Amino acid dipepetide frequency for Serratia nematodiphila DZ0503SBS1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.38AlaAla: 13.38 ± 0.21	1.371AlaCys: 1.371 ± 0.06	5.524AlaAsp: 5.524 ± 0.115	6.414AlaGlu: 6.414 ± 0.133	3.902AlaPhe: 3.902 ± 0.092	8.649AlaGly: 8.649 ± 0.147	2.066AlaHis: 2.066 ± 0.062	5.832AlaIle: 5.832 ± 0.127	3.784AlaLys: 3.784 ± 0.085	13.425AlaLeu: 13.425 ± 0.223	3.19AlaMet: 3.19 ± 0.08	2.979AlaAsn: 2.979 ± 0.079	4.616AlaPro: 4.616 ± 0.099	5.262AlaGln: 5.262 ± 0.118	6.238AlaArg: 6.238 ± 0.118	5.522AlaSer: 5.522 ± 0.112	4.853AlaThr: 4.853 ± 0.098	7.459AlaVal: 7.459 ± 0.124	1.493AlaTrp: 1.493 ± 0.054	2.328AlaTyr: 2.328 ± 0.068	0.0AlaXaa: 0.0 ± 0.0
Cys	1.332CysAla: 1.332 ± 0.053	0.357CysCys: 0.357 ± 0.028	0.562CysAsp: 0.562 ± 0.036	0.592CysGlu: 0.592 ± 0.033	0.412CysPhe: 0.412 ± 0.028	1.239CysGly: 1.239 ± 0.053	0.308CysHis: 0.308 ± 0.027	0.57CysIle: 0.57 ± 0.039	0.3CysLys: 0.3 ± 0.024	1.091CysLeu: 1.091 ± 0.048	0.341CysMet: 0.341 ± 0.026	0.314CysAsn: 0.314 ± 0.026	0.497CysPro: 0.497 ± 0.032	0.43CysGln: 0.43 ± 0.031	1.152CysArg: 1.152 ± 0.05	0.921CysSer: 0.921 ± 0.041	0.574CysThr: 0.574 ± 0.035	0.795CysVal: 0.795 ± 0.041	0.365CysTrp: 0.365 ± 0.023	0.318CysTyr: 0.318 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	5.5AspAla: 5.5 ± 0.113	0.505AspCys: 0.505 ± 0.037	2.851AspAsp: 2.851 ± 0.099	3.222AspGlu: 3.222 ± 0.099	1.963AspPhe: 1.963 ± 0.063	3.898AspGly: 3.898 ± 0.108	1.006AspHis: 1.006 ± 0.054	3.058AspIle: 3.058 ± 0.074	2.283AspLys: 2.283 ± 0.071	4.658AspLeu: 4.658 ± 0.117	1.253AspMet: 1.253 ± 0.052	1.892AspAsn: 1.892 ± 0.065	2.062AspPro: 2.062 ± 0.067	1.669AspGln: 1.669 ± 0.063	3.241AspArg: 3.241 ± 0.084	2.811AspSer: 2.811 ± 0.081	2.202AspThr: 2.202 ± 0.071	3.5AspVal: 3.5 ± 0.088	0.769AspTrp: 0.769 ± 0.04	1.746AspTyr: 1.746 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.179GluAla: 5.179 ± 0.118	0.399GluCys: 0.399 ± 0.031	2.277GluAsp: 2.277 ± 0.086	3.084GluGlu: 3.084 ± 0.099	1.728GluPhe: 1.728 ± 0.057	3.305GluGly: 3.305 ± 0.082	1.46GluHis: 1.46 ± 0.062	2.936GluIle: 2.936 ± 0.085	2.34GluLys: 2.34 ± 0.082	5.863GluLeu: 5.863 ± 0.119	1.655GluMet: 1.655 ± 0.056	1.955GluAsn: 1.955 ± 0.059	2.212GluPro: 2.212 ± 0.069	3.628GluGln: 3.628 ± 0.096	4.121GluArg: 4.121 ± 0.099	2.582GluSer: 2.582 ± 0.064	2.687GluThr: 2.687 ± 0.08	3.589GluVal: 3.589 ± 0.095	0.726GluTrp: 0.726 ± 0.04	1.282GluTyr: 1.282 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.788PheAla: 3.788 ± 0.088	0.564PheCys: 0.564 ± 0.036	2.31PheAsp: 2.31 ± 0.065	1.738PheGlu: 1.738 ± 0.069	1.462PhePhe: 1.462 ± 0.061	3.149PheGly: 3.149 ± 0.08	0.884PheHis: 0.884 ± 0.041	2.259PheIle: 2.259 ± 0.069	1.16PheLys: 1.16 ± 0.05	3.103PheLeu: 3.103 ± 0.085	0.939PheMet: 0.939 ± 0.044	1.71PheAsn: 1.71 ± 0.051	1.43PhePro: 1.43 ± 0.053	1.154PheGln: 1.154 ± 0.05	1.894PheArg: 1.894 ± 0.059	2.837PheSer: 2.837 ± 0.087	2.16PheThr: 2.16 ± 0.07	2.571PheVal: 2.571 ± 0.073	0.56PheTrp: 0.56 ± 0.034	1.065PheTyr: 1.065 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	6.96GlyAla: 6.96 ± 0.136	1.142GlyCys: 1.142 ± 0.05	3.841GlyAsp: 3.841 ± 0.094	4.561GlyGlu: 4.561 ± 0.092	3.105GlyPhe: 3.105 ± 0.079	5.986GlyGly: 5.986 ± 0.147	1.693GlyHis: 1.693 ± 0.057	4.5GlyIle: 4.5 ± 0.101	3.733GlyLys: 3.733 ± 0.097	7.599GlyLeu: 7.599 ± 0.142	2.287GlyMet: 2.287 ± 0.066	2.624GlyAsn: 2.624 ± 0.09	2.083GlyPro: 2.083 ± 0.062	3.162GlyGln: 3.162 ± 0.087	4.271GlyArg: 4.271 ± 0.101	4.279GlySer: 4.279 ± 0.09	3.35GlyThr: 3.35 ± 0.08	5.905GlyVal: 5.905 ± 0.118	1.369GlyTrp: 1.369 ± 0.054	2.584GlyTyr: 2.584 ± 0.085	0.0GlyXaa: 0.0 ± 0.0
His	2.144HisAla: 2.144 ± 0.071	0.363HisCys: 0.363 ± 0.029	1.061HisAsp: 1.061 ± 0.052	1.008HisGlu: 1.008 ± 0.044	1.121HisPhe: 1.121 ± 0.05	1.821HisGly: 1.821 ± 0.063	0.854HisHis: 0.854 ± 0.045	1.188HisIle: 1.188 ± 0.049	0.612HisLys: 0.612 ± 0.036	2.405HisLeu: 2.405 ± 0.08	0.515HisMet: 0.515 ± 0.029	0.73HisAsn: 0.73 ± 0.035	1.407HisPro: 1.407 ± 0.058	1.397HisGln: 1.397 ± 0.062	1.61HisArg: 1.61 ± 0.068	1.29HisSer: 1.29 ± 0.057	1.024HisThr: 1.024 ± 0.05	1.314HisVal: 1.314 ± 0.05	0.44HisTrp: 0.44 ± 0.029	0.866HisTyr: 0.866 ± 0.041	0.0HisXaa: 0.0 ± 0.0
Ile	6.581IleAla: 6.581 ± 0.12	0.665IleCys: 0.665 ± 0.038	3.437IleAsp: 3.437 ± 0.089	3.066IleGlu: 3.066 ± 0.084	1.714IlePhe: 1.714 ± 0.063	4.796IleGly: 4.796 ± 0.122	1.097IleHis: 1.097 ± 0.048	2.665IleIle: 2.665 ± 0.076	2.056IleLys: 2.056 ± 0.064	4.453IleLeu: 4.453 ± 0.094	1.079IleMet: 1.079 ± 0.052	2.172IleAsn: 2.172 ± 0.067	2.342IlePro: 2.342 ± 0.075	1.705IleGln: 1.705 ± 0.068	2.993IleArg: 2.993 ± 0.085	3.34IleSer: 3.34 ± 0.082	3.011IleThr: 3.011 ± 0.086	3.758IleVal: 3.758 ± 0.082	0.657IleTrp: 0.657 ± 0.035	1.397IleTyr: 1.397 ± 0.057	0.0IleXaa: 0.0 ± 0.0
Lys	3.861LysAla: 3.861 ± 0.1	0.266LysCys: 0.266 ± 0.022	1.724LysAsp: 1.724 ± 0.064	1.876LysGlu: 1.876 ± 0.072	0.949LysPhe: 0.949 ± 0.045	2.511LysGly: 2.511 ± 0.083	0.835LysHis: 0.835 ± 0.046	1.965LysIle: 1.965 ± 0.061	1.547LysLys: 1.547 ± 0.066	4.098LysLeu: 4.098 ± 0.088	1.128LysMet: 1.128 ± 0.049	1.201LysAsn: 1.201 ± 0.048	2.156LysPro: 2.156 ± 0.07	1.943LysGln: 1.943 ± 0.061	2.586LysArg: 2.586 ± 0.075	2.091LysSer: 2.091 ± 0.073	2.156LysThr: 2.156 ± 0.063	2.65LysVal: 2.65 ± 0.079	0.438LysTrp: 0.438 ± 0.031	0.909LysTyr: 0.909 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	13.159LeuAla: 13.159 ± 0.167	1.407LeuCys: 1.407 ± 0.05	5.585LeuAsp: 5.585 ± 0.113	5.256LeuGlu: 5.256 ± 0.121	4.269LeuPhe: 4.269 ± 0.098	7.702LeuGly: 7.702 ± 0.135	2.375LeuHis: 2.375 ± 0.081	5.538LeuIle: 5.538 ± 0.122	4.044LeuLys: 4.044 ± 0.111	13.133LeuLeu: 13.133 ± 0.225	3.117LeuMet: 3.117 ± 0.087	3.888LeuAsn: 3.888 ± 0.092	5.999LeuPro: 5.999 ± 0.139	5.009LeuGln: 5.009 ± 0.1	6.712LeuArg: 6.712 ± 0.129	7.44LeuSer: 7.44 ± 0.137	6.138LeuThr: 6.138 ± 0.118	7.037LeuVal: 7.037 ± 0.108	1.462LeuTrp: 1.462 ± 0.065	2.715LeuTyr: 2.715 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	3.107MetAla: 3.107 ± 0.08	0.225MetCys: 0.225 ± 0.019	1.152MetAsp: 1.152 ± 0.048	1.134MetGlu: 1.134 ± 0.047	0.872MetPhe: 0.872 ± 0.039	1.732MetGly: 1.732 ± 0.057	0.493MetHis: 0.493 ± 0.035	1.377MetIle: 1.377 ± 0.058	1.259MetLys: 1.259 ± 0.052	3.381MetLeu: 3.381 ± 0.083	0.813MetMet: 0.813 ± 0.046	0.929MetAsn: 0.929 ± 0.036	1.454MetPro: 1.454 ± 0.054	1.316MetGln: 1.316 ± 0.048	1.657MetArg: 1.657 ± 0.061	1.876MetSer: 1.876 ± 0.058	1.742MetThr: 1.742 ± 0.061	1.88MetVal: 1.88 ± 0.072	0.233MetTrp: 0.233 ± 0.021	0.517MetTyr: 0.517 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.504AsnAla: 3.504 ± 0.083	0.367AsnCys: 0.367 ± 0.024	1.805AsnAsp: 1.805 ± 0.068	1.555AsnGlu: 1.555 ± 0.053	1.097AsnPhe: 1.097 ± 0.051	2.971AsnGly: 2.971 ± 0.086	0.785AsnHis: 0.785 ± 0.037	1.888AsnIle: 1.888 ± 0.058	1.205AsnLys: 1.205 ± 0.05	3.291AsnLeu: 3.291 ± 0.089	0.842AsnMet: 0.842 ± 0.044	1.326AsnAsn: 1.326 ± 0.061	1.892AsnPro: 1.892 ± 0.064	1.377AsnGln: 1.377 ± 0.061	2.133AsnArg: 2.133 ± 0.073	1.734AsnSer: 1.734 ± 0.059	1.683AsnThr: 1.683 ± 0.05	2.275AsnVal: 2.275 ± 0.071	0.523AsnTrp: 0.523 ± 0.034	1.04AsnTyr: 1.04 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	5.632ProAla: 5.632 ± 0.116	0.529ProCys: 0.529 ± 0.032	2.513ProAsp: 2.513 ± 0.081	3.123ProGlu: 3.123 ± 0.076	1.831ProPhe: 1.831 ± 0.059	3.324ProGly: 3.324 ± 0.089	1.059ProHis: 1.059 ± 0.05	2.058ProIle: 2.058 ± 0.069	1.493ProLys: 1.493 ± 0.054	5.611ProLeu: 5.611 ± 0.132	1.18ProMet: 1.18 ± 0.047	1.336ProAsn: 1.336 ± 0.054	2.417ProPro: 2.417 ± 0.094	2.75ProGln: 2.75 ± 0.08	2.348ProArg: 2.348 ± 0.069	2.484ProSer: 2.484 ± 0.075	2.292ProThr: 2.292 ± 0.06	3.299ProVal: 3.299 ± 0.079	0.655ProTrp: 0.655 ± 0.036	1.298ProTyr: 1.298 ± 0.06	0.0ProXaa: 0.0 ± 0.0
Gln	5.597GlnAla: 5.597 ± 0.122	0.456GlnCys: 0.456 ± 0.03	1.951GlnAsp: 1.951 ± 0.064	2.241GlnGlu: 2.241 ± 0.067	1.474GlnPhe: 1.474 ± 0.056	3.23GlnGly: 3.23 ± 0.087	1.411GlnHis: 1.411 ± 0.057	2.332GlnIle: 2.332 ± 0.074	1.351GlnLys: 1.351 ± 0.05	5.611GlnLeu: 5.611 ± 0.119	1.217GlnMet: 1.217 ± 0.05	1.215GlnAsn: 1.215 ± 0.058	2.657GlnPro: 2.657 ± 0.088	4.044GlnGln: 4.044 ± 0.13	4.242GlnArg: 4.242 ± 0.113	2.18GlnSer: 2.18 ± 0.072	2.235GlnThr: 2.235 ± 0.063	3.243GlnVal: 3.243 ± 0.076	0.683GlnTrp: 0.683 ± 0.043	1.101GlnTyr: 1.101 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	5.745ArgAla: 5.745 ± 0.121	1.081ArgCys: 1.081 ± 0.056	3.007ArgAsp: 3.007 ± 0.086	3.595ArgGlu: 3.595 ± 0.089	2.612ArgPhe: 2.612 ± 0.072	3.628ArgGly: 3.628 ± 0.086	1.961ArgHis: 1.961 ± 0.067	3.561ArgIle: 3.561 ± 0.091	2.375ArgLys: 2.375 ± 0.067	7.556ArgLeu: 7.556 ± 0.14	1.977ArgMet: 1.977 ± 0.066	1.931ArgAsn: 1.931 ± 0.07	2.78ArgPro: 2.78 ± 0.068	3.892ArgGln: 3.892 ± 0.098	5.569ArgArg: 5.569 ± 0.145	3.557ArgSer: 3.557 ± 0.096	2.612ArgThr: 2.612 ± 0.075	3.952ArgVal: 3.952 ± 0.081	1.284ArgTrp: 1.284 ± 0.056	2.312ArgTyr: 2.312 ± 0.07	0.0ArgXaa: 0.0 ± 0.0
Ser	6.321SerAla: 6.321 ± 0.124	0.817SerCys: 0.817 ± 0.039	2.636SerAsp: 2.636 ± 0.08	2.904SerGlu: 2.904 ± 0.081	2.18SerPhe: 2.18 ± 0.065	5.222SerGly: 5.222 ± 0.098	1.28SerHis: 1.28 ± 0.054	2.914SerIle: 2.914 ± 0.091	1.945SerLys: 1.945 ± 0.058	6.493SerLeu: 6.493 ± 0.13	1.428SerMet: 1.428 ± 0.056	1.827SerAsn: 1.827 ± 0.059	2.888SerPro: 2.888 ± 0.075	2.45SerGln: 2.45 ± 0.071	3.705SerArg: 3.705 ± 0.091	3.581SerSer: 3.581 ± 0.099	2.815SerThr: 2.815 ± 0.062	3.902SerVal: 3.902 ± 0.093	0.911SerTrp: 0.911 ± 0.045	1.647SerTyr: 1.647 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	5.277ThrAla: 5.277 ± 0.103	0.529ThrCys: 0.529 ± 0.033	2.287ThrAsp: 2.287 ± 0.072	2.277ThrGlu: 2.277 ± 0.07	1.837ThrPhe: 1.837 ± 0.065	4.064ThrGly: 4.064 ± 0.091	1.19ThrHis: 1.19 ± 0.051	2.419ThrIle: 2.419 ± 0.07	1.267ThrLys: 1.267 ± 0.056	7.444ThrLeu: 7.444 ± 0.139	1.032ThrMet: 1.032 ± 0.045	1.328ThrAsn: 1.328 ± 0.05	3.261ThrPro: 3.261 ± 0.082	1.977ThrGln: 1.977 ± 0.072	2.997ThrArg: 2.997 ± 0.069	2.697ThrSer: 2.697 ± 0.084	2.567ThrThr: 2.567 ± 0.079	3.721ThrVal: 3.721 ± 0.092	0.588ThrTrp: 0.588 ± 0.038	1.101ThrTyr: 1.101 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	7.434ValAla: 7.434 ± 0.128	0.84ValCys: 0.84 ± 0.045	3.591ValAsp: 3.591 ± 0.086	3.833ValGlu: 3.833 ± 0.095	2.517ValPhe: 2.517 ± 0.086	4.835ValGly: 4.835 ± 0.108	1.318ValHis: 1.318 ± 0.052	4.084ValIle: 4.084 ± 0.087	2.894ValLys: 2.894 ± 0.087	7.242ValLeu: 7.242 ± 0.133	2.129ValMet: 2.129 ± 0.06	2.624ValAsn: 2.624 ± 0.08	2.886ValPro: 2.886 ± 0.078	2.537ValGln: 2.537 ± 0.07	3.768ValArg: 3.768 ± 0.088	4.291ValSer: 4.291 ± 0.081	4.005ValThr: 4.005 ± 0.081	5.2ValVal: 5.2 ± 0.115	0.85ValTrp: 0.85 ± 0.041	1.71ValTyr: 1.71 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	1.14TrpAla: 1.14 ± 0.052	0.253TrpCys: 0.253 ± 0.023	0.582TrpAsp: 0.582 ± 0.033	0.527TrpGlu: 0.527 ± 0.033	0.523TrpPhe: 0.523 ± 0.036	0.856TrpGly: 0.856 ± 0.046	0.397TrpHis: 0.397 ± 0.031	0.655TrpIle: 0.655 ± 0.032	0.444TrpLys: 0.444 ± 0.028	2.318TrpLeu: 2.318 ± 0.084	0.47TrpMet: 0.47 ± 0.033	0.432TrpAsn: 0.432 ± 0.03	0.746TrpPro: 0.746 ± 0.037	1.093TrpGln: 1.093 ± 0.044	1.519TrpArg: 1.519 ± 0.062	0.752TrpSer: 0.752 ± 0.039	0.493TrpThr: 0.493 ± 0.035	0.868TrpVal: 0.868 ± 0.043	0.316TrpTrp: 0.316 ± 0.024	0.349TrpTyr: 0.349 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.648TyrAla: 2.648 ± 0.074	0.333TyrCys: 0.333 ± 0.025	1.393TyrAsp: 1.393 ± 0.051	1.002TyrGlu: 1.002 ± 0.043	1.168TyrPhe: 1.168 ± 0.043	2.115TyrGly: 2.115 ± 0.069	0.698TyrHis: 0.698 ± 0.037	1.184TyrIle: 1.184 ± 0.055	0.795TyrLys: 0.795 ± 0.039	3.21TyrLeu: 3.21 ± 0.078	0.554TyrMet: 0.554 ± 0.034	0.882TyrAsn: 0.882 ± 0.046	1.448TyrPro: 1.448 ± 0.055	1.677TyrGln: 1.677 ± 0.065	2.231TyrArg: 2.231 ± 0.067	1.6TyrSer: 1.6 ± 0.059	1.265TyrThr: 1.265 ± 0.052	1.667TyrVal: 1.667 ± 0.055	0.414TyrTrp: 0.414 ± 0.026	0.882TyrTyr: 0.882 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2715 proteins (493119 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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