Amino acid dipepetide frequency for Ovine gammaherpesvirus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.238AlaAla: 7.238 ± 0.478
2.194AlaCys: 2.194 ± 0.211
2.935AlaAsp: 2.935 ± 0.281
3.419AlaGlu: 3.419 ± 0.332
3.191AlaPhe: 3.191 ± 0.283
2.906AlaGly: 2.906 ± 0.256
1.681AlaHis: 1.681 ± 0.222
3.134AlaIle: 3.134 ± 0.271
2.992AlaLys: 2.992 ± 0.288
7.751AlaLeu: 7.751 ± 0.596
1.824AlaMet: 1.824 ± 0.214
3.59AlaAsn: 3.59 ± 0.303
4.588AlaPro: 4.588 ± 0.431
2.793AlaGln: 2.793 ± 0.388
2.935AlaArg: 2.935 ± 0.258
5.927AlaSer: 5.927 ± 0.428
4.132AlaThr: 4.132 ± 0.301
4.787AlaVal: 4.787 ± 0.334
0.94AlaTrp: 0.94 ± 0.162
2.08AlaTyr: 2.08 ± 0.215
0.028AlaXaa: 0.028 ± 0.028
Cys
1.909CysAla: 1.909 ± 0.298
0.712CysCys: 0.712 ± 0.168
0.798CysAsp: 0.798 ± 0.153
1.111CysGlu: 1.111 ± 0.196
1.14CysPhe: 1.14 ± 0.192
1.225CysGly: 1.225 ± 0.209
0.627CysHis: 0.627 ± 0.137
0.883CysIle: 0.883 ± 0.179
1.225CysLys: 1.225 ± 0.207
3.562CysLeu: 3.562 ± 0.384
0.598CysMet: 0.598 ± 0.142
0.997CysAsn: 0.997 ± 0.181
1.482CysPro: 1.482 ± 0.222
1.425CysGln: 1.425 ± 0.184
0.969CysArg: 0.969 ± 0.147
1.824CysSer: 1.824 ± 0.298
1.653CysThr: 1.653 ± 0.212
1.71CysVal: 1.71 ± 0.194
0.199CysTrp: 0.199 ± 0.068
0.94CysTyr: 0.94 ± 0.167
0.0CysXaa: 0.0 ± 0.0
Asp
2.622AspAla: 2.622 ± 0.28
0.798AspCys: 0.798 ± 0.162
1.824AspAsp: 1.824 ± 0.244
2.65AspGlu: 2.65 ± 0.299
2.166AspPhe: 2.166 ± 0.238
1.995AspGly: 1.995 ± 0.281
0.769AspHis: 0.769 ± 0.133
3.163AspIle: 3.163 ± 0.287
1.824AspLys: 1.824 ± 0.213
5.243AspLeu: 5.243 ± 0.436
1.054AspMet: 1.054 ± 0.165
1.824AspAsn: 1.824 ± 0.293
3.334AspPro: 3.334 ± 0.306
0.94AspGln: 0.94 ± 0.161
2.194AspArg: 2.194 ± 0.245
3.305AspSer: 3.305 ± 0.358
2.508AspThr: 2.508 ± 0.267
3.02AspVal: 3.02 ± 0.324
0.513AspTrp: 0.513 ± 0.13
1.852AspTyr: 1.852 ± 0.199
0.0AspXaa: 0.0 ± 0.0
Glu
4.303GluAla: 4.303 ± 0.398
1.282GluCys: 1.282 ± 0.219
3.277GluAsp: 3.277 ± 0.338
6.126GluGlu: 6.126 ± 1.975
1.881GluPhe: 1.881 ± 0.21
4.844GluGly: 4.844 ± 2.614
1.482GluHis: 1.482 ± 0.163
2.422GluIle: 2.422 ± 0.222
2.08GluLys: 2.08 ± 0.232
5.329GluLeu: 5.329 ± 0.47
1.311GluMet: 1.311 ± 0.198
2.394GluAsn: 2.394 ± 0.359
3.362GluPro: 3.362 ± 0.584
2.223GluGln: 2.223 ± 0.351
1.938GluArg: 1.938 ± 0.253
4.474GluSer: 4.474 ± 0.309
2.821GluThr: 2.821 ± 0.31
4.046GluVal: 4.046 ± 0.413
0.313GluTrp: 0.313 ± 0.083
1.681GluTyr: 1.681 ± 0.296
0.0GluXaa: 0.0 ± 0.0
Phe
2.793PheAla: 2.793 ± 0.317
1.168PheCys: 1.168 ± 0.23
1.995PheAsp: 1.995 ± 0.232
1.71PheGlu: 1.71 ± 0.248
2.736PhePhe: 2.736 ± 0.346
1.824PheGly: 1.824 ± 0.245
1.168PheHis: 1.168 ± 0.175
2.565PheIle: 2.565 ± 0.349
2.935PheLys: 2.935 ± 0.299
4.787PheLeu: 4.787 ± 0.385
1.083PheMet: 1.083 ± 0.187
1.909PheAsn: 1.909 ± 0.294
2.565PhePro: 2.565 ± 0.249
1.852PheGln: 1.852 ± 0.217
1.681PheArg: 1.681 ± 0.215
3.847PheSer: 3.847 ± 0.369
2.935PheThr: 2.935 ± 0.393
2.764PheVal: 2.764 ± 0.256
0.541PheTrp: 0.541 ± 0.1
2.137PheTyr: 2.137 ± 0.247
0.0PheXaa: 0.0 ± 0.0
Gly
3.647GlyAla: 3.647 ± 0.374
1.168GlyCys: 1.168 ± 0.198
2.166GlyAsp: 2.166 ± 0.214
4.901GlyGlu: 4.901 ± 2.531
1.767GlyPhe: 1.767 ± 0.265
3.676GlyGly: 3.676 ± 1.479
1.225GlyHis: 1.225 ± 0.208
1.738GlyIle: 1.738 ± 0.176
2.023GlyLys: 2.023 ± 0.261
5.557GlyLeu: 5.557 ± 0.426
1.111GlyMet: 1.111 ± 0.152
1.852GlyAsn: 1.852 ± 0.232
4.616GlyPro: 4.616 ± 1.564
2.451GlyGln: 2.451 ± 0.369
2.565GlyArg: 2.565 ± 0.342
4.246GlySer: 4.246 ± 0.365
2.707GlyThr: 2.707 ± 0.26
3.476GlyVal: 3.476 ± 0.375
0.541GlyTrp: 0.541 ± 0.148
1.282GlyTyr: 1.282 ± 0.223
0.0GlyXaa: 0.0 ± 0.0
His
1.624HisAla: 1.624 ± 0.189
0.769HisCys: 0.769 ± 0.138
0.712HisAsp: 0.712 ± 0.127
1.339HisGlu: 1.339 ± 0.212
1.168HisPhe: 1.168 ± 0.186
1.51HisGly: 1.51 ± 0.232
1.197HisHis: 1.197 ± 0.187
1.339HisIle: 1.339 ± 0.188
1.311HisLys: 1.311 ± 0.165
2.935HisLeu: 2.935 ± 0.301
0.826HisMet: 0.826 ± 0.145
1.254HisAsn: 1.254 ± 0.203
1.852HisPro: 1.852 ± 0.26
0.94HisGln: 0.94 ± 0.165
1.453HisArg: 1.453 ± 0.202
2.593HisSer: 2.593 ± 0.235
1.824HisThr: 1.824 ± 0.219
1.396HisVal: 1.396 ± 0.182
0.427HisTrp: 0.427 ± 0.108
1.168HisTyr: 1.168 ± 0.145
0.0HisXaa: 0.0 ± 0.0
Ile
2.479IleAla: 2.479 ± 0.306
1.368IleCys: 1.368 ± 0.202
2.251IleAsp: 2.251 ± 0.347
2.365IleGlu: 2.365 ± 0.334
2.679IlePhe: 2.679 ± 0.275
1.767IleGly: 1.767 ± 0.249
1.425IleHis: 1.425 ± 0.186
2.622IleIle: 2.622 ± 0.286
2.736IleLys: 2.736 ± 0.249
4.958IleLeu: 4.958 ± 0.422
1.083IleMet: 1.083 ± 0.191
2.565IleAsn: 2.565 ± 0.286
2.935IlePro: 2.935 ± 0.271
1.909IleGln: 1.909 ± 0.245
1.71IleArg: 1.71 ± 0.23
4.645IleSer: 4.645 ± 0.41
2.422IleThr: 2.422 ± 0.272
3.334IleVal: 3.334 ± 0.296
0.57IleTrp: 0.57 ± 0.097
2.052IleTyr: 2.052 ± 0.254
0.0IleXaa: 0.0 ± 0.0
Lys
3.248LysAla: 3.248 ± 0.29
1.054LysCys: 1.054 ± 0.184
1.567LysAsp: 1.567 ± 0.258
2.194LysGlu: 2.194 ± 0.259
1.453LysPhe: 1.453 ± 0.171
1.852LysGly: 1.852 ± 0.228
1.681LysHis: 1.681 ± 0.179
2.422LysIle: 2.422 ± 0.278
3.448LysLys: 3.448 ± 0.36
5.414LysLeu: 5.414 ± 0.443
0.969LysMet: 0.969 ± 0.202
2.052LysAsn: 2.052 ± 0.225
2.736LysPro: 2.736 ± 0.297
2.422LysGln: 2.422 ± 0.29
2.565LysArg: 2.565 ± 0.268
3.647LysSer: 3.647 ± 0.35
3.077LysThr: 3.077 ± 0.252
3.505LysVal: 3.505 ± 0.343
0.399LysTrp: 0.399 ± 0.114
1.681LysTyr: 1.681 ± 0.23
0.0LysXaa: 0.0 ± 0.0
Leu
7.295LeuAla: 7.295 ± 0.474
2.65LeuCys: 2.65 ± 0.278
4.873LeuAsp: 4.873 ± 0.38
5.841LeuGlu: 5.841 ± 0.396
5.158LeuPhe: 5.158 ± 0.341
5.129LeuGly: 5.129 ± 0.508
3.02LeuHis: 3.02 ± 0.28
4.417LeuIle: 4.417 ± 0.372
5.443LeuLys: 5.443 ± 0.391
11.455LeuLeu: 11.455 ± 0.663
2.137LeuMet: 2.137 ± 0.241
4.73LeuAsn: 4.73 ± 0.38
6.639LeuPro: 6.639 ± 0.569
5.756LeuGln: 5.756 ± 0.442
5.129LeuArg: 5.129 ± 0.401
10.059LeuSer: 10.059 ± 0.617
6.867LeuThr: 6.867 ± 0.547
6.155LeuVal: 6.155 ± 0.441
1.026LeuTrp: 1.026 ± 0.17
4.132LeuTyr: 4.132 ± 0.417
0.028LeuXaa: 0.028 ± 0.026
Met
1.995MetAla: 1.995 ± 0.192
0.712MetCys: 0.712 ± 0.128
1.168MetAsp: 1.168 ± 0.176
1.596MetGlu: 1.596 ± 0.232
1.197MetPhe: 1.197 ± 0.184
0.912MetGly: 0.912 ± 0.178
0.513MetHis: 0.513 ± 0.13
0.712MetIle: 0.712 ± 0.168
0.798MetLys: 0.798 ± 0.137
2.536MetLeu: 2.536 ± 0.212
0.427MetMet: 0.427 ± 0.1
0.513MetAsn: 0.513 ± 0.109
0.94MetPro: 0.94 ± 0.178
0.769MetGln: 0.769 ± 0.157
1.111MetArg: 1.111 ± 0.16
1.738MetSer: 1.738 ± 0.196
0.912MetThr: 0.912 ± 0.178
1.282MetVal: 1.282 ± 0.18
0.285MetTrp: 0.285 ± 0.093
1.054MetTyr: 1.054 ± 0.184
0.0MetXaa: 0.0 ± 0.0
Asn
2.764AsnAla: 2.764 ± 0.29
1.197AsnCys: 1.197 ± 0.164
1.596AsnAsp: 1.596 ± 0.211
1.567AsnGlu: 1.567 ± 0.197
2.08AsnPhe: 2.08 ± 0.32
1.995AsnGly: 1.995 ± 0.256
1.054AsnHis: 1.054 ± 0.175
2.992AsnIle: 2.992 ± 0.279
2.451AsnLys: 2.451 ± 0.264
4.816AsnLeu: 4.816 ± 0.399
1.225AsnMet: 1.225 ± 0.193
1.995AsnAsn: 1.995 ± 0.305
2.308AsnPro: 2.308 ± 0.262
1.51AsnGln: 1.51 ± 0.203
1.909AsnArg: 1.909 ± 0.252
3.932AsnSer: 3.932 ± 0.388
2.679AsnThr: 2.679 ± 0.216
2.793AsnVal: 2.793 ± 0.332
0.513AsnTrp: 0.513 ± 0.112
1.396AsnTyr: 1.396 ± 0.188
0.0AsnXaa: 0.0 ± 0.0
Pro
4.246ProAla: 4.246 ± 0.473
1.425ProCys: 1.425 ± 0.217
2.736ProAsp: 2.736 ± 0.301
3.847ProGlu: 3.847 ± 0.452
2.394ProPhe: 2.394 ± 0.201
5.101ProGly: 5.101 ± 1.369
2.052ProHis: 2.052 ± 0.283
2.593ProIle: 2.593 ± 0.239
2.679ProLys: 2.679 ± 0.373
5.784ProLeu: 5.784 ± 0.541
0.94ProMet: 0.94 ± 0.153
2.479ProAsn: 2.479 ± 0.277
6.554ProPro: 6.554 ± 0.886
2.821ProGln: 2.821 ± 0.298
3.077ProArg: 3.077 ± 0.505
5.386ProSer: 5.386 ± 0.561
3.989ProThr: 3.989 ± 0.398
4.559ProVal: 4.559 ± 0.351
0.769ProTrp: 0.769 ± 0.164
1.738ProTyr: 1.738 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
3.59GlnAla: 3.59 ± 0.407
1.026GlnCys: 1.026 ± 0.167
1.938GlnAsp: 1.938 ± 0.256
2.479GlnGlu: 2.479 ± 0.276
2.023GlnPhe: 2.023 ± 0.226
2.394GlnGly: 2.394 ± 0.26
1.197GlnHis: 1.197 ± 0.175
1.824GlnIle: 1.824 ± 0.262
1.767GlnLys: 1.767 ± 0.255
4.816GlnLeu: 4.816 ± 0.435
0.883GlnMet: 0.883 ± 0.164
1.567GlnAsn: 1.567 ± 0.221
2.679GlnPro: 2.679 ± 0.327
2.536GlnGln: 2.536 ± 0.304
1.966GlnArg: 1.966 ± 0.278
3.22GlnSer: 3.22 ± 0.352
2.166GlnThr: 2.166 ± 0.276
2.394GlnVal: 2.394 ± 0.219
0.798GlnTrp: 0.798 ± 0.161
1.254GlnTyr: 1.254 ± 0.186
0.0GlnXaa: 0.0 ± 0.0
Arg
3.79ArgAla: 3.79 ± 0.304
1.282ArgCys: 1.282 ± 0.198
2.052ArgAsp: 2.052 ± 0.235
2.793ArgGlu: 2.793 ± 0.306
1.425ArgPhe: 1.425 ± 0.203
3.049ArgGly: 3.049 ± 0.358
1.767ArgHis: 1.767 ± 0.248
1.852ArgIle: 1.852 ± 0.218
1.767ArgLys: 1.767 ± 0.271
4.36ArgLeu: 4.36 ± 0.363
1.254ArgMet: 1.254 ± 0.186
1.653ArgAsn: 1.653 ± 0.225
2.793ArgPro: 2.793 ± 0.399
1.909ArgGln: 1.909 ± 0.211
3.163ArgArg: 3.163 ± 0.514
3.248ArgSer: 3.248 ± 0.242
1.938ArgThr: 1.938 ± 0.221
2.849ArgVal: 2.849 ± 0.332
0.57ArgTrp: 0.57 ± 0.112
1.51ArgTyr: 1.51 ± 0.18
0.0ArgXaa: 0.0 ± 0.0
Ser
5.414SerAla: 5.414 ± 0.359
1.71SerCys: 1.71 ± 0.252
4.36SerAsp: 4.36 ± 0.413
4.873SerGlu: 4.873 ± 0.342
3.932SerPhe: 3.932 ± 0.369
4.274SerGly: 4.274 ± 0.407
1.938SerHis: 1.938 ± 0.24
4.388SerIle: 4.388 ± 0.415
4.189SerLys: 4.189 ± 0.357
9.688SerLeu: 9.688 ± 0.616
1.482SerMet: 1.482 ± 0.202
3.419SerAsn: 3.419 ± 0.32
5.813SerPro: 5.813 ± 0.546
3.733SerGln: 3.733 ± 0.482
3.505SerArg: 3.505 ± 0.34
8.776SerSer: 8.776 ± 0.752
6.041SerThr: 6.041 ± 0.479
5.186SerVal: 5.186 ± 0.279
0.741SerTrp: 0.741 ± 0.144
2.707SerTyr: 2.707 ± 0.27
0.028SerXaa: 0.028 ± 0.032
Thr
3.875ThrAla: 3.875 ± 0.326
1.282ThrCys: 1.282 ± 0.167
2.963ThrAsp: 2.963 ± 0.338
3.277ThrGlu: 3.277 ± 0.265
2.878ThrPhe: 2.878 ± 0.303
2.736ThrGly: 2.736 ± 0.213
1.653ThrHis: 1.653 ± 0.222
3.077ThrIle: 3.077 ± 0.361
2.508ThrLys: 2.508 ± 0.326
6.582ThrLeu: 6.582 ± 0.517
0.741ThrMet: 0.741 ± 0.139
2.622ThrAsn: 2.622 ± 0.273
3.647ThrPro: 3.647 ± 0.326
2.308ThrGln: 2.308 ± 0.281
2.137ThrArg: 2.137 ± 0.276
5.613ThrSer: 5.613 ± 0.445
3.562ThrThr: 3.562 ± 0.399
4.93ThrVal: 4.93 ± 0.357
0.541ThrTrp: 0.541 ± 0.15
2.337ThrTyr: 2.337 ± 0.263
0.0ThrXaa: 0.0 ± 0.0
Val
5.186ValAla: 5.186 ± 0.451
1.881ValCys: 1.881 ± 0.218
2.821ValAsp: 2.821 ± 0.301
3.334ValGlu: 3.334 ± 0.386
3.448ValPhe: 3.448 ± 0.361
3.163ValGly: 3.163 ± 0.33
1.938ValHis: 1.938 ± 0.217
3.077ValIle: 3.077 ± 0.278
2.992ValLys: 2.992 ± 0.342
6.782ValLeu: 6.782 ± 0.334
1.197ValMet: 1.197 ± 0.177
3.248ValAsn: 3.248 ± 0.3
3.847ValPro: 3.847 ± 0.324
2.593ValGln: 2.593 ± 0.194
3.277ValArg: 3.277 ± 0.298
5.414ValSer: 5.414 ± 0.464
4.018ValThr: 4.018 ± 0.329
4.16ValVal: 4.16 ± 0.409
0.798ValTrp: 0.798 ± 0.117
2.65ValTyr: 2.65 ± 0.399
0.028ValXaa: 0.028 ± 0.028
Trp
0.855TrpAla: 0.855 ± 0.141
0.285TrpCys: 0.285 ± 0.088
0.342TrpAsp: 0.342 ± 0.099
0.484TrpGlu: 0.484 ± 0.096
0.285TrpPhe: 0.285 ± 0.089
0.627TrpGly: 0.627 ± 0.133
0.199TrpHis: 0.199 ± 0.074
0.598TrpIle: 0.598 ± 0.118
0.541TrpLys: 0.541 ± 0.136
1.596TrpLeu: 1.596 ± 0.204
0.171TrpMet: 0.171 ± 0.072
0.541TrpAsn: 0.541 ± 0.096
0.684TrpPro: 0.684 ± 0.116
0.541TrpGln: 0.541 ± 0.118
0.228TrpArg: 0.228 ± 0.074
0.94TrpSer: 0.94 ± 0.177
0.826TrpThr: 0.826 ± 0.145
0.798TrpVal: 0.798 ± 0.155
0.085TrpTrp: 0.085 ± 0.043
0.285TrpTyr: 0.285 ± 0.116
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.166TyrAla: 2.166 ± 0.2
1.026TyrCys: 1.026 ± 0.163
1.225TyrAsp: 1.225 ± 0.17
1.653TyrGlu: 1.653 ± 0.225
1.995TyrPhe: 1.995 ± 0.206
1.71TyrGly: 1.71 ± 0.21
1.054TyrHis: 1.054 ± 0.206
2.08TyrIle: 2.08 ± 0.231
1.681TyrLys: 1.681 ± 0.242
3.989TyrLeu: 3.989 ± 0.371
0.826TyrMet: 0.826 ± 0.132
1.567TyrAsn: 1.567 ± 0.261
1.795TyrPro: 1.795 ± 0.24
1.083TyrGln: 1.083 ± 0.152
1.482TyrArg: 1.482 ± 0.203
3.362TyrSer: 3.362 ± 0.298
2.194TyrThr: 2.194 ± 0.249
2.707TyrVal: 2.707 ± 0.286
0.342TyrTrp: 0.342 ± 0.076
1.282TyrTyr: 1.282 ± 0.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.028XaaAla: 0.028 ± 0.028
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.028XaaGlu: 0.028 ± 0.032
0.0XaaPhe: 0.0 ± 0.0
0.028XaaGly: 0.028 ± 0.028
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.028XaaArg: 0.028 ± 0.026
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (35095 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski