Amino acid dipepetide frequency for Phenylobacterium parvum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.632AlaAla: 21.632 ± 0.304	1.314AlaCys: 1.314 ± 0.041	7.747AlaAsp: 7.747 ± 0.132	8.437AlaGlu: 8.437 ± 0.153	5.027AlaPhe: 5.027 ± 0.085	14.425AlaGly: 14.425 ± 0.235	2.112AlaHis: 2.112 ± 0.046	4.799AlaIle: 4.799 ± 0.067	2.847AlaLys: 2.847 ± 0.081	15.116AlaLeu: 15.116 ± 0.188	3.068AlaMet: 3.068 ± 0.062	2.729AlaAsn: 2.729 ± 0.094	8.119AlaPro: 8.119 ± 0.151	3.85AlaGln: 3.85 ± 0.078	12.007AlaArg: 12.007 ± 0.165	6.968AlaSer: 6.968 ± 0.118	5.427AlaThr: 5.427 ± 0.136	9.467AlaVal: 9.467 ± 0.132	2.196AlaTrp: 2.196 ± 0.052	2.571AlaTyr: 2.571 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.104CysAla: 1.104 ± 0.035	0.076CysCys: 0.076 ± 0.009	0.534CysAsp: 0.534 ± 0.027	0.438CysGlu: 0.438 ± 0.023	0.253CysPhe: 0.253 ± 0.019	0.836CysGly: 0.836 ± 0.031	0.16CysHis: 0.16 ± 0.014	0.304CysIle: 0.304 ± 0.018	0.142CysLys: 0.142 ± 0.015	0.759CysLeu: 0.759 ± 0.026	0.14CysMet: 0.14 ± 0.012	0.169CysAsn: 0.169 ± 0.014	0.456CysPro: 0.456 ± 0.027	0.229CysGln: 0.229 ± 0.018	0.542CysArg: 0.542 ± 0.027	0.344CysSer: 0.344 ± 0.022	0.373CysThr: 0.373 ± 0.021	0.552CysVal: 0.552 ± 0.025	0.087CysTrp: 0.087 ± 0.01	0.152CysTyr: 0.152 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.314AspAla: 7.314 ± 0.097	0.4AspCys: 0.4 ± 0.024	2.765AspAsp: 2.765 ± 0.082	3.053AspGlu: 3.053 ± 0.081	2.295AspPhe: 2.295 ± 0.057	5.289AspGly: 5.289 ± 0.113	1.096AspHis: 1.096 ± 0.038	2.534AspIle: 2.534 ± 0.052	1.182AspLys: 1.182 ± 0.04	7.198AspLeu: 7.198 ± 0.092	1.262AspMet: 1.262 ± 0.041	1.051AspAsn: 1.051 ± 0.041	4.582AspPro: 4.582 ± 0.082	1.721AspGln: 1.721 ± 0.047	5.0AspArg: 5.0 ± 0.089	2.19AspSer: 2.19 ± 0.09	2.323AspThr: 2.323 ± 0.13	3.705AspVal: 3.705 ± 0.065	1.083AspTrp: 1.083 ± 0.043	1.41AspTyr: 1.41 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	10.351GluAla: 10.351 ± 0.183	0.257GluCys: 0.257 ± 0.015	3.042GluAsp: 3.042 ± 0.065	2.646GluGlu: 2.646 ± 0.069	1.478GluPhe: 1.478 ± 0.046	5.588GluGly: 5.588 ± 0.097	0.914GluHis: 0.914 ± 0.038	2.984GluIle: 2.984 ± 0.069	1.652GluLys: 1.652 ± 0.05	4.611GluLeu: 4.611 ± 0.087	1.324GluMet: 1.324 ± 0.04	1.098GluAsn: 1.098 ± 0.036	2.893GluPro: 2.893 ± 0.065	1.484GluGln: 1.484 ± 0.043	4.65GluArg: 4.65 ± 0.087	2.277GluSer: 2.277 ± 0.063	3.722GluThr: 3.722 ± 0.076	4.492GluVal: 4.492 ± 0.082	0.646GluTrp: 0.646 ± 0.03	0.793GluTyr: 0.793 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.425PheAla: 4.425 ± 0.066	0.38PheCys: 0.38 ± 0.022	2.505PheAsp: 2.505 ± 0.054	2.247PheGlu: 2.247 ± 0.049	1.159PhePhe: 1.159 ± 0.036	3.718PheGly: 3.718 ± 0.073	0.629PheHis: 0.629 ± 0.03	1.443PheIle: 1.443 ± 0.045	0.716PheLys: 0.716 ± 0.03	3.427PheLeu: 3.427 ± 0.075	0.727PheMet: 0.727 ± 0.031	0.987PheAsn: 0.987 ± 0.037	1.588PhePro: 1.588 ± 0.046	0.984PheGln: 0.984 ± 0.036	2.57PheArg: 2.57 ± 0.057	2.093PheSer: 2.093 ± 0.061	2.078PheThr: 2.078 ± 0.066	2.387PheVal: 2.387 ± 0.056	0.546PheTrp: 0.546 ± 0.025	0.699PheTyr: 0.699 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	12.744GlyAla: 12.744 ± 0.283	0.799GlyCys: 0.799 ± 0.032	5.394GlyAsp: 5.394 ± 0.139	5.672GlyGlu: 5.672 ± 0.09	3.879GlyPhe: 3.879 ± 0.084	9.834GlyGly: 9.834 ± 0.28	1.578GlyHis: 1.578 ± 0.047	3.031GlyIle: 3.031 ± 0.062	2.518GlyLys: 2.518 ± 0.064	11.047GlyLeu: 11.047 ± 0.14	2.198GlyMet: 2.198 ± 0.052	1.919GlyAsn: 1.919 ± 0.129	5.062GlyPro: 5.062 ± 0.092	3.06GlyGln: 3.06 ± 0.067	8.249GlyArg: 8.249 ± 0.126	4.567GlySer: 4.567 ± 0.138	3.547GlyThr: 3.547 ± 0.168	8.02GlyVal: 8.02 ± 0.105	1.607GlyTrp: 1.607 ± 0.046	2.241GlyTyr: 2.241 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.121HisAla: 2.121 ± 0.053	0.189HisCys: 0.189 ± 0.014	0.906HisAsp: 0.906 ± 0.033	0.909HisGlu: 0.909 ± 0.032	0.657HisPhe: 0.657 ± 0.026	1.623HisGly: 1.623 ± 0.052	0.431HisHis: 0.431 ± 0.028	0.676HisIle: 0.676 ± 0.027	0.33HisLys: 0.33 ± 0.018	1.744HisLeu: 1.744 ± 0.054	0.385HisMet: 0.385 ± 0.025	0.348HisAsn: 0.348 ± 0.018	1.309HisPro: 1.309 ± 0.039	0.505HisGln: 0.505 ± 0.023	1.298HisArg: 1.298 ± 0.036	0.653HisSer: 0.653 ± 0.029	0.603HisThr: 0.603 ± 0.023	1.255HisVal: 1.255 ± 0.043	0.274HisTrp: 0.274 ± 0.017	0.433HisTyr: 0.433 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.577IleAla: 5.577 ± 0.076	0.39IleCys: 0.39 ± 0.021	2.879IleAsp: 2.879 ± 0.054	2.673IleGlu: 2.673 ± 0.07	1.34IlePhe: 1.34 ± 0.043	3.832IleGly: 3.832 ± 0.071	0.693IleHis: 0.693 ± 0.026	1.475IleIle: 1.475 ± 0.045	0.798IleLys: 0.798 ± 0.037	4.284IleLeu: 4.284 ± 0.075	0.681IleMet: 0.681 ± 0.031	1.079IleAsn: 1.079 ± 0.045	1.99IlePro: 1.99 ± 0.048	1.146IleGln: 1.146 ± 0.034	3.123IleArg: 3.123 ± 0.069	2.284IleSer: 2.284 ± 0.082	2.17IleThr: 2.17 ± 0.078	2.921IleVal: 2.921 ± 0.057	0.479IleTrp: 0.479 ± 0.024	0.796IleTyr: 0.796 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.881LysAla: 3.881 ± 0.084	0.091LysCys: 0.091 ± 0.01	1.431LysAsp: 1.431 ± 0.045	0.991LysGlu: 0.991 ± 0.041	0.689LysPhe: 0.689 ± 0.028	2.416LysGly: 2.416 ± 0.069	0.362LysHis: 0.362 ± 0.018	1.181LysIle: 1.181 ± 0.034	0.693LysLys: 0.693 ± 0.033	2.148LysLeu: 2.148 ± 0.059	0.587LysMet: 0.587 ± 0.029	0.462LysAsn: 0.462 ± 0.023	1.693LysPro: 1.693 ± 0.055	0.574LysGln: 0.574 ± 0.032	1.708LysArg: 1.708 ± 0.053	1.386LysSer: 1.386 ± 0.044	1.576LysThr: 1.576 ± 0.051	2.206LysVal: 2.206 ± 0.061	0.285LysTrp: 0.285 ± 0.018	0.424LysTyr: 0.424 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	16.327LeuAla: 16.327 ± 0.199	0.757LeuCys: 0.757 ± 0.033	6.274LeuAsp: 6.274 ± 0.092	6.096LeuGlu: 6.096 ± 0.103	3.353LeuPhe: 3.353 ± 0.067	9.152LeuGly: 9.152 ± 0.128	1.701LeuHis: 1.701 ± 0.048	3.956LeuIle: 3.956 ± 0.079	3.486LeuLys: 3.486 ± 0.071	8.617LeuLeu: 8.617 ± 0.148	2.186LeuMet: 2.186 ± 0.052	2.442LeuAsn: 2.442 ± 0.055	5.791LeuPro: 5.791 ± 0.107	2.59LeuGln: 2.59 ± 0.052	7.245LeuArg: 7.245 ± 0.11	6.778LeuSer: 6.778 ± 0.129	5.79LeuThr: 5.79 ± 0.13	7.961LeuVal: 7.961 ± 0.106	1.185LeuTrp: 1.185 ± 0.041	1.814LeuTyr: 1.814 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.077MetAla: 3.077 ± 0.068	0.152MetCys: 0.152 ± 0.014	1.181MetAsp: 1.181 ± 0.034	1.06MetGlu: 1.06 ± 0.037	0.585MetPhe: 0.585 ± 0.028	1.941MetGly: 1.941 ± 0.057	0.333MetHis: 0.333 ± 0.024	1.037MetIle: 1.037 ± 0.034	0.828MetLys: 0.828 ± 0.029	1.815MetLeu: 1.815 ± 0.048	0.543MetMet: 0.543 ± 0.027	0.62MetAsn: 0.62 ± 0.028	1.183MetPro: 1.183 ± 0.039	0.589MetGln: 0.589 ± 0.026	1.544MetArg: 1.544 ± 0.043	1.627MetSer: 1.627 ± 0.044	1.779MetThr: 1.779 ± 0.047	1.414MetVal: 1.414 ± 0.044	0.171MetTrp: 0.171 ± 0.016	0.26MetTyr: 0.26 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.891AsnAla: 2.891 ± 0.082	0.193AsnCys: 0.193 ± 0.016	1.152AsnAsp: 1.152 ± 0.083	0.809AsnGlu: 0.809 ± 0.031	0.824AsnPhe: 0.824 ± 0.036	2.083AsnGly: 2.083 ± 0.063	0.372AsnHis: 0.372 ± 0.022	1.053AsnIle: 1.053 ± 0.04	0.372AsnLys: 0.372 ± 0.024	2.405AsnLeu: 2.405 ± 0.064	0.475AsnMet: 0.475 ± 0.024	0.535AsnAsn: 0.535 ± 0.035	1.83AsnPro: 1.83 ± 0.054	0.557AsnGln: 0.557 ± 0.029	1.685AsnArg: 1.685 ± 0.047	0.98AsnSer: 0.98 ± 0.036	1.107AsnThr: 1.107 ± 0.06	1.646AsnVal: 1.646 ± 0.056	0.337AsnTrp: 0.337 ± 0.019	0.629AsnTyr: 0.629 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	8.386ProAla: 8.386 ± 0.151	0.357ProCys: 0.357 ± 0.02	4.387ProAsp: 4.387 ± 0.08	4.51ProGlu: 4.51 ± 0.094	1.993ProPhe: 1.993 ± 0.057	6.533ProGly: 6.533 ± 0.099	0.962ProHis: 0.962 ± 0.039	1.919ProIle: 1.919 ± 0.051	1.368ProLys: 1.368 ± 0.038	5.115ProLeu: 5.115 ± 0.086	1.157ProMet: 1.157 ± 0.033	1.195ProAsn: 1.195 ± 0.044	3.906ProPro: 3.906 ± 0.105	1.566ProGln: 1.566 ± 0.041	3.909ProArg: 3.909 ± 0.083	2.877ProSer: 2.877 ± 0.059	2.529ProThr: 2.529 ± 0.063	4.645ProVal: 4.645 ± 0.078	0.818ProTrp: 0.818 ± 0.032	1.021ProTyr: 1.021 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.591GlnAla: 4.591 ± 0.088	0.16GlnCys: 0.16 ± 0.015	1.369GlnAsp: 1.369 ± 0.044	1.237GlnGlu: 1.237 ± 0.042	0.881GlnPhe: 0.881 ± 0.038	2.741GlnGly: 2.741 ± 0.059	0.456GlnHis: 0.456 ± 0.022	1.27GlnIle: 1.27 ± 0.042	0.947GlnLys: 0.947 ± 0.036	2.353GlnLeu: 2.353 ± 0.061	0.703GlnMet: 0.703 ± 0.028	0.554GlnAsn: 0.554 ± 0.028	1.519GlnPro: 1.519 ± 0.047	0.718GlnGln: 0.718 ± 0.035	1.948GlnArg: 1.948 ± 0.046	1.396GlnSer: 1.396 ± 0.04	1.567GlnThr: 1.567 ± 0.047	2.695GlnVal: 2.695 ± 0.052	0.314GlnTrp: 0.314 ± 0.018	0.422GlnTyr: 0.422 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.751ArgAla: 9.751 ± 0.148	0.478ArgCys: 0.478 ± 0.022	4.206ArgAsp: 4.206 ± 0.076	4.564ArgGlu: 4.564 ± 0.093	3.038ArgPhe: 3.038 ± 0.069	5.87ArgGly: 5.87 ± 0.097	1.333ArgHis: 1.333 ± 0.04	4.184ArgIle: 4.184 ± 0.079	2.13ArgLys: 2.13 ± 0.051	9.884ArgLeu: 9.884 ± 0.154	1.949ArgMet: 1.949 ± 0.052	1.78ArgAsn: 1.78 ± 0.047	5.049ArgPro: 5.049 ± 0.118	2.478ArgGln: 2.478 ± 0.055	7.587ArgArg: 7.587 ± 0.145	3.831ArgSer: 3.831 ± 0.069	4.207ArgThr: 4.207 ± 0.069	5.327ArgVal: 5.327 ± 0.091	1.11ArgTrp: 1.11 ± 0.036	1.614ArgTyr: 1.614 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.553SerAla: 6.553 ± 0.132	0.313SerCys: 0.313 ± 0.021	2.82SerAsp: 2.82 ± 0.065	2.674SerGlu: 2.674 ± 0.052	1.786SerPhe: 1.786 ± 0.048	6.397SerGly: 6.397 ± 0.219	0.837SerHis: 0.837 ± 0.032	1.889SerIle: 1.889 ± 0.059	1.103SerLys: 1.103 ± 0.039	5.502SerLeu: 5.502 ± 0.112	1.042SerMet: 1.042 ± 0.037	1.175SerAsn: 1.175 ± 0.053	3.383SerPro: 3.383 ± 0.066	1.524SerGln: 1.524 ± 0.042	4.109SerArg: 4.109 ± 0.075	2.381SerSer: 2.381 ± 0.084	2.449SerThr: 2.449 ± 0.076	3.797SerVal: 3.797 ± 0.078	0.693SerTrp: 0.693 ± 0.028	0.995SerTyr: 0.995 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.147ThrAla: 6.147 ± 0.117	0.395ThrCys: 0.395 ± 0.025	2.607ThrAsp: 2.607 ± 0.063	2.374ThrGlu: 2.374 ± 0.056	1.94ThrPhe: 1.94 ± 0.057	5.839ThrGly: 5.839 ± 0.177	0.814ThrHis: 0.814 ± 0.031	1.689ThrIle: 1.689 ± 0.072	0.84ThrLys: 0.84 ± 0.042	6.019ThrLeu: 6.019 ± 0.166	0.766ThrMet: 0.766 ± 0.032	1.017ThrAsn: 1.017 ± 0.05	4.04ThrPro: 4.04 ± 0.081	1.272ThrGln: 1.272 ± 0.044	3.556ThrArg: 3.556 ± 0.068	2.475ThrSer: 2.475 ± 0.08	2.393ThrThr: 2.393 ± 0.075	3.842ThrVal: 3.842 ± 0.104	0.742ThrTrp: 0.742 ± 0.032	1.154ThrTyr: 1.154 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	8.943ValAla: 8.943 ± 0.097	0.63ValCys: 0.63 ± 0.032	4.253ValAsp: 4.253 ± 0.071	4.779ValGlu: 4.779 ± 0.102	2.831ValPhe: 2.831 ± 0.068	5.823ValGly: 5.823 ± 0.111	1.289ValHis: 1.289 ± 0.041	3.792ValIle: 3.792 ± 0.078	1.946ValLys: 1.946 ± 0.05	8.068ValLeu: 8.068 ± 0.115	1.688ValMet: 1.688 ± 0.044	1.872ValAsn: 1.872 ± 0.064	3.007ValPro: 3.007 ± 0.06	2.089ValGln: 2.089 ± 0.047	6.462ValArg: 6.462 ± 0.088	4.294ValSer: 4.294 ± 0.088	4.401ValThr: 4.401 ± 0.106	5.664ValVal: 5.664 ± 0.087	1.001ValTrp: 1.001 ± 0.034	1.421ValTyr: 1.421 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.44TrpAla: 1.44 ± 0.047	0.154TrpCys: 0.154 ± 0.014	0.678TrpAsp: 0.678 ± 0.031	0.657TrpGlu: 0.657 ± 0.026	0.514TrpPhe: 0.514 ± 0.023	1.081TrpGly: 1.081 ± 0.04	0.213TrpHis: 0.213 ± 0.016	0.67TrpIle: 0.67 ± 0.031	0.464TrpLys: 0.464 ± 0.025	1.492TrpLeu: 1.492 ± 0.042	0.42TrpMet: 0.42 ± 0.02	0.414TrpAsn: 0.414 ± 0.021	0.795TrpPro: 0.795 ± 0.03	0.322TrpGln: 0.322 ± 0.02	1.539TrpArg: 1.539 ± 0.043	0.975TrpSer: 0.975 ± 0.041	0.942TrpThr: 0.942 ± 0.036	0.841TrpVal: 0.841 ± 0.034	0.225TrpTrp: 0.225 ± 0.017	0.272TrpTyr: 0.272 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.603TyrAla: 2.603 ± 0.06	0.167TyrCys: 0.167 ± 0.015	1.328TyrAsp: 1.328 ± 0.057	1.078TyrGlu: 1.078 ± 0.045	0.784TyrPhe: 0.784 ± 0.03	1.943TyrGly: 1.943 ± 0.057	0.362TyrHis: 0.362 ± 0.02	0.722TyrIle: 0.722 ± 0.028	0.422TyrLys: 0.422 ± 0.025	1.901TyrLeu: 1.901 ± 0.05	0.438TyrMet: 0.438 ± 0.021	0.486TyrAsn: 0.486 ± 0.031	0.958TyrPro: 0.958 ± 0.032	0.581TyrGln: 0.581 ± 0.026	1.64TyrArg: 1.64 ± 0.048	1.045TyrSer: 1.045 ± 0.045	0.936TyrThr: 0.936 ± 0.045	1.416TyrVal: 1.416 ± 0.042	0.31TyrTrp: 0.31 ± 0.018	0.457TyrTyr: 0.457 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2596 proteins (863946 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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