Amino acid dipepetide frequency for Streptococcus phage Javan306

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.355AlaAla: 3.355 ± 0.845
0.508AlaCys: 0.508 ± 0.242
3.863AlaAsp: 3.863 ± 0.653
6.1AlaGlu: 6.1 ± 0.684
3.253AlaPhe: 3.253 ± 0.603
3.05AlaGly: 3.05 ± 0.602
0.407AlaHis: 0.407 ± 0.207
6.1AlaIle: 6.1 ± 0.855
4.778AlaLys: 4.778 ± 0.772
7.117AlaLeu: 7.117 ± 0.845
2.237AlaMet: 2.237 ± 0.371
3.66AlaAsn: 3.66 ± 0.866
1.932AlaPro: 1.932 ± 0.518
2.847AlaGln: 2.847 ± 0.635
2.745AlaArg: 2.745 ± 0.466
3.355AlaSer: 3.355 ± 0.823
4.067AlaThr: 4.067 ± 0.65
4.778AlaVal: 4.778 ± 0.834
1.22AlaTrp: 1.22 ± 0.326
2.745AlaTyr: 2.745 ± 0.493
0.0AlaXaa: 0.0 ± 0.0
Cys
0.305CysAla: 0.305 ± 0.249
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.61CysGlu: 0.61 ± 0.247
0.407CysPhe: 0.407 ± 0.346
0.305CysGly: 0.305 ± 0.165
0.203CysHis: 0.203 ± 0.127
0.305CysIle: 0.305 ± 0.215
0.407CysLys: 0.407 ± 0.246
0.61CysLeu: 0.61 ± 0.261
0.102CysMet: 0.102 ± 0.129
0.0CysAsn: 0.0 ± 0.0
0.203CysPro: 0.203 ± 0.159
0.508CysGln: 0.508 ± 0.206
0.508CysArg: 0.508 ± 0.287
0.508CysSer: 0.508 ± 0.251
0.102CysThr: 0.102 ± 0.113
0.203CysVal: 0.203 ± 0.139
0.102CysTrp: 0.102 ± 0.081
0.61CysTyr: 0.61 ± 0.213
0.0CysXaa: 0.0 ± 0.0
Asp
2.847AspAla: 2.847 ± 0.606
0.508AspCys: 0.508 ± 0.203
4.067AspAsp: 4.067 ± 0.83
4.677AspGlu: 4.677 ± 0.89
2.847AspPhe: 2.847 ± 0.549
6.202AspGly: 6.202 ± 1.155
1.22AspHis: 1.22 ± 0.454
5.49AspIle: 5.49 ± 0.751
4.982AspLys: 4.982 ± 0.675
5.49AspLeu: 5.49 ± 0.808
1.525AspMet: 1.525 ± 0.489
3.152AspAsn: 3.152 ± 0.859
1.525AspPro: 1.525 ± 0.465
0.712AspGln: 0.712 ± 0.329
1.932AspArg: 1.932 ± 0.473
3.558AspSer: 3.558 ± 0.464
1.932AspThr: 1.932 ± 0.524
3.457AspVal: 3.457 ± 0.569
0.915AspTrp: 0.915 ± 0.27
2.643AspTyr: 2.643 ± 0.512
0.0AspXaa: 0.0 ± 0.0
Glu
6.507GluAla: 6.507 ± 1.369
0.407GluCys: 0.407 ± 0.226
4.982GluAsp: 4.982 ± 0.788
7.727GluGlu: 7.727 ± 1.342
3.762GluPhe: 3.762 ± 0.645
3.152GluGly: 3.152 ± 0.639
1.322GluHis: 1.322 ± 0.326
5.388GluIle: 5.388 ± 0.756
8.54GluLys: 8.54 ± 1.04
9.048GluLeu: 9.048 ± 0.953
3.355GluMet: 3.355 ± 0.857
4.473GluAsn: 4.473 ± 0.651
1.627GluPro: 1.627 ± 0.722
3.253GluGln: 3.253 ± 0.665
4.168GluArg: 4.168 ± 0.804
3.457GluSer: 3.457 ± 0.522
3.965GluThr: 3.965 ± 0.565
5.49GluVal: 5.49 ± 0.702
1.017GluTrp: 1.017 ± 0.41
3.152GluTyr: 3.152 ± 0.598
0.0GluXaa: 0.0 ± 0.0
Phe
2.948PheAla: 2.948 ± 0.557
0.203PheCys: 0.203 ± 0.169
2.643PheAsp: 2.643 ± 0.558
4.067PheGlu: 4.067 ± 0.795
2.643PhePhe: 2.643 ± 0.657
3.05PheGly: 3.05 ± 0.641
0.407PheHis: 0.407 ± 0.251
3.253PheIle: 3.253 ± 0.604
3.66PheLys: 3.66 ± 0.538
2.135PheLeu: 2.135 ± 0.533
1.118PheMet: 1.118 ± 0.443
2.643PheAsn: 2.643 ± 0.388
1.118PhePro: 1.118 ± 0.376
1.83PheGln: 1.83 ± 0.514
2.135PheArg: 2.135 ± 0.427
2.237PheSer: 2.237 ± 0.494
2.542PheThr: 2.542 ± 0.507
2.643PheVal: 2.643 ± 0.526
0.915PheTrp: 0.915 ± 0.284
1.627PheTyr: 1.627 ± 0.437
0.0PheXaa: 0.0 ± 0.0
Gly
4.677GlyAla: 4.677 ± 0.762
0.203GlyCys: 0.203 ± 0.162
4.88GlyAsp: 4.88 ± 0.831
4.778GlyGlu: 4.778 ± 0.87
3.05GlyPhe: 3.05 ± 0.565
3.355GlyGly: 3.355 ± 0.608
0.813GlyHis: 0.813 ± 0.311
4.575GlyIle: 4.575 ± 1.194
4.677GlyLys: 4.677 ± 0.594
5.592GlyLeu: 5.592 ± 0.793
1.627GlyMet: 1.627 ± 0.413
4.067GlyAsn: 4.067 ± 0.776
0.813GlyPro: 0.813 ± 0.361
1.83GlyGln: 1.83 ± 0.483
2.948GlyArg: 2.948 ± 0.638
3.152GlySer: 3.152 ± 0.596
3.152GlyThr: 3.152 ± 0.424
3.863GlyVal: 3.863 ± 0.528
1.83GlyTrp: 1.83 ± 0.593
3.253GlyTyr: 3.253 ± 0.624
0.0GlyXaa: 0.0 ± 0.0
His
0.61HisAla: 0.61 ± 0.223
0.102HisCys: 0.102 ± 0.089
1.118HisAsp: 1.118 ± 0.378
0.407HisGlu: 0.407 ± 0.203
1.017HisPhe: 1.017 ± 0.281
0.915HisGly: 0.915 ± 0.23
0.305HisHis: 0.305 ± 0.215
1.525HisIle: 1.525 ± 0.379
0.407HisLys: 0.407 ± 0.171
1.118HisLeu: 1.118 ± 0.381
0.305HisMet: 0.305 ± 0.169
1.22HisAsn: 1.22 ± 0.361
0.407HisPro: 0.407 ± 0.243
0.813HisGln: 0.813 ± 0.366
0.102HisArg: 0.102 ± 0.117
1.017HisSer: 1.017 ± 0.339
0.813HisThr: 0.813 ± 0.269
1.017HisVal: 1.017 ± 0.342
0.102HisTrp: 0.102 ± 0.094
0.407HisTyr: 0.407 ± 0.216
0.0HisXaa: 0.0 ± 0.0
Ile
5.287IleAla: 5.287 ± 0.774
0.61IleCys: 0.61 ± 0.287
4.575IleAsp: 4.575 ± 0.642
5.287IleGlu: 5.287 ± 1.135
3.152IlePhe: 3.152 ± 0.469
4.575IleGly: 4.575 ± 0.779
1.017IleHis: 1.017 ± 0.324
3.762IleIle: 3.762 ± 0.657
7.828IleLys: 7.828 ± 1.058
5.083IleLeu: 5.083 ± 0.98
1.322IleMet: 1.322 ± 0.302
4.168IleAsn: 4.168 ± 0.704
1.83IlePro: 1.83 ± 0.462
2.847IleGln: 2.847 ± 0.46
2.237IleArg: 2.237 ± 0.472
5.185IleSer: 5.185 ± 0.891
4.778IleThr: 4.778 ± 0.806
3.152IleVal: 3.152 ± 0.627
0.712IleTrp: 0.712 ± 0.306
2.542IleTyr: 2.542 ± 0.613
0.0IleXaa: 0.0 ± 0.0
Lys
6.202LysAla: 6.202 ± 0.895
0.203LysCys: 0.203 ± 0.115
4.88LysAsp: 4.88 ± 0.991
6.71LysGlu: 6.71 ± 0.884
2.135LysPhe: 2.135 ± 0.415
4.372LysGly: 4.372 ± 0.716
1.118LysHis: 1.118 ± 0.322
5.795LysIle: 5.795 ± 0.896
7.32LysLys: 7.32 ± 0.887
7.117LysLeu: 7.117 ± 0.962
3.05LysMet: 3.05 ± 0.461
4.372LysAsn: 4.372 ± 0.755
3.66LysPro: 3.66 ± 0.739
4.88LysGln: 4.88 ± 0.687
4.27LysArg: 4.27 ± 0.997
4.982LysSer: 4.982 ± 0.892
4.88LysThr: 4.88 ± 0.692
5.897LysVal: 5.897 ± 0.879
1.22LysTrp: 1.22 ± 0.303
2.643LysTyr: 2.643 ± 0.601
0.0LysXaa: 0.0 ± 0.0
Leu
5.795LeuAla: 5.795 ± 0.823
0.305LeuCys: 0.305 ± 0.198
5.998LeuAsp: 5.998 ± 0.895
8.337LeuGlu: 8.337 ± 1.031
2.643LeuPhe: 2.643 ± 0.546
5.795LeuGly: 5.795 ± 0.93
0.915LeuHis: 0.915 ± 0.298
5.083LeuIle: 5.083 ± 0.85
8.54LeuLys: 8.54 ± 0.759
6.202LeuLeu: 6.202 ± 1.118
2.44LeuMet: 2.44 ± 0.489
3.762LeuAsn: 3.762 ± 0.551
2.237LeuPro: 2.237 ± 0.647
2.338LeuGln: 2.338 ± 0.664
4.575LeuArg: 4.575 ± 1.143
5.998LeuSer: 5.998 ± 0.866
4.982LeuThr: 4.982 ± 0.647
3.965LeuVal: 3.965 ± 0.629
1.017LeuTrp: 1.017 ± 0.277
2.542LeuTyr: 2.542 ± 0.557
0.0LeuXaa: 0.0 ± 0.0
Met
1.627MetAla: 1.627 ± 0.402
0.305MetCys: 0.305 ± 0.235
1.322MetAsp: 1.322 ± 0.396
2.745MetGlu: 2.745 ± 0.544
1.118MetPhe: 1.118 ± 0.371
1.22MetGly: 1.22 ± 0.284
0.0MetHis: 0.0 ± 0.0
1.627MetIle: 1.627 ± 0.476
2.44MetLys: 2.44 ± 0.537
1.932MetLeu: 1.932 ± 0.4
0.407MetMet: 0.407 ± 0.257
2.033MetAsn: 2.033 ± 0.459
0.712MetPro: 0.712 ± 0.314
0.712MetGln: 0.712 ± 0.238
1.322MetArg: 1.322 ± 0.473
1.423MetSer: 1.423 ± 0.322
1.932MetThr: 1.932 ± 0.504
1.423MetVal: 1.423 ± 0.355
0.407MetTrp: 0.407 ± 0.23
0.712MetTyr: 0.712 ± 0.263
0.0MetXaa: 0.0 ± 0.0
Asn
3.253AsnAla: 3.253 ± 0.606
0.203AsnCys: 0.203 ± 0.181
2.948AsnAsp: 2.948 ± 0.578
5.083AsnGlu: 5.083 ± 0.737
3.05AsnPhe: 3.05 ± 0.548
4.778AsnGly: 4.778 ± 0.821
0.508AsnHis: 0.508 ± 0.202
2.948AsnIle: 2.948 ± 0.591
5.388AsnLys: 5.388 ± 0.829
3.355AsnLeu: 3.355 ± 0.726
0.813AsnMet: 0.813 ± 0.451
3.355AsnAsn: 3.355 ± 0.603
2.847AsnPro: 2.847 ± 0.605
2.847AsnGln: 2.847 ± 0.497
2.338AsnArg: 2.338 ± 0.542
3.558AsnSer: 3.558 ± 0.704
2.745AsnThr: 2.745 ± 0.516
3.253AsnVal: 3.253 ± 0.64
0.813AsnTrp: 0.813 ± 0.28
1.728AsnTyr: 1.728 ± 0.544
0.0AsnXaa: 0.0 ± 0.0
Pro
1.932ProAla: 1.932 ± 0.426
0.508ProCys: 0.508 ± 0.272
1.423ProAsp: 1.423 ± 0.507
2.237ProGlu: 2.237 ± 0.485
1.322ProPhe: 1.322 ± 0.437
1.017ProGly: 1.017 ± 0.295
0.61ProHis: 0.61 ± 0.261
2.745ProIle: 2.745 ± 0.439
1.627ProLys: 1.627 ± 0.6
2.847ProLeu: 2.847 ± 0.491
0.508ProMet: 0.508 ± 0.228
0.508ProAsn: 0.508 ± 0.216
0.407ProPro: 0.407 ± 0.275
1.627ProGln: 1.627 ± 0.377
0.813ProArg: 0.813 ± 0.385
2.135ProSer: 2.135 ± 0.505
2.237ProThr: 2.237 ± 0.575
1.932ProVal: 1.932 ± 0.404
0.407ProTrp: 0.407 ± 0.196
0.813ProTyr: 0.813 ± 0.342
0.0ProXaa: 0.0 ± 0.0
Gln
4.168GlnAla: 4.168 ± 0.685
0.102GlnCys: 0.102 ± 0.094
1.118GlnAsp: 1.118 ± 0.297
4.473GlnGlu: 4.473 ± 0.597
1.017GlnPhe: 1.017 ± 0.316
1.728GlnGly: 1.728 ± 0.344
0.305GlnHis: 0.305 ± 0.183
2.135GlnIle: 2.135 ± 0.541
3.457GlnLys: 3.457 ± 0.472
3.965GlnLeu: 3.965 ± 0.688
1.22GlnMet: 1.22 ± 0.314
2.338GlnAsn: 2.338 ± 0.475
0.813GlnPro: 0.813 ± 0.258
1.423GlnGln: 1.423 ± 0.371
1.423GlnArg: 1.423 ± 0.419
2.745GlnSer: 2.745 ± 0.6
3.457GlnThr: 3.457 ± 0.586
2.033GlnVal: 2.033 ± 0.328
0.102GlnTrp: 0.102 ± 0.112
1.017GlnTyr: 1.017 ± 0.341
0.0GlnXaa: 0.0 ± 0.0
Arg
2.643ArgAla: 2.643 ± 0.628
0.203ArgCys: 0.203 ± 0.169
2.643ArgAsp: 2.643 ± 0.629
3.66ArgGlu: 3.66 ± 0.773
1.728ArgPhe: 1.728 ± 0.52
2.237ArgGly: 2.237 ± 0.422
0.915ArgHis: 0.915 ± 0.368
2.745ArgIle: 2.745 ± 0.625
5.592ArgLys: 5.592 ± 1.187
3.253ArgLeu: 3.253 ± 0.677
0.915ArgMet: 0.915 ± 0.287
2.948ArgAsn: 2.948 ± 0.563
0.915ArgPro: 0.915 ± 0.421
1.627ArgGln: 1.627 ± 0.421
2.135ArgArg: 2.135 ± 0.503
2.643ArgSer: 2.643 ± 0.498
2.338ArgThr: 2.338 ± 0.505
2.135ArgVal: 2.135 ± 0.679
0.61ArgTrp: 0.61 ± 0.222
2.338ArgTyr: 2.338 ± 0.421
0.0ArgXaa: 0.0 ± 0.0
Ser
4.372SerAla: 4.372 ± 0.587
0.508SerCys: 0.508 ± 0.23
2.643SerAsp: 2.643 ± 0.501
5.083SerGlu: 5.083 ± 1.005
3.253SerPhe: 3.253 ± 0.469
4.27SerGly: 4.27 ± 0.872
0.407SerHis: 0.407 ± 0.25
4.677SerIle: 4.677 ± 0.786
3.253SerLys: 3.253 ± 0.501
3.965SerLeu: 3.965 ± 0.596
1.423SerMet: 1.423 ± 0.386
3.66SerAsn: 3.66 ± 0.653
2.135SerPro: 2.135 ± 0.39
2.643SerGln: 2.643 ± 0.757
2.847SerArg: 2.847 ± 0.567
3.863SerSer: 3.863 ± 0.915
3.355SerThr: 3.355 ± 0.735
3.965SerVal: 3.965 ± 0.74
0.813SerTrp: 0.813 ± 0.276
2.643SerTyr: 2.643 ± 0.602
0.0SerXaa: 0.0 ± 0.0
Thr
4.372ThrAla: 4.372 ± 1.391
0.0ThrCys: 0.0 ± 0.0
3.66ThrAsp: 3.66 ± 0.696
3.355ThrGlu: 3.355 ± 0.784
2.847ThrPhe: 2.847 ± 0.544
4.778ThrGly: 4.778 ± 0.73
1.423ThrHis: 1.423 ± 0.381
4.067ThrIle: 4.067 ± 0.679
4.677ThrLys: 4.677 ± 0.67
4.473ThrLeu: 4.473 ± 0.598
1.017ThrMet: 1.017 ± 0.277
2.338ThrAsn: 2.338 ± 0.348
1.118ThrPro: 1.118 ± 0.31
2.033ThrGln: 2.033 ± 0.562
3.05ThrArg: 3.05 ± 0.505
3.05ThrSer: 3.05 ± 0.716
2.745ThrThr: 2.745 ± 0.561
4.473ThrVal: 4.473 ± 0.761
0.61ThrTrp: 0.61 ± 0.266
2.033ThrTyr: 2.033 ± 0.575
0.0ThrXaa: 0.0 ± 0.0
Val
4.168ValAla: 4.168 ± 0.717
0.203ValCys: 0.203 ± 0.154
4.372ValAsp: 4.372 ± 0.697
4.778ValGlu: 4.778 ± 0.65
1.932ValPhe: 1.932 ± 0.492
4.677ValGly: 4.677 ± 0.801
1.017ValHis: 1.017 ± 0.311
4.27ValIle: 4.27 ± 0.652
4.677ValLys: 4.677 ± 0.721
4.88ValLeu: 4.88 ± 0.687
1.118ValMet: 1.118 ± 0.273
3.457ValAsn: 3.457 ± 0.504
1.728ValPro: 1.728 ± 0.517
1.627ValGln: 1.627 ± 0.439
1.525ValArg: 1.525 ± 0.366
4.27ValSer: 4.27 ± 0.636
4.168ValThr: 4.168 ± 0.751
4.677ValVal: 4.677 ± 0.736
1.118ValTrp: 1.118 ± 0.427
2.033ValTyr: 2.033 ± 0.613
0.0ValXaa: 0.0 ± 0.0
Trp
0.712TrpAla: 0.712 ± 0.253
0.203TrpCys: 0.203 ± 0.18
0.305TrpAsp: 0.305 ± 0.166
1.22TrpGlu: 1.22 ± 0.387
1.017TrpPhe: 1.017 ± 0.305
0.813TrpGly: 0.813 ± 0.262
0.203TrpHis: 0.203 ± 0.171
1.22TrpIle: 1.22 ± 0.318
1.017TrpLys: 1.017 ± 0.309
1.22TrpLeu: 1.22 ± 0.297
0.203TrpMet: 0.203 ± 0.157
1.322TrpAsn: 1.322 ± 0.588
0.203TrpPro: 0.203 ± 0.128
0.915TrpGln: 0.915 ± 0.289
0.712TrpArg: 0.712 ± 0.25
0.508TrpSer: 0.508 ± 0.269
0.508TrpThr: 0.508 ± 0.204
1.017TrpVal: 1.017 ± 0.273
0.305TrpTrp: 0.305 ± 0.216
0.915TrpTyr: 0.915 ± 0.561
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.44TyrAla: 2.44 ± 0.488
0.712TyrCys: 0.712 ± 0.3
2.237TyrAsp: 2.237 ± 0.432
3.457TyrGlu: 3.457 ± 0.517
1.627TyrPhe: 1.627 ± 0.423
2.847TyrGly: 2.847 ± 0.518
0.61TyrHis: 0.61 ± 0.24
2.237TyrIle: 2.237 ± 0.547
2.44TyrLys: 2.44 ± 0.467
4.067TyrLeu: 4.067 ± 0.668
0.61TyrMet: 0.61 ± 0.293
2.338TyrAsn: 2.338 ± 0.528
1.423TyrPro: 1.423 ± 0.445
1.728TyrGln: 1.728 ± 0.526
2.44TyrArg: 2.44 ± 0.538
2.135TyrSer: 2.135 ± 0.446
1.423TyrThr: 1.423 ± 0.457
1.322TyrVal: 1.322 ± 0.361
0.305TyrTrp: 0.305 ± 0.184
1.932TyrTyr: 1.932 ± 0.613
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (9837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski