Amino acid dipepetide frequency for Gregarina niphandrodes (Septate eugregarine)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.739AlaAla: 9.739 ± 0.115	1.483AlaCys: 1.483 ± 0.027	4.528AlaAsp: 4.528 ± 0.045	5.691AlaGlu: 5.691 ± 0.058	2.62AlaPhe: 2.62 ± 0.037	6.344AlaGly: 6.344 ± 0.06	1.819AlaHis: 1.819 ± 0.029	3.257AlaIle: 3.257 ± 0.04	3.894AlaLys: 3.894 ± 0.057	7.969AlaLeu: 7.969 ± 0.085	1.736AlaMet: 1.736 ± 0.029	2.57AlaAsn: 2.57 ± 0.033	4.728AlaPro: 4.728 ± 0.06	3.152AlaGln: 3.152 ± 0.045	4.949AlaArg: 4.949 ± 0.052	6.382AlaSer: 6.382 ± 0.059	5.346AlaThr: 5.346 ± 0.05	6.37AlaVal: 6.37 ± 0.067	0.963AlaTrp: 0.963 ± 0.018	1.867AlaTyr: 1.867 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.477CysAla: 1.477 ± 0.029	0.47CysCys: 0.47 ± 0.015	1.031CysAsp: 1.031 ± 0.027	1.07CysGlu: 1.07 ± 0.021	0.689CysPhe: 0.689 ± 0.014	1.429CysGly: 1.429 ± 0.027	0.532CysHis: 0.532 ± 0.015	0.825CysIle: 0.825 ± 0.019	0.735CysLys: 0.735 ± 0.017	2.042CysLeu: 2.042 ± 0.029	0.35CysMet: 0.35 ± 0.011	0.659CysAsn: 0.659 ± 0.017	1.062CysPro: 1.062 ± 0.028	0.755CysGln: 0.755 ± 0.018	1.347CysArg: 1.347 ± 0.026	1.466CysSer: 1.466 ± 0.026	0.939CysThr: 0.939 ± 0.019	1.542CysVal: 1.542 ± 0.028	0.268CysTrp: 0.268 ± 0.01	0.583CysTyr: 0.583 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.62AspAla: 4.62 ± 0.048	1.107AspCys: 1.107 ± 0.025	4.034AspAsp: 4.034 ± 0.058	4.145AspGlu: 4.145 ± 0.041	1.905AspPhe: 1.905 ± 0.025	4.079AspGly: 4.079 ± 0.047	1.418AspHis: 1.418 ± 0.027	2.482AspIle: 2.482 ± 0.035	2.255AspLys: 2.255 ± 0.034	5.731AspLeu: 5.731 ± 0.048	1.207AspMet: 1.207 ± 0.023	1.733AspAsn: 1.733 ± 0.028	3.402AspPro: 3.402 ± 0.042	2.354AspGln: 2.354 ± 0.037	3.771AspArg: 3.771 ± 0.046	4.066AspSer: 4.066 ± 0.054	2.844AspThr: 2.844 ± 0.036	4.043AspVal: 4.043 ± 0.038	0.926AspTrp: 0.926 ± 0.02	1.611AspTyr: 1.611 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	5.763GluAla: 5.763 ± 0.056	1.226GluCys: 1.226 ± 0.027	4.089GluAsp: 4.089 ± 0.044	5.763GluGlu: 5.763 ± 0.093	2.053GluPhe: 2.053 ± 0.032	4.157GluGly: 4.157 ± 0.051	1.424GluHis: 1.424 ± 0.028	2.624GluIle: 2.624 ± 0.037	3.094GluLys: 3.094 ± 0.042	6.305GluLeu: 6.305 ± 0.063	1.401GluMet: 1.401 ± 0.023	2.069GluAsn: 2.069 ± 0.032	3.192GluPro: 3.192 ± 0.05	2.772GluGln: 2.772 ± 0.039	4.359GluArg: 4.359 ± 0.047	4.568GluSer: 4.568 ± 0.048	3.92GluThr: 3.92 ± 0.04	4.24GluVal: 4.24 ± 0.046	0.994GluTrp: 0.994 ± 0.021	1.7GluTyr: 1.7 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	2.587PheAla: 2.587 ± 0.035	0.712PheCys: 0.712 ± 0.019	2.081PheAsp: 2.081 ± 0.03	2.041PheGlu: 2.041 ± 0.03	1.002PhePhe: 1.002 ± 0.019	2.599PheGly: 2.599 ± 0.033	0.751PheHis: 0.751 ± 0.017	1.368PheIle: 1.368 ± 0.025	1.431PheLys: 1.431 ± 0.024	2.869PheLeu: 2.869 ± 0.041	0.703PheMet: 0.703 ± 0.016	1.244PheAsn: 1.244 ± 0.022	1.493PhePro: 1.493 ± 0.028	1.22PheGln: 1.22 ± 0.023	2.003PheArg: 2.003 ± 0.031	2.279PheSer: 2.279 ± 0.03	1.719PheThr: 1.719 ± 0.026	2.434PheVal: 2.434 ± 0.032	0.53PheTrp: 0.53 ± 0.013	0.893PheTyr: 0.893 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	5.702GlyAla: 5.702 ± 0.062	1.421GlyCys: 1.421 ± 0.025	3.831GlyAsp: 3.831 ± 0.044	4.146GlyGlu: 4.146 ± 0.053	2.219GlyPhe: 2.219 ± 0.033	6.539GlyGly: 6.539 ± 0.096	1.585GlyHis: 1.585 ± 0.03	2.679GlyIle: 2.679 ± 0.038	3.021GlyLys: 3.021 ± 0.047	6.161GlyLeu: 6.161 ± 0.054	1.474GlyMet: 1.474 ± 0.028	2.293GlyAsn: 2.293 ± 0.038	3.702GlyPro: 3.702 ± 0.061	2.646GlyGln: 2.646 ± 0.044	4.799GlyArg: 4.799 ± 0.061	6.262GlySer: 6.262 ± 0.066	4.173GlyThr: 4.173 ± 0.051	4.822GlyVal: 4.822 ± 0.05	0.923GlyTrp: 0.923 ± 0.019	1.938GlyTyr: 1.938 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	1.675HisAla: 1.675 ± 0.028	0.463HisCys: 0.463 ± 0.013	1.333HisAsp: 1.333 ± 0.024	1.308HisGlu: 1.308 ± 0.024	0.856HisPhe: 0.856 ± 0.015	1.579HisGly: 1.579 ± 0.029	0.763HisHis: 0.763 ± 0.023	0.965HisIle: 0.965 ± 0.019	0.949HisLys: 0.949 ± 0.021	2.242HisLeu: 2.242 ± 0.031	0.459HisMet: 0.459 ± 0.014	0.782HisAsn: 0.782 ± 0.018	1.51HisPro: 1.51 ± 0.021	0.96HisGln: 0.96 ± 0.018	1.579HisArg: 1.579 ± 0.025	1.694HisSer: 1.694 ± 0.029	1.383HisThr: 1.383 ± 0.025	1.615HisVal: 1.615 ± 0.027	0.369HisTrp: 0.369 ± 0.012	0.711HisTyr: 0.711 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	3.256IleAla: 3.256 ± 0.037	0.839IleCys: 0.839 ± 0.018	2.507IleAsp: 2.507 ± 0.029	2.557IleGlu: 2.557 ± 0.034	1.276IlePhe: 1.276 ± 0.023	2.538IleGly: 2.538 ± 0.036	0.962IleHis: 0.962 ± 0.02	1.895IleIle: 1.895 ± 0.034	2.087IleLys: 2.087 ± 0.031	3.755IleLeu: 3.755 ± 0.043	0.833IleMet: 0.833 ± 0.017	1.605IleAsn: 1.605 ± 0.027	2.482IlePro: 2.482 ± 0.034	1.757IleGln: 1.757 ± 0.03	2.675IleArg: 2.675 ± 0.032	2.93IleSer: 2.93 ± 0.033	2.329IleThr: 2.329 ± 0.035	2.774IleVal: 2.774 ± 0.036	0.519IleTrp: 0.519 ± 0.013	1.098IleTyr: 1.098 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.916LysAla: 3.916 ± 0.059	0.857LysCys: 0.857 ± 0.019	2.462LysAsp: 2.462 ± 0.037	3.217LysGlu: 3.217 ± 0.046	1.403LysPhe: 1.403 ± 0.024	2.676LysGly: 2.676 ± 0.045	1.184LysHis: 1.184 ± 0.022	2.059LysIle: 2.059 ± 0.035	3.021LysLys: 3.021 ± 0.053	4.41LysLeu: 4.41 ± 0.045	1.004LysMet: 1.004 ± 0.019	1.683LysAsn: 1.683 ± 0.027	2.422LysPro: 2.422 ± 0.049	1.981LysGln: 1.981 ± 0.037	3.115LysArg: 3.115 ± 0.041	3.234LysSer: 3.234 ± 0.035	3.123LysThr: 3.123 ± 0.042	2.912LysVal: 2.912 ± 0.039	0.587LysTrp: 0.587 ± 0.015	1.301LysTyr: 1.301 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	8.046LeuAla: 8.046 ± 0.071	1.879LeuCys: 1.879 ± 0.031	5.589LeuAsp: 5.589 ± 0.049	6.056LeuGlu: 6.056 ± 0.053	3.065LeuPhe: 3.065 ± 0.043	6.094LeuGly: 6.094 ± 0.06	2.169LeuHis: 2.169 ± 0.026	3.73LeuIle: 3.73 ± 0.047	4.77LeuLys: 4.77 ± 0.047	9.507LeuLeu: 9.507 ± 0.086	1.973LeuMet: 1.973 ± 0.028	3.327LeuAsn: 3.327 ± 0.04	5.504LeuPro: 5.504 ± 0.056	4.054LeuGln: 4.054 ± 0.046	6.379LeuArg: 6.379 ± 0.059	7.289LeuSer: 7.289 ± 0.057	5.275LeuThr: 5.275 ± 0.049	6.373LeuVal: 6.373 ± 0.058	1.279LeuTrp: 1.279 ± 0.026	2.405LeuTyr: 2.405 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	1.796MetAla: 1.796 ± 0.027	0.354MetCys: 0.354 ± 0.011	1.213MetAsp: 1.213 ± 0.024	1.296MetGlu: 1.296 ± 0.025	0.656MetPhe: 0.656 ± 0.017	1.348MetGly: 1.348 ± 0.028	0.373MetHis: 0.373 ± 0.011	0.864MetIle: 0.864 ± 0.021	1.167MetLys: 1.167 ± 0.024	1.952MetLeu: 1.952 ± 0.031	0.532MetMet: 0.532 ± 0.016	0.793MetAsn: 0.793 ± 0.02	1.124MetPro: 1.124 ± 0.019	0.767MetGln: 0.767 ± 0.019	1.331MetArg: 1.331 ± 0.025	1.651MetSer: 1.651 ± 0.027	1.395MetThr: 1.395 ± 0.023	1.398MetVal: 1.398 ± 0.024	0.225MetTrp: 0.225 ± 0.009	0.474MetTyr: 0.474 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.786AsnAla: 2.786 ± 0.04	0.648AsnCys: 0.648 ± 0.016	1.961AsnAsp: 1.961 ± 0.029	2.165AsnGlu: 2.165 ± 0.033	1.031AsnPhe: 1.031 ± 0.021	2.485AsnGly: 2.485 ± 0.041	0.833AsnHis: 0.833 ± 0.019	1.553AsnIle: 1.553 ± 0.029	1.667AsnLys: 1.667 ± 0.027	3.087AsnLeu: 3.087 ± 0.039	0.747AsnMet: 0.747 ± 0.017	1.36AsnAsn: 1.36 ± 0.031	1.996AsnPro: 1.996 ± 0.031	1.409AsnGln: 1.409 ± 0.024	2.103AsnArg: 2.103 ± 0.029	2.455AsnSer: 2.455 ± 0.034	1.957AsnThr: 1.957 ± 0.032	2.394AsnVal: 2.394 ± 0.034	0.505AsnTrp: 0.505 ± 0.014	1.017AsnTyr: 1.017 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.233ProAla: 5.233 ± 0.074	0.838ProCys: 0.838 ± 0.02	3.152ProAsp: 3.152 ± 0.039	3.943ProGlu: 3.943 ± 0.055	1.782ProPhe: 1.782 ± 0.028	4.197ProGly: 4.197 ± 0.064	1.236ProHis: 1.236 ± 0.025	2.075ProIle: 2.075 ± 0.025	2.359ProLys: 2.359 ± 0.047	4.989ProLeu: 4.989 ± 0.049	1.083ProMet: 1.083 ± 0.024	1.889ProAsn: 1.889 ± 0.029	4.223ProPro: 4.223 ± 0.067	2.068ProGln: 2.068 ± 0.032	3.448ProArg: 3.448 ± 0.043	4.892ProSer: 4.892 ± 0.061	3.757ProThr: 3.757 ± 0.06	4.302ProVal: 4.302 ± 0.053	0.721ProTrp: 0.721 ± 0.016	1.293ProTyr: 1.293 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.161GlnAla: 3.161 ± 0.043	0.708GlnCys: 0.708 ± 0.017	2.323GlnAsp: 2.323 ± 0.036	2.544GlnGlu: 2.544 ± 0.037	1.264GlnPhe: 1.264 ± 0.023	2.339GlnGly: 2.339 ± 0.036	0.958GlnHis: 0.958 ± 0.019	1.668GlnIle: 1.668 ± 0.024	1.879GlnLys: 1.879 ± 0.033	4.233GlnLeu: 4.233 ± 0.048	0.909GlnMet: 0.909 ± 0.019	1.371GlnAsn: 1.371 ± 0.027	2.257GlnPro: 2.257 ± 0.038	2.176GlnGln: 2.176 ± 0.051	2.694GlnArg: 2.694 ± 0.033	2.84GlnSer: 2.84 ± 0.039	2.458GlnThr: 2.458 ± 0.035	2.709GlnVal: 2.709 ± 0.034	0.619GlnTrp: 0.619 ± 0.015	1.061GlnTyr: 1.061 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.838ArgAla: 4.838 ± 0.047	1.252ArgCys: 1.252 ± 0.022	3.465ArgAsp: 3.465 ± 0.048	4.15ArgGlu: 4.15 ± 0.05	2.133ArgPhe: 2.133 ± 0.032	4.049ArgGly: 4.049 ± 0.052	1.664ArgHis: 1.664 ± 0.025	2.677ArgIle: 2.677 ± 0.035	3.199ArgLys: 3.199 ± 0.034	6.72ArgLeu: 6.72 ± 0.06	1.339ArgMet: 1.339 ± 0.022	2.301ArgAsn: 2.301 ± 0.027	3.686ArgPro: 3.686 ± 0.052	2.83ArgGln: 2.83 ± 0.036	5.555ArgArg: 5.555 ± 0.066	5.121ArgSer: 5.121 ± 0.058	3.667ArgThr: 3.667 ± 0.042	4.266ArgVal: 4.266 ± 0.041	0.993ArgTrp: 0.993 ± 0.019	1.766ArgTyr: 1.766 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	6.308SerAla: 6.308 ± 0.06	1.42SerCys: 1.42 ± 0.027	4.18SerAsp: 4.18 ± 0.05	4.774SerGlu: 4.774 ± 0.06	2.481SerPhe: 2.481 ± 0.033	6.216SerGly: 6.216 ± 0.066	1.64SerHis: 1.64 ± 0.029	2.996SerIle: 2.996 ± 0.037	3.294SerLys: 3.294 ± 0.045	6.946SerLeu: 6.946 ± 0.06	1.544SerMet: 1.544 ± 0.023	2.558SerAsn: 2.558 ± 0.036	4.763SerPro: 4.763 ± 0.064	2.864SerGln: 2.864 ± 0.037	5.034SerArg: 5.034 ± 0.056	7.162SerSer: 7.162 ± 0.088	4.607SerThr: 4.607 ± 0.053	5.37SerVal: 5.37 ± 0.047	1.019SerTrp: 1.019 ± 0.022	1.795SerTyr: 1.795 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.453ThrAla: 5.453 ± 0.058	1.091ThrCys: 1.091 ± 0.021	3.309ThrAsp: 3.309 ± 0.033	3.773ThrGlu: 3.773 ± 0.047	1.753ThrPhe: 1.753 ± 0.027	4.505ThrGly: 4.505 ± 0.056	1.356ThrHis: 1.356 ± 0.027	2.424ThrIle: 2.424 ± 0.031	2.665ThrLys: 2.665 ± 0.039	5.259ThrLeu: 5.259 ± 0.054	1.168ThrMet: 1.168 ± 0.02	2.025ThrAsn: 2.025 ± 0.027	3.755ThrPro: 3.755 ± 0.048	2.169ThrGln: 2.169 ± 0.036	3.494ThrArg: 3.494 ± 0.038	4.588ThrSer: 4.588 ± 0.049	4.874ThrThr: 4.874 ± 0.089	4.053ThrVal: 4.053 ± 0.04	0.689ThrTrp: 0.689 ± 0.019	1.37ThrTyr: 1.37 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	6.276ValAla: 6.276 ± 0.056	1.629ValCys: 1.629 ± 0.027	4.274ValAsp: 4.274 ± 0.041	4.701ValGlu: 4.701 ± 0.047	2.275ValPhe: 2.275 ± 0.029	4.621ValGly: 4.621 ± 0.043	1.505ValHis: 1.505 ± 0.024	2.802ValIle: 2.802 ± 0.04	3.197ValLys: 3.197 ± 0.043	6.485ValLeu: 6.485 ± 0.061	1.395ValMet: 1.395 ± 0.021	2.272ValAsn: 2.272 ± 0.034	4.251ValPro: 4.251 ± 0.048	2.648ValGln: 2.648 ± 0.031	4.22ValArg: 4.22 ± 0.035	5.18ValSer: 5.18 ± 0.044	3.847ValThr: 3.847 ± 0.039	5.345ValVal: 5.345 ± 0.052	0.966ValTrp: 0.966 ± 0.023	1.77ValTyr: 1.77 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.951TrpAla: 0.951 ± 0.021	0.268TrpCys: 0.268 ± 0.008	0.744TrpAsp: 0.744 ± 0.019	0.806TrpGlu: 0.806 ± 0.018	0.544TrpPhe: 0.544 ± 0.014	0.701TrpGly: 0.701 ± 0.017	0.314TrpHis: 0.314 ± 0.011	0.6TrpIle: 0.6 ± 0.016	0.717TrpLys: 0.717 ± 0.018	1.54TrpLeu: 1.54 ± 0.03	0.332TrpMet: 0.332 ± 0.012	0.595TrpAsn: 0.595 ± 0.014	0.622TrpPro: 0.622 ± 0.017	0.544TrpGln: 0.544 ± 0.012	1.02TrpArg: 1.02 ± 0.02	1.135TrpSer: 1.135 ± 0.028	0.864TrpThr: 0.864 ± 0.02	0.842TrpVal: 0.842 ± 0.017	0.303TrpTrp: 0.303 ± 0.013	0.381TrpTyr: 0.381 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.823TyrAla: 1.823 ± 0.028	0.607TyrCys: 0.607 ± 0.014	1.627TyrAsp: 1.627 ± 0.027	1.566TyrGlu: 1.566 ± 0.023	0.951TyrPhe: 0.951 ± 0.021	1.841TyrGly: 1.841 ± 0.032	0.709TyrHis: 0.709 ± 0.017	1.133TyrIle: 1.133 ± 0.02	1.166TyrLys: 1.166 ± 0.02	2.562TyrLeu: 2.562 ± 0.032	0.52TyrMet: 0.52 ± 0.016	1.028TyrAsn: 1.028 ± 0.02	1.306TyrPro: 1.306 ± 0.024	1.045TyrGln: 1.045 ± 0.023	1.795TyrArg: 1.795 ± 0.029	1.778TyrSer: 1.778 ± 0.026	1.297TyrThr: 1.297 ± 0.028	1.858TyrVal: 1.858 ± 0.03	0.424TyrTrp: 0.424 ± 0.014	0.916TyrTyr: 0.916 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6341 proteins (2913775 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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