Amino acid dipepetide frequency for Bunyavirus La Crosse (isolate Human/United States/L78/1978)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.481AlaAla: 2.481 ± 3.212
1.985AlaCys: 1.985 ± 0.873
2.233AlaAsp: 2.233 ± 0.561
2.978AlaGlu: 2.978 ± 1.299
1.241AlaPhe: 1.241 ± 0.493
1.737AlaGly: 1.737 ± 1.076
0.993AlaHis: 0.993 ± 0.346
5.955AlaIle: 5.955 ± 0.875
3.97AlaLys: 3.97 ± 2.682
3.722AlaLeu: 3.722 ± 1.14
1.737AlaMet: 1.737 ± 0.555
2.978AlaAsn: 2.978 ± 1.09
0.993AlaPro: 0.993 ± 0.346
1.241AlaGln: 1.241 ± 0.346
3.226AlaArg: 3.226 ± 0.274
3.722AlaSer: 3.722 ± 2.021
2.233AlaThr: 2.233 ± 0.644
2.233AlaVal: 2.233 ± 1.103
0.248AlaTrp: 0.248 ± 0.159
3.474AlaTyr: 3.474 ± 1.328
0.0AlaXaa: 0.0 ± 0.0
Cys
0.744CysAla: 0.744 ± 0.477
0.248CysCys: 0.248 ± 0.159
0.496CysAsp: 0.496 ± 0.463
1.737CysGlu: 1.737 ± 0.951
1.985CysPhe: 1.985 ± 0.873
1.985CysGly: 1.985 ± 1.509
0.248CysHis: 0.248 ± 0.232
1.985CysIle: 1.985 ± 0.634
2.481CysLys: 2.481 ± 1.023
4.218CysLeu: 4.218 ± 1.447
0.744CysMet: 0.744 ± 0.477
1.241CysAsn: 1.241 ± 0.511
1.241CysPro: 1.241 ± 0.511
1.241CysGln: 1.241 ± 0.511
1.241CysArg: 1.241 ± 1.158
0.993CysSer: 0.993 ± 0.317
2.481CysThr: 2.481 ± 1.971
1.737CysVal: 1.737 ± 0.768
0.248CysTrp: 0.248 ± 0.232
0.496CysTyr: 0.496 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
3.226AspAla: 3.226 ± 0.365
0.744AspCys: 0.744 ± 0.364
2.73AspAsp: 2.73 ± 0.483
3.226AspGlu: 3.226 ± 0.274
3.722AspPhe: 3.722 ± 0.344
1.737AspGly: 1.737 ± 0.492
0.496AspHis: 0.496 ± 0.318
6.203AspIle: 6.203 ± 2.463
4.963AspLys: 4.963 ± 0.766
5.707AspLeu: 5.707 ± 1.138
1.985AspMet: 1.985 ± 0.805
2.978AspAsn: 2.978 ± 1.29
2.481AspPro: 2.481 ± 1.671
1.985AspGln: 1.985 ± 0.508
2.233AspArg: 2.233 ± 0.651
2.233AspSer: 2.233 ± 0.771
1.241AspThr: 1.241 ± 0.798
3.722AspVal: 3.722 ± 1.39
0.496AspTrp: 0.496 ± 0.159
4.467AspTyr: 4.467 ± 0.841
0.0AspXaa: 0.0 ± 0.0
Glu
3.97GluAla: 3.97 ± 1.11
0.993GluCys: 0.993 ± 0.317
2.73GluAsp: 2.73 ± 0.975
3.97GluGlu: 3.97 ± 1.269
4.467GluPhe: 4.467 ± 1.935
2.978GluGly: 2.978 ± 0.952
1.241GluHis: 1.241 ± 0.346
4.218GluIle: 4.218 ± 0.916
3.97GluLys: 3.97 ± 1.383
6.452GluLeu: 6.452 ± 0.533
2.233GluMet: 2.233 ± 0.378
3.474GluAsn: 3.474 ± 1.164
1.985GluPro: 1.985 ± 0.555
2.73GluGln: 2.73 ± 1.107
3.474GluArg: 3.474 ± 1.164
4.467GluSer: 4.467 ± 1.301
