Amino acid dipepetide frequency for Providencia phage vB_PreS-Stilesk

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.878AlaAla: 8.878 ± 1.174
0.528AlaCys: 0.528 ± 0.186
5.02AlaAsp: 5.02 ± 0.452
6.658AlaGlu: 6.658 ± 0.561
3.54AlaPhe: 3.54 ± 0.399
7.028AlaGly: 7.028 ± 0.81
1.427AlaHis: 1.427 ± 0.258
5.971AlaIle: 5.971 ± 0.721
5.866AlaLys: 5.866 ± 0.724
7.715AlaLeu: 7.715 ± 0.914
2.906AlaMet: 2.906 ± 0.372
3.223AlaAsn: 3.223 ± 0.374
3.593AlaPro: 3.593 ± 0.348
4.175AlaGln: 4.175 ± 0.673
4.492AlaArg: 4.492 ± 0.701
5.39AlaSer: 5.39 ± 0.624
5.654AlaThr: 5.654 ± 0.649
5.496AlaVal: 5.496 ± 0.563
1.215AlaTrp: 1.215 ± 0.195
2.906AlaTyr: 2.906 ± 0.392
0.0AlaXaa: 0.0 ± 0.0
Cys
0.634CysAla: 0.634 ± 0.177
0.317CysCys: 0.317 ± 0.12
0.898CysAsp: 0.898 ± 0.26
0.37CysGlu: 0.37 ± 0.12
0.476CysPhe: 0.476 ± 0.148
0.845CysGly: 0.845 ± 0.286
0.211CysHis: 0.211 ± 0.105
0.37CysIle: 0.37 ± 0.122
0.264CysLys: 0.264 ± 0.11
0.581CysLeu: 0.581 ± 0.165
0.37CysMet: 0.37 ± 0.128
0.528CysAsn: 0.528 ± 0.171
0.634CysPro: 0.634 ± 0.249
0.37CysGln: 0.37 ± 0.148
0.687CysArg: 0.687 ± 0.19
0.687CysSer: 0.687 ± 0.201
0.423CysThr: 0.423 ± 0.14
0.37CysVal: 0.37 ± 0.154
0.106CysTrp: 0.106 ± 0.067
0.423CysTyr: 0.423 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
5.496AspAla: 5.496 ± 0.363
0.581AspCys: 0.581 ± 0.156
4.914AspAsp: 4.914 ± 0.687
4.967AspGlu: 4.967 ± 0.599
2.378AspPhe: 2.378 ± 0.392
5.39AspGly: 5.39 ± 0.631
0.951AspHis: 0.951 ± 0.237
3.382AspIle: 3.382 ± 0.455
3.752AspLys: 3.752 ± 0.468
5.02AspLeu: 5.02 ± 0.488
2.008AspMet: 2.008 ± 0.236
2.061AspAsn: 2.061 ± 0.331
3.593AspPro: 3.593 ± 0.471
1.85AspGln: 1.85 ± 0.301
3.488AspArg: 3.488 ± 0.417
2.642AspSer: 2.642 ± 0.385
3.963AspThr: 3.963 ± 0.44
4.544AspVal: 4.544 ± 0.482
1.532AspTrp: 1.532 ± 0.308
2.484AspTyr: 2.484 ± 0.266
0.0AspXaa: 0.0 ± 0.0
Glu
6.5GluAla: 6.5 ± 0.662
1.11GluCys: 1.11 ± 0.282
4.333GluAsp: 4.333 ± 0.539
5.02GluGlu: 5.02 ± 0.603
2.589GluPhe: 2.589 ± 0.409
3.329GluGly: 3.329 ± 0.394
1.215GluHis: 1.215 ± 0.326
4.492GluIle: 4.492 ± 0.392
3.329GluLys: 3.329 ± 0.379
4.914GluLeu: 4.914 ± 0.52
2.272GluMet: 2.272 ± 0.354
3.276GluAsn: 3.276 ± 0.393
2.431GluPro: 2.431 ± 0.415
2.272GluGln: 2.272 ± 0.311
3.593GluArg: 3.593 ± 0.394
3.91GluSer: 3.91 ± 0.33
3.699GluThr: 3.699 ± 0.374
5.337GluVal: 5.337 ± 0.505
1.532GluTrp: 1.532 ± 0.231
2.061GluTyr: 2.061 ± 0.278
0.0GluXaa: 0.0 ± 0.0
Phe
3.699PheAla: 3.699 ± 0.426
0.476PheCys: 0.476 ± 0.165
3.858PheAsp: 3.858 ± 0.477
2.906PheGlu: 2.906 ± 0.374
1.268PhePhe: 1.268 ± 0.262
2.589PheGly: 2.589 ± 0.317
0.793PheHis: 0.793 ± 0.202
1.532PheIle: 1.532 ± 0.295
2.854PheLys: 2.854 ± 0.376
1.955PheLeu: 1.955 ± 0.342
1.163PheMet: 1.163 ± 0.282
1.797PheAsn: 1.797 ± 0.267
1.427PhePro: 1.427 ± 0.28
0.793PheGln: 0.793 ± 0.209
2.061PheArg: 2.061 ± 0.294
1.902PheSer: 1.902 ± 0.269
2.378PheThr: 2.378 ± 0.397
2.325PheVal: 2.325 ± 0.336
0.476PheTrp: 0.476 ± 0.172
1.11PheTyr: 1.11 ± 0.207
0.0PheXaa: 0.0 ± 0.0
Gly
5.813GlyAla: 5.813 ± 0.526
0.898GlyCys: 0.898 ± 0.242
4.122GlyAsp: 4.122 ± 0.433
4.492GlyGlu: 4.492 ± 0.492
3.012GlyPhe: 3.012 ± 0.403
6.077GlyGly: 6.077 ± 1.042
1.48GlyHis: 1.48 ± 0.349
3.963GlyIle: 3.963 ± 0.523
4.492GlyLys: 4.492 ± 0.451
4.809GlyLeu: 4.809 ± 0.528
2.325GlyMet: 2.325 ± 0.346
2.959GlyAsn: 2.959 ± 0.375
1.638GlyPro: 1.638 ± 0.408
2.378GlyGln: 2.378 ± 0.522
4.175GlyArg: 4.175 ± 0.512
3.276GlySer: 3.276 ± 0.349
4.756GlyThr: 4.756 ± 0.722
5.073GlyVal: 5.073 ± 0.48
1.691GlyTrp: 1.691 ± 0.277
2.801GlyTyr: 2.801 ± 0.427
0.0GlyXaa: 0.0 ± 0.0
His
1.321HisAla: 1.321 ± 0.265
0.159HisCys: 0.159 ± 0.088
1.374HisAsp: 1.374 ± 0.363
0.898HisGlu: 0.898 ± 0.229
0.423HisPhe: 0.423 ± 0.151
1.215HisGly: 1.215 ± 0.241
0.317HisHis: 0.317 ± 0.119
1.11HisIle: 1.11 ± 0.236
1.163HisLys: 1.163 ± 0.287
1.585HisLeu: 1.585 ± 0.219
0.317HisMet: 0.317 ± 0.142
0.74HisAsn: 0.74 ± 0.176
0.951HisPro: 0.951 ± 0.295
0.634HisGln: 0.634 ± 0.209
1.11HisArg: 1.11 ± 0.254
0.687HisSer: 0.687 ± 0.21
1.057HisThr: 1.057 ± 0.282
1.691HisVal: 1.691 ± 0.367
0.264HisTrp: 0.264 ± 0.139
1.004HisTyr: 1.004 ± 0.252
0.0HisXaa: 0.0 ± 0.0
Ile
5.654IleAla: 5.654 ± 0.475
0.528IleCys: 0.528 ± 0.183
3.858IleAsp: 3.858 ± 0.357
4.703IleGlu: 4.703 ± 0.465
1.797IlePhe: 1.797 ± 0.238
4.227IleGly: 4.227 ± 0.419
1.11IleHis: 1.11 ± 0.214
3.276IleIle: 3.276 ± 0.4
3.646IleLys: 3.646 ± 0.392
2.959IleLeu: 2.959 ± 0.279
1.004IleMet: 1.004 ± 0.232
3.118IleAsn: 3.118 ± 0.399
2.431IlePro: 2.431 ± 0.253
2.167IleGln: 2.167 ± 0.351
3.118IleArg: 3.118 ± 0.389
2.906IleSer: 2.906 ± 0.421
3.276IleThr: 3.276 ± 0.393
4.544IleVal: 4.544 ± 0.487
0.423IleTrp: 0.423 ± 0.128
1.744IleTyr: 1.744 ± 0.247
0.0IleXaa: 0.0 ± 0.0
Lys
5.231LysAla: 5.231 ± 0.458
0.476LysCys: 0.476 ± 0.141
3.276LysAsp: 3.276 ± 0.397
4.809LysGlu: 4.809 ± 0.624
1.585LysPhe: 1.585 ± 0.329
3.54LysGly: 3.54 ± 0.441
1.321LysHis: 1.321 ± 0.236
3.329LysIle: 3.329 ± 0.441
3.699LysLys: 3.699 ± 0.491
3.858LysLeu: 3.858 ± 0.572
2.589LysMet: 2.589 ± 0.365
2.536LysAsn: 2.536 ± 0.339
2.589LysPro: 2.589 ± 0.4
2.167LysGln: 2.167 ± 0.342
4.122LysArg: 4.122 ± 0.555
3.752LysSer: 3.752 ± 0.474
3.329LysThr: 3.329 ± 0.527
2.589LysVal: 2.589 ± 0.373
1.11LysTrp: 1.11 ± 0.294
2.167LysTyr: 2.167 ± 0.302
0.0LysXaa: 0.0 ± 0.0
Leu
8.138LeuAla: 8.138 ± 1.061
0.634LeuCys: 0.634 ± 0.159
5.654LeuAsp: 5.654 ± 0.594
4.862LeuGlu: 4.862 ± 0.501
3.012LeuPhe: 3.012 ± 0.448
4.756LeuGly: 4.756 ± 0.565
1.163LeuHis: 1.163 ± 0.256
3.382LeuIle: 3.382 ± 0.458
4.809LeuLys: 4.809 ± 0.531
4.914LeuLeu: 4.914 ± 0.423
1.902LeuMet: 1.902 ± 0.399
3.012LeuAsn: 3.012 ± 0.396
4.069LeuPro: 4.069 ± 0.597
2.854LeuGln: 2.854 ± 0.452
4.175LeuArg: 4.175 ± 0.586
4.862LeuSer: 4.862 ± 0.47
4.809LeuThr: 4.809 ± 0.502
4.227LeuVal: 4.227 ± 0.383
1.057LeuTrp: 1.057 ± 0.2
1.955LeuTyr: 1.955 ± 0.346
0.0LeuXaa: 0.0 ± 0.0
Met
3.012MetAla: 3.012 ± 0.377
0.159MetCys: 0.159 ± 0.087
1.321MetAsp: 1.321 ± 0.235
1.427MetGlu: 1.427 ± 0.294
0.951MetPhe: 0.951 ± 0.214
2.061MetGly: 2.061 ± 0.34
0.793MetHis: 0.793 ± 0.166
1.638MetIle: 1.638 ± 0.296
1.585MetLys: 1.585 ± 0.348
2.325MetLeu: 2.325 ± 0.305
0.74MetMet: 0.74 ± 0.191
1.268MetAsn: 1.268 ± 0.315
1.902MetPro: 1.902 ± 0.325
1.268MetGln: 1.268 ± 0.272
2.167MetArg: 2.167 ± 0.349
2.695MetSer: 2.695 ± 0.446
2.114MetThr: 2.114 ± 0.31
1.744MetVal: 1.744 ± 0.25
0.423MetTrp: 0.423 ± 0.121
1.321MetTyr: 1.321 ± 0.292
0.0MetXaa: 0.0 ± 0.0
Asn
4.333AsnAla: 4.333 ± 0.493
0.211AsnCys: 0.211 ± 0.102
2.325AsnAsp: 2.325 ± 0.314
2.431AsnGlu: 2.431 ± 0.325
1.215AsnPhe: 1.215 ± 0.21
4.28AsnGly: 4.28 ± 0.387
0.528AsnHis: 0.528 ± 0.189
2.378AsnIle: 2.378 ± 0.252
1.744AsnLys: 1.744 ± 0.304
3.382AsnLeu: 3.382 ± 0.403
0.951AsnMet: 0.951 ± 0.232
1.797AsnAsn: 1.797 ± 0.422
2.854AsnPro: 2.854 ± 0.403
1.638AsnGln: 1.638 ± 0.321
2.219AsnArg: 2.219 ± 0.353
2.484AsnSer: 2.484 ± 0.288
3.223AsnThr: 3.223 ± 0.404
2.325AsnVal: 2.325 ± 0.286
0.634AsnTrp: 0.634 ± 0.171
1.691AsnTyr: 1.691 ± 0.375
0.0AsnXaa: 0.0 ± 0.0
Pro
3.699ProAla: 3.699 ± 0.407
0.37ProCys: 0.37 ± 0.189
3.276ProAsp: 3.276 ± 0.475
3.329ProGlu: 3.329 ± 0.4
2.008ProPhe: 2.008 ± 0.337
3.329ProGly: 3.329 ± 0.445
1.374ProHis: 1.374 ± 0.247
2.959ProIle: 2.959 ± 0.533
2.642ProLys: 2.642 ± 0.356
3.171ProLeu: 3.171 ± 0.387
1.215ProMet: 1.215 ± 0.346
2.378ProAsn: 2.378 ± 0.327
1.955ProPro: 1.955 ± 0.493
1.427ProGln: 1.427 ± 0.39
1.427ProArg: 1.427 ± 0.349
2.801ProSer: 2.801 ± 0.543
2.854ProThr: 2.854 ± 0.449
2.642ProVal: 2.642 ± 0.444
0.793ProTrp: 0.793 ± 0.199
2.325ProTyr: 2.325 ± 0.41
0.0ProXaa: 0.0 ± 0.0
Gln
3.699GlnAla: 3.699 ± 0.618
0.264GlnCys: 0.264 ± 0.127
2.008GlnAsp: 2.008 ± 0.281
1.797GlnGlu: 1.797 ± 0.348
1.955GlnPhe: 1.955 ± 0.326
2.431GlnGly: 2.431 ± 0.322
0.687GlnHis: 0.687 ± 0.163
2.008GlnIle: 2.008 ± 0.328
2.114GlnLys: 2.114 ± 0.536
3.329GlnLeu: 3.329 ± 0.364
1.902GlnMet: 1.902 ± 0.391
1.215GlnAsn: 1.215 ± 0.214
1.691GlnPro: 1.691 ± 0.41
1.585GlnGln: 1.585 ± 0.368
2.272GlnArg: 2.272 ± 0.413
2.219GlnSer: 2.219 ± 0.361
2.431GlnThr: 2.431 ± 0.526
2.748GlnVal: 2.748 ± 0.638
0.528GlnTrp: 0.528 ± 0.161
1.427GlnTyr: 1.427 ± 0.241
0.0GlnXaa: 0.0 ± 0.0
Arg
4.756ArgAla: 4.756 ± 0.569
0.476ArgCys: 0.476 ± 0.182
3.91ArgAsp: 3.91 ± 0.394
2.854ArgGlu: 2.854 ± 0.368
2.642ArgPhe: 2.642 ± 0.297
3.012ArgGly: 3.012 ± 0.419
0.951ArgHis: 0.951 ± 0.223
3.223ArgIle: 3.223 ± 0.32
3.223ArgLys: 3.223 ± 0.425
4.756ArgLeu: 4.756 ± 0.493
1.85ArgMet: 1.85 ± 0.3
1.797ArgAsn: 1.797 ± 0.324
2.219ArgPro: 2.219 ± 0.292
2.008ArgGln: 2.008 ± 0.418
3.171ArgArg: 3.171 ± 0.439
3.118ArgSer: 3.118 ± 0.424
3.118ArgThr: 3.118 ± 0.377
5.073ArgVal: 5.073 ± 0.523
0.845ArgTrp: 0.845 ± 0.209
1.691ArgTyr: 1.691 ± 0.302
0.0ArgXaa: 0.0 ± 0.0
Ser
4.967SerAla: 4.967 ± 0.633
0.793SerCys: 0.793 ± 0.204
3.329SerAsp: 3.329 ± 0.506
3.118SerGlu: 3.118 ± 0.361
2.008SerPhe: 2.008 ± 0.325
4.703SerGly: 4.703 ± 0.55
0.898SerHis: 0.898 ± 0.208
3.488SerIle: 3.488 ± 0.439
3.91SerLys: 3.91 ± 0.57
4.439SerLeu: 4.439 ± 0.448
2.378SerMet: 2.378 ± 0.289
2.589SerAsn: 2.589 ± 0.404
2.906SerPro: 2.906 ± 0.429
2.536SerGln: 2.536 ± 0.513
2.695SerArg: 2.695 ± 0.454
3.012SerSer: 3.012 ± 0.346
2.854SerThr: 2.854 ± 0.466
3.699SerVal: 3.699 ± 0.366
1.163SerTrp: 1.163 ± 0.199
2.167SerTyr: 2.167 ± 0.332
0.0SerXaa: 0.0 ± 0.0
Thr
5.284ThrAla: 5.284 ± 0.536
0.211ThrCys: 0.211 ± 0.11
4.069ThrAsp: 4.069 ± 0.397
3.54ThrGlu: 3.54 ± 0.47
2.378ThrPhe: 2.378 ± 0.385
4.227ThrGly: 4.227 ± 0.611
0.845ThrHis: 0.845 ± 0.207
3.752ThrIle: 3.752 ± 0.519
3.435ThrLys: 3.435 ± 0.441
4.862ThrLeu: 4.862 ± 0.518
1.638ThrMet: 1.638 ± 0.331
2.748ThrAsn: 2.748 ± 0.324
3.752ThrPro: 3.752 ± 0.497
2.695ThrGln: 2.695 ± 0.303
2.906ThrArg: 2.906 ± 0.342
3.276ThrSer: 3.276 ± 0.403
4.333ThrThr: 4.333 ± 0.568
5.549ThrVal: 5.549 ± 0.74
0.951ThrTrp: 0.951 ± 0.226
1.955ThrTyr: 1.955 ± 0.306
0.0ThrXaa: 0.0 ± 0.0
Val
6.341ValAla: 6.341 ± 0.822
0.793ValCys: 0.793 ± 0.18
3.646ValAsp: 3.646 ± 0.352
5.39ValGlu: 5.39 ± 0.498
1.955ValPhe: 1.955 ± 0.233
4.492ValGly: 4.492 ± 0.584
0.845ValHis: 0.845 ± 0.219
3.646ValIle: 3.646 ± 0.382
3.223ValLys: 3.223 ± 0.436
5.918ValLeu: 5.918 ± 0.586
1.902ValMet: 1.902 ± 0.366
3.223ValAsn: 3.223 ± 0.428
2.642ValPro: 2.642 ± 0.345
2.801ValGln: 2.801 ± 0.339
4.069ValArg: 4.069 ± 0.547
4.227ValSer: 4.227 ± 0.462
4.65ValThr: 4.65 ± 0.446
4.756ValVal: 4.756 ± 0.615
0.898ValTrp: 0.898 ± 0.227
2.272ValTyr: 2.272 ± 0.441
0.0ValXaa: 0.0 ± 0.0
Trp
2.008TrpAla: 2.008 ± 0.334
0.106TrpCys: 0.106 ± 0.07
1.427TrpAsp: 1.427 ± 0.267
1.268TrpGlu: 1.268 ± 0.255
0.793TrpPhe: 0.793 ± 0.206
0.898TrpGly: 0.898 ± 0.208
0.317TrpHis: 0.317 ± 0.121
0.634TrpIle: 0.634 ± 0.157
0.845TrpLys: 0.845 ± 0.207
1.321TrpLeu: 1.321 ± 0.312
0.211TrpMet: 0.211 ± 0.108
0.74TrpAsn: 0.74 ± 0.192
0.74TrpPro: 0.74 ± 0.224
1.004TrpGln: 1.004 ± 0.214
0.687TrpArg: 0.687 ± 0.202
1.163TrpSer: 1.163 ± 0.184
0.74TrpThr: 0.74 ± 0.198
0.687TrpVal: 0.687 ± 0.198
0.423TrpTrp: 0.423 ± 0.166
0.581TrpTyr: 0.581 ± 0.177
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.219TyrAla: 2.219 ± 0.376
0.476TyrCys: 0.476 ± 0.168
2.378TyrAsp: 2.378 ± 0.375
2.378TyrGlu: 2.378 ± 0.404
1.374TyrPhe: 1.374 ± 0.331
1.85TyrGly: 1.85 ± 0.258
0.793TyrHis: 0.793 ± 0.198
1.955TyrIle: 1.955 ± 0.365
1.48TyrLys: 1.48 ± 0.324
2.431TyrLeu: 2.431 ± 0.43
1.215TyrMet: 1.215 ± 0.238
1.638TyrAsn: 1.638 ± 0.282
1.955TyrPro: 1.955 ± 0.351
1.691TyrGln: 1.691 ± 0.336
2.061TyrArg: 2.061 ± 0.274
2.642TyrSer: 2.642 ± 0.423
2.748TyrThr: 2.748 ± 0.354
2.272TyrVal: 2.272 ± 0.307
0.528TyrTrp: 0.528 ± 0.157
1.163TyrTyr: 1.163 ± 0.252
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 73 proteins (18925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski