Amino acid dipepetide frequency for Roseibium sp. RKSG952

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.457AlaAla: 13.457 ± 0.104
1.046AlaCys: 1.046 ± 0.02
6.51AlaAsp: 6.51 ± 0.057
7.259AlaGlu: 7.259 ± 0.055
4.31AlaPhe: 4.31 ± 0.042
9.429AlaGly: 9.429 ± 0.06
2.133AlaHis: 2.133 ± 0.027
5.894AlaIle: 5.894 ± 0.048
3.849AlaLys: 3.849 ± 0.039
11.753AlaLeu: 11.753 ± 0.071
3.27AlaMet: 3.27 ± 0.03
2.976AlaAsn: 2.976 ± 0.03
4.771AlaPro: 4.771 ± 0.05
3.918AlaGln: 3.918 ± 0.04
7.06AlaArg: 7.06 ± 0.056
5.924AlaSer: 5.924 ± 0.05
5.253AlaThr: 5.253 ± 0.039
7.738AlaVal: 7.738 ± 0.063
1.267AlaTrp: 1.267 ± 0.024
2.599AlaTyr: 2.599 ± 0.033
0.0AlaXaa: 0.0 ± 0.0
Cys
0.992CysAla: 0.992 ± 0.018
0.126CysCys: 0.126 ± 0.007
0.595CysAsp: 0.595 ± 0.015
0.513CysGlu: 0.513 ± 0.014
0.371CysPhe: 0.371 ± 0.012
0.974CysGly: 0.974 ± 0.022
0.261CysHis: 0.261 ± 0.01
0.434CysIle: 0.434 ± 0.012
0.274CysLys: 0.274 ± 0.011
0.94CysLeu: 0.94 ± 0.018
0.2CysMet: 0.2 ± 0.009
0.264CysAsn: 0.264 ± 0.01
0.489CysPro: 0.489 ± 0.014
0.279CysGln: 0.279 ± 0.01
0.578CysArg: 0.578 ± 0.012
0.549CysSer: 0.549 ± 0.013
0.451CysThr: 0.451 ± 0.011
0.64CysVal: 0.64 ± 0.016
0.124CysTrp: 0.124 ± 0.006
0.236CysTyr: 0.236 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.414AspAla: 6.414 ± 0.05
0.557AspCys: 0.557 ± 0.015
3.512AspAsp: 3.512 ± 0.058
3.709AspGlu: 3.709 ± 0.041
2.43AspPhe: 2.43 ± 0.03
5.471AspGly: 5.471 ± 0.061
1.401AspHis: 1.401 ± 0.025
3.383AspIle: 3.383 ± 0.035
2.049AspLys: 2.049 ± 0.029
6.629AspLeu: 6.629 ± 0.053
1.603AspMet: 1.603 ± 0.027
1.557AspAsn: 1.557 ± 0.026
3.554AspPro: 3.554 ± 0.038
2.152AspGln: 2.152 ± 0.026
4.104AspArg: 4.104 ± 0.036
2.4AspSer: 2.4 ± 0.034
3.128AspThr: 3.128 ± 0.049
4.37AspVal: 4.37 ± 0.042
1.1AspTrp: 1.1 ± 0.02
1.665AspTyr: 1.665 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
7.421GluAla: 7.421 ± 0.061
0.432GluCys: 0.432 ± 0.012
3.583GluAsp: 3.583 ± 0.038
3.735GluGlu: 3.735 ± 0.043
2.12GluPhe: 2.12 ± 0.027
4.421GluGly: 4.421 ± 0.042
1.257GluHis: 1.257 ± 0.017
3.93GluIle: 3.93 ± 0.041
2.55GluLys: 2.55 ± 0.035
5.726GluLeu: 5.726 ± 0.047
1.709GluMet: 1.709 ± 0.024
2.213GluAsn: 2.213 ± 0.031
2.627GluPro: 2.627 ± 0.032
2.319GluGln: 2.319 ± 0.031
4.309GluArg: 4.309 ± 0.041
2.463GluSer: 2.463 ± 0.031
4.255GluThr: 4.255 ± 0.04
4.108GluVal: 4.108 ± 0.047
0.761GluTrp: 0.761 ± 0.017
1.237GluTyr: 1.237 ± 0.021
0.0GluXaa: 0.0 ± 0.0
Phe
4.326PheAla: 4.326 ± 0.04
0.464PheCys: 0.464 ± 0.011
2.93PheAsp: 2.93 ± 0.03
2.587PheGlu: 2.587 ± 0.035
1.597PhePhe: 1.597 ± 0.024
3.782PheGly: 3.782 ± 0.039
0.762PheHis: 0.762 ± 0.017
1.791PheIle: 1.791 ± 0.026
1.216PheLys: 1.216 ± 0.023
3.737PheLeu: 3.737 ± 0.044
0.932PheMet: 0.932 ± 0.018
1.205PheAsn: 1.205 ± 0.021
1.609PhePro: 1.609 ± 0.026
1.169PheGln: 1.169 ± 0.022
2.186PheArg: 2.186 ± 0.029
2.554PheSer: 2.554 ± 0.03
2.044PheThr: 2.044 ± 0.028
2.89PheVal: 2.89 ± 0.033
0.616PheTrp: 0.616 ± 0.018
1.031PheTyr: 1.031 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
8.338GlyAla: 8.338 ± 0.058
0.865GlyCys: 0.865 ± 0.018
4.715GlyAsp: 4.715 ± 0.058
4.721GlyGlu: 4.721 ± 0.043
3.757GlyPhe: 3.757 ± 0.035
7.058GlyGly: 7.058 ± 0.094
1.947GlyHis: 1.947 ± 0.023
4.597GlyIle: 4.597 ± 0.041
3.48GlyLys: 3.48 ± 0.042
8.669GlyLeu: 8.669 ± 0.066
2.362GlyMet: 2.362 ± 0.034
2.521GlyAsn: 2.521 ± 0.046
3.406GlyPro: 3.406 ± 0.032
3.065GlyGln: 3.065 ± 0.038
5.101GlyArg: 5.101 ± 0.048
4.817GlySer: 4.817 ± 0.052
4.722GlyThr: 4.722 ± 0.046
6.017GlyVal: 6.017 ± 0.048
1.428GlyTrp: 1.428 ± 0.025
2.518GlyTyr: 2.518 ± 0.029
0.0GlyXaa: 0.0 ± 0.0
His
2.095HisAla: 2.095 ± 0.031
0.254HisCys: 0.254 ± 0.01
1.268HisAsp: 1.268 ± 0.021
1.161HisGlu: 1.161 ± 0.02
0.884HisPhe: 0.884 ± 0.02
1.84HisGly: 1.84 ± 0.028
0.6HisHis: 0.6 ± 0.019
1.0HisIle: 1.0 ± 0.018
0.664HisLys: 0.664 ± 0.015
2.168HisLeu: 2.168 ± 0.026
0.532HisMet: 0.532 ± 0.013
0.526HisAsn: 0.526 ± 0.013
1.33HisPro: 1.33 ± 0.023
0.66HisGln: 0.66 ± 0.016
1.292HisArg: 1.292 ± 0.022
1.058HisSer: 1.058 ± 0.02
0.888HisThr: 0.888 ± 0.018
1.539HisVal: 1.539 ± 0.024
0.338HisTrp: 0.338 ± 0.011
0.584HisTyr: 0.584 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
6.685IleAla: 6.685 ± 0.052
0.617IleCys: 0.617 ± 0.015
3.682IleAsp: 3.682 ± 0.041
3.776IleGlu: 3.776 ± 0.043
1.835IlePhe: 1.835 ± 0.027
4.999IleGly: 4.999 ± 0.048
0.975IleHis: 0.975 ± 0.017
2.462IleIle: 2.462 ± 0.034
1.73IleLys: 1.73 ± 0.025
5.027IleLeu: 5.027 ± 0.044
1.122IleMet: 1.122 ± 0.018
1.601IleAsn: 1.601 ± 0.026
2.459IlePro: 2.459 ± 0.032
1.458IleGln: 1.458 ± 0.024
3.317IleArg: 3.317 ± 0.037
3.516IleSer: 3.516 ± 0.035
2.923IleThr: 2.923 ± 0.033
3.981IleVal: 3.981 ± 0.036
0.753IleTrp: 0.753 ± 0.018
1.321IleTyr: 1.321 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
4.299LysAla: 4.299 ± 0.044
0.222LysCys: 0.222 ± 0.009
2.097LysAsp: 2.097 ± 0.028
1.921LysGlu: 1.921 ± 0.029
1.104LysPhe: 1.104 ± 0.022
2.838LysGly: 2.838 ± 0.038
0.733LysHis: 0.733 ± 0.016
2.027LysIle: 2.027 ± 0.029
1.569LysLys: 1.569 ± 0.03
3.493LysLeu: 3.493 ± 0.037
0.913LysMet: 0.913 ± 0.019
1.106LysAsn: 1.106 ± 0.026
2.148LysPro: 2.148 ± 0.032
1.232LysGln: 1.232 ± 0.021
2.521LysArg: 2.521 ± 0.032
2.264LysSer: 2.264 ± 0.029
2.342LysThr: 2.342 ± 0.025
2.571LysVal: 2.571 ± 0.032
0.441LysTrp: 0.441 ± 0.014
0.761LysTyr: 0.761 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
11.451LeuAla: 11.451 ± 0.084
0.959LeuCys: 0.959 ± 0.018
6.08LeuAsp: 6.08 ± 0.048
5.98LeuGlu: 5.98 ± 0.053
3.806LeuPhe: 3.806 ± 0.041
7.925LeuGly: 7.925 ± 0.065
1.836LeuHis: 1.836 ± 0.026
5.383LeuIle: 5.383 ± 0.045
4.02LeuLys: 4.02 ± 0.043
8.757LeuLeu: 8.757 ± 0.07
2.421LeuMet: 2.421 ± 0.028
3.174LeuAsn: 3.174 ± 0.034
5.256LeuPro: 5.256 ± 0.045
3.034LeuGln: 3.034 ± 0.034
6.042LeuArg: 6.042 ± 0.05
7.045LeuSer: 7.045 ± 0.052
5.8LeuThr: 5.8 ± 0.043
6.887LeuVal: 6.887 ± 0.055
1.187LeuTrp: 1.187 ± 0.02
2.09LeuTyr: 2.09 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
3.013MetAla: 3.013 ± 0.034
0.224MetCys: 0.224 ± 0.009
1.332MetAsp: 1.332 ± 0.022
1.326MetGlu: 1.326 ± 0.023
0.819MetPhe: 0.819 ± 0.017
1.934MetGly: 1.934 ± 0.027
0.476MetHis: 0.476 ± 0.014
1.504MetIle: 1.504 ± 0.025
1.106MetLys: 1.106 ± 0.021
2.409MetLeu: 2.409 ± 0.033
0.74MetMet: 0.74 ± 0.017
0.89MetAsn: 0.89 ± 0.017
1.427MetPro: 1.427 ± 0.022
0.915MetGln: 0.915 ± 0.016
1.737MetArg: 1.737 ± 0.025
1.82MetSer: 1.82 ± 0.024
1.943MetThr: 1.943 ± 0.026
1.769MetVal: 1.769 ± 0.025
0.233MetTrp: 0.233 ± 0.01
0.375MetTyr: 0.375 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.345AsnAla: 3.345 ± 0.035
0.288AsnCys: 0.288 ± 0.01
1.712AsnAsp: 1.712 ± 0.03
1.501AsnGlu: 1.501 ± 0.021
1.078AsnPhe: 1.078 ± 0.022
2.856AsnGly: 2.856 ± 0.036
0.611AsnHis: 0.611 ± 0.016
1.586AsnIle: 1.586 ± 0.023
0.95AsnLys: 0.95 ± 0.022
2.853AsnLeu: 2.853 ± 0.031
0.76AsnMet: 0.76 ± 0.016
0.88AsnAsn: 0.88 ± 0.02
2.04AsnPro: 2.04 ± 0.024
0.941AsnGln: 0.941 ± 0.016
2.009AsnArg: 2.009 ± 0.025
1.619AsnSer: 1.619 ± 0.031
1.63AsnThr: 1.63 ± 0.026
2.048AsnVal: 2.048 ± 0.027
0.526AsnTrp: 0.526 ± 0.012
0.792AsnTyr: 0.792 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
5.055ProAla: 5.055 ± 0.045
0.357ProCys: 0.357 ± 0.011
3.945ProAsp: 3.945 ± 0.039
4.133ProGlu: 4.133 ± 0.042
2.063ProPhe: 2.063 ± 0.026
4.214ProGly: 4.214 ± 0.042
1.017ProHis: 1.017 ± 0.02
2.339ProIle: 2.339 ± 0.03
1.908ProLys: 1.908 ± 0.024
4.393ProLeu: 4.393 ± 0.04
1.167ProMet: 1.167 ± 0.023
1.475ProAsn: 1.475 ± 0.021
2.037ProPro: 2.037 ± 0.028
1.598ProGln: 1.598 ± 0.024
2.369ProArg: 2.369 ± 0.028
2.711ProSer: 2.711 ± 0.037
2.221ProThr: 2.221 ± 0.027
4.235ProVal: 4.235 ± 0.041
0.624ProTrp: 0.624 ± 0.017
1.179ProTyr: 1.179 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.888GlnAla: 3.888 ± 0.043
0.215GlnCys: 0.215 ± 0.01
1.867GlnAsp: 1.867 ± 0.026
1.817GlnGlu: 1.817 ± 0.024
1.173GlnPhe: 1.173 ± 0.02
2.469GlnGly: 2.469 ± 0.034
0.665GlnHis: 0.665 ± 0.014
2.137GlnIle: 2.137 ± 0.023
1.351GlnLys: 1.351 ± 0.023
3.072GlnLeu: 3.072 ± 0.031
1.035GlnMet: 1.035 ± 0.019
1.138GlnAsn: 1.138 ± 0.018
1.649GlnPro: 1.649 ± 0.023
1.233GlnGln: 1.233 ± 0.025
2.16GlnArg: 2.16 ± 0.028
2.078GlnSer: 2.078 ± 0.032
2.042GlnThr: 2.042 ± 0.027
2.449GlnVal: 2.449 ± 0.029
0.381GlnTrp: 0.381 ± 0.012
0.665GlnTyr: 0.665 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
6.303ArgAla: 6.303 ± 0.054
0.471ArgCys: 0.471 ± 0.012
3.818ArgAsp: 3.818 ± 0.034
3.81ArgGlu: 3.81 ± 0.041
2.723ArgPhe: 2.723 ± 0.031
4.092ArgGly: 4.092 ± 0.038
1.472ArgHis: 1.472 ± 0.023
3.796ArgIle: 3.796 ± 0.037
2.688ArgLys: 2.688 ± 0.034
6.792ArgLeu: 6.792 ± 0.059
1.729ArgMet: 1.729 ± 0.024
1.955ArgAsn: 1.955 ± 0.025
2.992ArgPro: 2.992 ± 0.036
2.401ArgGln: 2.401 ± 0.03
4.296ArgArg: 4.296 ± 0.053
3.525ArgSer: 3.525 ± 0.034
3.072ArgThr: 3.072 ± 0.033
4.241ArgVal: 4.241 ± 0.039
0.839ArgTrp: 0.839 ± 0.018
1.538ArgTyr: 1.538 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
6.125SerAla: 6.125 ± 0.055
0.519SerCys: 0.519 ± 0.015
3.812SerAsp: 3.812 ± 0.045
3.565SerGlu: 3.565 ± 0.037
2.452SerPhe: 2.452 ± 0.028
6.134SerGly: 6.134 ± 0.06
1.198SerHis: 1.198 ± 0.021
2.966SerIle: 2.966 ± 0.033
1.938SerLys: 1.938 ± 0.026
5.559SerLeu: 5.559 ± 0.048
1.445SerMet: 1.445 ± 0.024
1.728SerAsn: 1.728 ± 0.027
2.637SerPro: 2.637 ± 0.031
1.82SerGln: 1.82 ± 0.027
3.462SerArg: 3.462 ± 0.039
3.347SerSer: 3.347 ± 0.042
2.748SerThr: 2.748 ± 0.036
4.38SerVal: 4.38 ± 0.037
0.776SerTrp: 0.776 ± 0.015
1.439SerTyr: 1.439 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
5.856ThrAla: 5.856 ± 0.047
0.512ThrCys: 0.512 ± 0.014
3.23ThrAsp: 3.23 ± 0.042
3.102ThrGlu: 3.102 ± 0.037
2.148ThrPhe: 2.148 ± 0.029
5.394ThrGly: 5.394 ± 0.048
1.103ThrHis: 1.103 ± 0.021
2.985ThrIle: 2.985 ± 0.034
1.635ThrLys: 1.635 ± 0.023
5.638ThrLeu: 5.638 ± 0.047
1.199ThrMet: 1.199 ± 0.025
1.518ThrAsn: 1.518 ± 0.022
3.142ThrPro: 3.142 ± 0.031
1.674ThrGln: 1.674 ± 0.022
3.184ThrArg: 3.184 ± 0.036
3.197ThrSer: 3.197 ± 0.037
2.809ThrThr: 2.809 ± 0.035
4.334ThrVal: 4.334 ± 0.04
0.654ThrTrp: 0.654 ± 0.014
1.371ThrTyr: 1.371 ± 0.024
0.0ThrXaa: 0.0 ± 0.0
Val
7.709ValAla: 7.709 ± 0.056
0.721ValCys: 0.721 ± 0.017
4.122ValAsp: 4.122 ± 0.041
4.486ValGlu: 4.486 ± 0.042
3.156ValPhe: 3.156 ± 0.034
5.116ValGly: 5.116 ± 0.046
1.34ValHis: 1.34 ± 0.024
4.21ValIle: 4.21 ± 0.04
2.354ValLys: 2.354 ± 0.033
7.507ValLeu: 7.507 ± 0.056
1.964ValMet: 1.964 ± 0.027
2.138ValAsn: 2.138 ± 0.026
3.655ValPro: 3.655 ± 0.042
2.166ValGln: 2.166 ± 0.026
4.2ValArg: 4.2 ± 0.042
4.88ValSer: 4.88 ± 0.048
4.469ValThr: 4.469 ± 0.038
5.545ValVal: 5.545 ± 0.061
0.934ValTrp: 0.934 ± 0.02
1.632ValTyr: 1.632 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.212TrpAla: 1.212 ± 0.022
0.156TrpCys: 0.156 ± 0.007
0.737TrpAsp: 0.737 ± 0.017
0.623TrpGlu: 0.623 ± 0.015
0.604TrpPhe: 0.604 ± 0.016
0.933TrpGly: 0.933 ± 0.02
0.343TrpHis: 0.343 ± 0.011
0.762TrpIle: 0.762 ± 0.017
0.519TrpLys: 0.519 ± 0.015
1.542TrpLeu: 1.542 ± 0.024
0.388TrpMet: 0.388 ± 0.013
0.469TrpAsn: 0.469 ± 0.012
0.681TrpPro: 0.681 ± 0.016
0.604TrpGln: 0.604 ± 0.015
0.984TrpArg: 0.984 ± 0.018
0.893TrpSer: 0.893 ± 0.02
0.754TrpThr: 0.754 ± 0.018
0.859TrpVal: 0.859 ± 0.016
0.231TrpTrp: 0.231 ± 0.01
0.306TrpTyr: 0.306 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.427TyrAla: 2.427 ± 0.027
0.283TyrCys: 0.283 ± 0.009
1.644TyrAsp: 1.644 ± 0.027
1.452TyrGlu: 1.452 ± 0.024
0.999TyrPhe: 0.999 ± 0.02
2.228TyrGly: 2.228 ± 0.036
0.551TyrHis: 0.551 ± 0.015
1.054TyrIle: 1.054 ± 0.02
0.753TyrLys: 0.753 ± 0.016
2.466TyrLeu: 2.466 ± 0.03
0.501TyrMet: 0.501 ± 0.014
0.691TyrAsn: 0.691 ± 0.016
1.135TyrPro: 1.135 ± 0.016
0.844TyrGln: 0.844 ± 0.018
1.643TyrArg: 1.643 ± 0.025
1.388TyrSer: 1.388 ± 0.024
1.19TyrThr: 1.19 ± 0.02
1.702TyrVal: 1.702 ± 0.026
0.387TyrTrp: 0.387 ± 0.014
0.662TyrTyr: 0.662 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9448 proteins (2960375 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski