Amino acid dipepetide frequency for Galbitalea soli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.192AlaAla: 20.192 ± 0.249	0.592AlaCys: 0.592 ± 0.026	7.143AlaAsp: 7.143 ± 0.087	7.701AlaGlu: 7.701 ± 0.135	3.937AlaPhe: 3.937 ± 0.075	12.287AlaGly: 12.287 ± 0.148	2.465AlaHis: 2.465 ± 0.053	6.545AlaIle: 6.545 ± 0.087	2.752AlaLys: 2.752 ± 0.083	14.453AlaLeu: 14.453 ± 0.148	2.512AlaMet: 2.512 ± 0.052	2.565AlaAsn: 2.565 ± 0.063	6.631AlaPro: 6.631 ± 0.128	3.657AlaGln: 3.657 ± 0.06	9.639AlaArg: 9.639 ± 0.129	7.714AlaSer: 7.714 ± 0.099	8.172AlaThr: 8.172 ± 0.117	11.203AlaVal: 11.203 ± 0.134	1.763AlaTrp: 1.763 ± 0.046	2.289AlaTyr: 2.289 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.633CysAla: 0.633 ± 0.031	0.042CysCys: 0.042 ± 0.007	0.283CysAsp: 0.283 ± 0.018	0.228CysGlu: 0.228 ± 0.015	0.151CysPhe: 0.151 ± 0.013	0.536CysGly: 0.536 ± 0.026	0.107CysHis: 0.107 ± 0.01	0.17CysIle: 0.17 ± 0.013	0.06CysLys: 0.06 ± 0.007	0.439CysLeu: 0.439 ± 0.024	0.102CysMet: 0.102 ± 0.012	0.099CysAsn: 0.099 ± 0.011	0.287CysPro: 0.287 ± 0.018	0.103CysGln: 0.103 ± 0.01	0.293CysArg: 0.293 ± 0.02	0.359CysSer: 0.359 ± 0.02	0.318CysThr: 0.318 ± 0.021	0.406CysVal: 0.406 ± 0.023	0.074CysTrp: 0.074 ± 0.009	0.108CysTyr: 0.108 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.787AspAla: 7.787 ± 0.112	0.231AspCys: 0.231 ± 0.017	3.766AspAsp: 3.766 ± 0.072	3.714AspGlu: 3.714 ± 0.073	1.8AspPhe: 1.8 ± 0.041	5.238AspGly: 5.238 ± 0.093	1.199AspHis: 1.199 ± 0.044	2.375AspIle: 2.375 ± 0.054	0.921AspLys: 0.921 ± 0.037	5.546AspLeu: 5.546 ± 0.086	0.705AspMet: 0.705 ± 0.026	1.011AspAsn: 1.011 ± 0.032	3.88AspPro: 3.88 ± 0.071	1.455AspGln: 1.455 ± 0.042	4.326AspArg: 4.326 ± 0.084	2.958AspSer: 2.958 ± 0.069	2.799AspThr: 2.799 ± 0.063	4.608AspVal: 4.608 ± 0.068	0.965AspTrp: 0.965 ± 0.036	1.415AspTyr: 1.415 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.245GluAla: 6.245 ± 0.097	0.228GluCys: 0.228 ± 0.018	2.01GluAsp: 2.01 ± 0.056	2.753GluGlu: 2.753 ± 0.072	1.893GluPhe: 1.893 ± 0.054	3.662GluGly: 3.662 ± 0.075	1.367GluHis: 1.367 ± 0.043	2.673GluIle: 2.673 ± 0.07	1.376GluLys: 1.376 ± 0.052	7.022GluLeu: 7.022 ± 0.106	0.837GluMet: 0.837 ± 0.032	1.148GluAsn: 1.148 ± 0.035	2.709GluPro: 2.709 ± 0.068	1.917GluGln: 1.917 ± 0.053	4.648GluArg: 4.648 ± 0.087	3.018GluSer: 3.018 ± 0.056	2.86GluThr: 2.86 ± 0.061	4.598GluVal: 4.598 ± 0.069	0.869GluTrp: 0.869 ± 0.03	1.162GluTyr: 1.162 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.337PheAla: 4.337 ± 0.076	0.203PheCys: 0.203 ± 0.015	2.313PheAsp: 2.313 ± 0.051	1.764PheGlu: 1.764 ± 0.037	1.122PhePhe: 1.122 ± 0.043	3.396PheGly: 3.396 ± 0.074	0.57PheHis: 0.57 ± 0.025	1.302PheIle: 1.302 ± 0.044	0.5PheLys: 0.5 ± 0.027	2.943PheLeu: 2.943 ± 0.067	0.417PheMet: 0.417 ± 0.025	0.746PheAsn: 0.746 ± 0.027	1.433PhePro: 1.433 ± 0.04	0.798PheGln: 0.798 ± 0.033	1.944PheArg: 1.944 ± 0.05	1.964PheSer: 1.964 ± 0.047	2.133PheThr: 2.133 ± 0.051	2.833PheVal: 2.833 ± 0.063	0.471PheTrp: 0.471 ± 0.022	0.718PheTyr: 0.718 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.68GlyAla: 10.68 ± 0.136	0.561GlyCys: 0.561 ± 0.023	4.697GlyAsp: 4.697 ± 0.068	4.576GlyGlu: 4.576 ± 0.069	3.291GlyPhe: 3.291 ± 0.059	7.692GlyGly: 7.692 ± 0.12	1.959GlyHis: 1.959 ± 0.048	5.129GlyIle: 5.129 ± 0.081	2.163GlyLys: 2.163 ± 0.066	8.857GlyLeu: 8.857 ± 0.119	1.877GlyMet: 1.877 ± 0.047	1.843GlyAsn: 1.843 ± 0.057	3.775GlyPro: 3.775 ± 0.068	2.482GlyGln: 2.482 ± 0.05	6.246GlyArg: 6.246 ± 0.093	5.761GlySer: 5.761 ± 0.09	5.685GlyThr: 5.685 ± 0.097	8.057GlyVal: 8.057 ± 0.105	1.518GlyTrp: 1.518 ± 0.042	2.333GlyTyr: 2.333 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.305HisAla: 2.305 ± 0.06	0.11HisCys: 0.11 ± 0.012	1.227HisAsp: 1.227 ± 0.04	1.093HisGlu: 1.093 ± 0.04	0.607HisPhe: 0.607 ± 0.026	1.973HisGly: 1.973 ± 0.047	0.513HisHis: 0.513 ± 0.03	0.775HisIle: 0.775 ± 0.025	0.259HisLys: 0.259 ± 0.017	2.214HisLeu: 2.214 ± 0.053	0.33HisMet: 0.33 ± 0.018	0.424HisAsn: 0.424 ± 0.021	1.659HisPro: 1.659 ± 0.051	0.484HisGln: 0.484 ± 0.022	1.631HisArg: 1.631 ± 0.044	1.221HisSer: 1.221 ± 0.039	1.031HisThr: 1.031 ± 0.037	1.497HisVal: 1.497 ± 0.037	0.299HisTrp: 0.299 ± 0.018	0.469HisTyr: 0.469 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.421IleAla: 7.421 ± 0.11	0.248IleCys: 0.248 ± 0.016	3.417IleAsp: 3.417 ± 0.063	2.899IleGlu: 2.899 ± 0.067	1.213IlePhe: 1.213 ± 0.036	4.81IleGly: 4.81 ± 0.085	0.784IleHis: 0.784 ± 0.026	2.041IleIle: 2.041 ± 0.058	0.885IleLys: 0.885 ± 0.04	4.256IleLeu: 4.256 ± 0.078	0.609IleMet: 0.609 ± 0.025	1.057IleAsn: 1.057 ± 0.04	2.672IlePro: 2.672 ± 0.052	1.148IleGln: 1.148 ± 0.035	2.939IleArg: 2.939 ± 0.059	2.572IleSer: 2.572 ± 0.056	3.059IleThr: 3.059 ± 0.066	4.972IleVal: 4.972 ± 0.085	0.475IleTrp: 0.475 ± 0.022	0.84IleTyr: 0.84 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	2.571LysAla: 2.571 ± 0.086	0.086LysCys: 0.086 ± 0.009	1.052LysAsp: 1.052 ± 0.044	0.844LysGlu: 0.844 ± 0.037	0.545LysPhe: 0.545 ± 0.027	1.698LysGly: 1.698 ± 0.061	0.429LysHis: 0.429 ± 0.022	0.982LysIle: 0.982 ± 0.041	0.763LysLys: 0.763 ± 0.043	1.914LysLeu: 1.914 ± 0.052	0.389LysMet: 0.389 ± 0.021	0.594LysAsn: 0.594 ± 0.037	1.232LysPro: 1.232 ± 0.044	0.706LysGln: 0.706 ± 0.033	1.517LysArg: 1.517 ± 0.047	1.429LysSer: 1.429 ± 0.051	1.4LysThr: 1.4 ± 0.049	1.627LysVal: 1.627 ± 0.052	0.266LysTrp: 0.266 ± 0.015	0.555LysTyr: 0.555 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.27LeuAla: 15.27 ± 0.151	0.512LeuCys: 0.512 ± 0.024	6.499LeuAsp: 6.499 ± 0.092	5.026LeuGlu: 5.026 ± 0.088	2.994LeuPhe: 2.994 ± 0.07	9.699LeuGly: 9.699 ± 0.12	1.921LeuHis: 1.921 ± 0.05	4.568LeuIle: 4.568 ± 0.076	1.847LeuLys: 1.847 ± 0.061	10.601LeuLeu: 10.601 ± 0.154	1.522LeuMet: 1.522 ± 0.041	1.841LeuAsn: 1.841 ± 0.049	5.645LeuPro: 5.645 ± 0.078	2.522LeuGln: 2.522 ± 0.054	7.505LeuArg: 7.505 ± 0.105	6.344LeuSer: 6.344 ± 0.089	6.293LeuThr: 6.293 ± 0.083	9.65LeuVal: 9.65 ± 0.12	1.197LeuTrp: 1.197 ± 0.037	1.829LeuTyr: 1.829 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.983MetAla: 1.983 ± 0.051	0.093MetCys: 0.093 ± 0.011	0.725MetAsp: 0.725 ± 0.025	0.6MetGlu: 0.6 ± 0.025	0.471MetPhe: 0.471 ± 0.023	1.189MetGly: 1.189 ± 0.034	0.317MetHis: 0.317 ± 0.02	0.918MetIle: 0.918 ± 0.028	0.445MetLys: 0.445 ± 0.023	1.624MetLeu: 1.624 ± 0.043	0.252MetMet: 0.252 ± 0.023	0.498MetAsn: 0.498 ± 0.023	1.033MetPro: 1.033 ± 0.034	0.474MetGln: 0.474 ± 0.024	1.269MetArg: 1.269 ± 0.038	1.376MetSer: 1.376 ± 0.037	1.724MetThr: 1.724 ± 0.039	1.269MetVal: 1.269 ± 0.041	0.159MetTrp: 0.159 ± 0.012	0.27MetTyr: 0.27 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.584AsnAla: 2.584 ± 0.057	0.134AsnCys: 0.134 ± 0.013	1.15AsnAsp: 1.15 ± 0.044	0.95AsnGlu: 0.95 ± 0.032	0.717AsnPhe: 0.717 ± 0.031	2.083AsnGly: 2.083 ± 0.056	0.389AsnHis: 0.389 ± 0.022	0.929AsnIle: 0.929 ± 0.035	0.454AsnLys: 0.454 ± 0.029	1.971AsnLeu: 1.971 ± 0.04	0.338AsnMet: 0.338 ± 0.019	0.543AsnAsn: 0.543 ± 0.032	1.646AsnPro: 1.646 ± 0.049	0.636AsnGln: 0.636 ± 0.028	1.311AsnArg: 1.311 ± 0.037	1.198AsnSer: 1.198 ± 0.041	1.24AsnThr: 1.24 ± 0.042	1.664AsnVal: 1.664 ± 0.044	0.374AsnTrp: 0.374 ± 0.019	0.599AsnTyr: 0.599 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.545ProAla: 7.545 ± 0.129	0.179ProCys: 0.179 ± 0.017	3.275ProAsp: 3.275 ± 0.063	3.485ProGlu: 3.485 ± 0.072	1.739ProPhe: 1.739 ± 0.044	5.149ProGly: 5.149 ± 0.086	1.153ProHis: 1.153 ± 0.039	2.306ProIle: 2.306 ± 0.05	1.092ProLys: 1.092 ± 0.037	5.053ProLeu: 5.053 ± 0.082	0.806ProMet: 0.806 ± 0.031	1.077ProAsn: 1.077 ± 0.032	2.328ProPro: 2.328 ± 0.076	1.466ProGln: 1.466 ± 0.04	3.576ProArg: 3.576 ± 0.067	3.407ProSer: 3.407 ± 0.065	3.637ProThr: 3.637 ± 0.08	4.733ProVal: 4.733 ± 0.071	0.806ProTrp: 0.806 ± 0.034	1.032ProTyr: 1.032 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.217GlnAla: 3.217 ± 0.072	0.119GlnCys: 0.119 ± 0.012	1.091GlnAsp: 1.091 ± 0.031	1.18GlnGlu: 1.18 ± 0.042	0.947GlnPhe: 0.947 ± 0.029	1.964GlnGly: 1.964 ± 0.052	0.621GlnHis: 0.621 ± 0.031	1.379GlnIle: 1.379 ± 0.04	0.789GlnLys: 0.789 ± 0.033	3.5GlnLeu: 3.5 ± 0.063	0.466GlnMet: 0.466 ± 0.024	0.698GlnAsn: 0.698 ± 0.035	1.411GlnPro: 1.411 ± 0.04	1.189GlnGln: 1.189 ± 0.047	2.277GlnArg: 2.277 ± 0.057	1.631GlnSer: 1.631 ± 0.043	1.549GlnThr: 1.549 ± 0.045	2.231GlnVal: 2.231 ± 0.054	0.452GlnTrp: 0.452 ± 0.023	0.702GlnTyr: 0.702 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	9.199ArgAla: 9.199 ± 0.116	0.28ArgCys: 0.28 ± 0.018	3.945ArgAsp: 3.945 ± 0.072	4.294ArgGlu: 4.294 ± 0.087	2.379ArgPhe: 2.379 ± 0.052	5.469ArgGly: 5.469 ± 0.093	1.554ArgHis: 1.554 ± 0.046	3.656ArgIle: 3.656 ± 0.063	1.309ArgLys: 1.309 ± 0.039	7.492ArgLeu: 7.492 ± 0.103	1.579ArgMet: 1.579 ± 0.042	1.318ArgAsn: 1.318 ± 0.042	3.625ArgPro: 3.625 ± 0.072	2.035ArgGln: 2.035 ± 0.056	6.289ArgArg: 6.289 ± 0.102	4.314ArgSer: 4.314 ± 0.075	4.006ArgThr: 4.006 ± 0.077	6.292ArgVal: 6.292 ± 0.092	1.168ArgTrp: 1.168 ± 0.037	1.657ArgTyr: 1.657 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.604SerAla: 7.604 ± 0.106	0.291SerCys: 0.291 ± 0.02	3.33SerAsp: 3.33 ± 0.061	2.764SerGlu: 2.764 ± 0.065	1.966SerPhe: 1.966 ± 0.048	6.112SerGly: 6.112 ± 0.091	1.172SerHis: 1.172 ± 0.036	2.936SerIle: 2.936 ± 0.055	1.324SerLys: 1.324 ± 0.044	5.87SerLeu: 5.87 ± 0.084	1.098SerMet: 1.098 ± 0.031	1.366SerAsn: 1.366 ± 0.043	3.358SerPro: 3.358 ± 0.064	1.485SerGln: 1.485 ± 0.043	4.028SerArg: 4.028 ± 0.073	4.015SerSer: 4.015 ± 0.088	4.224SerThr: 4.224 ± 0.076	5.117SerVal: 5.117 ± 0.075	1.006SerTrp: 1.006 ± 0.033	1.43SerTyr: 1.43 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	8.481ThrAla: 8.481 ± 0.117	0.221ThrCys: 0.221 ± 0.018	3.285ThrAsp: 3.285 ± 0.059	2.941ThrGlu: 2.941 ± 0.058	1.89ThrPhe: 1.89 ± 0.046	5.929ThrGly: 5.929 ± 0.095	1.192ThrHis: 1.192 ± 0.031	3.267ThrIle: 3.267 ± 0.063	1.278ThrLys: 1.278 ± 0.051	6.369ThrLeu: 6.369 ± 0.095	0.887ThrMet: 0.887 ± 0.031	1.286ThrAsn: 1.286 ± 0.045	4.263ThrPro: 4.263 ± 0.081	1.508ThrGln: 1.508 ± 0.037	3.94ThrArg: 3.94 ± 0.07	3.765ThrSer: 3.765 ± 0.079	4.371ThrThr: 4.371 ± 0.104	6.229ThrVal: 6.229 ± 0.087	0.759ThrTrp: 0.759 ± 0.033	1.001ThrTyr: 1.001 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	12.107ValAla: 12.107 ± 0.149	0.443ValCys: 0.443 ± 0.021	5.492ValAsp: 5.492 ± 0.079	4.459ValGlu: 4.459 ± 0.082	2.87ValPhe: 2.87 ± 0.055	7.293ValGly: 7.293 ± 0.083	1.74ValHis: 1.74 ± 0.05	4.914ValIle: 4.914 ± 0.083	1.685ValLys: 1.685 ± 0.053	9.068ValLeu: 9.068 ± 0.125	1.329ValMet: 1.329 ± 0.037	1.874ValAsn: 1.874 ± 0.051	4.439ValPro: 4.439 ± 0.073	2.17ValGln: 2.17 ± 0.054	5.728ValArg: 5.728 ± 0.088	5.172ValSer: 5.172 ± 0.085	6.287ValThr: 6.287 ± 0.083	8.882ValVal: 8.882 ± 0.13	1.067ValTrp: 1.067 ± 0.035	1.618ValTyr: 1.618 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.539TrpAla: 1.539 ± 0.038	0.08TrpCys: 0.08 ± 0.011	0.718TrpAsp: 0.718 ± 0.027	0.63TrpGlu: 0.63 ± 0.026	0.559TrpPhe: 0.559 ± 0.024	1.047TrpGly: 1.047 ± 0.034	0.32TrpHis: 0.32 ± 0.018	0.715TrpIle: 0.715 ± 0.03	0.317TrpLys: 0.317 ± 0.02	1.639TrpLeu: 1.639 ± 0.044	0.383TrpMet: 0.383 ± 0.02	0.419TrpAsn: 0.419 ± 0.025	0.694TrpPro: 0.694 ± 0.027	0.526TrpGln: 0.526 ± 0.025	1.116TrpArg: 1.116 ± 0.034	0.957TrpSer: 0.957 ± 0.038	0.886TrpThr: 0.886 ± 0.033	1.135TrpVal: 1.135 ± 0.036	0.323TrpTrp: 0.323 ± 0.021	0.33TrpTyr: 0.33 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.511TyrAla: 2.511 ± 0.06	0.144TyrCys: 0.144 ± 0.012	1.279TyrAsp: 1.279 ± 0.054	1.098TyrGlu: 1.098 ± 0.036	0.816TyrPhe: 0.816 ± 0.032	1.957TyrGly: 1.957 ± 0.065	0.349TyrHis: 0.349 ± 0.021	0.738TyrIle: 0.738 ± 0.034	0.382TyrLys: 0.382 ± 0.02	2.453TyrLeu: 2.453 ± 0.051	0.248TyrMet: 0.248 ± 0.018	0.505TyrAsn: 0.505 ± 0.03	1.122TyrPro: 1.122 ± 0.033	0.652TyrGln: 0.652 ± 0.026	1.636TyrArg: 1.636 ± 0.046	1.324TyrSer: 1.324 ± 0.039	1.188TyrThr: 1.188 ± 0.045	1.631TyrVal: 1.631 ± 0.043	0.322TyrTrp: 0.322 ± 0.018	0.488TyrTyr: 0.488 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2831 proteins (922278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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