Amino acid dipepetide frequency for Vibrio phage JSF14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.909AlaAla: 3.909 ± 0.474
0.754AlaCys: 0.754 ± 0.12
2.904AlaAsp: 2.904 ± 0.319
3.909AlaGlu: 3.909 ± 0.389
2.15AlaPhe: 2.15 ± 0.234
2.904AlaGly: 2.904 ± 0.319
0.921AlaHis: 0.921 ± 0.159
3.686AlaIle: 3.686 ± 0.301
3.714AlaLys: 3.714 ± 0.353
4.942AlaLeu: 4.942 ± 0.429
1.229AlaMet: 1.229 ± 0.216
2.318AlaAsn: 2.318 ± 0.24
1.173AlaPro: 1.173 ± 0.185
1.564AlaGln: 1.564 ± 0.231
1.899AlaArg: 1.899 ± 0.237
2.904AlaSer: 2.904 ± 0.372
3.016AlaThr: 3.016 ± 0.277
3.044AlaVal: 3.044 ± 0.345
0.866AlaTrp: 0.866 ± 0.147
2.234AlaTyr: 2.234 ± 0.238
0.0AlaXaa: 0.0 ± 0.0
Cys
0.894CysAla: 0.894 ± 0.171
0.419CysCys: 0.419 ± 0.121
0.866CysAsp: 0.866 ± 0.153
1.368CysGlu: 1.368 ± 0.213
0.642CysPhe: 0.642 ± 0.146
1.731CysGly: 1.731 ± 0.269
0.475CysHis: 0.475 ± 0.149
0.977CysIle: 0.977 ± 0.174
1.675CysLys: 1.675 ± 0.192
0.921CysLeu: 0.921 ± 0.174
0.447CysMet: 0.447 ± 0.107
0.782CysAsn: 0.782 ± 0.15
0.67CysPro: 0.67 ± 0.151
0.558CysGln: 0.558 ± 0.105
0.782CysArg: 0.782 ± 0.128
1.201CysSer: 1.201 ± 0.245
0.894CysThr: 0.894 ± 0.166
1.089CysVal: 1.089 ± 0.147
0.251CysTrp: 0.251 ± 0.101
0.866CysTyr: 0.866 ± 0.178
0.0CysXaa: 0.0 ± 0.0
Asp
2.541AspAla: 2.541 ± 0.256
1.34AspCys: 1.34 ± 0.167
3.462AspAsp: 3.462 ± 0.361
4.551AspGlu: 4.551 ± 0.357
3.099AspPhe: 3.099 ± 0.308
4.663AspGly: 4.663 ± 0.312
0.949AspHis: 0.949 ± 0.163
4.635AspIle: 4.635 ± 0.34
5.501AspLys: 5.501 ± 0.374
5.696AspLeu: 5.696 ± 0.427
1.927AspMet: 1.927 ± 0.274
3.518AspAsn: 3.518 ± 0.29
1.647AspPro: 1.647 ± 0.244
1.899AspGln: 1.899 ± 0.242
2.541AspArg: 2.541 ± 0.27
3.686AspSer: 3.686 ± 0.327
3.993AspThr: 3.993 ± 0.318
4.161AspVal: 4.161 ± 0.384
1.145AspTrp: 1.145 ± 0.179
3.825AspTyr: 3.825 ± 0.36
0.0AspXaa: 0.0 ± 0.0
Glu
4.161GluAla: 4.161 ± 0.349
1.257GluCys: 1.257 ± 0.198
6.227GluAsp: 6.227 ± 0.392
7.93GluGlu: 7.93 ± 0.581
3.351GluPhe: 3.351 ± 0.318
5.11GluGly: 5.11 ± 0.416
1.62GluHis: 1.62 ± 0.215
4.691GluIle: 4.691 ± 0.385
5.305GluLys: 5.305 ± 0.384
6.506GluLeu: 6.506 ± 0.494
2.178GluMet: 2.178 ± 0.254
3.658GluAsn: 3.658 ± 0.299
1.564GluPro: 1.564 ± 0.244
2.541GluGln: 2.541 ± 0.324
3.072GluArg: 3.072 ± 0.311
4.719GluSer: 4.719 ± 0.312
3.099GluThr: 3.099 ± 0.277
5.585GluVal: 5.585 ± 0.412
1.34GluTrp: 1.34 ± 0.213
3.658GluTyr: 3.658 ± 0.294
0.0GluXaa: 0.0 ± 0.0
Phe
2.178PheAla: 2.178 ± 0.267
0.726PheCys: 0.726 ± 0.145
3.602PheAsp: 3.602 ± 0.349
3.267PheGlu: 3.267 ± 0.296
1.312PhePhe: 1.312 ± 0.209
2.82PheGly: 2.82 ± 0.301
0.949PheHis: 0.949 ± 0.147
3.044PheIle: 3.044 ± 0.332
3.435PheLys: 3.435 ± 0.285
2.848PheLeu: 2.848 ± 0.264
0.977PheMet: 0.977 ± 0.167
2.15PheAsn: 2.15 ± 0.211
1.34PhePro: 1.34 ± 0.209
1.201PheGln: 1.201 ± 0.202
1.396PheArg: 1.396 ± 0.221
2.764PheSer: 2.764 ± 0.257
3.239PheThr: 3.239 ± 0.253
3.267PheVal: 3.267 ± 0.282
0.642PheTrp: 0.642 ± 0.142
1.843PheTyr: 1.843 ± 0.253
0.0PheXaa: 0.0 ± 0.0
Gly
2.736GlyAla: 2.736 ± 0.281
1.201GlyCys: 1.201 ± 0.172
4.44GlyAsp: 4.44 ± 0.344
5.166GlyGlu: 5.166 ± 0.368
3.127GlyPhe: 3.127 ± 0.263
4.133GlyGly: 4.133 ± 0.446
0.754GlyHis: 0.754 ± 0.143
3.714GlyIle: 3.714 ± 0.329
5.445GlyLys: 5.445 ± 0.373
4.691GlyLeu: 4.691 ± 0.395
1.229GlyMet: 1.229 ± 0.183
3.825GlyAsn: 3.825 ± 0.319
0.223GlyPro: 0.223 ± 0.085
1.787GlyGln: 1.787 ± 0.213
2.429GlyArg: 2.429 ± 0.275
3.965GlySer: 3.965 ± 0.387
3.742GlyThr: 3.742 ± 0.33
5.836GlyVal: 5.836 ± 0.48
1.564GlyTrp: 1.564 ± 0.175
3.602GlyTyr: 3.602 ± 0.32
0.0GlyXaa: 0.0 ± 0.0
His
0.698HisAla: 0.698 ± 0.147
0.447HisCys: 0.447 ± 0.113
0.921HisAsp: 0.921 ± 0.166
1.396HisGlu: 1.396 ± 0.176
1.033HisPhe: 1.033 ± 0.186
1.173HisGly: 1.173 ± 0.174
0.586HisHis: 0.586 ± 0.119
1.62HisIle: 1.62 ± 0.209
1.899HisLys: 1.899 ± 0.214
1.48HisLeu: 1.48 ± 0.195
0.558HisMet: 0.558 ± 0.129
1.089HisAsn: 1.089 ± 0.146
0.586HisPro: 0.586 ± 0.13
0.866HisGln: 0.866 ± 0.189
0.754HisArg: 0.754 ± 0.153
1.34HisSer: 1.34 ± 0.19
1.34HisThr: 1.34 ± 0.205
0.977HisVal: 0.977 ± 0.17
0.223HisTrp: 0.223 ± 0.082
0.838HisTyr: 0.838 ± 0.143
0.0HisXaa: 0.0 ± 0.0
Ile
3.49IleAla: 3.49 ± 0.269
0.894IleCys: 0.894 ± 0.157
4.831IleAsp: 4.831 ± 0.349
4.244IleGlu: 4.244 ± 0.351
2.234IlePhe: 2.234 ± 0.212
3.462IleGly: 3.462 ± 0.262
1.312IleHis: 1.312 ± 0.203
4.216IleIle: 4.216 ± 0.322
5.808IleLys: 5.808 ± 0.384
4.886IleLeu: 4.886 ± 0.332
1.061IleMet: 1.061 ± 0.159
3.602IleAsn: 3.602 ± 0.284
2.569IlePro: 2.569 ± 0.3
1.843IleGln: 1.843 ± 0.233
2.904IleArg: 2.904 ± 0.281
4.105IleSer: 4.105 ± 0.297
4.161IleThr: 4.161 ± 0.324
4.635IleVal: 4.635 ± 0.389
0.586IleTrp: 0.586 ± 0.121
2.597IleTyr: 2.597 ± 0.252
0.0IleXaa: 0.0 ± 0.0
Lys
4.049LysAla: 4.049 ± 0.372
1.229LysCys: 1.229 ± 0.187
5.249LysAsp: 5.249 ± 0.333
6.422LysGlu: 6.422 ± 0.397
3.351LysPhe: 3.351 ± 0.293
5.501LysGly: 5.501 ± 0.429
2.01LysHis: 2.01 ± 0.214
4.859LysIle: 4.859 ± 0.397
4.44LysLys: 4.44 ± 0.396
7.679LysLeu: 7.679 ± 0.56
2.234LysMet: 2.234 ± 0.254
3.183LysAsn: 3.183 ± 0.268
2.15LysPro: 2.15 ± 0.268
3.239LysGln: 3.239 ± 0.302
4.161LysArg: 4.161 ± 0.397
5.277LysSer: 5.277 ± 0.387
3.742LysThr: 3.742 ± 0.296
6.227LysVal: 6.227 ± 0.366
1.061LysTrp: 1.061 ± 0.176
4.161LysTyr: 4.161 ± 0.393
0.0LysXaa: 0.0 ± 0.0
Leu
4.607LeuAla: 4.607 ± 0.459
1.508LeuCys: 1.508 ± 0.174
5.808LeuAsp: 5.808 ± 0.466
7.064LeuGlu: 7.064 ± 0.463
3.211LeuPhe: 3.211 ± 0.321
5.305LeuGly: 5.305 ± 0.388
1.675LeuHis: 1.675 ± 0.224
4.133LeuIle: 4.133 ± 0.357
6.199LeuLys: 6.199 ± 0.48
7.316LeuLeu: 7.316 ± 0.49
2.178LeuMet: 2.178 ± 0.224
4.635LeuAsn: 4.635 ± 0.347
2.988LeuPro: 2.988 ± 0.281
2.904LeuGln: 2.904 ± 0.286
3.574LeuArg: 3.574 ± 0.363
6.674LeuSer: 6.674 ± 0.529
4.831LeuThr: 4.831 ± 0.425
5.333LeuVal: 5.333 ± 0.385
1.312LeuTrp: 1.312 ± 0.204
3.407LeuTyr: 3.407 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
1.592MetAla: 1.592 ± 0.227
0.447MetCys: 0.447 ± 0.099
1.424MetAsp: 1.424 ± 0.215
1.452MetGlu: 1.452 ± 0.199
1.201MetPhe: 1.201 ± 0.189
0.977MetGly: 0.977 ± 0.161
0.586MetHis: 0.586 ± 0.127
1.62MetIle: 1.62 ± 0.254
2.262MetLys: 2.262 ± 0.243
1.787MetLeu: 1.787 ± 0.229
0.782MetMet: 0.782 ± 0.158
1.62MetAsn: 1.62 ± 0.216
0.754MetPro: 0.754 ± 0.159
1.284MetGln: 1.284 ± 0.155
1.229MetArg: 1.229 ± 0.192
2.178MetSer: 2.178 ± 0.224
1.48MetThr: 1.48 ± 0.204
1.229MetVal: 1.229 ± 0.203
0.168MetTrp: 0.168 ± 0.065
1.089MetTyr: 1.089 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
2.346AsnAla: 2.346 ± 0.252
0.67AsnCys: 0.67 ± 0.142
2.848AsnAsp: 2.848 ± 0.265
2.764AsnGlu: 2.764 ± 0.248
2.318AsnPhe: 2.318 ± 0.225
4.161AsnGly: 4.161 ± 0.325
1.284AsnHis: 1.284 ± 0.193
4.105AsnIle: 4.105 ± 0.362
4.831AsnLys: 4.831 ± 0.388
4.579AsnLeu: 4.579 ± 0.339
1.34AsnMet: 1.34 ± 0.206
3.127AsnAsn: 3.127 ± 0.278
2.094AsnPro: 2.094 ± 0.22
1.899AsnGln: 1.899 ± 0.226
2.038AsnArg: 2.038 ± 0.225
3.351AsnSer: 3.351 ± 0.256
2.988AsnThr: 2.988 ± 0.292
2.82AsnVal: 2.82 ± 0.268
0.866AsnTrp: 0.866 ± 0.117
2.401AsnTyr: 2.401 ± 0.283
0.0AsnXaa: 0.0 ± 0.0
Pro
1.508ProAla: 1.508 ± 0.176
0.531ProCys: 0.531 ± 0.133
1.927ProAsp: 1.927 ± 0.228
2.625ProGlu: 2.625 ± 0.257
1.564ProPhe: 1.564 ± 0.206
0.112ProGly: 0.112 ± 0.062
0.949ProHis: 0.949 ± 0.165
1.843ProIle: 1.843 ± 0.239
2.206ProLys: 2.206 ± 0.283
2.01ProLeu: 2.01 ± 0.25
0.698ProMet: 0.698 ± 0.139
1.508ProAsn: 1.508 ± 0.196
0.894ProPro: 0.894 ± 0.222
1.173ProGln: 1.173 ± 0.198
0.81ProArg: 0.81 ± 0.166
1.815ProSer: 1.815 ± 0.247
1.815ProThr: 1.815 ± 0.205
2.346ProVal: 2.346 ± 0.324
0.447ProTrp: 0.447 ± 0.096
1.424ProTyr: 1.424 ± 0.258
0.0ProXaa: 0.0 ± 0.0
Gln
1.983GlnAla: 1.983 ± 0.29
0.475GlnCys: 0.475 ± 0.108
2.066GlnAsp: 2.066 ± 0.233
3.742GlnGlu: 3.742 ± 0.402
1.005GlnPhe: 1.005 ± 0.158
2.122GlnGly: 2.122 ± 0.221
0.81GlnHis: 0.81 ± 0.14
1.927GlnIle: 1.927 ± 0.258
2.709GlnLys: 2.709 ± 0.269
2.541GlnLeu: 2.541 ± 0.253
0.81GlnMet: 0.81 ± 0.15
1.787GlnAsn: 1.787 ± 0.202
0.866GlnPro: 0.866 ± 0.153
1.62GlnGln: 1.62 ± 0.277
1.703GlnArg: 1.703 ± 0.202
2.206GlnSer: 2.206 ± 0.225
1.787GlnThr: 1.787 ± 0.217
2.122GlnVal: 2.122 ± 0.232
0.391GlnTrp: 0.391 ± 0.113
1.48GlnTyr: 1.48 ± 0.219
0.0GlnXaa: 0.0 ± 0.0
Arg
1.592ArgAla: 1.592 ± 0.21
0.949ArgCys: 0.949 ± 0.176
2.513ArgAsp: 2.513 ± 0.284
3.072ArgGlu: 3.072 ± 0.327
2.038ArgPhe: 2.038 ± 0.24
2.792ArgGly: 2.792 ± 0.315
0.726ArgHis: 0.726 ± 0.146
2.597ArgIle: 2.597 ± 0.276
3.462ArgLys: 3.462 ± 0.321
3.993ArgLeu: 3.993 ± 0.328
1.173ArgMet: 1.173 ± 0.193
2.15ArgAsn: 2.15 ± 0.227
1.033ArgPro: 1.033 ± 0.176
1.675ArgGln: 1.675 ± 0.184
1.647ArgArg: 1.647 ± 0.185
2.457ArgSer: 2.457 ± 0.251
1.927ArgThr: 1.927 ± 0.216
2.876ArgVal: 2.876 ± 0.292
0.754ArgTrp: 0.754 ± 0.154
1.871ArgTyr: 1.871 ± 0.188
0.0ArgXaa: 0.0 ± 0.0
Ser
2.848SerAla: 2.848 ± 0.279
1.005SerCys: 1.005 ± 0.196
4.161SerAsp: 4.161 ± 0.303
4.803SerGlu: 4.803 ± 0.371
2.988SerPhe: 2.988 ± 0.351
5.194SerGly: 5.194 ± 0.376
1.033SerHis: 1.033 ± 0.157
3.77SerIle: 3.77 ± 0.344
6.003SerLys: 6.003 ± 0.391
5.668SerLeu: 5.668 ± 0.537
1.62SerMet: 1.62 ± 0.211
3.267SerAsn: 3.267 ± 0.202
1.62SerPro: 1.62 ± 0.216
1.759SerGln: 1.759 ± 0.211
2.653SerArg: 2.653 ± 0.256
4.663SerSer: 4.663 ± 0.457
3.295SerThr: 3.295 ± 0.309
4.3SerVal: 4.3 ± 0.42
1.173SerTrp: 1.173 ± 0.192
3.211SerTyr: 3.211 ± 0.291
0.0SerXaa: 0.0 ± 0.0
Thr
3.211ThrAla: 3.211 ± 0.308
1.061ThrCys: 1.061 ± 0.184
2.681ThrAsp: 2.681 ± 0.301
3.574ThrGlu: 3.574 ± 0.381
2.764ThrPhe: 2.764 ± 0.312
3.798ThrGly: 3.798 ± 0.351
1.145ThrHis: 1.145 ± 0.169
4.607ThrIle: 4.607 ± 0.407
4.161ThrLys: 4.161 ± 0.37
5.92ThrLeu: 5.92 ± 0.362
1.452ThrMet: 1.452 ± 0.219
2.932ThrAsn: 2.932 ± 0.255
2.82ThrPro: 2.82 ± 0.285
1.62ThrGln: 1.62 ± 0.18
2.206ThrArg: 2.206 ± 0.292
3.546ThrSer: 3.546 ± 0.388
3.714ThrThr: 3.714 ± 0.402
3.798ThrVal: 3.798 ± 0.336
0.754ThrTrp: 0.754 ± 0.138
2.457ThrTyr: 2.457 ± 0.264
0.0ThrXaa: 0.0 ± 0.0
Val
3.462ValAla: 3.462 ± 0.352
1.201ValCys: 1.201 ± 0.218
4.775ValAsp: 4.775 ± 0.361
5.752ValGlu: 5.752 ± 0.461
2.988ValPhe: 2.988 ± 0.293
4.244ValGly: 4.244 ± 0.373
0.754ValHis: 0.754 ± 0.159
3.798ValIle: 3.798 ± 0.318
5.836ValLys: 5.836 ± 0.44
5.445ValLeu: 5.445 ± 0.328
1.675ValMet: 1.675 ± 0.21
4.133ValAsn: 4.133 ± 0.324
1.675ValPro: 1.675 ± 0.188
2.318ValGln: 2.318 ± 0.261
2.541ValArg: 2.541 ± 0.238
4.161ValSer: 4.161 ± 0.3
4.97ValThr: 4.97 ± 0.37
4.803ValVal: 4.803 ± 0.387
0.921ValTrp: 0.921 ± 0.161
3.044ValTyr: 3.044 ± 0.288
0.0ValXaa: 0.0 ± 0.0
Trp
0.391TrpAla: 0.391 ± 0.094
0.419TrpCys: 0.419 ± 0.125
1.173TrpAsp: 1.173 ± 0.198
1.34TrpGlu: 1.34 ± 0.17
0.586TrpPhe: 0.586 ± 0.12
0.586TrpGly: 0.586 ± 0.158
0.251TrpHis: 0.251 ± 0.072
0.81TrpIle: 0.81 ± 0.118
1.62TrpLys: 1.62 ± 0.216
1.508TrpLeu: 1.508 ± 0.231
0.475TrpMet: 0.475 ± 0.124
0.782TrpAsn: 0.782 ± 0.159
0.168TrpPro: 0.168 ± 0.063
0.698TrpGln: 0.698 ± 0.151
0.586TrpArg: 0.586 ± 0.122
0.866TrpSer: 0.866 ± 0.159
0.67TrpThr: 0.67 ± 0.121
1.424TrpVal: 1.424 ± 0.201
0.223TrpTrp: 0.223 ± 0.07
0.642TrpTyr: 0.642 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.843TyrAla: 1.843 ± 0.227
0.977TyrCys: 0.977 ± 0.164
2.904TyrAsp: 2.904 ± 0.324
3.127TyrGlu: 3.127 ± 0.279
2.038TyrPhe: 2.038 ± 0.285
2.82TyrGly: 2.82 ± 0.242
1.033TyrHis: 1.033 ± 0.169
2.792TyrIle: 2.792 ± 0.304
3.714TyrLys: 3.714 ± 0.364
4.244TyrLeu: 4.244 ± 0.35
1.089TyrMet: 1.089 ± 0.209
2.764TyrAsn: 2.764 ± 0.335
1.368TyrPro: 1.368 ± 0.2
1.703TyrGln: 1.703 ± 0.259
2.373TyrArg: 2.373 ± 0.225
3.155TyrSer: 3.155 ± 0.314
3.518TyrThr: 3.518 ± 0.322
2.625TyrVal: 2.625 ± 0.294
0.531TyrTrp: 0.531 ± 0.108
2.122TyrTyr: 2.122 ± 0.256
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 217 proteins (35814 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski