Amino acid dipepetide frequency for Corynebacterium sp. 2184

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.142AlaAla: 19.142 ± 0.301
1.073AlaCys: 1.073 ± 0.046
7.006AlaAsp: 7.006 ± 0.111
8.637AlaGlu: 8.637 ± 0.139
3.765AlaPhe: 3.765 ± 0.079
12.096AlaGly: 12.096 ± 0.156
2.771AlaHis: 2.771 ± 0.083
5.485AlaIle: 5.485 ± 0.09
3.305AlaLys: 3.305 ± 0.09
13.132AlaLeu: 13.132 ± 0.191
2.749AlaMet: 2.749 ± 0.062
2.746AlaAsn: 2.746 ± 0.066
6.316AlaPro: 6.316 ± 0.121
4.403AlaGln: 4.403 ± 0.097
8.965AlaArg: 8.965 ± 0.136
7.027AlaSer: 7.027 ± 0.105
6.926AlaThr: 6.926 ± 0.099
10.403AlaVal: 10.403 ± 0.145
1.753AlaTrp: 1.753 ± 0.06
2.605AlaTyr: 2.605 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
1.067CysAla: 1.067 ± 0.045
0.07CysCys: 0.07 ± 0.01
0.418CysAsp: 0.418 ± 0.027
0.485CysGlu: 0.485 ± 0.027
0.244CysPhe: 0.244 ± 0.019
0.766CysGly: 0.766 ± 0.039
0.17CysHis: 0.17 ± 0.015
0.277CysIle: 0.277 ± 0.017
0.128CysLys: 0.128 ± 0.013
0.55CysLeu: 0.55 ± 0.028
0.126CysMet: 0.126 ± 0.014
0.157CysAsn: 0.157 ± 0.016
0.393CysPro: 0.393 ± 0.028
0.181CysGln: 0.181 ± 0.017
0.431CysArg: 0.431 ± 0.03
0.434CysSer: 0.434 ± 0.028
0.438CysThr: 0.438 ± 0.031
0.597CysVal: 0.597 ± 0.029
0.081CysTrp: 0.081 ± 0.01
0.16CysTyr: 0.16 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
7.684AspAla: 7.684 ± 0.115
0.351AspCys: 0.351 ± 0.025
3.515AspAsp: 3.515 ± 0.084
3.965AspGlu: 3.965 ± 0.091
2.051AspPhe: 2.051 ± 0.055
5.041AspGly: 5.041 ± 0.097
1.18AspHis: 1.18 ± 0.042
2.898AspIle: 2.898 ± 0.076
1.71AspLys: 1.71 ± 0.051
5.405AspLeu: 5.405 ± 0.105
1.02AspMet: 1.02 ± 0.041
1.601AspAsn: 1.601 ± 0.044
3.882AspPro: 3.882 ± 0.084
1.54AspGln: 1.54 ± 0.042
3.335AspArg: 3.335 ± 0.069
2.959AspSer: 2.959 ± 0.068
3.103AspThr: 3.103 ± 0.073
5.048AspVal: 5.048 ± 0.085
0.717AspTrp: 0.717 ± 0.038
1.621AspTyr: 1.621 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
7.92GluAla: 7.92 ± 0.107
0.383GluCys: 0.383 ± 0.026
3.356GluAsp: 3.356 ± 0.079
4.207GluGlu: 4.207 ± 0.088
2.058GluPhe: 2.058 ± 0.054
4.981GluGly: 4.981 ± 0.093
1.457GluHis: 1.457 ± 0.05
3.232GluIle: 3.232 ± 0.075
2.067GluLys: 2.067 ± 0.06
6.98GluLeu: 6.98 ± 0.113
1.309GluMet: 1.309 ± 0.049
1.528GluAsn: 1.528 ± 0.056
3.071GluPro: 3.071 ± 0.076
2.255GluGln: 2.255 ± 0.057
5.042GluArg: 5.042 ± 0.085
2.956GluSer: 2.956 ± 0.063
3.26GluThr: 3.26 ± 0.08
5.489GluVal: 5.489 ± 0.108
0.846GluTrp: 0.846 ± 0.041
1.289GluTyr: 1.289 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
4.164PheAla: 4.164 ± 0.08
0.241PheCys: 0.241 ± 0.018
2.533PheAsp: 2.533 ± 0.058
1.877PheGlu: 1.877 ± 0.054
1.165PhePhe: 1.165 ± 0.046
3.443PheGly: 3.443 ± 0.075
0.642PheHis: 0.642 ± 0.028
1.514PheIle: 1.514 ± 0.048
0.61PheLys: 0.61 ± 0.03
2.766PheLeu: 2.766 ± 0.07
0.644PheMet: 0.644 ± 0.031
0.923PheAsn: 0.923 ± 0.039
1.388PhePro: 1.388 ± 0.044
0.74PheGln: 0.74 ± 0.033
1.596PheArg: 1.596 ± 0.044
2.145PheSer: 2.145 ± 0.057
2.078PheThr: 2.078 ± 0.062
2.522PheVal: 2.522 ± 0.068
0.399PheTrp: 0.399 ± 0.024
0.848PheTyr: 0.848 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
10.633GlyAla: 10.633 ± 0.15
0.671GlyCys: 0.671 ± 0.034
4.655GlyAsp: 4.655 ± 0.093
6.25GlyGlu: 6.25 ± 0.098
3.149GlyPhe: 3.149 ± 0.066
7.572GlyGly: 7.572 ± 0.119
1.856GlyHis: 1.856 ± 0.055
4.48GlyIle: 4.48 ± 0.078
2.887GlyLys: 2.887 ± 0.086
8.313GlyLeu: 8.313 ± 0.103
2.086GlyMet: 2.086 ± 0.053
2.215GlyAsn: 2.215 ± 0.06
3.787GlyPro: 3.787 ± 0.069
2.644GlyGln: 2.644 ± 0.059
5.901GlyArg: 5.901 ± 0.105
5.115GlySer: 5.115 ± 0.094
5.334GlyThr: 5.334 ± 0.086
7.749GlyVal: 7.749 ± 0.109
1.409GlyTrp: 1.409 ± 0.052
2.361GlyTyr: 2.361 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.309HisAla: 2.309 ± 0.065
0.179HisCys: 0.179 ± 0.017
1.27HisAsp: 1.27 ± 0.041
1.077HisGlu: 1.077 ± 0.04
0.626HisPhe: 0.626 ± 0.029
1.949HisGly: 1.949 ± 0.059
0.52HisHis: 0.52 ± 0.03
0.974HisIle: 0.974 ± 0.038
0.43HisLys: 0.43 ± 0.024
1.985HisLeu: 1.985 ± 0.06
0.415HisMet: 0.415 ± 0.025
0.575HisAsn: 0.575 ± 0.028
1.537HisPro: 1.537 ± 0.054
0.543HisGln: 0.543 ± 0.028
1.356HisArg: 1.356 ± 0.042
1.122HisSer: 1.122 ± 0.043
1.277HisThr: 1.277 ± 0.045
1.615HisVal: 1.615 ± 0.054
0.242HisTrp: 0.242 ± 0.02
0.491HisTyr: 0.491 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.684IleAla: 6.684 ± 0.101
0.34IleCys: 0.34 ± 0.019
3.76IleAsp: 3.76 ± 0.077
3.261IleGlu: 3.261 ± 0.079
1.386IlePhe: 1.386 ± 0.041
4.389IleGly: 4.389 ± 0.088
0.814IleHis: 0.814 ± 0.037
2.177IleIle: 2.177 ± 0.067
1.186IleLys: 1.186 ± 0.044
3.556IleLeu: 3.556 ± 0.084
0.83IleMet: 0.83 ± 0.035
1.409IleAsn: 1.409 ± 0.049
2.389IlePro: 2.389 ± 0.057
1.089IleGln: 1.089 ± 0.038
2.541IleArg: 2.541 ± 0.066
2.675IleSer: 2.675 ± 0.06
2.959IleThr: 2.959 ± 0.07
4.21IleVal: 4.21 ± 0.084
0.417IleTrp: 0.417 ± 0.024
0.993IleTyr: 0.993 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
3.311LysAla: 3.311 ± 0.081
0.132LysCys: 0.132 ± 0.013
1.633LysAsp: 1.633 ± 0.052
1.583LysGlu: 1.583 ± 0.057
0.747LysPhe: 0.747 ± 0.037
2.134LysGly: 2.134 ± 0.058
0.534LysHis: 0.534 ± 0.027
1.274LysIle: 1.274 ± 0.048
1.234LysLys: 1.234 ± 0.055
2.576LysLeu: 2.576 ± 0.064
0.628LysMet: 0.628 ± 0.03
0.813LysAsn: 0.813 ± 0.04
1.377LysPro: 1.377 ± 0.06
0.917LysGln: 0.917 ± 0.043
2.013LysArg: 2.013 ± 0.061
1.303LysSer: 1.303 ± 0.052
1.589LysThr: 1.589 ± 0.052
2.253LysVal: 2.253 ± 0.064
0.328LysTrp: 0.328 ± 0.019
0.594LysTyr: 0.594 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
13.434LeuAla: 13.434 ± 0.178
0.695LeuCys: 0.695 ± 0.033
5.898LeuAsp: 5.898 ± 0.085
5.264LeuGlu: 5.264 ± 0.092
2.705LeuPhe: 2.705 ± 0.071
9.096LeuGly: 9.096 ± 0.131
1.727LeuHis: 1.727 ± 0.054
4.63LeuIle: 4.63 ± 0.1
2.274LeuLys: 2.274 ± 0.062
7.936LeuLeu: 7.936 ± 0.149
1.819LeuMet: 1.819 ± 0.047
2.247LeuAsn: 2.247 ± 0.053
4.991LeuPro: 4.991 ± 0.089
2.106LeuGln: 2.106 ± 0.06
6.61LeuArg: 6.61 ± 0.114
5.798LeuSer: 5.798 ± 0.106
5.781LeuThr: 5.781 ± 0.1
7.964LeuVal: 7.964 ± 0.114
1.102LeuTrp: 1.102 ± 0.048
1.797LeuTyr: 1.797 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.498MetAla: 2.498 ± 0.057
0.141MetCys: 0.141 ± 0.013
1.046MetAsp: 1.046 ± 0.037
1.102MetGlu: 1.102 ± 0.041
0.684MetPhe: 0.684 ± 0.031
1.739MetGly: 1.739 ± 0.048
0.399MetHis: 0.399 ± 0.022
1.068MetIle: 1.068 ± 0.041
0.592MetLys: 0.592 ± 0.028
1.93MetLeu: 1.93 ± 0.055
0.441MetMet: 0.441 ± 0.022
0.599MetAsn: 0.599 ± 0.029
1.16MetPro: 1.16 ± 0.047
0.556MetGln: 0.556 ± 0.029
1.531MetArg: 1.531 ± 0.052
1.46MetSer: 1.46 ± 0.049
1.55MetThr: 1.55 ± 0.042
1.575MetVal: 1.575 ± 0.052
0.312MetTrp: 0.312 ± 0.023
0.358MetTyr: 0.358 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.811AsnAla: 2.811 ± 0.068
0.17AsnCys: 0.17 ± 0.017
1.338AsnAsp: 1.338 ± 0.047
1.328AsnGlu: 1.328 ± 0.047
0.784AsnPhe: 0.784 ± 0.033
2.067AsnGly: 2.067 ± 0.059
0.52AsnHis: 0.52 ± 0.026
1.247AsnIle: 1.247 ± 0.045
0.73AsnLys: 0.73 ± 0.036
2.335AsnLeu: 2.335 ± 0.057
0.515AsnMet: 0.515 ± 0.032
0.79AsnAsn: 0.79 ± 0.044
2.023AsnPro: 2.023 ± 0.06
0.803AsnGln: 0.803 ± 0.042
1.589AsnArg: 1.589 ± 0.052
1.38AsnSer: 1.38 ± 0.048
1.462AsnThr: 1.462 ± 0.048
1.993AsnVal: 1.993 ± 0.056
0.364AsnTrp: 0.364 ± 0.022
0.72AsnTyr: 0.72 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
7.116ProAla: 7.116 ± 0.135
0.266ProCys: 0.266 ± 0.02
3.205ProAsp: 3.205 ± 0.071
4.186ProGlu: 4.186 ± 0.092
1.618ProPhe: 1.618 ± 0.047
5.284ProGly: 5.284 ± 0.117
1.135ProHis: 1.135 ± 0.043
1.98ProIle: 1.98 ± 0.062
1.325ProLys: 1.325 ± 0.047
4.515ProLeu: 4.515 ± 0.086
0.975ProMet: 0.975 ± 0.038
1.235ProAsn: 1.235 ± 0.05
2.044ProPro: 2.044 ± 0.071
1.7ProGln: 1.7 ± 0.048
3.335ProArg: 3.335 ± 0.084
2.852ProSer: 2.852 ± 0.078
3.138ProThr: 3.138 ± 0.075
4.502ProVal: 4.502 ± 0.091
0.688ProTrp: 0.688 ± 0.037
1.136ProTyr: 1.136 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.909GlnAla: 3.909 ± 0.085
0.183GlnCys: 0.183 ± 0.019
1.3GlnAsp: 1.3 ± 0.049
1.605GlnGlu: 1.605 ± 0.055
0.945GlnPhe: 0.945 ± 0.041
2.253GlnGly: 2.253 ± 0.062
0.575GlnHis: 0.575 ± 0.026
1.405GlnIle: 1.405 ± 0.046
0.771GlnLys: 0.771 ± 0.038
3.342GlnLeu: 3.342 ± 0.079
0.634GlnMet: 0.634 ± 0.028
0.585GlnAsn: 0.585 ± 0.026
1.572GlnPro: 1.572 ± 0.054
1.128GlnGln: 1.128 ± 0.044
2.588GlnArg: 2.588 ± 0.067
1.369GlnSer: 1.369 ± 0.051
1.25GlnThr: 1.25 ± 0.045
2.47GlnVal: 2.47 ± 0.057
0.547GlnTrp: 0.547 ± 0.033
0.598GlnTyr: 0.598 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
8.335ArgAla: 8.335 ± 0.13
0.398ArgCys: 0.398 ± 0.027
3.988ArgAsp: 3.988 ± 0.086
5.071ArgGlu: 5.071 ± 0.09
2.315ArgPhe: 2.315 ± 0.06
5.447ArgGly: 5.447 ± 0.099
1.393ArgHis: 1.393 ± 0.052
3.328ArgIle: 3.328 ± 0.068
1.885ArgLys: 1.885 ± 0.055
6.136ArgLeu: 6.136 ± 0.093
1.66ArgMet: 1.66 ± 0.046
1.55ArgAsn: 1.55 ± 0.043
3.277ArgPro: 3.277 ± 0.075
2.097ArgGln: 2.097 ± 0.057
5.676ArgArg: 5.676 ± 0.126
3.57ArgSer: 3.57 ± 0.073
3.689ArgThr: 3.689 ± 0.08
5.472ArgVal: 5.472 ± 0.088
0.945ArgTrp: 0.945 ± 0.04
1.724ArgTyr: 1.724 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.968SerAla: 6.968 ± 0.112
0.377SerCys: 0.377 ± 0.026
2.74SerAsp: 2.74 ± 0.064
3.133SerGlu: 3.133 ± 0.071
1.89SerPhe: 1.89 ± 0.053
5.418SerGly: 5.418 ± 0.09
1.218SerHis: 1.218 ± 0.038
2.524SerIle: 2.524 ± 0.07
1.431SerLys: 1.431 ± 0.057
5.387SerLeu: 5.387 ± 0.102
1.319SerMet: 1.319 ± 0.044
1.358SerAsn: 1.358 ± 0.052
3.154SerPro: 3.154 ± 0.071
1.685SerGln: 1.685 ± 0.056
3.721SerArg: 3.721 ± 0.073
3.46SerSer: 3.46 ± 0.088
3.659SerThr: 3.659 ± 0.079
4.459SerVal: 4.459 ± 0.082
0.823SerTrp: 0.823 ± 0.035
1.388SerTyr: 1.388 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
6.942ThrAla: 6.942 ± 0.119
0.44ThrCys: 0.44 ± 0.026
3.131ThrAsp: 3.131 ± 0.06
3.08ThrGlu: 3.08 ± 0.07
2.025ThrPhe: 2.025 ± 0.061
5.509ThrGly: 5.509 ± 0.105
1.218ThrHis: 1.218 ± 0.047
2.853ThrIle: 2.853 ± 0.076
1.479ThrLys: 1.479 ± 0.055
5.649ThrLeu: 5.649 ± 0.099
1.144ThrMet: 1.144 ± 0.036
1.411ThrAsn: 1.411 ± 0.05
3.659ThrPro: 3.659 ± 0.082
1.713ThrGln: 1.713 ± 0.056
3.724ThrArg: 3.724 ± 0.074
3.266ThrSer: 3.266 ± 0.073
3.621ThrThr: 3.621 ± 0.086
5.415ThrVal: 5.415 ± 0.084
0.803ThrTrp: 0.803 ± 0.039
1.462ThrTyr: 1.462 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
11.132ValAla: 11.132 ± 0.148
0.758ValCys: 0.758 ± 0.032
5.762ValAsp: 5.762 ± 0.074
5.615ValGlu: 5.615 ± 0.1
2.724ValPhe: 2.724 ± 0.067
6.949ValGly: 6.949 ± 0.102
1.611ValHis: 1.611 ± 0.049
4.173ValIle: 4.173 ± 0.081
2.061ValLys: 2.061 ± 0.058
7.666ValLeu: 7.666 ± 0.143
1.692ValMet: 1.692 ± 0.05
2.112ValAsn: 2.112 ± 0.067
4.277ValPro: 4.277 ± 0.083
1.736ValGln: 1.736 ± 0.053
5.319ValArg: 5.319 ± 0.095
5.106ValSer: 5.106 ± 0.084
5.385ValThr: 5.385 ± 0.099
8.126ValVal: 8.126 ± 0.144
1.041ValTrp: 1.041 ± 0.037
1.627ValTyr: 1.627 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.626TrpAla: 1.626 ± 0.057
0.118TrpCys: 0.118 ± 0.014
0.679TrpAsp: 0.679 ± 0.032
0.766TrpGlu: 0.766 ± 0.035
0.496TrpPhe: 0.496 ± 0.031
0.894TrpGly: 0.894 ± 0.035
0.295TrpHis: 0.295 ± 0.021
0.628TrpIle: 0.628 ± 0.029
0.347TrpLys: 0.347 ± 0.026
1.514TrpLeu: 1.514 ± 0.062
0.354TrpMet: 0.354 ± 0.023
0.403TrpAsn: 0.403 ± 0.023
0.636TrpPro: 0.636 ± 0.03
0.527TrpGln: 0.527 ± 0.029
1.026TrpArg: 1.026 ± 0.041
0.688TrpSer: 0.688 ± 0.034
0.631TrpThr: 0.631 ± 0.031
1.289TrpVal: 1.289 ± 0.052
0.292TrpTrp: 0.292 ± 0.022
0.264TrpTyr: 0.264 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.623TyrAla: 2.623 ± 0.058
0.19TyrCys: 0.19 ± 0.016
1.393TyrAsp: 1.393 ± 0.047
1.194TyrGlu: 1.194 ± 0.048
0.861TyrPhe: 0.861 ± 0.038
2.041TyrGly: 2.041 ± 0.055
0.459TyrHis: 0.459 ± 0.028
0.917TyrIle: 0.917 ± 0.038
0.524TyrLys: 0.524 ± 0.027
2.197TyrLeu: 2.197 ± 0.059
0.377TyrMet: 0.377 ± 0.022
0.711TyrAsn: 0.711 ± 0.036
1.302TyrPro: 1.302 ± 0.044
0.665TyrGln: 0.665 ± 0.033
1.657TyrArg: 1.657 ± 0.055
1.427TyrSer: 1.427 ± 0.048
1.411TyrThr: 1.411 ± 0.05
1.721TyrVal: 1.721 ± 0.043
0.364TyrTrp: 0.364 ± 0.022
0.543TyrTyr: 0.543 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2114 proteins (689009 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski