Amino acid dipepetide frequency for Alcanivorax pacificus W11-5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.314AlaAla: 13.314 ± 0.156
1.183AlaCys: 1.183 ± 0.035
6.349AlaAsp: 6.349 ± 0.08
6.61AlaGlu: 6.61 ± 0.07
3.524AlaPhe: 3.524 ± 0.059
10.215AlaGly: 10.215 ± 0.139
2.23AlaHis: 2.23 ± 0.043
4.556AlaIle: 4.556 ± 0.06
2.228AlaLys: 2.228 ± 0.051
14.525AlaLeu: 14.525 ± 0.175
3.083AlaMet: 3.083 ± 0.056
2.548AlaAsn: 2.548 ± 0.06
5.38AlaPro: 5.38 ± 0.101
4.504AlaGln: 4.504 ± 0.079
8.768AlaArg: 8.768 ± 0.109
5.961AlaSer: 5.961 ± 0.078
5.343AlaThr: 5.343 ± 0.086
7.928AlaVal: 7.928 ± 0.095
1.681AlaTrp: 1.681 ± 0.044
2.218AlaTyr: 2.218 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.045CysAla: 1.045 ± 0.035
0.135CysCys: 0.135 ± 0.01
0.588CysAsp: 0.588 ± 0.023
0.549CysGlu: 0.549 ± 0.022
0.328CysPhe: 0.328 ± 0.016
0.988CysGly: 0.988 ± 0.031
0.334CysHis: 0.334 ± 0.017
0.391CysIle: 0.391 ± 0.02
0.225CysLys: 0.225 ± 0.015
1.042CysLeu: 1.042 ± 0.031
0.187CysMet: 0.187 ± 0.011
0.231CysAsn: 0.231 ± 0.015
0.515CysPro: 0.515 ± 0.022
0.363CysGln: 0.363 ± 0.017
0.698CysArg: 0.698 ± 0.03
0.468CysSer: 0.468 ± 0.02
0.449CysThr: 0.449 ± 0.02
0.647CysVal: 0.647 ± 0.025
0.155CysTrp: 0.155 ± 0.012
0.242CysTyr: 0.242 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.795AspAla: 6.795 ± 0.092
0.511AspCys: 0.511 ± 0.022
3.923AspAsp: 3.923 ± 0.081
3.614AspGlu: 3.614 ± 0.062
2.181AspPhe: 2.181 ± 0.043
5.247AspGly: 5.247 ± 0.098
1.256AspHis: 1.256 ± 0.033
3.239AspIle: 3.239 ± 0.056
1.543AspLys: 1.543 ± 0.037
5.554AspLeu: 5.554 ± 0.071
1.537AspMet: 1.537 ± 0.035
1.924AspAsn: 1.924 ± 0.043
2.903AspPro: 2.903 ± 0.058
2.224AspGln: 2.224 ± 0.038
3.603AspArg: 3.603 ± 0.056
2.962AspSer: 2.962 ± 0.05
3.49AspThr: 3.49 ± 0.069
4.135AspVal: 4.135 ± 0.07
1.048AspTrp: 1.048 ± 0.03
1.865AspTyr: 1.865 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.609GluAla: 6.609 ± 0.076
0.418GluCys: 0.418 ± 0.022
3.006GluAsp: 3.006 ± 0.046
3.323GluGlu: 3.323 ± 0.069
1.765GluPhe: 1.765 ± 0.043
4.021GluGly: 4.021 ± 0.056
1.574GluHis: 1.574 ± 0.045
2.759GluIle: 2.759 ± 0.051
2.053GluLys: 2.053 ± 0.054
5.928GluLeu: 5.928 ± 0.071
1.47GluMet: 1.47 ± 0.033
1.571GluAsn: 1.571 ± 0.039
2.386GluPro: 2.386 ± 0.046
3.879GluGln: 3.879 ± 0.067
4.826GluArg: 4.826 ± 0.079
2.466GluSer: 2.466 ± 0.048
2.84GluThr: 2.84 ± 0.05
4.12GluVal: 4.12 ± 0.06
0.736GluTrp: 0.736 ± 0.026
1.48GluTyr: 1.48 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.592PheAla: 3.592 ± 0.057
0.424PheCys: 0.424 ± 0.02
2.481PheAsp: 2.481 ± 0.047
2.005PheGlu: 2.005 ± 0.041
1.398PhePhe: 1.398 ± 0.042
3.217PheGly: 3.217 ± 0.055
0.805PheHis: 0.805 ± 0.03
1.563PheIle: 1.563 ± 0.04
0.726PheLys: 0.726 ± 0.023
3.155PheLeu: 3.155 ± 0.06
0.884PheMet: 0.884 ± 0.027
1.249PheAsn: 1.249 ± 0.029
1.511PhePro: 1.511 ± 0.036
1.047PheGln: 1.047 ± 0.031
2.451PheArg: 2.451 ± 0.056
2.427PheSer: 2.427 ± 0.048
1.958PheThr: 1.958 ± 0.04
2.381PheVal: 2.381 ± 0.048
0.544PheTrp: 0.544 ± 0.022
1.008PheTyr: 1.008 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
8.018GlyAla: 8.018 ± 0.117
0.927GlyCys: 0.927 ± 0.033
4.935GlyAsp: 4.935 ± 0.099
5.215GlyGlu: 5.215 ± 0.073
3.094GlyPhe: 3.094 ± 0.052
7.145GlyGly: 7.145 ± 0.372
1.909GlyHis: 1.909 ± 0.036
4.025GlyIle: 4.025 ± 0.067
2.556GlyLys: 2.556 ± 0.056
8.748GlyLeu: 8.748 ± 0.098
2.351GlyMet: 2.351 ± 0.049
2.552GlyAsn: 2.552 ± 0.084
2.598GlyPro: 2.598 ± 0.051
3.409GlyGln: 3.409 ± 0.057
5.512GlyArg: 5.512 ± 0.066
4.362GlySer: 4.362 ± 0.091
4.397GlyThr: 4.397 ± 0.084
6.072GlyVal: 6.072 ± 0.08
1.419GlyTrp: 1.419 ± 0.036
2.442GlyTyr: 2.442 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.418HisAla: 2.418 ± 0.046
0.339HisCys: 0.339 ± 0.018
1.341HisAsp: 1.341 ± 0.035
1.125HisGlu: 1.125 ± 0.028
1.017HisPhe: 1.017 ± 0.031
2.052HisGly: 2.052 ± 0.045
0.74HisHis: 0.74 ± 0.028
1.029HisIle: 1.029 ± 0.032
0.452HisLys: 0.452 ± 0.019
2.592HisLeu: 2.592 ± 0.046
0.546HisMet: 0.546 ± 0.021
0.626HisAsn: 0.626 ± 0.021
1.508HisPro: 1.508 ± 0.038
0.98HisGln: 0.98 ± 0.03
1.806HisArg: 1.806 ± 0.045
1.187HisSer: 1.187 ± 0.03
1.157HisThr: 1.157 ± 0.033
1.347HisVal: 1.347 ± 0.039
0.466HisTrp: 0.466 ± 0.017
0.801HisTyr: 0.801 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.03IleAla: 5.03 ± 0.064
0.431IleCys: 0.431 ± 0.019
2.992IleAsp: 2.992 ± 0.05
3.033IleGlu: 3.033 ± 0.051
1.315IlePhe: 1.315 ± 0.038
3.877IleGly: 3.877 ± 0.068
1.008IleHis: 1.008 ± 0.031
1.956IleIle: 1.956 ± 0.046
1.238IleLys: 1.238 ± 0.035
3.897IleLeu: 3.897 ± 0.063
0.877IleMet: 0.877 ± 0.028
1.751IleAsn: 1.751 ± 0.039
2.097IlePro: 2.097 ± 0.045
1.491IleGln: 1.491 ± 0.033
3.265IleArg: 3.265 ± 0.057
2.917IleSer: 2.917 ± 0.056
2.724IleThr: 2.724 ± 0.056
2.919IleVal: 2.919 ± 0.052
0.559IleTrp: 0.559 ± 0.022
1.07IleTyr: 1.07 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.99LysAla: 2.99 ± 0.063
0.164LysCys: 0.164 ± 0.013
1.337LysAsp: 1.337 ± 0.039
1.327LysGlu: 1.327 ± 0.041
0.659LysPhe: 0.659 ± 0.027
1.811LysGly: 1.811 ± 0.047
0.558LysHis: 0.558 ± 0.02
1.165LysIle: 1.165 ± 0.04
1.117LysLys: 1.117 ± 0.041
2.692LysLeu: 2.692 ± 0.052
0.62LysMet: 0.62 ± 0.024
0.723LysAsn: 0.723 ± 0.031
1.502LysPro: 1.502 ± 0.036
1.181LysGln: 1.181 ± 0.031
1.849LysArg: 1.849 ± 0.045
1.29LysSer: 1.29 ± 0.036
1.432LysThr: 1.432 ± 0.038
2.117LysVal: 2.117 ± 0.045
0.297LysTrp: 0.297 ± 0.018
0.578LysTyr: 0.578 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
14.127LeuAla: 14.127 ± 0.141
1.248LeuCys: 1.248 ± 0.033
6.83LeuAsp: 6.83 ± 0.085
5.921LeuGlu: 5.921 ± 0.074
4.031LeuPhe: 4.031 ± 0.069
8.546LeuGly: 8.546 ± 0.104
2.692LeuHis: 2.692 ± 0.054
4.757LeuIle: 4.757 ± 0.071
3.073LeuLys: 3.073 ± 0.063
13.337LeuLeu: 13.337 ± 0.16
2.675LeuMet: 2.675 ± 0.051
3.191LeuAsn: 3.191 ± 0.051
6.755LeuPro: 6.755 ± 0.095
3.929LeuGln: 3.929 ± 0.063
8.442LeuArg: 8.442 ± 0.09
6.712LeuSer: 6.712 ± 0.073
6.118LeuThr: 6.118 ± 0.077
8.16LeuVal: 8.16 ± 0.096
1.53LeuTrp: 1.53 ± 0.046
2.602LeuTyr: 2.602 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.965MetAla: 2.965 ± 0.053
0.147MetCys: 0.147 ± 0.012
1.262MetAsp: 1.262 ± 0.035
1.174MetGlu: 1.174 ± 0.034
0.686MetPhe: 0.686 ± 0.026
1.566MetGly: 1.566 ± 0.038
0.495MetHis: 0.495 ± 0.02
1.134MetIle: 1.134 ± 0.031
0.884MetLys: 0.884 ± 0.029
2.97MetLeu: 2.97 ± 0.052
0.607MetMet: 0.607 ± 0.021
0.833MetAsn: 0.833 ± 0.028
1.482MetPro: 1.482 ± 0.036
1.114MetGln: 1.114 ± 0.031
1.605MetArg: 1.605 ± 0.037
1.564MetSer: 1.564 ± 0.038
1.618MetThr: 1.618 ± 0.04
1.689MetVal: 1.689 ± 0.036
0.193MetTrp: 0.193 ± 0.012
0.383MetTyr: 0.383 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.069AsnAla: 3.069 ± 0.061
0.225AsnCys: 0.225 ± 0.018
1.699AsnAsp: 1.699 ± 0.039
1.476AsnGlu: 1.476 ± 0.041
0.881AsnPhe: 0.881 ± 0.027
2.528AsnGly: 2.528 ± 0.06
0.562AsnHis: 0.562 ± 0.023
1.469AsnIle: 1.469 ± 0.039
0.671AsnLys: 0.671 ± 0.026
2.961AsnLeu: 2.961 ± 0.054
0.627AsnMet: 0.627 ± 0.024
0.916AsnAsn: 0.916 ± 0.031
1.843AsnPro: 1.843 ± 0.044
1.029AsnGln: 1.029 ± 0.031
1.926AsnArg: 1.926 ± 0.043
1.361AsnSer: 1.361 ± 0.038
1.523AsnThr: 1.523 ± 0.04
1.943AsnVal: 1.943 ± 0.043
0.4AsnTrp: 0.4 ± 0.018
0.721AsnTyr: 0.721 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
6.711ProAla: 6.711 ± 0.102
0.352ProCys: 0.352 ± 0.02
3.712ProAsp: 3.712 ± 0.054
3.612ProGlu: 3.612 ± 0.065
1.717ProPhe: 1.717 ± 0.039
4.616ProGly: 4.616 ± 0.068
1.082ProHis: 1.082 ± 0.028
1.629ProIle: 1.629 ± 0.037
1.063ProLys: 1.063 ± 0.031
5.665ProLeu: 5.665 ± 0.087
1.222ProMet: 1.222 ± 0.032
1.14ProAsn: 1.14 ± 0.034
2.582ProPro: 2.582 ± 0.065
1.914ProGln: 1.914 ± 0.041
2.797ProArg: 2.797 ± 0.057
2.264ProSer: 2.264 ± 0.046
2.084ProThr: 2.084 ± 0.043
4.699ProVal: 4.699 ± 0.09
0.803ProTrp: 0.803 ± 0.029
1.142ProTyr: 1.142 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
5.431GlnAla: 5.431 ± 0.074
0.391GlnCys: 0.391 ± 0.019
2.033GlnAsp: 2.033 ± 0.043
1.918GlnGlu: 1.918 ± 0.049
1.297GlnPhe: 1.297 ± 0.032
3.33GlnGly: 3.33 ± 0.061
1.126GlnHis: 1.126 ± 0.031
1.799GlnIle: 1.799 ± 0.038
1.017GlnLys: 1.017 ± 0.033
4.717GlnLeu: 4.717 ± 0.074
0.949GlnMet: 0.949 ± 0.03
0.892GlnAsn: 0.892 ± 0.028
2.333GlnPro: 2.333 ± 0.05
2.649GlnGln: 2.649 ± 0.066
3.683GlnArg: 3.683 ± 0.059
1.978GlnSer: 1.978 ± 0.064
1.808GlnThr: 1.808 ± 0.04
3.378GlnVal: 3.378 ± 0.061
0.722GlnTrp: 0.722 ± 0.024
0.991GlnTyr: 0.991 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
7.385ArgAla: 7.385 ± 0.093
0.602ArgCys: 0.602 ± 0.023
4.642ArgAsp: 4.642 ± 0.068
4.862ArgGlu: 4.862 ± 0.073
3.069ArgPhe: 3.069 ± 0.05
4.557ArgGly: 4.557 ± 0.07
2.171ArgHis: 2.171 ± 0.049
3.577ArgIle: 3.577 ± 0.056
1.95ArgLys: 1.95 ± 0.05
8.89ArgLeu: 8.89 ± 0.096
1.808ArgMet: 1.808 ± 0.034
1.986ArgAsn: 1.986 ± 0.041
3.129ArgPro: 3.129 ± 0.059
3.563ArgGln: 3.563 ± 0.062
5.79ArgArg: 5.79 ± 0.092
3.283ArgSer: 3.283 ± 0.058
3.386ArgThr: 3.386 ± 0.057
5.205ArgVal: 5.205 ± 0.071
1.266ArgTrp: 1.266 ± 0.033
2.282ArgTyr: 2.282 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
5.805SerAla: 5.805 ± 0.076
0.426SerCys: 0.426 ± 0.018
3.113SerAsp: 3.113 ± 0.057
2.913SerGlu: 2.913 ± 0.047
1.93SerPhe: 1.93 ± 0.041
5.22SerGly: 5.22 ± 0.094
1.248SerHis: 1.248 ± 0.034
2.261SerIle: 2.261 ± 0.054
1.255SerLys: 1.255 ± 0.038
6.339SerLeu: 6.339 ± 0.077
1.242SerMet: 1.242 ± 0.03
1.392SerAsn: 1.392 ± 0.04
2.657SerPro: 2.657 ± 0.044
2.08SerGln: 2.08 ± 0.044
3.698SerArg: 3.698 ± 0.061
2.957SerSer: 2.957 ± 0.068
2.653SerThr: 2.653 ± 0.048
3.999SerVal: 3.999 ± 0.083
0.745SerTrp: 0.745 ± 0.025
1.28SerTyr: 1.28 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.346ThrAla: 5.346 ± 0.087
0.448ThrCys: 0.448 ± 0.02
3.12ThrAsp: 3.12 ± 0.062
2.665ThrGlu: 2.665 ± 0.041
1.734ThrPhe: 1.734 ± 0.046
5.049ThrGly: 5.049 ± 0.07
1.119ThrHis: 1.119 ± 0.035
1.877ThrIle: 1.877 ± 0.05
0.816ThrLys: 0.816 ± 0.028
7.655ThrLeu: 7.655 ± 0.098
0.903ThrMet: 0.903 ± 0.029
1.052ThrAsn: 1.052 ± 0.037
3.501ThrPro: 3.501 ± 0.061
1.872ThrGln: 1.872 ± 0.044
3.693ThrArg: 3.693 ± 0.058
2.477ThrSer: 2.477 ± 0.048
2.591ThrThr: 2.591 ± 0.05
4.193ThrVal: 4.193 ± 0.087
0.71ThrTrp: 0.71 ± 0.023
1.104ThrTyr: 1.104 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.023ValAla: 8.023 ± 0.102
0.703ValCys: 0.703 ± 0.022
4.148ValAsp: 4.148 ± 0.069
4.058ValGlu: 4.058 ± 0.061
2.627ValPhe: 2.627 ± 0.042
4.723ValGly: 4.723 ± 0.084
1.511ValHis: 1.511 ± 0.032
3.682ValIle: 3.682 ± 0.061
1.731ValLys: 1.731 ± 0.044
8.648ValLeu: 8.648 ± 0.098
1.877ValMet: 1.877 ± 0.04
2.203ValAsn: 2.203 ± 0.046
4.083ValPro: 4.083 ± 0.065
2.805ValGln: 2.805 ± 0.059
5.298ValArg: 5.298 ± 0.074
4.504ValSer: 4.504 ± 0.083
4.459ValThr: 4.459 ± 0.094
5.595ValVal: 5.595 ± 0.09
0.902ValTrp: 0.902 ± 0.03
1.624ValTyr: 1.624 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.137TrpAla: 1.137 ± 0.03
0.207TrpCys: 0.207 ± 0.013
0.641TrpAsp: 0.641 ± 0.022
0.614TrpGlu: 0.614 ± 0.023
0.585TrpPhe: 0.585 ± 0.022
0.877TrpGly: 0.877 ± 0.031
0.479TrpHis: 0.479 ± 0.019
0.588TrpIle: 0.588 ± 0.021
0.309TrpLys: 0.309 ± 0.015
2.435TrpLeu: 2.435 ± 0.053
0.411TrpMet: 0.411 ± 0.019
0.339TrpAsn: 0.339 ± 0.018
0.769TrpPro: 0.769 ± 0.028
1.137TrpGln: 1.137 ± 0.034
1.362TrpArg: 1.362 ± 0.044
0.689TrpSer: 0.689 ± 0.023
0.598TrpThr: 0.598 ± 0.023
1.016TrpVal: 1.016 ± 0.028
0.265TrpTrp: 0.265 ± 0.017
0.356TrpTyr: 0.356 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.339TyrAla: 2.339 ± 0.041
0.3TyrCys: 0.3 ± 0.015
1.402TyrAsp: 1.402 ± 0.04
1.211TyrGlu: 1.211 ± 0.036
0.985TyrPhe: 0.985 ± 0.031
2.103TyrGly: 2.103 ± 0.047
0.628TyrHis: 0.628 ± 0.021
0.993TyrIle: 0.993 ± 0.033
0.502TyrLys: 0.502 ± 0.021
2.928TyrLeu: 2.928 ± 0.05
0.494TyrMet: 0.494 ± 0.021
0.711TyrAsn: 0.711 ± 0.026
1.269TyrPro: 1.269 ± 0.036
1.269TyrGln: 1.269 ± 0.035
2.333TyrArg: 2.333 ± 0.048
1.382TyrSer: 1.382 ± 0.034
1.299TyrThr: 1.299 ± 0.036
1.664TyrVal: 1.664 ± 0.043
0.375TyrTrp: 0.375 ± 0.019
0.704TyrTyr: 0.704 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3686 proteins (1228667 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski