Amino acid dipepetide frequency for Grapevine leafroll-associated virus 7 (isolate Grapevine/Albania/AA42/-)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.981AlaAla: 2.981 ± 1.23
0.373AlaCys: 0.373 ± 0.18
1.304AlaAsp: 1.304 ± 0.238
1.304AlaGlu: 1.304 ± 0.398
1.863AlaPhe: 1.863 ± 0.744
0.745AlaGly: 0.745 ± 0.427
0.932AlaHis: 0.932 ± 0.451
2.422AlaIle: 2.422 ± 0.544
2.422AlaLys: 2.422 ± 0.457
2.422AlaLeu: 2.422 ± 0.625
0.745AlaMet: 0.745 ± 0.352
2.236AlaAsn: 2.236 ± 0.47
0.932AlaPro: 0.932 ± 0.498
0.559AlaGln: 0.559 ± 0.258
0.745AlaArg: 0.745 ± 0.287
3.168AlaSer: 3.168 ± 0.636
1.491AlaThr: 1.491 ± 0.529
2.236AlaVal: 2.236 ± 0.504
0.0AlaTrp: 0.0 ± 0.0
1.118AlaTyr: 1.118 ± 0.465
0.0AlaXaa: 0.0 ± 0.0
Cys
1.118CysAla: 1.118 ± 0.312
0.559CysCys: 0.559 ± 0.345
2.05CysAsp: 2.05 ± 0.421
0.559CysGlu: 0.559 ± 0.272
1.491CysPhe: 1.491 ± 0.464
1.491CysGly: 1.491 ± 0.425
0.373CysHis: 0.373 ± 0.238
1.118CysIle: 1.118 ± 0.359
2.236CysLys: 2.236 ± 0.818
2.981CysLeu: 2.981 ± 0.59
0.373CysMet: 0.373 ± 0.345
0.932CysAsn: 0.932 ± 0.36
0.745CysPro: 0.745 ± 0.287
0.186CysGln: 0.186 ± 0.222
0.745CysArg: 0.745 ± 0.358
1.118CysSer: 1.118 ± 0.535
0.932CysThr: 0.932 ± 0.474
1.677CysVal: 1.677 ± 0.746
0.559CysTrp: 0.559 ± 0.267
0.559CysTyr: 0.559 ± 0.368
0.0CysXaa: 0.0 ± 0.0
Asp
2.422AspAla: 2.422 ± 0.53
1.304AspCys: 1.304 ± 0.529
4.285AspAsp: 4.285 ± 0.53
3.913AspGlu: 3.913 ± 0.923
4.658AspPhe: 4.658 ± 1.011
3.726AspGly: 3.726 ± 0.775
0.745AspHis: 0.745 ± 0.282
4.099AspIle: 4.099 ± 0.999
5.776AspLys: 5.776 ± 1.292
6.521AspLeu: 6.521 ± 1.023
2.05AspMet: 2.05 ± 0.847
3.354AspAsn: 3.354 ± 0.919
0.932AspPro: 0.932 ± 0.369
0.745AspGln: 0.745 ± 0.42
2.236AspArg: 2.236 ± 0.599
2.981AspSer: 2.981 ± 0.352
1.677AspThr: 1.677 ± 0.563
6.521AspVal: 6.521 ± 1.452
0.373AspTrp: 0.373 ± 0.238
1.863AspTyr: 1.863 ± 0.494
0.0AspXaa: 0.0 ± 0.0
Glu
0.932GluAla: 0.932 ± 0.729
1.304GluCys: 1.304 ± 0.654
3.168GluAsp: 3.168 ± 0.805
3.354GluGlu: 3.354 ± 1.025
3.168GluPhe: 3.168 ± 0.839
2.05GluGly: 2.05 ± 0.553
1.491GluHis: 1.491 ± 0.438
7.826GluIle: 7.826 ± 0.904
5.217GluLys: 5.217 ± 1.623
5.403GluLeu: 5.403 ± 1.545
1.118GluMet: 1.118 ± 0.489
3.354GluAsn: 3.354 ± 0.378
0.745GluPro: 0.745 ± 0.484
1.677GluGln: 1.677 ± 0.586
3.913GluArg: 3.913 ± 0.577
4.844GluSer: 4.844 ± 0.734
2.422GluThr: 2.422 ± 0.479
3.913GluVal: 3.913 ± 0.644
0.932GluTrp: 0.932 ± 0.301
2.236GluTyr: 2.236 ± 0.551
0.0GluXaa: 0.0 ± 0.0
Phe
2.236PheAla: 2.236 ± 0.957
1.491PheCys: 1.491 ± 0.646
4.844PheAsp: 4.844 ± 0.606
4.099PheGlu: 4.099 ± 1.161
3.54PhePhe: 3.54 ± 0.487
2.795PheGly: 2.795 ± 0.695
1.304PheHis: 1.304 ± 0.429
3.726PheIle: 3.726 ± 0.782
5.59PheLys: 5.59 ± 0.781
5.403PheLeu: 5.403 ± 0.749
1.118PheMet: 1.118 ± 0.352
4.472PheAsn: 4.472 ± 1.083
1.491PhePro: 1.491 ± 0.436
2.05PheGln: 2.05 ± 0.528
2.236PheArg: 2.236 ± 0.638
5.031PheSer: 5.031 ± 0.995
3.913PheThr: 3.913 ± 0.55
2.795PheVal: 2.795 ± 0.551
0.373PheTrp: 0.373 ± 0.352
1.118PheTyr: 1.118 ± 0.679
0.0PheXaa: 0.0 ± 0.0
Gly
0.745GlyAla: 0.745 ± 0.25
1.677GlyCys: 1.677 ± 0.537
3.168GlyAsp: 3.168 ± 0.588
3.168GlyGlu: 3.168 ± 0.73
2.609GlyPhe: 2.609 ± 0.67
4.472GlyGly: 4.472 ± 1.284
0.745GlyHis: 0.745 ± 0.238
2.609GlyIle: 2.609 ± 1.097
3.354GlyLys: 3.354 ± 0.553
2.981GlyLeu: 2.981 ± 0.621
1.118GlyMet: 1.118 ± 0.443
2.609GlyAsn: 2.609 ± 0.898
0.373GlyPro: 0.373 ± 0.226
0.745GlyGln: 0.745 ± 0.331
2.981GlyArg: 2.981 ± 0.643
4.658GlySer: 4.658 ± 0.774
1.491GlyThr: 1.491 ± 0.481
3.913GlyVal: 3.913 ± 0.68
0.559GlyTrp: 0.559 ± 0.295
2.236GlyTyr: 2.236 ± 0.495
0.0GlyXaa: 0.0 ± 0.0
His
0.745HisAla: 0.745 ± 0.261
0.373HisCys: 0.373 ± 0.238
0.745HisAsp: 0.745 ± 0.311
0.745HisGlu: 0.745 ± 0.3
0.745HisPhe: 0.745 ± 0.475
0.559HisGly: 0.559 ± 0.266
0.559HisHis: 0.559 ± 0.357
1.304HisIle: 1.304 ± 0.454
1.118HisLys: 1.118 ± 0.528
1.677HisLeu: 1.677 ± 0.607
0.0HisMet: 0.0 ± 0.0
0.373HisAsn: 0.373 ± 0.238
1.118HisPro: 1.118 ± 0.475
0.0HisGln: 0.0 ± 0.0
1.304HisArg: 1.304 ± 0.433
2.236HisSer: 2.236 ± 0.539
1.491HisThr: 1.491 ± 0.469
0.932HisVal: 0.932 ± 0.327
0.0HisTrp: 0.0 ± 0.0
1.118HisTyr: 1.118 ± 0.535
0.0HisXaa: 0.0 ± 0.0
Ile
0.932IleAla: 0.932 ± 0.36
1.677IleCys: 1.677 ± 0.691
4.844IleAsp: 4.844 ± 2.091
3.54IleGlu: 3.54 ± 0.776
3.913IlePhe: 3.913 ± 1.162
3.354IleGly: 3.354 ± 0.979
2.05IleHis: 2.05 ± 0.519
3.913IleIle: 3.913 ± 0.742
5.403IleLys: 5.403 ± 0.632
6.521IleLeu: 6.521 ± 1.194
1.304IleMet: 1.304 ± 0.659
5.031IleAsn: 5.031 ± 0.838
2.981IlePro: 2.981 ± 0.622
2.609IleGln: 2.609 ± 0.707
3.726IleArg: 3.726 ± 1.36
5.031IleSer: 5.031 ± 0.613
4.285IleThr: 4.285 ± 1.264
4.472IleVal: 4.472 ± 1.103
0.186IleTrp: 0.186 ± 0.119
3.54IleTyr: 3.54 ± 0.737
0.0IleXaa: 0.0 ± 0.0
Lys
2.05LysAla: 2.05 ± 0.577
0.745LysCys: 0.745 ± 0.238
3.913LysAsp: 3.913 ± 0.576
3.913LysGlu: 3.913 ± 0.686
7.267LysPhe: 7.267 ± 1.528
2.422LysGly: 2.422 ± 0.682
1.304LysHis: 1.304 ± 0.606
5.962LysIle: 5.962 ± 0.836
5.031LysLys: 5.031 ± 1.083
8.571LysLeu: 8.571 ± 0.877
2.05LysMet: 2.05 ± 0.671
5.59LysAsn: 5.59 ± 1.06
1.863LysPro: 1.863 ± 0.549
2.609LysGln: 2.609 ± 0.67
5.403LysArg: 5.403 ± 0.763
6.521LysSer: 6.521 ± 1.11
5.59LysThr: 5.59 ± 1.162
6.149LysVal: 6.149 ± 0.646
0.559LysTrp: 0.559 ± 0.476
3.354LysTyr: 3.354 ± 0.555
0.0LysXaa: 0.0 ± 0.0
Leu
2.422LeuAla: 2.422 ± 0.499
3.354LeuCys: 3.354 ± 0.822
6.521LeuAsp: 6.521 ± 1.373
5.776LeuGlu: 5.776 ± 0.811
6.335LeuPhe: 6.335 ± 1.092
4.844LeuGly: 4.844 ± 0.504
0.932LeuHis: 0.932 ± 0.375
6.335LeuIle: 6.335 ± 0.841
9.689LeuLys: 9.689 ± 0.564
8.944LeuLeu: 8.944 ± 0.598
2.236LeuMet: 2.236 ± 0.384
9.13LeuAsn: 9.13 ± 1.743
3.913LeuPro: 3.913 ± 0.757
1.863LeuGln: 1.863 ± 0.444
3.726LeuArg: 3.726 ± 0.71
9.503LeuSer: 9.503 ± 1.624
5.59LeuThr: 5.59 ± 0.62
6.894LeuVal: 6.894 ± 1.357
0.0LeuTrp: 0.0 ± 0.0
3.168LeuTyr: 3.168 ± 0.401
0.0LeuXaa: 0.0 ± 0.0
Met
0.745MetAla: 0.745 ± 0.329
0.559MetCys: 0.559 ± 0.314
0.932MetAsp: 0.932 ± 0.653
2.236MetGlu: 2.236 ± 0.985
2.05MetPhe: 2.05 ± 0.464
1.304MetGly: 1.304 ± 0.428
0.373MetHis: 0.373 ± 0.238
0.932MetIle: 0.932 ± 0.291
1.677MetLys: 1.677 ± 0.406
0.745MetLeu: 0.745 ± 0.3
0.559MetMet: 0.559 ± 0.372
1.863MetAsn: 1.863 ± 0.747
0.559MetPro: 0.559 ± 0.447
0.186MetGln: 0.186 ± 0.119
1.304MetArg: 1.304 ± 0.513
1.677MetSer: 1.677 ± 0.464
1.863MetThr: 1.863 ± 0.87
2.05MetVal: 2.05 ± 0.517
0.373MetTrp: 0.373 ± 0.201
1.304MetTyr: 1.304 ± 0.349
0.0MetXaa: 0.0 ± 0.0
Asn
2.05AsnAla: 2.05 ± 0.723
1.118AsnCys: 1.118 ± 0.602
4.099AsnAsp: 4.099 ± 0.688
5.031AsnGlu: 5.031 ± 0.787
4.658AsnPhe: 4.658 ± 1.002
3.726AsnGly: 3.726 ± 0.888
0.745AsnHis: 0.745 ± 0.353
4.844AsnIle: 4.844 ± 0.849
5.776AsnLys: 5.776 ± 0.374
7.453AsnLeu: 7.453 ± 1.2
1.491AsnMet: 1.491 ± 0.45
4.472AsnAsn: 4.472 ± 0.916
1.304AsnPro: 1.304 ± 0.407
2.05AsnGln: 2.05 ± 0.669
2.981AsnArg: 2.981 ± 0.906
5.962AsnSer: 5.962 ± 0.967
3.354AsnThr: 3.354 ± 0.904
4.844AsnVal: 4.844 ± 1.221
0.373AsnTrp: 0.373 ± 0.238
2.981AsnTyr: 2.981 ± 0.947
0.0AsnXaa: 0.0 ± 0.0
Pro
0.559ProAla: 0.559 ± 0.237
0.373ProCys: 0.373 ± 0.444
1.491ProAsp: 1.491 ± 0.281
0.932ProGlu: 0.932 ± 0.307
1.863ProPhe: 1.863 ± 0.843
0.932ProGly: 0.932 ± 0.355
0.373ProHis: 0.373 ± 0.238
2.05ProIle: 2.05 ± 0.34
2.236ProLys: 2.236 ± 0.581
3.54ProLeu: 3.54 ± 0.554
0.932ProMet: 0.932 ± 0.297
2.236ProAsn: 2.236 ± 0.716
0.559ProPro: 0.559 ± 0.251
0.559ProGln: 0.559 ± 0.453
0.745ProArg: 0.745 ± 0.353
2.609ProSer: 2.609 ± 0.825
2.236ProThr: 2.236 ± 0.66
1.863ProVal: 1.863 ± 0.836
0.186ProTrp: 0.186 ± 0.209
1.491ProTyr: 1.491 ± 0.649
0.0ProXaa: 0.0 ± 0.0
Gln
1.118GlnAla: 1.118 ± 0.752
0.932GlnCys: 0.932 ± 0.472
1.304GlnAsp: 1.304 ± 0.494
1.863GlnGlu: 1.863 ± 0.256
1.118GlnPhe: 1.118 ± 0.294
1.304GlnGly: 1.304 ± 0.55
0.373GlnHis: 0.373 ± 0.238
1.677GlnIle: 1.677 ± 0.412
0.932GlnLys: 0.932 ± 0.364
3.726GlnLeu: 3.726 ± 0.749
0.559GlnMet: 0.559 ± 0.251
0.932GlnAsn: 0.932 ± 0.44
0.745GlnPro: 0.745 ± 0.297
0.373GlnGln: 0.373 ± 0.353
0.932GlnArg: 0.932 ± 0.314
2.422GlnSer: 2.422 ± 0.898
1.677GlnThr: 1.677 ± 0.476
1.118GlnVal: 1.118 ± 0.452
0.559GlnTrp: 0.559 ± 0.33
0.745GlnTyr: 0.745 ± 0.475
0.0GlnXaa: 0.0 ± 0.0
Arg
1.304ArgAla: 1.304 ± 0.337
0.932ArgCys: 0.932 ± 0.451
2.609ArgAsp: 2.609 ± 1.031
2.422ArgGlu: 2.422 ± 0.917
2.609ArgPhe: 2.609 ± 0.754
2.422ArgGly: 2.422 ± 1.176
0.745ArgHis: 0.745 ± 0.475
2.795ArgIle: 2.795 ± 0.797
2.236ArgLys: 2.236 ± 0.592
5.962ArgLeu: 5.962 ± 0.902
1.304ArgMet: 1.304 ± 0.521
2.795ArgAsn: 2.795 ± 0.922
1.491ArgPro: 1.491 ± 0.654
0.745ArgGln: 0.745 ± 0.327
2.609ArgArg: 2.609 ± 0.569
4.285ArgSer: 4.285 ± 1.443
2.236ArgThr: 2.236 ± 0.571
2.981ArgVal: 2.981 ± 1.227
0.373ArgTrp: 0.373 ± 0.29
4.099ArgTyr: 4.099 ± 0.533
0.0ArgXaa: 0.0 ± 0.0
Ser
2.236SerAla: 2.236 ± 0.761
1.118SerCys: 1.118 ± 0.529
5.403SerAsp: 5.403 ± 1.047
5.776SerGlu: 5.776 ± 1.132
2.981SerPhe: 2.981 ± 0.382
3.726SerGly: 3.726 ± 0.523
1.491SerHis: 1.491 ± 0.464
5.776SerIle: 5.776 ± 1.073
7.826SerLys: 7.826 ± 1.448
7.08SerLeu: 7.08 ± 1.405
2.05SerMet: 2.05 ± 0.553
6.521SerAsn: 6.521 ± 1.267
1.863SerPro: 1.863 ± 0.722
2.795SerGln: 2.795 ± 0.822
3.54SerArg: 3.54 ± 0.835
8.571SerSer: 8.571 ± 0.912
4.099SerThr: 4.099 ± 0.837
7.639SerVal: 7.639 ± 2.033
0.745SerTrp: 0.745 ± 0.33
3.168SerTyr: 3.168 ± 0.74
0.0SerXaa: 0.0 ± 0.0
Thr
1.304ThrAla: 1.304 ± 0.476
0.559ThrCys: 0.559 ± 0.364
2.05ThrAsp: 2.05 ± 0.723
2.795ThrGlu: 2.795 ± 0.823
3.168ThrPhe: 3.168 ± 0.855
2.236ThrGly: 2.236 ± 0.411
1.491ThrHis: 1.491 ± 0.301
3.913ThrIle: 3.913 ± 0.766
4.285ThrLys: 4.285 ± 0.991
7.639ThrLeu: 7.639 ± 1.144
0.932ThrMet: 0.932 ± 0.375
4.472ThrAsn: 4.472 ± 0.823
2.609ThrPro: 2.609 ± 0.795
2.05ThrGln: 2.05 ± 0.526
1.118ThrArg: 1.118 ± 0.423
4.285ThrSer: 4.285 ± 0.807
4.285ThrThr: 4.285 ± 1.253
2.795ThrVal: 2.795 ± 0.657
0.373ThrTrp: 0.373 ± 0.444
1.863ThrTyr: 1.863 ± 0.539
0.0ThrXaa: 0.0 ± 0.0
Val
1.863ValAla: 1.863 ± 0.828
1.863ValCys: 1.863 ± 0.699
5.031ValAsp: 5.031 ± 0.771
4.472ValGlu: 4.472 ± 0.637
2.981ValPhe: 2.981 ± 0.915
2.609ValGly: 2.609 ± 0.769
0.745ValHis: 0.745 ± 0.243
5.031ValIle: 5.031 ± 0.973
6.894ValLys: 6.894 ± 1.538
8.757ValLeu: 8.757 ± 1.655
2.05ValMet: 2.05 ± 0.556
5.031ValAsn: 5.031 ± 0.499
2.609ValPro: 2.609 ± 0.745
1.491ValGln: 1.491 ± 0.601
4.099ValArg: 4.099 ± 0.818
6.521ValSer: 6.521 ± 0.964
3.168ValThr: 3.168 ± 0.731
6.894ValVal: 6.894 ± 1.504
0.373ValTrp: 0.373 ± 0.201
2.609ValTyr: 2.609 ± 0.677
0.0ValXaa: 0.0 ± 0.0
Trp
0.186TrpAla: 0.186 ± 0.119
0.186TrpCys: 0.186 ± 0.209
0.186TrpAsp: 0.186 ± 0.29
0.373TrpGlu: 0.373 ± 0.323
0.373TrpPhe: 0.373 ± 0.226
0.186TrpGly: 0.186 ± 0.23
0.0TrpHis: 0.0 ± 0.0
0.559TrpIle: 0.559 ± 0.256
0.373TrpLys: 0.373 ± 0.238
0.745TrpLeu: 0.745 ± 0.401
0.559TrpMet: 0.559 ± 0.347
0.745TrpAsn: 0.745 ± 0.39
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.186TrpArg: 0.186 ± 0.222
0.186TrpSer: 0.186 ± 0.222
0.373TrpThr: 0.373 ± 0.176
1.491TrpVal: 1.491 ± 0.382
0.0TrpTrp: 0.0 ± 0.0
0.373TrpTyr: 0.373 ± 0.243
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.05TyrAla: 2.05 ± 0.439
1.304TyrCys: 1.304 ± 0.394
2.236TyrAsp: 2.236 ± 1.217
2.795TyrGlu: 2.795 ± 0.648
2.236TyrPhe: 2.236 ± 0.766
1.304TyrGly: 1.304 ± 0.175
0.373TyrHis: 0.373 ± 0.238
2.422TyrIle: 2.422 ± 0.816
2.981TyrLys: 2.981 ± 0.712
4.099TyrLeu: 4.099 ± 0.838
0.559TyrMet: 0.559 ± 0.288
3.168TyrAsn: 3.168 ± 1.212
0.932TyrPro: 0.932 ± 0.369
1.118TyrGln: 1.118 ± 0.372
2.422TyrArg: 2.422 ± 0.637
2.795TyrSer: 2.795 ± 0.885
2.05TyrThr: 2.05 ± 0.372
3.913TyrVal: 3.913 ± 0.841
0.186TyrTrp: 0.186 ± 0.119
3.168TyrTyr: 3.168 ± 0.791
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (5368 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski