 0.012	6.154ValLeu: 6.154 ± 0.02	1.272ValMet: 1.272 ± 0.008	2.258ValAsn: 2.258 ± 0.013	4.151ValPro: 4.151 ± 0.025	2.762ValGln: 2.762 ± 0.014	3.071ValArg: 3.071 ± 0.015	4.938ValSer: 4.938 ± 0.023	3.849ValThr: 3.849 ± 0.024	3.882ValVal: 3.882 ± 0.017	0.725ValTrp: 0.725 ± 0.008	1.586ValTyr: 1.586 ± 0.011	0.0ValXaa: 0.0 ± 0.0
Trp	0.768TrpAla: 0.768 ± 0.007	0.257TrpCys: 0.257 ± 0.004	0.707TrpAsp: 0.707 ± 0.008	0.833TrpGlu: 0.833 ± 0.008	0.435TrpPhe: 0.435 ± 0.006	0.949TrpGly: 0.949 ± 0.015	0.322TrpHis: 0.322 ± 0.004	0.579TrpIle: 0.579 ± 0.006	0.783TrpLys: 0.783 ± 0.007	1.19TrpLeu: 1.19 ± 0.008	0.309TrpMet: 0.309 ± 0.004	0.545TrpAsn: 0.545 ± 0.006	0.512TrpPro: 0.512 ± 0.005	0.536TrpGln: 0.536 ± 0.005	0.721TrpArg: 0.721 ± 0.006	0.904TrpSer: 0.904 ± 0.008	0.63TrpThr: 0.63 ± 0.006	0.686TrpVal: 0.686 ± 0.007	0.198TrpTrp: 0.198 ± 0.003	0.332TrpTyr: 0.332 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.355TyrAla: 1.355 ± 0.008	0.659TyrCys: 0.659 ± 0.006	1.289TyrAsp: 1.289 ± 0.011	1.706TyrGlu: 1.706 ± 0.01	1.182TyrPhe: 1.182 ± 0.01	1.686TyrGly: 1.686 ± 0.011	0.717TyrHis: 0.717 ± 0.007	1.399TyrIle: 1.399 ± 0.01	1.493TyrLys: 1.493 ± 0.012	2.548TyrLeu: 2.548 ± 0.014	0.588TyrMet: 0.588 ± 0.005	1.124TyrAsn: 1.124 ± 0.008	1.262TyrPro: 1.262 ± 0.01	1.199TyrGln: 1.199 ± 0.008	1.587TyrArg: 1.587 ± 0.011	2.19TyrSer: 2.19 ± 0.013	1.447TyrThr: 1.447 ± 0.01	1.494TyrVal: 1.494 ± 0.009	0.378TyrTrp: 0.378 ± 0.008	0.907TyrTyr: 0.907 ± 0.008	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.014XaaXaa: 0.014 ± 0.005

Statistics based on 31342 proteins (21258392 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---