Amino acid dipepetide frequency for Halobacillus sp. BAB-2008

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.954AlaAla: 6.954 ± 0.109	0.624AlaCys: 0.624 ± 0.024	4.244AlaAsp: 4.244 ± 0.073	5.433AlaGlu: 5.433 ± 0.087	3.604AlaPhe: 3.604 ± 0.056	6.34AlaGly: 6.34 ± 0.079	1.342AlaHis: 1.342 ± 0.034	4.963AlaIle: 4.963 ± 0.077	3.978AlaLys: 3.978 ± 0.067	7.584AlaLeu: 7.584 ± 0.085	2.235AlaMet: 2.235 ± 0.051	2.169AlaAsn: 2.169 ± 0.045	2.403AlaPro: 2.403 ± 0.055	2.129AlaGln: 2.129 ± 0.05	2.941AlaArg: 2.941 ± 0.054	4.653AlaSer: 4.653 ± 0.082	3.197AlaThr: 3.197 ± 0.057	6.928AlaVal: 6.928 ± 0.098	0.769AlaTrp: 0.769 ± 0.029	2.548AlaTyr: 2.548 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.408CysAla: 0.408 ± 0.019	0.087CysCys: 0.087 ± 0.009	0.356CysAsp: 0.356 ± 0.02	0.39CysGlu: 0.39 ± 0.021	0.288CysPhe: 0.288 ± 0.017	0.646CysGly: 0.646 ± 0.025	0.191CysHis: 0.191 ± 0.013	0.386CysIle: 0.386 ± 0.021	0.272CysLys: 0.272 ± 0.017	0.652CysLeu: 0.652 ± 0.022	0.183CysMet: 0.183 ± 0.014	0.206CysAsn: 0.206 ± 0.014	0.335CysPro: 0.335 ± 0.019	0.206CysGln: 0.206 ± 0.014	0.35CysArg: 0.35 ± 0.017	0.478CysSer: 0.478 ± 0.022	0.371CysThr: 0.371 ± 0.018	0.401CysVal: 0.401 ± 0.02	0.063CysTrp: 0.063 ± 0.007	0.237CysTyr: 0.237 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.866AspAla: 3.866 ± 0.071	0.344AspCys: 0.344 ± 0.018	2.78AspAsp: 2.78 ± 0.059	4.504AspGlu: 4.504 ± 0.065	2.401AspPhe: 2.401 ± 0.043	4.03AspGly: 4.03 ± 0.073	1.538AspHis: 1.538 ± 0.042	3.908AspIle: 3.908 ± 0.072	3.114AspLys: 3.114 ± 0.053	5.202AspLeu: 5.202 ± 0.079	1.571AspMet: 1.571 ± 0.043	1.587AspAsn: 1.587 ± 0.041	2.477AspPro: 2.477 ± 0.053	2.308AspGln: 2.308 ± 0.052	3.116AspArg: 3.116 ± 0.055	2.779AspSer: 2.779 ± 0.053	2.827AspThr: 2.827 ± 0.052	4.333AspVal: 4.333 ± 0.065	0.751AspTrp: 0.751 ± 0.026	2.267AspTyr: 2.267 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	6.766GluAla: 6.766 ± 0.095	0.34GluCys: 0.34 ± 0.018	4.689GluAsp: 4.689 ± 0.07	9.124GluGlu: 9.124 ± 0.128	2.263GluPhe: 2.263 ± 0.046	5.378GluGly: 5.378 ± 0.079	1.596GluHis: 1.596 ± 0.039	4.638GluIle: 4.638 ± 0.068	5.97GluLys: 5.97 ± 0.089	6.55GluLeu: 6.55 ± 0.083	2.49GluMet: 2.49 ± 0.048	3.065GluAsn: 3.065 ± 0.053	2.242GluPro: 2.242 ± 0.051	3.772GluGln: 3.772 ± 0.069	4.225GluArg: 4.225 ± 0.07	3.807GluSer: 3.807 ± 0.058	4.202GluThr: 4.202 ± 0.065	5.544GluVal: 5.544 ± 0.074	1.049GluTrp: 1.049 ± 0.037	2.113GluTyr: 2.113 ± 0.048	0.001GluXaa: 0.001 ± 0.001
Phe	3.033PheAla: 3.033 ± 0.058	0.295PheCys: 0.295 ± 0.016	2.438PheAsp: 2.438 ± 0.053	2.714PheGlu: 2.714 ± 0.058	2.374PhePhe: 2.374 ± 0.053	3.43PheGly: 3.43 ± 0.067	1.215PheHis: 1.215 ± 0.039	3.138PheIle: 3.138 ± 0.054	1.853PheLys: 1.853 ± 0.039	4.933PheLeu: 4.933 ± 0.08	1.165PheMet: 1.165 ± 0.032	1.346PheAsn: 1.346 ± 0.035	1.722PhePro: 1.722 ± 0.043	1.834PheGln: 1.834 ± 0.046	2.024PheArg: 2.024 ± 0.044	2.894PheSer: 2.894 ± 0.053	2.557PheThr: 2.557 ± 0.05	2.988PheVal: 2.988 ± 0.061	0.444PheTrp: 0.444 ± 0.021	1.68PheTyr: 1.68 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.463GlyAla: 5.463 ± 0.082	0.619GlyCys: 0.619 ± 0.028	3.734GlyAsp: 3.734 ± 0.066	5.169GlyGlu: 5.169 ± 0.076	3.556GlyPhe: 3.556 ± 0.055	5.49GlyGly: 5.49 ± 0.082	1.46GlyHis: 1.46 ± 0.033	5.691GlyIle: 5.691 ± 0.087	4.621GlyLys: 4.621 ± 0.064	6.876GlyLeu: 6.876 ± 0.095	2.492GlyMet: 2.492 ± 0.051	2.465GlyAsn: 2.465 ± 0.045	2.027GlyPro: 2.027 ± 0.05	2.212GlyGln: 2.212 ± 0.044	3.356GlyArg: 3.356 ± 0.055	4.455GlySer: 4.455 ± 0.075	4.309GlyThr: 4.309 ± 0.067	5.629GlyVal: 5.629 ± 0.076	0.946GlyTrp: 0.946 ± 0.03	2.931GlyTyr: 2.931 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.528HisAla: 1.528 ± 0.041	0.175HisCys: 0.175 ± 0.014	1.105HisAsp: 1.105 ± 0.028	1.452HisGlu: 1.452 ± 0.037	1.094HisPhe: 1.094 ± 0.034	1.613HisGly: 1.613 ± 0.041	0.733HisHis: 0.733 ± 0.031	1.487HisIle: 1.487 ± 0.04	1.096HisLys: 1.096 ± 0.034	2.315HisLeu: 2.315 ± 0.049	0.631HisMet: 0.631 ± 0.025	0.663HisAsn: 0.663 ± 0.024	1.308HisPro: 1.308 ± 0.034	0.851HisGln: 0.851 ± 0.026	1.037HisArg: 1.037 ± 0.033	1.212HisSer: 1.212 ± 0.031	1.267HisThr: 1.267 ± 0.035	1.544HisVal: 1.544 ± 0.037	0.275HisTrp: 0.275 ± 0.015	0.939HisTyr: 0.939 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.718IleAla: 5.718 ± 0.082	0.545IleCys: 0.545 ± 0.024	4.094IleAsp: 4.094 ± 0.061	4.777IleGlu: 4.777 ± 0.065	2.788IlePhe: 2.788 ± 0.054	5.84IleGly: 5.84 ± 0.09	1.763IleHis: 1.763 ± 0.046	4.664IleIle: 4.664 ± 0.079	3.226IleLys: 3.226 ± 0.061	6.268IleLeu: 6.268 ± 0.093	1.594IleMet: 1.594 ± 0.036	2.364IleAsn: 2.364 ± 0.047	3.169IlePro: 3.169 ± 0.059	2.65IleGln: 2.65 ± 0.057	3.25IleArg: 3.25 ± 0.056	4.059IleSer: 4.059 ± 0.052	3.751IleThr: 3.751 ± 0.063	4.96IleVal: 4.96 ± 0.088	0.602IleTrp: 0.602 ± 0.024	2.046IleTyr: 2.046 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.606LysAla: 4.606 ± 0.064	0.229LysCys: 0.229 ± 0.014	3.714LysAsp: 3.714 ± 0.067	7.004LysGlu: 7.004 ± 0.087	1.5LysPhe: 1.5 ± 0.04	4.261LysGly: 4.261 ± 0.062	1.291LysHis: 1.291 ± 0.042	3.111LysIle: 3.111 ± 0.047	4.834LysLys: 4.834 ± 0.082	4.689LysLeu: 4.689 ± 0.068	1.8LysMet: 1.8 ± 0.042	2.403LysAsn: 2.403 ± 0.05	2.05LysPro: 2.05 ± 0.043	3.109LysGln: 3.109 ± 0.06	3.503LysArg: 3.503 ± 0.064	2.9LysSer: 2.9 ± 0.056	3.023LysThr: 3.023 ± 0.053	4.1LysVal: 4.1 ± 0.062	0.769LysTrp: 0.769 ± 0.031	1.721LysTyr: 1.721 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	7.569LeuAla: 7.569 ± 0.089	0.611LeuCys: 0.611 ± 0.022	5.108LeuAsp: 5.108 ± 0.083	6.812LeuGlu: 6.812 ± 0.089	4.922LeuPhe: 4.922 ± 0.091	6.526LeuGly: 6.526 ± 0.088	2.13LeuHis: 2.13 ± 0.049	6.433LeuIle: 6.433 ± 0.081	5.674LeuLys: 5.674 ± 0.091	10.243LeuLeu: 10.243 ± 0.136	2.662LeuMet: 2.662 ± 0.045	3.487LeuAsn: 3.487 ± 0.057	4.176LeuPro: 4.176 ± 0.063	3.313LeuGln: 3.313 ± 0.051	3.88LeuArg: 3.88 ± 0.06	6.657LeuSer: 6.657 ± 0.083	5.513LeuThr: 5.513 ± 0.071	6.336LeuVal: 6.336 ± 0.079	0.93LeuTrp: 0.93 ± 0.027	3.084LeuTyr: 3.084 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.138MetAla: 2.138 ± 0.045	0.118MetCys: 0.118 ± 0.01	1.892MetAsp: 1.892 ± 0.046	2.673MetGlu: 2.673 ± 0.054	1.027MetPhe: 1.027 ± 0.031	1.875MetGly: 1.875 ± 0.038	0.447MetHis: 0.447 ± 0.019	2.13MetIle: 2.13 ± 0.049	2.608MetLys: 2.608 ± 0.045	2.473MetLeu: 2.473 ± 0.05	0.974MetMet: 0.974 ± 0.034	1.626MetAsn: 1.626 ± 0.035	1.082MetPro: 1.082 ± 0.039	0.95MetGln: 0.95 ± 0.03	1.193MetArg: 1.193 ± 0.033	1.689MetSer: 1.689 ± 0.035	1.906MetThr: 1.906 ± 0.043	2.005MetVal: 2.005 ± 0.046	0.234MetTrp: 0.234 ± 0.015	0.79MetTyr: 0.79 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.357AsnAla: 2.357 ± 0.048	0.217AsnCys: 0.217 ± 0.013	2.042AsnAsp: 2.042 ± 0.049	2.718AsnGlu: 2.718 ± 0.053	1.347AsnPhe: 1.347 ± 0.039	2.986AsnGly: 2.986 ± 0.057	0.911AsnHis: 0.911 ± 0.03	2.444AsnIle: 2.444 ± 0.053	2.183AsnLys: 2.183 ± 0.049	2.904AsnLeu: 2.904 ± 0.051	0.986AsnMet: 0.986 ± 0.028	1.341AsnAsn: 1.341 ± 0.036	1.853AsnPro: 1.853 ± 0.047	1.544AsnGln: 1.544 ± 0.041	1.925AsnArg: 1.925 ± 0.044	1.689AsnSer: 1.689 ± 0.04	1.755AsnThr: 1.755 ± 0.042	2.659AsnVal: 2.659 ± 0.045	0.452AsnTrp: 0.452 ± 0.023	1.232AsnTyr: 1.232 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	2.773ProAla: 2.773 ± 0.054	0.226ProCys: 0.226 ± 0.017	2.574ProAsp: 2.574 ± 0.052	3.527ProGlu: 3.527 ± 0.059	2.029ProPhe: 2.029 ± 0.05	2.653ProGly: 2.653 ± 0.054	0.815ProHis: 0.815 ± 0.032	2.429ProIle: 2.429 ± 0.05	1.968ProLys: 1.968 ± 0.044	3.731ProLeu: 3.731 ± 0.067	1.031ProMet: 1.031 ± 0.031	1.34ProAsn: 1.34 ± 0.04	1.083ProPro: 1.083 ± 0.036	1.015ProGln: 1.015 ± 0.032	1.176ProArg: 1.176 ± 0.033	2.503ProSer: 2.503 ± 0.051	1.837ProThr: 1.837 ± 0.039	3.408ProVal: 3.408 ± 0.059	0.446ProTrp: 0.446 ± 0.022	1.449ProTyr: 1.449 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.963GlnAla: 2.963 ± 0.052	0.16GlnCys: 0.16 ± 0.012	1.756GlnAsp: 1.756 ± 0.041	3.281GlnGlu: 3.281 ± 0.057	1.375GlnPhe: 1.375 ± 0.038	2.469GlnGly: 2.469 ± 0.051	0.73GlnHis: 0.73 ± 0.025	2.146GlnIle: 2.146 ± 0.045	2.493GlnLys: 2.493 ± 0.051	3.733GlnLeu: 3.733 ± 0.063	1.307GlnMet: 1.307 ± 0.036	1.273GlnAsn: 1.273 ± 0.041	1.327GlnPro: 1.327 ± 0.032	1.728GlnGln: 1.728 ± 0.043	1.701GlnArg: 1.701 ± 0.042	2.195GlnSer: 2.195 ± 0.043	2.193GlnThr: 2.193 ± 0.042	2.529GlnVal: 2.529 ± 0.051	0.508GlnTrp: 0.508 ± 0.023	1.182GlnTyr: 1.182 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.796ArgAla: 2.796 ± 0.052	0.275ArgCys: 0.275 ± 0.015	2.312ArgAsp: 2.312 ± 0.044	3.65ArgGlu: 3.65 ± 0.062	2.079ArgPhe: 2.079 ± 0.052	2.612ArgGly: 2.612 ± 0.044	1.015ArgHis: 1.015 ± 0.032	3.257ArgIle: 3.257 ± 0.051	3.432ArgLys: 3.432 ± 0.062	4.691ArgLeu: 4.691 ± 0.075	1.72ArgMet: 1.72 ± 0.042	1.898ArgAsn: 1.898 ± 0.038	1.579ArgPro: 1.579 ± 0.041	1.715ArgGln: 1.715 ± 0.045	2.449ArgArg: 2.449 ± 0.054	2.703ArgSer: 2.703 ± 0.051	2.546ArgThr: 2.546 ± 0.051	2.982ArgVal: 2.982 ± 0.053	0.527ArgTrp: 0.527 ± 0.02	1.725ArgTyr: 1.725 ± 0.037	0.001ArgXaa: 0.001 ± 0.001
Ser	3.877SerAla: 3.877 ± 0.068	0.385SerCys: 0.385 ± 0.02	3.023SerAsp: 3.023 ± 0.053	4.017SerGlu: 4.017 ± 0.067	3.276SerPhe: 3.276 ± 0.057	4.934SerGly: 4.934 ± 0.078	1.242SerHis: 1.242 ± 0.03	4.57SerIle: 4.57 ± 0.064	3.216SerLys: 3.216 ± 0.055	6.026SerLeu: 6.026 ± 0.082	1.939SerMet: 1.939 ± 0.043	2.034SerAsn: 2.034 ± 0.041	2.183SerPro: 2.183 ± 0.051	1.805SerGln: 1.805 ± 0.037	2.54SerArg: 2.54 ± 0.047	3.841SerSer: 3.841 ± 0.073	2.944SerThr: 2.944 ± 0.051	4.215SerVal: 4.215 ± 0.072	0.635SerTrp: 0.635 ± 0.026	2.261SerTyr: 2.261 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.345ThrAla: 4.345 ± 0.073	0.346ThrCys: 0.346 ± 0.019	2.89ThrAsp: 2.89 ± 0.053	3.614ThrGlu: 3.614 ± 0.054	2.664ThrPhe: 2.664 ± 0.048	4.449ThrGly: 4.449 ± 0.072	1.069ThrHis: 1.069 ± 0.03	4.264ThrIle: 4.264 ± 0.057	3.044ThrLys: 3.044 ± 0.042	5.069ThrLeu: 5.069 ± 0.069	1.527ThrMet: 1.527 ± 0.032	2.046ThrAsn: 2.046 ± 0.043	2.287ThrPro: 2.287 ± 0.046	1.388ThrGln: 1.388 ± 0.033	1.969ThrArg: 1.969 ± 0.038	3.279ThrSer: 3.279 ± 0.055	2.849ThrThr: 2.849 ± 0.054	4.272ThrVal: 4.272 ± 0.061	0.567ThrTrp: 0.567 ± 0.023	2.036ThrTyr: 2.036 ± 0.041	0.001ThrXaa: 0.001 ± 0.001
Val	5.065ValAla: 5.065 ± 0.076	0.593ValCys: 0.593 ± 0.024	4.296ValAsp: 4.296 ± 0.065	5.473ValGlu: 5.473 ± 0.077	3.281ValPhe: 3.281 ± 0.059	4.744ValGly: 4.744 ± 0.073	1.699ValHis: 1.699 ± 0.035	5.33ValIle: 5.33 ± 0.068	4.262ValLys: 4.262 ± 0.06	7.631ValLeu: 7.631 ± 0.099	2.097ValMet: 2.097 ± 0.048	2.481ValAsn: 2.481 ± 0.056	2.94ValPro: 2.94 ± 0.059	2.589ValGln: 2.589 ± 0.047	3.145ValArg: 3.145 ± 0.057	4.603ValSer: 4.603 ± 0.064	4.4ValThr: 4.4 ± 0.071	5.335ValVal: 5.335 ± 0.085	0.788ValTrp: 0.788 ± 0.029	2.448ValTyr: 2.448 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.592TrpAla: 0.592 ± 0.025	0.071TrpCys: 0.071 ± 0.009	0.535TrpAsp: 0.535 ± 0.022	0.808TrpGlu: 0.808 ± 0.029	0.544TrpPhe: 0.544 ± 0.024	0.7TrpGly: 0.7 ± 0.026	0.206TrpHis: 0.206 ± 0.014	0.909TrpIle: 0.909 ± 0.033	0.961TrpLys: 0.961 ± 0.026	1.153TrpLeu: 1.153 ± 0.036	0.485TrpMet: 0.485 ± 0.022	0.569TrpAsn: 0.569 ± 0.023	0.259TrpPro: 0.259 ± 0.016	0.417TrpGln: 0.417 ± 0.02	0.467TrpArg: 0.467 ± 0.018	0.687TrpSer: 0.687 ± 0.027	0.67TrpThr: 0.67 ± 0.024	0.745TrpVal: 0.745 ± 0.027	0.16TrpTrp: 0.16 ± 0.013	0.375TrpTyr: 0.375 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.218TyrAla: 2.218 ± 0.049	0.244TyrCys: 0.244 ± 0.016	2.121TyrAsp: 2.121 ± 0.046	2.686TyrGlu: 2.686 ± 0.055	1.665TyrPhe: 1.665 ± 0.041	2.525TyrGly: 2.525 ± 0.044	0.933TyrHis: 0.933 ± 0.032	2.227TyrIle: 2.227 ± 0.045	1.812TyrLys: 1.812 ± 0.04	3.343TyrLeu: 3.343 ± 0.058	0.944TyrMet: 0.944 ± 0.031	1.181TyrAsn: 1.181 ± 0.033	1.511TyrPro: 1.511 ± 0.036	1.516TyrGln: 1.516 ± 0.042	1.716TyrArg: 1.716 ± 0.043	1.88TyrSer: 1.88 ± 0.04	1.86TyrThr: 1.86 ± 0.043	2.284TyrVal: 2.284 ± 0.047	0.397TyrTrp: 0.397 ± 0.018	1.302TyrTyr: 1.302 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3935 proteins (1089697 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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