3.474GluThr: 3.474 ± 0.94
3.226GluVal: 3.226 ± 0.531
0.744GluTrp: 0.744 ± 0.789
2.233GluTyr: 2.233 ± 0.836
0.0GluXaa: 0.0 ± 0.0
Phe
1.737PheAla: 1.737 ± 0.492
1.241PheCys: 1.241 ± 0.642
2.481PheAsp: 2.481 ± 0.382
3.474PheGlu: 3.474 ± 0.984
0.993PhePhe: 0.993 ± 1.625
2.233PheGly: 2.233 ± 1.279
0.744PheHis: 0.744 ± 0.695
2.73PheIle: 2.73 ± 0.899
5.211PheLys: 5.211 ± 0.737
4.715PheLeu: 4.715 ± 2.122
0.744PheMet: 0.744 ± 0.477
2.481PheAsn: 2.481 ± 1.271
1.489PhePro: 1.489 ± 1.484
0.496PheGln: 0.496 ± 0.463
2.233PheArg: 2.233 ± 1.113
4.218PheSer: 4.218 ± 1.781
2.978PheThr: 2.978 ± 1.038
1.737PheVal: 1.737 ± 0.8
0.744PheTrp: 0.744 ± 0.217
2.233PheTyr: 2.233 ± 1.306
0.0PheXaa: 0.0 ± 0.0
Gly
1.985GlyAla: 1.985 ± 0.623
2.73GlyCys: 2.73 ± 0.975
2.978GlyAsp: 2.978 ± 0.869
2.73GlyGlu: 2.73 ± 0.446
0.993GlyPhe: 0.993 ± 0.673
1.489GlyGly: 1.489 ± 0.545
0.993GlyHis: 0.993 ± 0.317
3.226GlyIle: 3.226 ± 2.588
2.233GlyLys: 2.233 ± 0.378
4.715GlyLeu: 4.715 ± 0.853
1.241GlyMet: 1.241 ± 0.642
3.474GlyAsn: 3.474 ± 1.075
2.233GlyPro: 2.233 ± 1.103
1.489GlyGln: 1.489 ± 0.476
1.737GlyArg: 1.737 ± 1.742
2.978GlySer: 2.978 ± 0.658
3.722GlyThr: 3.722 ± 2.488
1.985GlyVal: 1.985 ± 0.922
0.993GlyTrp: 0.993 ± 0.733
1.985GlyTyr: 1.985 ± 1.347
0.0GlyXaa: 0.0 ± 0.0
His
0.496HisAla: 0.496 ± 0.463
0.993HisCys: 0.993 ± 0.589
2.233HisAsp: 2.233 ± 0.819
1.489HisGlu: 1.489 ± 0.545
1.489HisPhe: 1.489 ± 0.545
1.241HisGly: 1.241 ± 0.493
0.744HisHis: 0.744 ± 0.217
1.985HisIle: 1.985 ± 0.555
1.985HisLys: 1.985 ± 0.956
1.489HisLeu: 1.489 ± 0.476
0.993HisMet: 0.993 ± 0.346
1.241HisAsn: 1.241 ± 0.493
0.496HisPro: 0.496 ± 0.159
0.744HisGln: 0.744 ± 0.852
1.489HisArg: 1.489 ± 1.712
1.737HisSer: 1.737 ± 1.112
0.496HisThr: 0.496 ± 0.463
0.496HisVal: 0.496 ± 0.159
0.248HisTrp: 0.248 ± 0.159
0.496HisTyr: 0.496 ± 0.159
0.0HisXaa: 0.0 ± 0.0
Ile
5.955IleAla: 5.955 ± 1.003
1.489IleCys: 1.489 ± 0.728
3.722IleAsp: 3.722 ± 1.478
5.955IleGlu: 5.955 ± 1.903
3.722IlePhe: 3.722 ± 0.797
3.722IleGly: 3.722 ± 1.39
2.233IleHis: 2.233 ± 1.429
6.948IleIle: 6.948 ± 2.307
7.196IleLys: 7.196 ± 2.066
9.429IleLeu: 9.429 ± 1.756
1.737IleMet: 1.737 ± 0.969
5.955IleAsn: 5.955 ± 0.718
1.489IlePro: 1.489 ± 0.434
1.489IleGln: 1.489 ± 0.434
3.226IleArg: 3.226 ± 1.138
5.459IleSer: 5.459 ± 2.273
5.955IleThr: 5.955 ± 1.737
3.474IleVal: 3.474 ± 0.984
0.993IleTrp: 0.993 ± 0.879
4.467IleTyr: 4.467 ± 0.643
0.0IleXaa: 0.0 ± 0.0
Lys
4.218LysAla: 4.218 ± 2.703
2.233LysCys: 2.233 ± 0.819
5.211LysAsp: 5.211 ± 0.612
7.94LysGlu: 7.94 ± 2.4
3.226LysPhe: 3.226 ± 1.946
2.978LysGly: 2.978 ± 0.55
2.233LysHis: 2.233 ± 0.644
5.211LysIle: 5.211 ± 1.52
5.211LysLys: 5.211 ± 0.612
6.452LysLeu: 6.452 ± 2.144
2.978LysMet: 2.978 ± 1.022
4.218LysAsn: 4.218 ± 0.916
2.978LysPro: 2.978 ± 0.359
2.978LysGln: 2.978 ± 0.55
1.489LysArg: 1.489 ± 0.434
7.444LysSer: 7.444 ± 1.531
4.963LysThr: 4.963 ± 1.071
3.97LysVal: 3.97 ± 0.766
1.241LysTrp: 1.241 ± 1.562
3.226LysTyr: 3.226 ± 1.132
0.0LysXaa: 0.0 ± 0.0
Leu
4.715LeuAla: 4.715 ± 0.708
1.985LeuCys: 1.985 ± 0.873
4.963LeuAsp: 4.963 ± 1.053
6.203LeuGlu: 6.203 ± 1.491
3.722LeuPhe: 3.722 ± 1.244
2.978LeuGly: 2.978 ± 1.543
2.73LeuHis: 2.73 ± 0.799
7.196LeuIle: 7.196 ± 1.04
7.196LeuLys: 7.196 ± 1.729
8.685LeuLeu: 8.685 ± 1.139
2.481LeuMet: 2.481 ± 0.82
4.218LeuAsn: 4.218 ± 1.372
3.226LeuPro: 3.226 ± 1.074
2.73LeuGln: 2.73 ± 1.13
3.226LeuArg: 3.226 ± 0.274
8.437LeuSer: 8.437 ± 2.744
7.94LeuThr: 7.94 ± 1.397
5.459LeuVal: 5.459 ± 0.936
0.248LeuTrp: 0.248 ± 0.159
3.474LeuTyr: 3.474 ± 1.328
0.0LeuXaa: 0.0 ± 0.0
Met
1.737MetAla: 1.737 ± 0.664
1.241MetCys: 1.241 ± 0.346
2.233MetAsp: 2.233 ± 2.077
0.993MetGlu: 0.993 ± 0.635
0.744MetPhe: 0.744 ± 0.789
0.993MetGly: 0.993 ± 0.635
0.248MetHis: 0.248 ± 0.159
1.489MetIle: 1.489 ± 0.434
3.474MetLys: 3.474 ± 0.984
1.489MetLeu: 1.489 ± 0.476
1.985MetMet: 1.985 ± 1.233
1.737MetAsn: 1.737 ± 0.8
1.241MetPro: 1.241 ± 0.774
1.241MetGln: 1.241 ± 1.752
0.744MetArg: 0.744 ± 0.477
2.73MetSer: 2.73 ± 1.92
1.489MetThr: 1.489 ± 0.953
1.985MetVal: 1.985 ± 0.692
0.0MetTrp: 0.0 ± 0.0
1.241MetTyr: 1.241 ± 0.346
0.0MetXaa: 0.0 ± 0.0
Asn
3.226AsnAla: 3.226 ± 1.334
1.985AsnCys: 1.985 ± 1.178
3.97AsnAsp: 3.97 ± 1.017
2.73AsnGlu: 2.73 ± 0.761
2.73AsnPhe: 2.73 ± 0.899
2.978AsnGly: 2.978 ± 1.09
1.241AsnHis: 1.241 ± 0.798
3.97AsnIle: 3.97 ± 1.2
2.233AsnLys: 2.233 ± 0.651
5.707AsnLeu: 5.707 ± 0.858
1.241AsnMet: 1.241 ± 0.794
3.226AsnAsn: 3.226 ± 2.222
3.722AsnPro: 3.722 ± 1.839
1.489AsnGln: 1.489 ± 0.434
2.481AsnArg: 2.481 ± 0.982
3.474AsnSer: 3.474 ± 0.984
2.233AsnThr: 2.233 ± 0.651
2.73AsnVal: 2.73 ± 0.975
1.489AsnTrp: 1.489 ± 0.476
2.233AsnTyr: 2.233 ± 0.976
0.0AsnXaa: 0.0 ± 0.0
Pro
2.233ProAla: 2.233 ± 0.819
0.248ProCys: 0.248 ± 0.232
2.481ProAsp: 2.481 ± 0.382
2.233ProGlu: 2.233 ± 1.625
1.489ProPhe: 1.489 ± 0.476
4.218ProGly: 4.218 ± 0.801
0.496ProHis: 0.496 ± 0.159
5.211ProIle: 5.211 ± 1.104
1.737ProLys: 1.737 ± 0.537
0.993ProLeu: 0.993 ± 0.797
0.993ProMet: 0.993 ± 0.675
1.489ProAsn: 1.489 ± 0.728
0.744ProPro: 0.744 ± 0.477
0.993ProGln: 0.993 ± 1.435
1.241ProArg: 1.241 ± 0.958
1.985ProSer: 1.985 ± 0.694
1.241ProThr: 1.241 ± 0.493
2.233ProVal: 2.233 ± 0.644
0.496ProTrp: 0.496 ± 0.318
0.744ProTyr: 0.744 ± 0.217
0.0ProXaa: 0.0 ± 0.0
Gln
0.993GlnAla: 0.993 ± 0.317
0.744GlnCys: 0.744 ± 0.364
1.985GlnAsp: 1.985 ± 0.555
1.241GlnGlu: 1.241 ± 0.346
1.985GlnPhe: 1.985 ± 0.555
1.241GlnGly: 1.241 ± 1.4
1.241GlnHis: 1.241 ± 0.798
2.233GlnIle: 2.233 ± 1.113
3.722GlnLys: 3.722 ± 0.912
2.481GlnLeu: 2.481 ± 1.99
0.248GlnMet: 0.248 ± 0.936
1.737GlnAsn: 1.737 ± 0.759
0.248GlnPro: 0.248 ± 0.159
0.993GlnGln: 0.993 ± 0.799
3.226GlnArg: 3.226 ± 2.043
1.737GlnSer: 1.737 ± 0.555
2.73GlnThr: 2.73 ± 0.975
2.233GlnVal: 2.233 ± 1.205
0.0GlnTrp: 0.0 ± 0.0
1.489GlnTyr: 1.489 ± 1.557
0.0GlnXaa: 0.0 ± 0.0
Arg
1.489ArgAla: 1.489 ± 0.434
1.241ArgCys: 1.241 ± 0.511
2.73ArgAsp: 2.73 ± 1.137
3.226ArgGlu: 3.226 ± 1.181
1.985ArgPhe: 1.985 ± 0.555
1.241ArgGly: 1.241 ± 0.791
1.985ArgHis: 1.985 ± 0.956
3.97ArgIle: 3.97 ± 1.106
4.218ArgLys: 4.218 ± 0.894
3.97ArgLeu: 3.97 ± 3.313
0.993ArgMet: 0.993 ± 0.537
2.73ArgAsn: 2.73 ± 1.107
0.744ArgPro: 0.744 ± 0.852
1.241ArgGln: 1.241 ± 0.642
0.993ArgArg: 0.993 ± 0.635
2.73ArgSer: 2.73 ± 0.769
1.489ArgThr: 1.489 ± 0.545
1.985ArgVal: 1.985 ± 1.191
0.993ArgTrp: 0.993 ± 1.423
2.233ArgTyr: 2.233 ± 0.486
0.0ArgXaa: 0.0 ± 0.0
Ser
2.481SerAla: 2.481 ± 0.793
2.73SerCys: 2.73 ± 1.54
4.218SerAsp: 4.218 ± 0.866
2.73SerGlu: 2.73 ± 1.137
1.489SerPhe: 1.489 ± 0.901
4.467SerGly: 4.467 ± 2.024
1.737SerHis: 1.737 ± 0.702
7.94SerIle: 7.94 ± 1.607
7.94SerLys: 7.94 ± 2.4
7.692SerLeu: 7.692 ± 2.462
1.489SerMet: 1.489 ± 0.85
3.722SerAsn: 3.722 ± 0.344
2.481SerPro: 2.481 ± 0.691
1.489SerGln: 1.489 ± 2.123
3.226SerArg: 3.226 ± 0.938
5.459SerSer: 5.459 ± 2.351
3.97SerThr: 3.97 ± 1.768
4.715SerVal: 4.715 ± 0.926
0.744SerTrp: 0.744 ± 0.364
2.481SerTyr: 2.481 ± 1.023
0.0SerXaa: 0.0 ± 0.0
Thr
2.978ThrAla: 2.978 ± 1.323
1.489ThrCys: 1.489 ± 1.048
3.226ThrAsp: 3.226 ± 0.689
4.218ThrGlu: 4.218 ± 0.727
3.97ThrPhe: 3.97 ± 0.873
2.978ThrGly: 2.978 ± 1.213
0.744ThrHis: 0.744 ± 0.217
5.707ThrIle: 5.707 ± 1.944
4.218ThrLys: 4.218 ± 1.18
3.97ThrLeu: 3.97 ± 1.706
0.993ThrMet: 0.993 ± 0.346
3.226ThrAsn: 3.226 ± 0.955
2.233ThrPro: 2.233 ± 0.651
1.737ThrGln: 1.737 ± 0.759
2.233ThrArg: 2.233 ± 1.43
4.715ThrSer: 4.715 ± 0.926
3.97ThrThr: 3.97 ± 1.836
2.978ThrVal: 2.978 ± 0.952
0.744ThrTrp: 0.744 ± 0.364
3.722ThrTyr: 3.722 ± 1.086
0.0ThrXaa: 0.0 ± 0.0
Val
2.73ValAla: 2.73 ± 1.267
1.985ValCys: 1.985 ± 0.873
2.73ValAsp: 2.73 ± 0.769
2.73ValGlu: 2.73 ± 1.168
2.73ValPhe: 2.73 ± 0.289
2.233ValGly: 2.233 ± 0.378
1.241ValHis: 1.241 ± 0.493
3.474ValIle: 3.474 ± 0.736
4.218ValLys: 4.218 ± 1.106
4.715ValLeu: 4.715 ± 0.542
1.241ValMet: 1.241 ± 0.493
1.489ValAsn: 1.489 ± 0.645
1.489ValPro: 1.489 ± 0.476
2.978ValGln: 2.978 ± 1.227
2.233ValArg: 2.233 ± 1.103
4.467ValSer: 4.467 ± 0.842
3.474ValThr: 3.474 ± 1.019
1.737ValVal: 1.737 ± 0.555
0.0ValTrp: 0.0 ± 0.0
2.978ValTyr: 2.978 ± 1.455
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.248TrpCys: 0.248 ± 0.159
0.744TrpAsp: 0.744 ± 0.856
0.496TrpGlu: 0.496 ± 0.159
0.496TrpPhe: 0.496 ± 0.159
0.993TrpGly: 0.993 ± 0.733
0.248TrpHis: 0.248 ± 0.232
0.0TrpIle: 0.0 ± 0.0
0.744TrpLys: 0.744 ± 0.477
0.993TrpLeu: 0.993 ± 0.317
1.241TrpMet: 1.241 ± 0.626
0.993TrpAsn: 0.993 ± 0.346
0.248TrpPro: 0.248 ± 0.232
0.993TrpGln: 0.993 ± 0.673
0.496TrpArg: 0.496 ± 0.93
0.744TrpSer: 0.744 ± 0.477
0.496TrpThr: 0.496 ± 0.89
0.496TrpVal: 0.496 ± 0.813
0.0TrpTrp: 0.0 ± 0.0
0.248TrpTyr: 0.248 ± 0.159
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.985TyrAla: 1.985 ± 1.178
1.241TyrCys: 1.241 ± 1.158
2.73TyrAsp: 2.73 ± 0.446
2.73TyrGlu: 2.73 ± 1.428
1.737TyrPhe: 1.737 ± 1.112
1.489TyrGly: 1.489 ± 0.545
0.744TyrHis: 0.744 ± 0.364
4.963TyrIle: 4.963 ± 1.794
3.474TyrLys: 3.474 ± 1.328
4.218TyrLeu: 4.218 ± 2.284
1.489TyrMet: 1.489 ± 0.649
2.481TyrAsn: 2.481 ± 0.382
1.737TyrPro: 1.737 ± 0.537
2.233TyrGln: 2.233 ± 0.651
1.737TyrArg: 1.737 ± 0.492
3.474TyrSer: 3.474 ± 1.019
3.474TyrThr: 3.474 ± 0.984
1.737TyrVal: 1.737 ± 0.664
0.248TyrTrp: 0.248 ± 0.159
1.737TyrTyr: 1.737 ± 0.664
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (4031 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski