human papillomavirus 200

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 2

Average proteome isoelectric point is 6.0

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A0H4M3P4|A0A0H4M3P4_9PAPI Minor capsid protein L2 OS=human papillomavirus 200 OX=1682339 GN=L2 PE=3 SV=1
MM1 pKa = 7.43SLPRR5 pKa = 11.84RR6 pKa = 11.84KK7 pKa = 9.58RR8 pKa = 11.84ASPTDD13 pKa = 3.72LYY15 pKa = 10.02KK16 pKa = 10.6TCLQGGDD23 pKa = 4.92CIPDD27 pKa = 3.32VKK29 pKa = 11.21NKK31 pKa = 10.3FEE33 pKa = 4.15NTTIADD39 pKa = 3.72WLLKK43 pKa = 10.07IFGSIVYY50 pKa = 9.49FGNLGIGSGKK60 pKa = 8.45GTGGSFGYY68 pKa = 10.22RR69 pKa = 11.84PLGSAGSGRR78 pKa = 11.84PAQEE82 pKa = 4.23LPITRR87 pKa = 11.84PNVVIEE93 pKa = 4.36PIGPQSIVPIDD104 pKa = 4.02PGASSIVPLAEE115 pKa = 4.87GGLDD119 pKa = 3.36TSFITPDD126 pKa = 3.31AGPGVGGEE134 pKa = 4.29DD135 pKa = 2.9IEE137 pKa = 5.81LFTFTDD143 pKa = 3.7PATDD147 pKa = 3.16VGGVSGGPHH156 pKa = 6.92IISTQEE162 pKa = 3.58NEE164 pKa = 3.99TAIIDD169 pKa = 3.98ASPTVPPRR177 pKa = 11.84QVLYY181 pKa = 10.76DD182 pKa = 3.8SYY184 pKa = 11.73SNTLFEE190 pKa = 4.24THH192 pKa = 6.4VNPFLNNSLNTTNIFVDD209 pKa = 3.85PQLAGDD215 pKa = 3.96TVGEE219 pKa = 4.34NIFEE223 pKa = 4.72NIPLEE228 pKa = 4.33DD229 pKa = 4.79LSLQTLPTEE238 pKa = 4.32STPIRR243 pKa = 11.84PGRR246 pKa = 11.84ILRR249 pKa = 11.84TPAQRR254 pKa = 11.84SYY256 pKa = 11.21NRR258 pKa = 11.84FMEE261 pKa = 4.09QYY263 pKa = 9.76PIQSLDD269 pKa = 3.64FLSQPSRR276 pKa = 11.84LVQFEE281 pKa = 4.31FEE283 pKa = 4.7NPAFDD288 pKa = 4.68PDD290 pKa = 3.26ISLEE294 pKa = 3.87FQRR297 pKa = 11.84DD298 pKa = 3.77VNRR301 pKa = 11.84LEE303 pKa = 4.32AAPNAAFADD312 pKa = 3.47IAYY315 pKa = 9.96LSRR318 pKa = 11.84PRR320 pKa = 11.84VSLTSEE326 pKa = 3.67GLVRR330 pKa = 11.84VSRR333 pKa = 11.84IGTRR337 pKa = 11.84AALQTRR343 pKa = 11.84SGLTVGPQVHH353 pKa = 5.92YY354 pKa = 10.74FMDD357 pKa = 4.47LSAIPSEE364 pKa = 4.35NIEE367 pKa = 4.21LQPLGDD373 pKa = 3.65FTSRR377 pKa = 11.84STVVDD382 pKa = 4.01DD383 pKa = 3.95YY384 pKa = 11.94LAVTEE389 pKa = 5.01IDD391 pKa = 3.89DD392 pKa = 4.26PANIANVTYY401 pKa = 10.85SEE403 pKa = 5.44DD404 pKa = 3.9DD405 pKa = 3.78LLDD408 pKa = 4.29PLLEE412 pKa = 4.52SFDD415 pKa = 3.96NSHH418 pKa = 6.27ITIQGVNEE426 pKa = 4.19EE427 pKa = 4.64GDD429 pKa = 4.21TVTLPLPSVSNASKK443 pKa = 10.75IFIADD448 pKa = 4.33LANGLIFNDD457 pKa = 4.44YY458 pKa = 10.69NPQIYY463 pKa = 8.34PASTVISGSPWYY475 pKa = 10.6SIIEE479 pKa = 4.01RR480 pKa = 11.84NFADD484 pKa = 4.79FVLDD488 pKa = 3.51PAFIPRR494 pKa = 11.84KK495 pKa = 9.12RR496 pKa = 11.84RR497 pKa = 11.84RR498 pKa = 11.84LEE500 pKa = 3.57ILL502 pKa = 3.33

Molecular weight: 54.67 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A0H4LNX5|A0A0H4LNX5_9PAPI Protein E7 OS=human papillomavirus 200 OX=1682339 GN=E7 PE=3 SV=1
MM1 pKa = 7.3QPEE4 pKa = 4.41TQEE7 pKa = 4.06SLSARR12 pKa = 11.84FAAQQEE18 pKa = 4.31IQLNLIEE25 pKa = 4.82KK26 pKa = 10.06EE27 pKa = 4.2SYY29 pKa = 10.16DD30 pKa = 4.07LKK32 pKa = 11.44DD33 pKa = 3.25HH34 pKa = 6.74LEE36 pKa = 3.72YY37 pKa = 10.32WKK39 pKa = 10.64AVRR42 pKa = 11.84AEE44 pKa = 3.99NVIAYY49 pKa = 7.06YY50 pKa = 10.49ARR52 pKa = 11.84KK53 pKa = 8.79EE54 pKa = 4.21HH55 pKa = 6.44INKK58 pKa = 10.1LGLQQLPTTAVTEE71 pKa = 4.42YY72 pKa = 10.29KK73 pKa = 10.6AKK75 pKa = 10.43EE76 pKa = 4.31AINMQLLIQSLMKK89 pKa = 10.58SSFAMEE95 pKa = 3.99RR96 pKa = 11.84WTLSEE101 pKa = 4.11TSAEE105 pKa = 4.64SINSSPRR112 pKa = 11.84NCFKK116 pKa = 10.81KK117 pKa = 10.53SPFIVTVWFDD127 pKa = 3.16NDD129 pKa = 3.18EE130 pKa = 4.52RR131 pKa = 11.84NSFPYY136 pKa = 9.67TCWDD140 pKa = 3.45YY141 pKa = 11.35IYY143 pKa = 10.76FQDD146 pKa = 5.01EE147 pKa = 3.69QNMWHH152 pKa = 6.32KK153 pKa = 8.96THH155 pKa = 6.74GLVDD159 pKa = 3.67HH160 pKa = 7.32DD161 pKa = 3.6GCYY164 pKa = 10.81YY165 pKa = 10.71KK166 pKa = 10.87DD167 pKa = 3.67NNGDD171 pKa = 3.29SVYY174 pKa = 10.66FILFHH179 pKa = 7.04PDD181 pKa = 2.47AVKK184 pKa = 10.9YY185 pKa = 10.89GNTGLWTVKK194 pKa = 10.17FKK196 pKa = 11.52NKK198 pKa = 9.19TISASVTSSSRR209 pKa = 11.84HH210 pKa = 5.59SIPSFEE216 pKa = 3.86GRR218 pKa = 11.84VWPSTSTSPEE228 pKa = 4.0SPGGGLQDD236 pKa = 3.62TSQNSSTEE244 pKa = 4.31SPTSSTPGLRR254 pKa = 11.84LRR256 pKa = 11.84RR257 pKa = 11.84RR258 pKa = 11.84RR259 pKa = 11.84RR260 pKa = 11.84QSGEE264 pKa = 3.65PGEE267 pKa = 4.97SGTADD272 pKa = 3.45EE273 pKa = 4.58TPKK276 pKa = 10.6RR277 pKa = 11.84RR278 pKa = 11.84GIKK281 pKa = 9.89RR282 pKa = 11.84KK283 pKa = 9.73LGSDD287 pKa = 3.56TAPSPSEE294 pKa = 3.88VGSRR298 pKa = 11.84SHH300 pKa = 4.87TLEE303 pKa = 3.63RR304 pKa = 11.84SGYY307 pKa = 8.52SRR309 pKa = 11.84LRR311 pKa = 11.84RR312 pKa = 11.84LQEE315 pKa = 3.72EE316 pKa = 4.18ARR318 pKa = 11.84DD319 pKa = 3.7PPIALFTGHH328 pKa = 6.24QNNLKK333 pKa = 9.88CWRR336 pKa = 11.84NRR338 pKa = 11.84CTTKK342 pKa = 10.65YY343 pKa = 10.59SSLFVAFSSVWKK355 pKa = 9.45WLGPNVSGGAAKK367 pKa = 10.64LLVAFSSNSQRR378 pKa = 11.84EE379 pKa = 4.31LFLSTVHH386 pKa = 6.07IPKK389 pKa = 8.88GTSVTLGNLNSLL401 pKa = 4.15

Molecular weight: 45.32 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2247

93

598

374.5

42.17

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.919 ± 0.277

2.403 ± 0.849

6.008 ± 0.474

6.142 ± 0.312

5.34 ± 0.452

5.518 ± 0.884

1.38 ± 0.302

5.518 ± 0.655

5.296 ± 0.97

9.39 ± 0.466

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.424 ± 0.271

5.696 ± 0.235

5.652 ± 0.903

3.961 ± 0.199

5.118 ± 0.484

8.767 ± 0.848

6.186 ± 0.35

5.385 ± 0.302

1.424 ± 0.284

3.471 ± 0.298
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski