Amino acid dipepetide frequency for Oceaniovalibus guishaninsula JLT2003

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.551AlaAla: 20.551 ± 0.26	1.179AlaCys: 1.179 ± 0.04	8.906AlaAsp: 8.906 ± 0.113	7.61AlaGlu: 7.61 ± 0.106	4.716AlaPhe: 4.716 ± 0.076	12.188AlaGly: 12.188 ± 0.15	2.328AlaHis: 2.328 ± 0.056	6.399AlaIle: 6.399 ± 0.089	2.611AlaLys: 2.611 ± 0.063	15.141AlaLeu: 15.141 ± 0.158	4.387AlaMet: 4.387 ± 0.077	2.466AlaAsn: 2.466 ± 0.055	6.669AlaPro: 6.669 ± 0.108	4.402AlaGln: 4.402 ± 0.068	11.525AlaArg: 11.525 ± 0.16	5.504AlaSer: 5.504 ± 0.081	6.481AlaThr: 6.481 ± 0.088	9.428AlaVal: 9.428 ± 0.116	1.762AlaTrp: 1.762 ± 0.054	2.408AlaTyr: 2.408 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.194CysAla: 1.194 ± 0.041	0.098CysCys: 0.098 ± 0.011	0.634CysAsp: 0.634 ± 0.028	0.363CysGlu: 0.363 ± 0.022	0.307CysPhe: 0.307 ± 0.019	0.901CysGly: 0.901 ± 0.035	0.257CysHis: 0.257 ± 0.018	0.435CysIle: 0.435 ± 0.027	0.152CysLys: 0.152 ± 0.013	0.89CysLeu: 0.89 ± 0.031	0.13CysMet: 0.13 ± 0.011	0.204CysAsn: 0.204 ± 0.013	0.509CysPro: 0.509 ± 0.025	0.185CysGln: 0.185 ± 0.016	0.678CysArg: 0.678 ± 0.027	0.343CysSer: 0.343 ± 0.021	0.411CysThr: 0.411 ± 0.022	0.537CysVal: 0.537 ± 0.028	0.108CysTrp: 0.108 ± 0.012	0.187CysTyr: 0.187 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	9.704AspAla: 9.704 ± 0.127	0.509AspCys: 0.509 ± 0.023	4.527AspAsp: 4.527 ± 0.091	3.624AspGlu: 3.624 ± 0.067	2.295AspPhe: 2.295 ± 0.057	6.784AspGly: 6.784 ± 0.094	1.299AspHis: 1.299 ± 0.038	3.031AspIle: 3.031 ± 0.053	1.316AspLys: 1.316 ± 0.046	7.187AspLeu: 7.187 ± 0.105	1.751AspMet: 1.751 ± 0.042	1.126AspAsn: 1.126 ± 0.038	4.634AspPro: 4.634 ± 0.079	1.491AspGln: 1.491 ± 0.04	6.33AspArg: 6.33 ± 0.081	2.083AspSer: 2.083 ± 0.05	3.136AspThr: 3.136 ± 0.063	4.403AspVal: 4.403 ± 0.08	1.398AspTrp: 1.398 ± 0.042	1.456AspTyr: 1.456 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.167GluAla: 7.167 ± 0.1	0.334GluCys: 0.334 ± 0.018	2.996GluAsp: 2.996 ± 0.059	2.422GluGlu: 2.422 ± 0.068	1.332GluPhe: 1.332 ± 0.039	4.695GluGly: 4.695 ± 0.072	0.911GluHis: 0.911 ± 0.036	2.938GluIle: 2.938 ± 0.046	1.455GluLys: 1.455 ± 0.049	4.094GluLeu: 4.094 ± 0.079	1.579GluMet: 1.579 ± 0.039	1.232GluAsn: 1.232 ± 0.036	2.278GluPro: 2.278 ± 0.058	1.499GluGln: 1.499 ± 0.052	4.501GluArg: 4.501 ± 0.083	1.867GluSer: 1.867 ± 0.042	3.414GluThr: 3.414 ± 0.07	3.815GluVal: 3.815 ± 0.074	0.729GluTrp: 0.729 ± 0.031	0.961GluTyr: 0.961 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.814PheAla: 4.814 ± 0.078	0.371PheCys: 0.371 ± 0.021	2.937PheAsp: 2.937 ± 0.06	1.765PheGlu: 1.765 ± 0.041	1.296PhePhe: 1.296 ± 0.048	3.624PheGly: 3.624 ± 0.075	0.634PheHis: 0.634 ± 0.026	1.446PheIle: 1.446 ± 0.039	0.618PheLys: 0.618 ± 0.028	3.224PheLeu: 3.224 ± 0.07	0.721PheMet: 0.721 ± 0.028	0.852PheAsn: 0.852 ± 0.036	1.507PhePro: 1.507 ± 0.038	0.905PheGln: 0.905 ± 0.035	2.359PheArg: 2.359 ± 0.056	1.636PheSer: 1.636 ± 0.044	1.888PheThr: 1.888 ± 0.045	2.865PheVal: 2.865 ± 0.065	0.597PheTrp: 0.597 ± 0.025	0.852PheTyr: 0.852 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	11.257GlyAla: 11.257 ± 0.134	0.912GlyCys: 0.912 ± 0.034	5.551GlyAsp: 5.551 ± 0.087	4.055GlyGlu: 4.055 ± 0.071	3.546GlyPhe: 3.546 ± 0.064	8.376GlyGly: 8.376 ± 0.137	1.977GlyHis: 1.977 ± 0.047	4.896GlyIle: 4.896 ± 0.075	2.423GlyLys: 2.423 ± 0.056	9.642GlyLeu: 9.642 ± 0.134	2.754GlyMet: 2.754 ± 0.058	1.919GlyAsn: 1.919 ± 0.051	4.345GlyPro: 4.345 ± 0.077	3.155GlyGln: 3.155 ± 0.06	7.696GlyArg: 7.696 ± 0.112	3.962GlySer: 3.962 ± 0.074	5.151GlyThr: 5.151 ± 0.079	6.29GlyVal: 6.29 ± 0.094	1.662GlyTrp: 1.662 ± 0.043	2.146GlyTyr: 2.146 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.407HisAla: 2.407 ± 0.056	0.237HisCys: 0.237 ± 0.018	1.497HisAsp: 1.497 ± 0.042	0.952HisGlu: 0.952 ± 0.034	0.685HisPhe: 0.685 ± 0.028	1.895HisGly: 1.895 ± 0.052	0.496HisHis: 0.496 ± 0.028	0.798HisIle: 0.798 ± 0.035	0.331HisLys: 0.331 ± 0.02	2.115HisLeu: 2.115 ± 0.055	0.463HisMet: 0.463 ± 0.023	0.363HisAsn: 0.363 ± 0.02	1.488HisPro: 1.488 ± 0.041	0.465HisGln: 0.465 ± 0.025	1.512HisArg: 1.512 ± 0.046	0.755HisSer: 0.755 ± 0.031	0.76HisThr: 0.76 ± 0.032	1.668HisVal: 1.668 ± 0.046	0.348HisTrp: 0.348 ± 0.02	0.509HisTyr: 0.509 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.649IleAla: 7.649 ± 0.102	0.537IleCys: 0.537 ± 0.023	3.702IleAsp: 3.702 ± 0.063	2.95IleGlu: 2.95 ± 0.064	1.596IlePhe: 1.596 ± 0.053	4.978IleGly: 4.978 ± 0.08	0.819IleHis: 0.819 ± 0.029	1.39IleIle: 1.39 ± 0.049	0.826IleLys: 0.826 ± 0.034	4.723IleLeu: 4.723 ± 0.084	0.873IleMet: 0.873 ± 0.032	0.929IleAsn: 0.929 ± 0.034	2.231IlePro: 2.231 ± 0.049	0.868IleGln: 0.868 ± 0.034	3.447IleArg: 3.447 ± 0.061	2.019IleSer: 2.019 ± 0.049	2.209IleThr: 2.209 ± 0.049	4.701IleVal: 4.701 ± 0.075	0.631IleTrp: 0.631 ± 0.025	1.006IleTyr: 1.006 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	2.999LysAla: 2.999 ± 0.066	0.142LysCys: 0.142 ± 0.012	1.494LysAsp: 1.494 ± 0.046	1.023LysGlu: 1.023 ± 0.041	0.593LysPhe: 0.593 ± 0.029	2.077LysGly: 2.077 ± 0.052	0.384LysHis: 0.384 ± 0.023	1.077LysIle: 1.077 ± 0.036	0.726LysLys: 0.726 ± 0.038	2.074LysLeu: 2.074 ± 0.048	0.555LysMet: 0.555 ± 0.026	0.502LysAsn: 0.502 ± 0.029	1.278LysPro: 1.278 ± 0.047	0.577LysGln: 0.577 ± 0.032	1.689LysArg: 1.689 ± 0.048	1.219LysSer: 1.219 ± 0.042	1.346LysThr: 1.346 ± 0.04	1.732LysVal: 1.732 ± 0.051	0.262LysTrp: 0.262 ± 0.017	0.447LysTyr: 0.447 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.611LeuAla: 14.611 ± 0.193	0.894LeuCys: 0.894 ± 0.03	7.033LeuAsp: 7.033 ± 0.105	4.335LeuGlu: 4.335 ± 0.068	3.164LeuPhe: 3.164 ± 0.064	8.941LeuGly: 8.941 ± 0.124	2.03LeuHis: 2.03 ± 0.056	4.831LeuIle: 4.831 ± 0.084	2.394LeuLys: 2.394 ± 0.061	9.359LeuLeu: 9.359 ± 0.151	2.467LeuMet: 2.467 ± 0.057	2.381LeuAsn: 2.381 ± 0.053	6.039LeuPro: 6.039 ± 0.082	2.35LeuGln: 2.35 ± 0.058	8.294LeuArg: 8.294 ± 0.1	5.799LeuSer: 5.799 ± 0.075	6.316LeuThr: 6.316 ± 0.087	6.965LeuVal: 6.965 ± 0.104	1.339LeuTrp: 1.339 ± 0.045	1.908LeuTyr: 1.908 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.834MetAla: 3.834 ± 0.067	0.188MetCys: 0.188 ± 0.014	1.532MetAsp: 1.532 ± 0.04	1.19MetGlu: 1.19 ± 0.041	0.694MetPhe: 0.694 ± 0.028	2.289MetGly: 2.289 ± 0.052	0.454MetHis: 0.454 ± 0.025	1.335MetIle: 1.335 ± 0.038	0.902MetLys: 0.902 ± 0.033	2.613MetLeu: 2.613 ± 0.057	0.659MetMet: 0.659 ± 0.028	0.795MetAsn: 0.795 ± 0.033	1.612MetPro: 1.612 ± 0.044	0.949MetGln: 0.949 ± 0.031	2.166MetArg: 2.166 ± 0.053	1.351MetSer: 1.351 ± 0.04	2.209MetThr: 2.209 ± 0.05	1.745MetVal: 1.745 ± 0.05	0.247MetTrp: 0.247 ± 0.016	0.3MetTyr: 0.3 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.007AsnAla: 3.007 ± 0.069	0.187AsnCys: 0.187 ± 0.015	1.282AsnAsp: 1.282 ± 0.037	0.928AsnGlu: 0.928 ± 0.035	0.747AsnPhe: 0.747 ± 0.033	1.969AsnGly: 1.969 ± 0.05	0.451AsnHis: 0.451 ± 0.027	1.088AsnIle: 1.088 ± 0.035	0.419AsnLys: 0.419 ± 0.023	2.191AsnLeu: 2.191 ± 0.049	0.559AsnMet: 0.559 ± 0.025	0.491AsnAsn: 0.491 ± 0.025	1.623AsnPro: 1.623 ± 0.05	0.473AsnGln: 0.473 ± 0.024	1.691AsnArg: 1.691 ± 0.049	0.809AsnSer: 0.809 ± 0.03	1.003AsnThr: 1.003 ± 0.031	1.733AsnVal: 1.733 ± 0.047	0.359AsnTrp: 0.359 ± 0.019	0.509AsnTyr: 0.509 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.042ProAla: 7.042 ± 0.118	0.419ProCys: 0.419 ± 0.023	4.972ProAsp: 4.972 ± 0.091	3.517ProGlu: 3.517 ± 0.056	2.022ProPhe: 2.022 ± 0.052	5.303ProGly: 5.303 ± 0.081	1.147ProHis: 1.147 ± 0.039	2.031ProIle: 2.031 ± 0.045	1.163ProLys: 1.163 ± 0.047	5.138ProLeu: 5.138 ± 0.076	1.349ProMet: 1.349 ± 0.04	1.034ProAsn: 1.034 ± 0.036	3.079ProPro: 3.079 ± 0.08	1.841ProGln: 1.841 ± 0.05	3.717ProArg: 3.717 ± 0.077	2.409ProSer: 2.409 ± 0.054	2.234ProThr: 2.234 ± 0.05	4.942ProVal: 4.942 ± 0.075	0.729ProTrp: 0.729 ± 0.033	1.107ProTyr: 1.107 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.012GlnAla: 4.012 ± 0.075	0.173GlnCys: 0.173 ± 0.014	1.681GlnAsp: 1.681 ± 0.044	1.099GlnGlu: 1.099 ± 0.037	0.962GlnPhe: 0.962 ± 0.038	2.714GlnGly: 2.714 ± 0.061	0.451GlnHis: 0.451 ± 0.024	1.813GlnIle: 1.813 ± 0.053	0.771GlnLys: 0.771 ± 0.03	2.288GlnLeu: 2.288 ± 0.053	0.911GlnMet: 0.911 ± 0.03	0.706GlnAsn: 0.706 ± 0.026	1.619GlnPro: 1.619 ± 0.047	0.969GlnGln: 0.969 ± 0.043	2.29GlnArg: 2.29 ± 0.055	1.443GlnSer: 1.443 ± 0.039	1.653GlnThr: 1.653 ± 0.046	2.123GlnVal: 2.123 ± 0.05	0.345GlnTrp: 0.345 ± 0.02	0.453GlnTyr: 0.453 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	10.26ArgAla: 10.26 ± 0.126	0.525ArgCys: 0.525 ± 0.025	5.923ArgAsp: 5.923 ± 0.093	3.632ArgGlu: 3.632 ± 0.068	2.95ArgPhe: 2.95 ± 0.061	5.798ArgGly: 5.798 ± 0.091	1.964ArgHis: 1.964 ± 0.057	4.813ArgIle: 4.813 ± 0.072	1.896ArgLys: 1.896 ± 0.053	8.739ArgLeu: 8.739 ± 0.122	2.542ArgMet: 2.542 ± 0.059	1.762ArgAsn: 1.762 ± 0.047	4.56ArgPro: 4.56 ± 0.083	2.585ArgGln: 2.585 ± 0.054	7.12ArgArg: 7.12 ± 0.119	3.266ArgSer: 3.266 ± 0.059	3.832ArgThr: 3.832 ± 0.068	5.225ArgVal: 5.225 ± 0.084	1.13ArgTrp: 1.13 ± 0.041	1.574ArgTyr: 1.574 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.424SerAla: 5.424 ± 0.088	0.34SerCys: 0.34 ± 0.02	3.088SerAsp: 3.088 ± 0.064	2.124SerGlu: 2.124 ± 0.053	1.871SerPhe: 1.871 ± 0.051	4.836SerGly: 4.836 ± 0.077	0.933SerHis: 0.933 ± 0.034	1.99SerIle: 1.99 ± 0.051	0.929SerLys: 0.929 ± 0.035	4.318SerLeu: 4.318 ± 0.069	1.111SerMet: 1.111 ± 0.036	0.965SerAsn: 0.965 ± 0.032	2.393SerPro: 2.393 ± 0.052	1.272SerGln: 1.272 ± 0.04	3.21SerArg: 3.21 ± 0.066	1.974SerSer: 1.974 ± 0.057	2.04SerThr: 2.04 ± 0.05	3.488SerVal: 3.488 ± 0.068	0.614SerTrp: 0.614 ± 0.026	1.053SerTyr: 1.053 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.59ThrAla: 6.59 ± 0.081	0.486ThrCys: 0.486 ± 0.025	3.762ThrAsp: 3.762 ± 0.075	2.752ThrGlu: 2.752 ± 0.062	2.008ThrPhe: 2.008 ± 0.047	5.762ThrGly: 5.762 ± 0.09	1.032ThrHis: 1.032 ± 0.037	2.508ThrIle: 2.508 ± 0.059	0.886ThrLys: 0.886 ± 0.029	5.944ThrLeu: 5.944 ± 0.092	1.345ThrMet: 1.345 ± 0.038	1.049ThrAsn: 1.049 ± 0.035	3.296ThrPro: 3.296 ± 0.065	1.323ThrGln: 1.323 ± 0.042	3.75ThrArg: 3.75 ± 0.063	2.214ThrSer: 2.214 ± 0.051	2.599ThrThr: 2.599 ± 0.059	4.324ThrVal: 4.324 ± 0.063	0.626ThrTrp: 0.626 ± 0.029	1.108ThrTyr: 1.108 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	10.152ValAla: 10.152 ± 0.134	0.649ValCys: 0.649 ± 0.023	4.084ValAsp: 4.084 ± 0.076	4.334ValGlu: 4.334 ± 0.073	2.774ValPhe: 2.774 ± 0.062	5.548ValGly: 5.548 ± 0.091	1.413ValHis: 1.413 ± 0.036	3.725ValIle: 3.725 ± 0.065	1.609ValLys: 1.609 ± 0.054	7.904ValLeu: 7.904 ± 0.116	2.064ValMet: 2.064 ± 0.054	1.816ValAsn: 1.816 ± 0.052	4.182ValPro: 4.182 ± 0.075	1.98ValGln: 1.98 ± 0.05	5.078ValArg: 5.078 ± 0.079	3.632ValSer: 3.632 ± 0.071	4.792ValThr: 4.792 ± 0.074	5.725ValVal: 5.725 ± 0.103	1.073ValTrp: 1.073 ± 0.039	1.434ValTyr: 1.434 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.437TrpAla: 1.437 ± 0.046	0.126TrpCys: 0.126 ± 0.014	0.849TrpAsp: 0.849 ± 0.037	0.531TrpGlu: 0.531 ± 0.027	0.586TrpPhe: 0.586 ± 0.026	1.047TrpGly: 1.047 ± 0.039	0.324TrpHis: 0.324 ± 0.02	0.772TrpIle: 0.772 ± 0.032	0.372TrpLys: 0.372 ± 0.019	1.705TrpLeu: 1.705 ± 0.049	0.399TrpMet: 0.399 ± 0.021	0.443TrpAsn: 0.443 ± 0.022	0.846TrpPro: 0.846 ± 0.03	0.628TrpGln: 0.628 ± 0.024	1.389TrpArg: 1.389 ± 0.043	0.719TrpSer: 0.719 ± 0.032	0.932TrpThr: 0.932 ± 0.033	0.885TrpVal: 0.885 ± 0.031	0.238TrpTrp: 0.238 ± 0.018	0.305TrpTyr: 0.305 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.063	0.217TyrCys: 0.217 ± 0.014	1.634TyrAsp: 1.634 ± 0.047	1.013TyrGlu: 1.013 ± 0.035	0.765TyrPhe: 0.765 ± 0.027	1.99TyrGly: 1.99 ± 0.053	0.442TyrHis: 0.442 ± 0.023	0.771TyrIle: 0.771 ± 0.031	0.397TyrLys: 0.397 ± 0.023	2.162TyrLeu: 2.162 ± 0.049	0.442TyrMet: 0.442 ± 0.02	0.486TyrAsn: 0.486 ± 0.026	1.005TyrPro: 1.005 ± 0.032	0.559TyrGln: 0.559 ± 0.026	1.653TyrArg: 1.653 ± 0.044	0.968TyrSer: 0.968 ± 0.033	0.959TyrThr: 0.959 ± 0.035	1.374TyrVal: 1.374 ± 0.039	0.337TyrTrp: 0.337 ± 0.019	0.505TyrTyr: 0.505 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2840 proteins (883308 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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