Amino acid dipepetide frequency for Helicobacter sp. MIT 99-10781

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.847AlaAla: 2.847 ± 0.088	1.096AlaCys: 1.096 ± 0.051	3.245AlaAsp: 3.245 ± 0.078	3.438AlaGlu: 3.438 ± 0.092	4.126AlaPhe: 4.126 ± 0.101	4.296AlaGly: 4.296 ± 0.11	1.981AlaHis: 1.981 ± 0.059	5.44AlaIle: 5.44 ± 0.121	6.994AlaLys: 6.994 ± 0.128	11.369AlaLeu: 11.369 ± 0.177	1.815AlaMet: 1.815 ± 0.06	4.017AlaAsn: 4.017 ± 0.095	2.927AlaPro: 2.927 ± 0.071	5.834AlaGln: 5.834 ± 0.122	4.341AlaArg: 4.341 ± 0.084	4.958AlaSer: 4.958 ± 0.098	3.376AlaThr: 3.376 ± 0.088	3.366AlaVal: 3.366 ± 0.083	0.536AlaTrp: 0.536 ± 0.028	2.846AlaTyr: 2.846 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	1.577CysAla: 1.577 ± 0.059	0.145CysCys: 0.145 ± 0.017	0.644CysAsp: 0.644 ± 0.039	1.064CysGlu: 1.064 ± 0.041	0.738CysPhe: 0.738 ± 0.037	1.079CysGly: 1.079 ± 0.047	0.198CysHis: 0.198 ± 0.021	0.923CysIle: 0.923 ± 0.047	0.91CysLys: 0.91 ± 0.035	0.978CysLeu: 0.978 ± 0.048	0.329CysMet: 0.329 ± 0.022	0.537CysAsn: 0.537 ± 0.033	0.331CysPro: 0.331 ± 0.023	0.273CysGln: 0.273 ± 0.022	0.253CysArg: 0.253 ± 0.021	0.577CysSer: 0.577 ± 0.036	0.471CysThr: 0.471 ± 0.029	1.217CysVal: 1.217 ± 0.042	0.073CysTrp: 0.073 ± 0.011	0.353CysTyr: 0.353 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.769AspAla: 2.769 ± 0.063	0.695AspCys: 0.695 ± 0.035	1.939AspAsp: 1.939 ± 0.063	3.496AspGlu: 3.496 ± 0.091	3.945AspPhe: 3.945 ± 0.082	2.663AspGly: 2.663 ± 0.073	0.368AspHis: 0.368 ± 0.024	4.196AspIle: 4.196 ± 0.089	3.611AspLys: 3.611 ± 0.082	4.66AspLeu: 4.66 ± 0.085	1.307AspMet: 1.307 ± 0.055	1.816AspAsn: 1.816 ± 0.055	1.093AspPro: 1.093 ± 0.044	0.452AspGln: 0.452 ± 0.031	1.435AspArg: 1.435 ± 0.043	6.548AspSer: 6.548 ± 0.124	2.588AspThr: 2.588 ± 0.075	2.247AspVal: 2.247 ± 0.067	0.314AspTrp: 0.314 ± 0.02	1.81AspTyr: 1.81 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.585GluAla: 4.585 ± 0.093	0.915GluCys: 0.915 ± 0.042	2.556GluAsp: 2.556 ± 0.081	3.963GluGlu: 3.963 ± 0.111	3.832GluPhe: 3.832 ± 0.083	3.488GluGly: 3.488 ± 0.084	1.104GluHis: 1.104 ± 0.049	6.026GluIle: 6.026 ± 0.109	4.743GluLys: 4.743 ± 0.102	7.083GluLeu: 7.083 ± 0.106	1.437GluMet: 1.437 ± 0.045	4.564GluAsn: 4.564 ± 0.086	1.552GluPro: 1.552 ± 0.054	2.543GluGln: 2.543 ± 0.078	3.094GluArg: 3.094 ± 0.082	6.165GluSer: 6.165 ± 0.111	1.999GluThr: 1.999 ± 0.065	4.451GluVal: 4.451 ± 0.091	0.547GluTrp: 0.547 ± 0.027	2.403GluTyr: 2.403 ± 0.065	0.0GluXaa: 0.0 ± 0.0
Phe	4.338PheAla: 4.338 ± 0.088	1.031PheCys: 1.031 ± 0.043	2.773PheAsp: 2.773 ± 0.072	3.832PheGlu: 3.832 ± 0.079	3.19PhePhe: 3.19 ± 0.101	4.522PheGly: 4.522 ± 0.093	0.805PheHis: 0.805 ± 0.039	3.582PheIle: 3.582 ± 0.087	3.37PheLys: 3.37 ± 0.086	5.869PheLeu: 5.869 ± 0.123	1.179PheMet: 1.179 ± 0.038	2.405PheAsn: 2.405 ± 0.069	1.266PhePro: 1.266 ± 0.05	1.148PheGln: 1.148 ± 0.043	1.548PheArg: 1.548 ± 0.057	4.762PheSer: 4.762 ± 0.094	2.036PheThr: 2.036 ± 0.068	3.692PheVal: 3.692 ± 0.106	0.526PheTrp: 0.526 ± 0.028	2.2PheTyr: 2.2 ± 0.068	0.0PheXaa: 0.0 ± 0.0
Gly	6.054GlyAla: 6.054 ± 0.118	0.677GlyCys: 0.677 ± 0.041	2.881GlyAsp: 2.881 ± 0.074	4.005GlyGlu: 4.005 ± 0.089	3.937GlyPhe: 3.937 ± 0.095	4.68GlyGly: 4.68 ± 0.115	0.867GlyHis: 0.867 ± 0.043	5.422GlyIle: 5.422 ± 0.112	4.411GlyLys: 4.411 ± 0.086	5.768GlyLeu: 5.768 ± 0.116	1.384GlyMet: 1.384 ± 0.051	2.761GlyAsn: 2.761 ± 0.087	0.667GlyPro: 0.667 ± 0.036	1.537GlyGln: 1.537 ± 0.059	2.214GlyArg: 2.214 ± 0.067	3.91GlySer: 3.91 ± 0.09	2.435GlyThr: 2.435 ± 0.114	5.284GlyVal: 5.284 ± 0.105	0.477GlyTrp: 0.477 ± 0.027	2.465GlyTyr: 2.465 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.424HisAla: 1.424 ± 0.058	0.261HisCys: 0.261 ± 0.023	0.617HisAsp: 0.617 ± 0.037	0.745HisGlu: 0.745 ± 0.032	1.292HisPhe: 1.292 ± 0.043	0.865HisGly: 0.865 ± 0.041	0.336HisHis: 0.336 ± 0.03	1.608HisIle: 1.608 ± 0.056	1.55HisLys: 1.55 ± 0.055	1.856HisLeu: 1.856 ± 0.057	0.301HisMet: 0.301 ± 0.021	1.048HisAsn: 1.048 ± 0.044	0.644HisPro: 0.644 ± 0.034	0.489HisGln: 0.489 ± 0.029	0.599HisArg: 0.599 ± 0.034	1.319HisSer: 1.319 ± 0.05	1.146HisThr: 1.146 ± 0.053	0.492HisVal: 0.492 ± 0.029	0.143HisTrp: 0.143 ± 0.018	0.71HisTyr: 0.71 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	7.143IleAla: 7.143 ± 0.129	1.049IleCys: 1.049 ± 0.045	4.145IleAsp: 4.145 ± 0.1	5.447IleGlu: 5.447 ± 0.093	4.078IlePhe: 4.078 ± 0.101	4.635IleGly: 4.635 ± 0.104	1.207IleHis: 1.207 ± 0.046	5.054IleIle: 5.054 ± 0.11	5.054IleLys: 5.054 ± 0.103	8.289IleLeu: 8.289 ± 0.135	1.346IleMet: 1.346 ± 0.046	3.659IleAsn: 3.659 ± 0.089	2.708IlePro: 2.708 ± 0.066	2.234IleGln: 2.234 ± 0.061	2.155IleArg: 2.155 ± 0.068	5.106IleSer: 5.106 ± 0.087	4.065IleThr: 4.065 ± 0.109	4.224IleVal: 4.224 ± 0.085	0.496IleTrp: 0.496 ± 0.028	2.516IleTyr: 2.516 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	5.958LysAla: 5.958 ± 0.106	0.607LysCys: 0.607 ± 0.035	4.712LysAsp: 4.712 ± 0.088	6.896LysGlu: 6.896 ± 0.127	2.516LysPhe: 2.516 ± 0.065	4.173LysGly: 4.173 ± 0.087	1.274LysHis: 1.274 ± 0.049	6.475LysIle: 6.475 ± 0.121	5.933LysLys: 5.933 ± 0.111	6.405LysLeu: 6.405 ± 0.115	1.793LysMet: 1.793 ± 0.057	5.58LysAsn: 5.58 ± 0.11	2.49LysPro: 2.49 ± 0.08	3.074LysGln: 3.074 ± 0.077	3.218LysArg: 3.218 ± 0.085	5.274LysSer: 5.274 ± 0.102	3.454LysThr: 3.454 ± 0.08	3.963LysVal: 3.963 ± 0.087	0.534LysTrp: 0.534 ± 0.032	2.2LysTyr: 2.2 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	8.113LeuAla: 8.113 ± 0.122	1.899LeuCys: 1.899 ± 0.061	5.695LeuAsp: 5.695 ± 0.103	8.524LeuGlu: 8.524 ± 0.157	5.151LeuPhe: 5.151 ± 0.112	7.148LeuGly: 7.148 ± 0.129	1.936LeuHis: 1.936 ± 0.061	5.909LeuIle: 5.909 ± 0.12	8.57LeuLys: 8.57 ± 0.133	10.538LeuLeu: 10.538 ± 0.189	1.848LeuMet: 1.848 ± 0.066	5.367LeuAsn: 5.367 ± 0.094	3.722LeuPro: 3.722 ± 0.079	5.354LeuGln: 5.354 ± 0.129	4.441LeuArg: 4.441 ± 0.074	8.915LeuSer: 8.915 ± 0.129	4.115LeuThr: 4.115 ± 0.101	5.028LeuVal: 5.028 ± 0.102	0.72LeuTrp: 0.72 ± 0.039	3.341LeuTyr: 3.341 ± 0.078	0.0LeuXaa: 0.0 ± 0.0
Met	1.467MetAla: 1.467 ± 0.05	0.216MetCys: 0.216 ± 0.021	0.91MetAsp: 0.91 ± 0.04	1.186MetGlu: 1.186 ± 0.046	0.943MetPhe: 0.943 ± 0.06	1.375MetGly: 1.375 ± 0.047	0.397MetHis: 0.397 ± 0.026	1.38MetIle: 1.38 ± 0.049	1.53MetLys: 1.53 ± 0.048	2.615MetLeu: 2.615 ± 0.062	0.378MetMet: 0.378 ± 0.028	0.842MetAsn: 0.842 ± 0.039	1.064MetPro: 1.064 ± 0.036	1.517MetGln: 1.517 ± 0.044	1.267MetArg: 1.267 ± 0.049	1.444MetSer: 1.444 ± 0.058	0.662MetThr: 0.662 ± 0.034	1.043MetVal: 1.043 ± 0.046	0.153MetTrp: 0.153 ± 0.017	0.481MetTyr: 0.481 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	5.841AsnAla: 5.841 ± 0.112	0.451AsnCys: 0.451 ± 0.032	2.332AsnAsp: 2.332 ± 0.065	3.333AsnGlu: 3.333 ± 0.078	2.812AsnPhe: 2.812 ± 0.076	3.225AsnGly: 3.225 ± 0.086	0.822AsnHis: 0.822 ± 0.04	4.224AsnIle: 4.224 ± 0.092	3.453AsnLys: 3.453 ± 0.08	6.353AsnLeu: 6.353 ± 0.108	1.088AsnMet: 1.088 ± 0.046	2.413AsnAsn: 2.413 ± 0.089	2.847AsnPro: 2.847 ± 0.076	1.731AsnGln: 1.731 ± 0.079	1.528AsnArg: 1.528 ± 0.055	3.19AsnSer: 3.19 ± 0.087	3.228AsnThr: 3.228 ± 0.102	2.829AsnVal: 2.829 ± 0.078	0.273AsnTrp: 0.273 ± 0.024	1.602AsnTyr: 1.602 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	2.004ProAla: 2.004 ± 0.063	0.376ProCys: 0.376 ± 0.028	1.096ProAsp: 1.096 ± 0.044	1.53ProGlu: 1.53 ± 0.057	1.768ProPhe: 1.768 ± 0.052	0.996ProGly: 0.996 ± 0.051	0.793ProHis: 0.793 ± 0.039	2.322ProIle: 2.322 ± 0.068	3.24ProLys: 3.24 ± 0.097	3.814ProLeu: 3.814 ± 0.089	0.644ProMet: 0.644 ± 0.033	2.175ProAsn: 2.175 ± 0.07	1.039ProPro: 1.039 ± 0.042	2.041ProGln: 2.041 ± 0.067	1.174ProArg: 1.174 ± 0.043	2.3ProSer: 2.3 ± 0.068	1.919ProThr: 1.919 ± 0.059	1.294ProVal: 1.294 ± 0.058	0.168ProTrp: 0.168 ± 0.018	1.332ProTyr: 1.332 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	3.094GlnAla: 3.094 ± 0.076	0.358GlnCys: 0.358 ± 0.023	2.408GlnAsp: 2.408 ± 0.07	3.476GlnGlu: 3.476 ± 0.087	1.192GlnPhe: 1.192 ± 0.04	2.365GlnGly: 2.365 ± 0.072	0.437GlnHis: 0.437 ± 0.028	3.395GlnIle: 3.395 ± 0.087	4.537GlnLys: 4.537 ± 0.11	2.034GlnLeu: 2.034 ± 0.053	0.835GlnMet: 0.835 ± 0.039	4.116GlnAsn: 4.116 ± 0.098	0.98GlnPro: 0.98 ± 0.05	1.094GlnGln: 1.094 ± 0.049	1.455GlnArg: 1.455 ± 0.048	3.596GlnSer: 3.596 ± 0.087	2.315GlnThr: 2.315 ± 0.072	1.833GlnVal: 1.833 ± 0.057	0.278GlnTrp: 0.278 ± 0.023	1.096GlnTyr: 1.096 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.809ArgAla: 3.809 ± 0.088	0.294ArgCys: 0.294 ± 0.024	2.111ArgAsp: 2.111 ± 0.059	3.288ArgGlu: 3.288 ± 0.076	2.445ArgPhe: 2.445 ± 0.067	2.304ArgGly: 2.304 ± 0.064	0.647ArgHis: 0.647 ± 0.029	3.275ArgIle: 3.275 ± 0.072	2.59ArgLys: 2.59 ± 0.056	4.047ArgLeu: 4.047 ± 0.081	0.725ArgMet: 0.725 ± 0.038	1.788ArgAsn: 1.788 ± 0.058	0.933ArgPro: 0.933 ± 0.038	1.256ArgGln: 1.256 ± 0.046	1.354ArgArg: 1.354 ± 0.052	1.906ArgSer: 1.906 ± 0.052	1.543ArgThr: 1.543 ± 0.051	2.616ArgVal: 2.616 ± 0.069	0.278ArgTrp: 0.278 ± 0.021	1.628ArgTyr: 1.628 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	7.356SerAla: 7.356 ± 0.124	0.68SerCys: 0.68 ± 0.038	3.069SerAsp: 3.069 ± 0.072	4.354SerGlu: 4.354 ± 0.099	4.276SerPhe: 4.276 ± 0.092	4.955SerGly: 4.955 ± 0.111	1.449SerHis: 1.449 ± 0.055	5.209SerIle: 5.209 ± 0.113	5.796SerLys: 5.796 ± 0.103	8.191SerLeu: 8.191 ± 0.116	1.65SerMet: 1.65 ± 0.054	3.341SerAsn: 3.341 ± 0.088	2.096SerPro: 2.096 ± 0.058	3.524SerGln: 3.524 ± 0.09	2.333SerArg: 2.333 ± 0.062	4.62SerSer: 4.62 ± 0.109	3.504SerThr: 3.504 ± 0.076	4.753SerVal: 4.753 ± 0.105	0.541SerTrp: 0.541 ± 0.035	2.571SerTyr: 2.571 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	2.624ThrAla: 2.624 ± 0.079	0.426ThrCys: 0.426 ± 0.029	1.676ThrAsp: 1.676 ± 0.052	1.688ThrGlu: 1.688 ± 0.055	2.139ThrPhe: 2.139 ± 0.054	2.195ThrGly: 2.195 ± 0.095	1.296ThrHis: 1.296 ± 0.047	3.429ThrIle: 3.429 ± 0.118	3.476ThrLys: 3.476 ± 0.09	5.961ThrLeu: 5.961 ± 0.116	0.86ThrMet: 0.86 ± 0.036	2.846ThrAsn: 2.846 ± 0.14	2.726ThrPro: 2.726 ± 0.085	3.503ThrGln: 3.503 ± 0.1	1.983ThrArg: 1.983 ± 0.059	3.258ThrSer: 3.258 ± 0.085	2.726ThrThr: 2.726 ± 0.098	0.639ThrVal: 0.639 ± 0.039	0.309ThrTrp: 0.309 ± 0.025	1.553ThrTyr: 1.553 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.444ValAla: 4.444 ± 0.09	0.955ValCys: 0.955 ± 0.043	2.894ValAsp: 2.894 ± 0.074	3.634ValGlu: 3.634 ± 0.081	3.202ValPhe: 3.202 ± 0.088	4.15ValGly: 4.15 ± 0.089	0.748ValHis: 0.748 ± 0.038	3.997ValIle: 3.997 ± 0.097	3.395ValLys: 3.395 ± 0.104	6.219ValLeu: 6.219 ± 0.115	1.151ValMet: 1.151 ± 0.046	2.169ValAsn: 2.169 ± 0.054	1.615ValPro: 1.615 ± 0.054	1.741ValGln: 1.741 ± 0.055	2.758ValArg: 2.758 ± 0.07	4.095ValSer: 4.095 ± 0.095	1.8ValThr: 1.8 ± 0.057	4.01ValVal: 4.01 ± 0.092	0.467ValTrp: 0.467 ± 0.029	1.736ValTyr: 1.736 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.489TrpAla: 0.489 ± 0.033	0.093TrpCys: 0.093 ± 0.014	0.432TrpAsp: 0.432 ± 0.035	0.552TrpGlu: 0.552 ± 0.032	0.334TrpPhe: 0.334 ± 0.028	0.554TrpGly: 0.554 ± 0.03	0.188TrpHis: 0.188 ± 0.017	0.514TrpIle: 0.514 ± 0.034	0.373TrpLys: 0.373 ± 0.026	0.878TrpLeu: 0.878 ± 0.042	0.113TrpMet: 0.113 ± 0.015	0.447TrpAsn: 0.447 ± 0.034	0.07TrpPro: 0.07 ± 0.012	0.376TrpGln: 0.376 ± 0.025	0.384TrpArg: 0.384 ± 0.025	0.406TrpSer: 0.406 ± 0.027	0.15TrpThr: 0.15 ± 0.017	0.491TrpVal: 0.491 ± 0.03	0.088TrpTrp: 0.088 ± 0.014	0.273TrpTyr: 0.273 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.912TyrAla: 2.912 ± 0.068	0.446TyrCys: 0.446 ± 0.027	1.82TyrAsp: 1.82 ± 0.06	2.6TyrGlu: 2.6 ± 0.069	2.155TyrPhe: 2.155 ± 0.069	2.165TyrGly: 2.165 ± 0.075	0.592TyrHis: 0.592 ± 0.035	2.232TyrIle: 2.232 ± 0.071	2.994TyrLys: 2.994 ± 0.074	3.406TyrLeu: 3.406 ± 0.09	0.687TyrMet: 0.687 ± 0.033	1.685TyrAsn: 1.685 ± 0.054	1.257TyrPro: 1.257 ± 0.05	1.174TyrGln: 1.174 ± 0.044	1.301TyrArg: 1.301 ± 0.045	1.921TyrSer: 1.921 ± 0.056	1.781TyrThr: 1.781 ± 0.061	1.705TyrVal: 1.705 ± 0.054	0.284TyrTrp: 0.284 ± 0.024	1.369TyrTyr: 1.369 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1914 proteins (601259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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