Amino acid dipepetide frequency for Peniophora sp. CBMAI 1063

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.817AlaAla: 10.817 ± 0.067	1.198AlaCys: 1.198 ± 0.015	4.872AlaAsp: 4.872 ± 0.025	5.463AlaGlu: 5.463 ± 0.035	3.507AlaPhe: 3.507 ± 0.02	6.346AlaGly: 6.346 ± 0.035	2.623AlaHis: 2.623 ± 0.019	4.248AlaIle: 4.248 ± 0.03	3.634AlaLys: 3.634 ± 0.028	10.267AlaLeu: 10.267 ± 0.048	2.097AlaMet: 2.097 ± 0.015	2.819AlaAsn: 2.819 ± 0.02	6.801AlaPro: 6.801 ± 0.049	3.827AlaGln: 3.827 ± 0.024	6.922AlaArg: 6.922 ± 0.037	8.53AlaSer: 8.53 ± 0.045	5.81AlaThr: 5.81 ± 0.028	6.184AlaVal: 6.184 ± 0.03	1.332AlaTrp: 1.332 ± 0.014	2.543AlaTyr: 2.543 ± 0.02	0.005AlaXaa: 0.005 ± 0.001
Cys	1.141CysAla: 1.141 ± 0.013	0.217CysCys: 0.217 ± 0.005	0.709CysAsp: 0.709 ± 0.01	0.596CysGlu: 0.596 ± 0.01	0.471CysPhe: 0.471 ± 0.008	0.856CysGly: 0.856 ± 0.01	0.323CysHis: 0.323 ± 0.007	0.654CysIle: 0.654 ± 0.01	0.438CysLys: 0.438 ± 0.008	1.194CysLeu: 1.194 ± 0.014	0.262CysMet: 0.262 ± 0.006	0.369CysAsn: 0.369 ± 0.007	0.696CysPro: 0.696 ± 0.011	0.404CysGln: 0.404 ± 0.008	0.801CysArg: 0.801 ± 0.012	0.929CysSer: 0.929 ± 0.012	0.781CysThr: 0.781 ± 0.01	0.795CysVal: 0.795 ± 0.011	0.178CysTrp: 0.178 ± 0.004	0.304CysTyr: 0.304 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	6.302AspAla: 6.302 ± 0.031	0.653AspCys: 0.653 ± 0.01	4.519AspAsp: 4.519 ± 0.033	4.649AspGlu: 4.649 ± 0.034	2.069AspPhe: 2.069 ± 0.018	4.314AspGly: 4.314 ± 0.027	1.215AspHis: 1.215 ± 0.014	2.976AspIle: 2.976 ± 0.022	1.928AspLys: 1.928 ± 0.016	5.159AspLeu: 5.159 ± 0.031	1.299AspMet: 1.299 ± 0.012	1.595AspAsn: 1.595 ± 0.014	3.345AspPro: 3.345 ± 0.02	1.442AspGln: 1.442 ± 0.014	3.003AspArg: 3.003 ± 0.023	3.851AspSer: 3.851 ± 0.026	3.058AspThr: 3.058 ± 0.021	4.509AspVal: 4.509 ± 0.025	0.98AspTrp: 0.98 ± 0.012	1.467AspTyr: 1.467 ± 0.012	0.003AspXaa: 0.003 ± 0.001
Glu	5.428GluAla: 5.428 ± 0.036	0.623GluCys: 0.623 ± 0.01	4.358GluAsp: 4.358 ± 0.035	5.04GluGlu: 5.04 ± 0.046	1.669GluPhe: 1.669 ± 0.015	3.841GluGly: 3.841 ± 0.025	1.621GluHis: 1.621 ± 0.014	2.456GluIle: 2.456 ± 0.018	2.684GluLys: 2.684 ± 0.022	5.679GluLeu: 5.679 ± 0.033	1.309GluMet: 1.309 ± 0.016	1.64GluAsn: 1.64 ± 0.014	2.975GluPro: 2.975 ± 0.024	2.128GluGln: 2.128 ± 0.019	4.644GluArg: 4.644 ± 0.038	3.757GluSer: 3.757 ± 0.023	2.946GluThr: 2.946 ± 0.02	3.553GluVal: 3.553 ± 0.023	0.928GluTrp: 0.928 ± 0.012	1.488GluTyr: 1.488 ± 0.015	0.002GluXaa: 0.002 ± 0.001
Phe	3.419PheAla: 3.419 ± 0.023	0.504PheCys: 0.504 ± 0.007	2.193PheAsp: 2.193 ± 0.017	2.01PheGlu: 2.01 ± 0.018	1.394PhePhe: 1.394 ± 0.014	2.706PheGly: 2.706 ± 0.023	0.81PheHis: 0.81 ± 0.011	1.633PheIle: 1.633 ± 0.016	1.268PheLys: 1.268 ± 0.013	3.181PheLeu: 3.181 ± 0.023	0.738PheMet: 0.738 ± 0.01	1.237PheAsn: 1.237 ± 0.013	1.902PhePro: 1.902 ± 0.017	1.032PheGln: 1.032 ± 0.011	1.905PheArg: 1.905 ± 0.018	2.695PheSer: 2.695 ± 0.02	2.101PheThr: 2.101 ± 0.018	2.479PheVal: 2.479 ± 0.021	0.596PheTrp: 0.596 ± 0.008	1.004PheTyr: 1.004 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	6.163GlyAla: 6.163 ± 0.034	0.822GlyCys: 0.822 ± 0.011	3.652GlyAsp: 3.652 ± 0.022	3.664GlyGlu: 3.664 ± 0.026	2.388GlyPhe: 2.388 ± 0.02	5.405GlyGly: 5.405 ± 0.051	1.758GlyHis: 1.758 ± 0.015	2.934GlyIle: 2.934 ± 0.022	2.86GlyLys: 2.86 ± 0.022	5.801GlyLeu: 5.801 ± 0.028	1.467GlyMet: 1.467 ± 0.017	2.008GlyAsn: 2.008 ± 0.019	3.651GlyPro: 3.651 ± 0.027	2.229GlyGln: 2.229 ± 0.017	4.28GlyArg: 4.28 ± 0.026	5.552GlySer: 5.552 ± 0.035	3.866GlyThr: 3.866 ± 0.027	4.48GlyVal: 4.48 ± 0.028	1.185GlyTrp: 1.185 ± 0.012	1.825GlyTyr: 1.825 ± 0.019	0.006GlyXaa: 0.006 ± 0.001
His	2.593HisAla: 2.593 ± 0.019	0.345HisCys: 0.345 ± 0.007	1.461HisAsp: 1.461 ± 0.015	1.372HisGlu: 1.372 ± 0.013	0.94HisPhe: 0.94 ± 0.012	1.713HisGly: 1.713 ± 0.015	0.826HisHis: 0.826 ± 0.011	1.29HisIle: 1.29 ± 0.013	0.823HisLys: 0.823 ± 0.012	2.606HisLeu: 2.606 ± 0.02	0.509HisMet: 0.509 ± 0.008	0.778HisAsn: 0.778 ± 0.01	1.918HisPro: 1.918 ± 0.018	0.774HisGln: 0.774 ± 0.011	1.722HisArg: 1.722 ± 0.016	1.968HisSer: 1.968 ± 0.018	1.554HisThr: 1.554 ± 0.013	1.759HisVal: 1.759 ± 0.014	0.376HisTrp: 0.376 ± 0.006	0.668HisTyr: 0.668 ± 0.009	0.001HisXaa: 0.001 ± 0.0
Ile	4.248IleAla: 4.248 ± 0.025	0.631IleCys: 0.631 ± 0.009	2.621IleAsp: 2.621 ± 0.021	2.498IleGlu: 2.498 ± 0.018	1.665IlePhe: 1.665 ± 0.015	2.718IleGly: 2.718 ± 0.022	1.091IleHis: 1.091 ± 0.012	2.058IleIle: 2.058 ± 0.021	1.544IleLys: 1.544 ± 0.015	4.175IleLeu: 4.175 ± 0.029	0.846IleMet: 0.846 ± 0.01	1.353IleAsn: 1.353 ± 0.013	2.895IlePro: 2.895 ± 0.019	1.481IleGln: 1.481 ± 0.013	2.693IleArg: 2.693 ± 0.019	3.309IleSer: 3.309 ± 0.021	2.514IleThr: 2.514 ± 0.02	3.173IleVal: 3.173 ± 0.021	0.71IleTrp: 0.71 ± 0.011	1.195IleTyr: 1.195 ± 0.013	0.001IleXaa: 0.001 ± 0.0
Lys	3.887LysAla: 3.887 ± 0.031	0.389LysCys: 0.389 ± 0.007	2.26LysAsp: 2.26 ± 0.019	2.549LysGlu: 2.549 ± 0.024	1.049LysPhe: 1.049 ± 0.011	2.475LysGly: 2.475 ± 0.022	0.999LysHis: 0.999 ± 0.012	1.56LysIle: 1.56 ± 0.014	2.32LysLys: 2.32 ± 0.029	3.441LysLeu: 3.441 ± 0.024	0.725LysMet: 0.725 ± 0.009	1.122LysAsn: 1.122 ± 0.012	2.327LysPro: 2.327 ± 0.023	1.278LysGln: 1.278 ± 0.013	3.254LysArg: 3.254 ± 0.028	2.543LysSer: 2.543 ± 0.02	2.181LysThr: 2.181 ± 0.018	2.143LysVal: 2.143 ± 0.022	0.521LysTrp: 0.521 ± 0.008	0.979LysTyr: 0.979 ± 0.013	0.002LysXaa: 0.002 ± 0.0
Leu	9.369LeuAla: 9.369 ± 0.041	1.289LeuCys: 1.289 ± 0.014	5.681LeuAsp: 5.681 ± 0.03	5.625LeuGlu: 5.625 ± 0.032	3.251LeuPhe: 3.251 ± 0.024	5.815LeuGly: 5.815 ± 0.031	2.687LeuHis: 2.687 ± 0.02	3.464LeuIle: 3.464 ± 0.022	3.53LeuLys: 3.53 ± 0.025	8.857LeuLeu: 8.857 ± 0.048	1.649LeuMet: 1.649 ± 0.016	2.938LeuAsn: 2.938 ± 0.023	6.591LeuPro: 6.591 ± 0.037	3.556LeuGln: 3.556 ± 0.023	7.041LeuArg: 7.041 ± 0.036	8.023LeuSer: 8.023 ± 0.041	5.159LeuThr: 5.159 ± 0.028	5.913LeuVal: 5.913 ± 0.03	1.373LeuTrp: 1.373 ± 0.014	2.493LeuTyr: 2.493 ± 0.021	0.004LeuXaa: 0.004 ± 0.001
Met	1.953MetAla: 1.953 ± 0.016	0.236MetCys: 0.236 ± 0.005	1.225MetAsp: 1.225 ± 0.012	1.027MetGlu: 1.027 ± 0.013	0.715MetPhe: 0.715 ± 0.009	1.21MetGly: 1.21 ± 0.014	0.611MetHis: 0.611 ± 0.008	0.799MetIle: 0.799 ± 0.011	0.781MetLys: 0.781 ± 0.01	1.945MetLeu: 1.945 ± 0.016	0.474MetMet: 0.474 ± 0.009	0.684MetAsn: 0.684 ± 0.009	1.441MetPro: 1.441 ± 0.015	0.806MetGln: 0.806 ± 0.01	1.476MetArg: 1.476 ± 0.015	1.931MetSer: 1.931 ± 0.014	1.157MetThr: 1.157 ± 0.011	1.064MetVal: 1.064 ± 0.01	0.266MetTrp: 0.266 ± 0.005	0.532MetTyr: 0.532 ± 0.009	0.001MetXaa: 0.001 ± 0.0
Asn	3.332AsnAla: 3.332 ± 0.022	0.334AsnCys: 0.334 ± 0.007	1.644AsnAsp: 1.644 ± 0.015	1.638AsnGlu: 1.638 ± 0.014	1.102AsnPhe: 1.102 ± 0.013	2.395AsnGly: 2.395 ± 0.024	0.676AsnHis: 0.676 ± 0.009	1.592AsnIle: 1.592 ± 0.017	1.075AsnLys: 1.075 ± 0.012	2.845AsnLeu: 2.845 ± 0.023	0.686AsnMet: 0.686 ± 0.01	1.058AsnAsn: 1.058 ± 0.014	1.952AsnPro: 1.952 ± 0.017	0.873AsnGln: 0.873 ± 0.011	1.552AsnArg: 1.552 ± 0.015	2.144AsnSer: 2.144 ± 0.02	1.868AsnThr: 1.868 ± 0.016	2.235AsnVal: 2.235 ± 0.018	0.46AsnTrp: 0.46 ± 0.008	0.767AsnTyr: 0.767 ± 0.01	0.001AsnXaa: 0.001 ± 0.0
Pro	6.943ProAla: 6.943 ± 0.043	0.532ProCys: 0.532 ± 0.009	3.596ProAsp: 3.596 ± 0.025	3.822ProGlu: 3.822 ± 0.024	2.132ProPhe: 2.132 ± 0.019	4.141ProGly: 4.141 ± 0.028	1.644ProHis: 1.644 ± 0.014	2.533ProIle: 2.533 ± 0.017	2.121ProLys: 2.121 ± 0.019	5.479ProLeu: 5.479 ± 0.029	1.132ProMet: 1.132 ± 0.013	1.94ProAsn: 1.94 ± 0.015	6.764ProPro: 6.764 ± 0.072	2.269ProGln: 2.269 ± 0.021	4.086ProArg: 4.086 ± 0.03	7.01ProSer: 7.01 ± 0.05	4.452ProThr: 4.452 ± 0.028	4.112ProVal: 4.112 ± 0.027	0.746ProTrp: 0.746 ± 0.01	1.545ProTyr: 1.545 ± 0.016	0.005ProXaa: 0.005 ± 0.001
Gln	3.527GlnAla: 3.527 ± 0.022	0.411GlnCys: 0.411 ± 0.006	1.924GlnAsp: 1.924 ± 0.016	1.943GlnGlu: 1.943 ± 0.016	1.059GlnPhe: 1.059 ± 0.011	2.033GlnGly: 2.033 ± 0.018	1.043GlnHis: 1.043 ± 0.013	1.388GlnIle: 1.388 ± 0.014	1.222GlnLys: 1.222 ± 0.015	3.282GlnLeu: 3.282 ± 0.023	0.709GlnMet: 0.709 ± 0.009	1.064GlnAsn: 1.064 ± 0.012	2.464GlnPro: 2.464 ± 0.024	1.802GlnGln: 1.802 ± 0.028	2.592GlnArg: 2.592 ± 0.018	2.763GlnSer: 2.763 ± 0.019	2.114GlnThr: 2.114 ± 0.016	1.912GlnVal: 1.912 ± 0.017	0.535GlnTrp: 0.535 ± 0.009	1.013GlnTyr: 1.013 ± 0.013	0.001GlnXaa: 0.001 ± 0.0
Arg	7.001ArgAla: 7.001 ± 0.037	0.824ArgCys: 0.824 ± 0.012	3.733ArgAsp: 3.733 ± 0.024	4.17ArgGlu: 4.17 ± 0.034	2.297ArgPhe: 2.297 ± 0.021	3.931ArgGly: 3.931 ± 0.026	1.755ArgHis: 1.755 ± 0.015	2.878ArgIle: 2.878 ± 0.019	2.985ArgLys: 2.985 ± 0.027	6.426ArgLeu: 6.426 ± 0.035	1.453ArgMet: 1.453 ± 0.013	1.88ArgAsn: 1.88 ± 0.016	4.024ArgPro: 4.024 ± 0.034	2.346ArgGln: 2.346 ± 0.019	6.0ArgArg: 6.0 ± 0.041	5.315ArgSer: 5.315 ± 0.034	3.955ArgThr: 3.955 ± 0.021	4.188ArgVal: 4.188 ± 0.024	1.093ArgTrp: 1.093 ± 0.012	1.692ArgTyr: 1.692 ± 0.016	0.004ArgXaa: 0.004 ± 0.001
Ser	8.178SerAla: 8.178 ± 0.044	0.875SerCys: 0.875 ± 0.011	4.424SerAsp: 4.424 ± 0.028	3.834SerGlu: 3.834 ± 0.026	2.866SerPhe: 2.866 ± 0.02	5.56SerGly: 5.56 ± 0.034	1.958SerHis: 1.958 ± 0.017	3.586SerIle: 3.586 ± 0.022	2.672SerLys: 2.672 ± 0.022	7.666SerLeu: 7.666 ± 0.043	1.607SerMet: 1.607 ± 0.013	2.393SerAsn: 2.393 ± 0.019	5.977SerPro: 5.977 ± 0.05	2.766SerGln: 2.766 ± 0.021	5.33SerArg: 5.33 ± 0.033	9.085SerSer: 9.085 ± 0.061	5.827SerThr: 5.827 ± 0.033	4.947SerVal: 4.947 ± 0.028	1.093SerTrp: 1.093 ± 0.012	1.945SerTyr: 1.945 ± 0.016	0.003SerXaa: 0.003 ± 0.001
Thr	5.625ThrAla: 5.625 ± 0.026	0.717ThrCys: 0.717 ± 0.01	2.815ThrAsp: 2.815 ± 0.019	2.627ThrGlu: 2.627 ± 0.017	2.299ThrPhe: 2.299 ± 0.016	3.867ThrGly: 3.867 ± 0.027	1.507ThrHis: 1.507 ± 0.015	2.753ThrIle: 2.753 ± 0.022	1.912ThrLys: 1.912 ± 0.017	6.024ThrLeu: 6.024 ± 0.028	1.153ThrMet: 1.153 ± 0.014	1.771ThrAsn: 1.771 ± 0.018	4.884ThrPro: 4.884 ± 0.038	1.943ThrGln: 1.943 ± 0.017	3.697ThrArg: 3.697 ± 0.024	5.605ThrSer: 5.605 ± 0.032	4.009ThrThr: 4.009 ± 0.028	3.851ThrVal: 3.851 ± 0.023	0.828ThrTrp: 0.828 ± 0.009	1.557ThrTyr: 1.557 ± 0.014	0.005ThrXaa: 0.005 ± 0.001
Val	6.072ValAla: 6.072 ± 0.032	0.913ValCys: 0.913 ± 0.01	4.046ValAsp: 4.046 ± 0.023	3.933ValGlu: 3.933 ± 0.025	2.402ValPhe: 2.402 ± 0.019	3.925ValGly: 3.925 ± 0.023	1.809ValHis: 1.809 ± 0.016	2.694ValIle: 2.694 ± 0.021	2.566ValLys: 2.566 ± 0.022	6.427ValLeu: 6.427 ± 0.036	1.274ValMet: 1.274 ± 0.014	2.082ValAsn: 2.082 ± 0.017	4.173ValPro: 4.173 ± 0.028	2.483ValGln: 2.483 ± 0.021	4.139ValArg: 4.139 ± 0.023	4.622ValSer: 4.622 ± 0.025	3.462ValThr: 3.462 ± 0.021	4.655ValVal: 4.655 ± 0.029	0.981ValTrp: 0.981 ± 0.014	1.824ValTyr: 1.824 ± 0.017	0.003ValXaa: 0.003 ± 0.001
Trp	1.329TrpAla: 1.329 ± 0.013	0.202TrpCys: 0.202 ± 0.005	0.935TrpAsp: 0.935 ± 0.011	0.845TrpGlu: 0.845 ± 0.01	0.504TrpPhe: 0.504 ± 0.007	0.839TrpGly: 0.839 ± 0.011	0.375TrpHis: 0.375 ± 0.007	0.671TrpIle: 0.671 ± 0.009	0.719TrpLys: 0.719 ± 0.009	1.38TrpLeu: 1.38 ± 0.014	0.363TrpMet: 0.363 ± 0.006	0.574TrpAsn: 0.574 ± 0.009	0.699TrpPro: 0.699 ± 0.009	0.528TrpGln: 0.528 ± 0.008	1.217TrpArg: 1.217 ± 0.012	1.137TrpSer: 1.137 ± 0.012	1.004TrpThr: 1.004 ± 0.011	0.859TrpVal: 0.859 ± 0.011	0.287TrpTrp: 0.287 ± 0.006	0.408TrpTyr: 0.408 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.512TyrAla: 2.512 ± 0.02	0.404TyrCys: 0.404 ± 0.007	1.667TyrAsp: 1.667 ± 0.016	1.459TyrGlu: 1.459 ± 0.014	1.03TyrPhe: 1.03 ± 0.013	1.9TyrGly: 1.9 ± 0.019	0.667TyrHis: 0.667 ± 0.01	1.251TyrIle: 1.251 ± 0.014	0.92TyrLys: 0.92 ± 0.013	2.471TyrLeu: 2.471 ± 0.019	0.581TyrMet: 0.581 ± 0.009	0.921TyrAsn: 0.921 ± 0.012	1.516TyrPro: 1.516 ± 0.014	0.831TyrGln: 0.831 ± 0.01	1.59TyrArg: 1.59 ± 0.016	1.818TyrSer: 1.818 ± 0.017	1.628TyrThr: 1.628 ± 0.015	1.674TyrVal: 1.674 ± 0.014	0.408TyrTrp: 0.408 ± 0.008	0.833TyrTyr: 0.833 ± 0.011	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.002XaaGlu: 0.002 ± 0.0	0.001XaaPhe: 0.001 ± 0.0	0.004XaaGly: 0.004 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.003XaaLeu: 0.003 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.006XaaPro: 0.006 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.006XaaArg: 0.006 ± 0.001	0.005XaaSer: 0.005 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.544XaaXaa: 0.544 ± 0.035

Statistics based on 17685 proteins (8329052 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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