Amino acid dipepetide frequency for Aeromonas phage 85AhydR10PP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.616AlaAla: 11.616 ± 1.327
1.14AlaCys: 1.14 ± 0.322
5.701AlaAsp: 5.701 ± 0.565
6.556AlaGlu: 6.556 ± 0.907
3.064AlaPhe: 3.064 ± 0.468
8.623AlaGly: 8.623 ± 0.918
1.497AlaHis: 1.497 ± 0.262
5.63AlaIle: 5.63 ± 0.709
7.269AlaLys: 7.269 ± 0.912
10.832AlaLeu: 10.832 ± 0.906
3.563AlaMet: 3.563 ± 0.622
2.851AlaAsn: 2.851 ± 0.674
3.92AlaPro: 3.92 ± 0.497
3.492AlaGln: 3.492 ± 0.446
5.844AlaArg: 5.844 ± 0.64
5.63AlaSer: 5.63 ± 0.751
6.2AlaThr: 6.2 ± 0.961
5.915AlaVal: 5.915 ± 0.743
1.069AlaTrp: 1.069 ± 0.405
2.993AlaTyr: 2.993 ± 0.387
0.0AlaXaa: 0.0 ± 0.0
Cys
1.497CysAla: 1.497 ± 0.426
0.143CysCys: 0.143 ± 0.104
0.855CysAsp: 0.855 ± 0.268
0.855CysGlu: 0.855 ± 0.262
0.499CysPhe: 0.499 ± 0.182
1.639CysGly: 1.639 ± 0.419
0.356CysHis: 0.356 ± 0.166
0.926CysIle: 0.926 ± 0.279
0.713CysLys: 0.713 ± 0.211
1.924CysLeu: 1.924 ± 0.396
0.214CysMet: 0.214 ± 0.121
0.57CysAsn: 0.57 ± 0.19
1.212CysPro: 1.212 ± 0.323
0.428CysGln: 0.428 ± 0.155
1.212CysArg: 1.212 ± 0.365
0.713CysSer: 0.713 ± 0.238
0.784CysThr: 0.784 ± 0.248
0.57CysVal: 0.57 ± 0.232
0.428CysTrp: 0.428 ± 0.185
0.641CysTyr: 0.641 ± 0.204
0.0CysXaa: 0.0 ± 0.0
Asp
6.556AspAla: 6.556 ± 0.544
1.069AspCys: 1.069 ± 0.249
2.566AspAsp: 2.566 ± 0.336
2.851AspGlu: 2.851 ± 0.511
2.138AspPhe: 2.138 ± 0.437
5.63AspGly: 5.63 ± 0.58
1.354AspHis: 1.354 ± 0.294
2.922AspIle: 2.922 ± 0.493
2.993AspLys: 2.993 ± 0.444
4.704AspLeu: 4.704 ± 0.631
1.568AspMet: 1.568 ± 0.275
2.423AspAsn: 2.423 ± 0.423
2.637AspPro: 2.637 ± 0.537
1.853AspGln: 1.853 ± 0.329
3.278AspArg: 3.278 ± 0.519
2.566AspSer: 2.566 ± 0.333
2.281AspThr: 2.281 ± 0.393
3.848AspVal: 3.848 ± 0.407
1.14AspTrp: 1.14 ± 0.324
0.784AspTyr: 0.784 ± 0.22
0.0AspXaa: 0.0 ± 0.0
Glu
7.412GluAla: 7.412 ± 0.707
0.784GluCys: 0.784 ± 0.244
2.352GluAsp: 2.352 ± 0.469
4.989GluGlu: 4.989 ± 0.832
1.71GluPhe: 1.71 ± 0.338
3.777GluGly: 3.777 ± 0.63
1.425GluHis: 1.425 ± 0.325
2.993GluIle: 2.993 ± 0.536
3.777GluLys: 3.777 ± 0.439
5.986GluLeu: 5.986 ± 0.707
1.71GluMet: 1.71 ± 0.333
1.354GluAsn: 1.354 ± 0.361
2.209GluPro: 2.209 ± 0.41
2.138GluGln: 2.138 ± 0.464
3.777GluArg: 3.777 ± 0.79
4.062GluSer: 4.062 ± 0.4
2.779GluThr: 2.779 ± 0.474
5.345GluVal: 5.345 ± 0.604
1.639GluTrp: 1.639 ± 0.353
1.782GluTyr: 1.782 ± 0.459
0.0GluXaa: 0.0 ± 0.0
Phe
2.067PheAla: 2.067 ± 0.281
0.499PheCys: 0.499 ± 0.164
2.352PheAsp: 2.352 ± 0.449
1.354PheGlu: 1.354 ± 0.241
0.356PhePhe: 0.356 ± 0.168
2.851PheGly: 2.851 ± 0.443
1.14PheHis: 1.14 ± 0.239
2.067PheIle: 2.067 ± 0.305
1.995PheLys: 1.995 ± 0.494
3.064PheLeu: 3.064 ± 0.426
0.428PheMet: 0.428 ± 0.15
0.926PheAsn: 0.926 ± 0.222
1.568PhePro: 1.568 ± 0.32
1.497PheGln: 1.497 ± 0.333
1.995PheArg: 1.995 ± 0.32
1.354PheSer: 1.354 ± 0.288
2.423PheThr: 2.423 ± 0.378
1.639PheVal: 1.639 ± 0.283
0.499PheTrp: 0.499 ± 0.204
0.57PheTyr: 0.57 ± 0.2
0.0PheXaa: 0.0 ± 0.0
Gly
6.058GlyAla: 6.058 ± 0.76
1.212GlyCys: 1.212 ± 0.314
3.349GlyAsp: 3.349 ± 0.483
5.701GlyGlu: 5.701 ± 0.557
2.779GlyPhe: 2.779 ± 0.532
6.129GlyGly: 6.129 ± 0.88
2.281GlyHis: 2.281 ± 0.465
4.276GlyIle: 4.276 ± 0.56
4.347GlyLys: 4.347 ± 0.501
6.913GlyLeu: 6.913 ± 0.685
3.349GlyMet: 3.349 ± 0.528
2.352GlyAsn: 2.352 ± 0.367
3.349GlyPro: 3.349 ± 0.473
3.136GlyGln: 3.136 ± 0.464
4.062GlyArg: 4.062 ± 0.616
4.846GlySer: 4.846 ± 0.514
4.062GlyThr: 4.062 ± 0.628
5.345GlyVal: 5.345 ± 0.711
1.497GlyTrp: 1.497 ± 0.294
1.995GlyTyr: 1.995 ± 0.334
0.0GlyXaa: 0.0 ± 0.0
His
1.639HisAla: 1.639 ± 0.464
0.784HisCys: 0.784 ± 0.232
1.497HisAsp: 1.497 ± 0.312
1.568HisGlu: 1.568 ± 0.32
0.926HisPhe: 0.926 ± 0.241
1.497HisGly: 1.497 ± 0.301
1.069HisHis: 1.069 ± 0.291
0.998HisIle: 0.998 ± 0.277
1.14HisLys: 1.14 ± 0.35
2.423HisLeu: 2.423 ± 0.468
0.499HisMet: 0.499 ± 0.161
0.214HisAsn: 0.214 ± 0.103
1.069HisPro: 1.069 ± 0.286
1.069HisGln: 1.069 ± 0.323
1.853HisArg: 1.853 ± 0.353
1.212HisSer: 1.212 ± 0.324
1.283HisThr: 1.283 ± 0.335
0.998HisVal: 0.998 ± 0.311
0.641HisTrp: 0.641 ± 0.184
0.855HisTyr: 0.855 ± 0.318
0.0HisXaa: 0.0 ± 0.0
Ile
5.131IleAla: 5.131 ± 0.627
0.713IleCys: 0.713 ± 0.191
3.064IleAsp: 3.064 ± 0.45
4.062IleGlu: 4.062 ± 0.547
1.069IlePhe: 1.069 ± 0.304
3.064IleGly: 3.064 ± 0.406
1.212IleHis: 1.212 ± 0.273
2.494IleIle: 2.494 ± 0.502
3.563IleLys: 3.563 ± 0.516
3.349IleLeu: 3.349 ± 0.418
1.354IleMet: 1.354 ± 0.322
1.924IleAsn: 1.924 ± 0.337
1.853IlePro: 1.853 ± 0.39
1.568IleGln: 1.568 ± 0.341
2.993IleArg: 2.993 ± 0.466
3.278IleSer: 3.278 ± 0.482
3.92IleThr: 3.92 ± 0.452
3.421IleVal: 3.421 ± 0.425
0.855IleTrp: 0.855 ± 0.224
0.926IleTyr: 0.926 ± 0.3
0.0IleXaa: 0.0 ± 0.0
Lys
9.478LysAla: 9.478 ± 0.846
0.641LysCys: 0.641 ± 0.229
3.349LysAsp: 3.349 ± 0.529
3.635LysGlu: 3.635 ± 0.617
1.853LysPhe: 1.853 ± 0.339
5.416LysGly: 5.416 ± 0.616
1.14LysHis: 1.14 ± 0.288
2.209LysIle: 2.209 ± 0.357
2.637LysLys: 2.637 ± 0.394
4.846LysLeu: 4.846 ± 0.642
2.779LysMet: 2.779 ± 0.477
1.283LysAsn: 1.283 ± 0.294
2.494LysPro: 2.494 ± 0.331
2.993LysGln: 2.993 ± 0.49
3.706LysArg: 3.706 ± 0.491
2.352LysSer: 2.352 ± 0.442
3.278LysThr: 3.278 ± 0.392
4.133LysVal: 4.133 ± 0.483
1.14LysTrp: 1.14 ± 0.258
1.354LysTyr: 1.354 ± 0.318
0.0LysXaa: 0.0 ± 0.0
Leu
7.34LeuAla: 7.34 ± 0.77
1.212LeuCys: 1.212 ± 0.279
6.2LeuAsp: 6.2 ± 0.722
6.2LeuGlu: 6.2 ± 0.71
1.71LeuPhe: 1.71 ± 0.283
4.989LeuGly: 4.989 ± 0.65
1.853LeuHis: 1.853 ± 0.364
4.276LeuIle: 4.276 ± 0.546
4.704LeuLys: 4.704 ± 0.572
5.986LeuLeu: 5.986 ± 0.637
2.423LeuMet: 2.423 ± 0.405
3.064LeuAsn: 3.064 ± 0.456
3.848LeuPro: 3.848 ± 0.481
2.281LeuGln: 2.281 ± 0.365
6.058LeuArg: 6.058 ± 0.579
6.485LeuSer: 6.485 ± 0.579
7.34LeuThr: 7.34 ± 0.869
6.058LeuVal: 6.058 ± 0.611
0.855LeuTrp: 0.855 ± 0.261
1.782LeuTyr: 1.782 ± 0.326
0.0LeuXaa: 0.0 ± 0.0
Met
4.846MetAla: 4.846 ± 1.021
0.214MetCys: 0.214 ± 0.12
2.067MetAsp: 2.067 ± 0.397
1.71MetGlu: 1.71 ± 0.413
0.713MetPhe: 0.713 ± 0.221
1.995MetGly: 1.995 ± 0.283
0.356MetHis: 0.356 ± 0.166
1.212MetIle: 1.212 ± 0.251
3.064MetLys: 3.064 ± 0.483
1.853MetLeu: 1.853 ± 0.312
0.998MetMet: 0.998 ± 0.297
1.212MetAsn: 1.212 ± 0.357
0.926MetPro: 0.926 ± 0.242
1.283MetGln: 1.283 ± 0.277
1.069MetArg: 1.069 ± 0.299
2.637MetSer: 2.637 ± 0.457
2.708MetThr: 2.708 ± 0.44
2.779MetVal: 2.779 ± 0.501
0.499MetTrp: 0.499 ± 0.203
0.641MetTyr: 0.641 ± 0.207
0.0MetXaa: 0.0 ± 0.0
Asn
2.851AsnAla: 2.851 ± 0.712
0.428AsnCys: 0.428 ± 0.161
1.354AsnAsp: 1.354 ± 0.289
1.853AsnGlu: 1.853 ± 0.423
0.641AsnPhe: 0.641 ± 0.173
3.136AsnGly: 3.136 ± 0.722
1.069AsnHis: 1.069 ± 0.315
1.354AsnIle: 1.354 ± 0.251
2.779AsnLys: 2.779 ± 0.413
2.779AsnLeu: 2.779 ± 0.394
1.283AsnMet: 1.283 ± 0.288
1.14AsnAsn: 1.14 ± 0.325
1.995AsnPro: 1.995 ± 0.321
1.71AsnGln: 1.71 ± 0.346
1.354AsnArg: 1.354 ± 0.29
1.924AsnSer: 1.924 ± 0.36
2.209AsnThr: 2.209 ± 0.452
2.281AsnVal: 2.281 ± 0.413
0.641AsnTrp: 0.641 ± 0.227
0.784AsnTyr: 0.784 ± 0.256
0.0AsnXaa: 0.0 ± 0.0
Pro
4.062ProAla: 4.062 ± 0.486
0.641ProCys: 0.641 ± 0.264
2.708ProAsp: 2.708 ± 0.387
3.136ProGlu: 3.136 ± 0.564
1.924ProPhe: 1.924 ± 0.374
3.064ProGly: 3.064 ± 0.384
0.998ProHis: 0.998 ± 0.279
1.568ProIle: 1.568 ± 0.288
2.993ProLys: 2.993 ± 0.446
3.349ProLeu: 3.349 ± 0.475
0.713ProMet: 0.713 ± 0.193
1.069ProAsn: 1.069 ± 0.273
1.995ProPro: 1.995 ± 0.425
1.425ProGln: 1.425 ± 0.323
1.639ProArg: 1.639 ± 0.422
3.136ProSer: 3.136 ± 0.517
2.993ProThr: 2.993 ± 0.467
4.418ProVal: 4.418 ± 0.646
0.428ProTrp: 0.428 ± 0.171
1.14ProTyr: 1.14 ± 0.314
0.0ProXaa: 0.0 ± 0.0
Gln
5.06GlnAla: 5.06 ± 0.533
1.069GlnCys: 1.069 ± 0.211
1.283GlnAsp: 1.283 ± 0.297
1.924GlnGlu: 1.924 ± 0.339
0.428GlnPhe: 0.428 ± 0.157
2.851GlnGly: 2.851 ± 0.371
1.212GlnHis: 1.212 ± 0.365
1.924GlnIle: 1.924 ± 0.311
1.568GlnLys: 1.568 ± 0.37
3.349GlnLeu: 3.349 ± 0.505
1.425GlnMet: 1.425 ± 0.338
1.14GlnAsn: 1.14 ± 0.265
1.354GlnPro: 1.354 ± 0.343
1.14GlnGln: 1.14 ± 0.332
1.995GlnArg: 1.995 ± 0.331
2.423GlnSer: 2.423 ± 0.346
1.924GlnThr: 1.924 ± 0.434
2.708GlnVal: 2.708 ± 0.362
0.926GlnTrp: 0.926 ± 0.249
0.784GlnTyr: 0.784 ± 0.252
0.0GlnXaa: 0.0 ± 0.0
Arg
5.131ArgAla: 5.131 ± 0.582
1.283ArgCys: 1.283 ± 0.295
3.349ArgAsp: 3.349 ± 0.347
2.922ArgGlu: 2.922 ± 0.518
2.708ArgPhe: 2.708 ± 0.5
3.777ArgGly: 3.777 ± 0.427
1.425ArgHis: 1.425 ± 0.39
2.708ArgIle: 2.708 ± 0.386
3.421ArgLys: 3.421 ± 0.526
5.701ArgLeu: 5.701 ± 0.587
1.924ArgMet: 1.924 ± 0.373
2.779ArgAsn: 2.779 ± 0.465
3.136ArgPro: 3.136 ± 0.53
1.853ArgGln: 1.853 ± 0.381
3.777ArgArg: 3.777 ± 0.685
3.563ArgSer: 3.563 ± 0.536
3.349ArgThr: 3.349 ± 0.433
4.49ArgVal: 4.49 ± 0.562
0.855ArgTrp: 0.855 ± 0.231
1.212ArgTyr: 1.212 ± 0.282
0.0ArgXaa: 0.0 ± 0.0
Ser
5.63SerAla: 5.63 ± 0.566
1.497SerCys: 1.497 ± 0.353
3.563SerAsp: 3.563 ± 0.575
2.494SerGlu: 2.494 ± 0.509
1.924SerPhe: 1.924 ± 0.35
5.274SerGly: 5.274 ± 0.593
1.14SerHis: 1.14 ± 0.317
3.136SerIle: 3.136 ± 0.452
3.349SerLys: 3.349 ± 0.415
5.915SerLeu: 5.915 ± 0.55
2.423SerMet: 2.423 ± 0.399
2.067SerAsn: 2.067 ± 0.449
2.708SerPro: 2.708 ± 0.445
1.924SerGln: 1.924 ± 0.352
3.207SerArg: 3.207 ± 0.464
2.708SerSer: 2.708 ± 0.435
3.635SerThr: 3.635 ± 0.474
3.064SerVal: 3.064 ± 0.494
1.283SerTrp: 1.283 ± 0.25
1.354SerTyr: 1.354 ± 0.343
0.0SerXaa: 0.0 ± 0.0
Thr
5.345ThrAla: 5.345 ± 0.555
0.926ThrCys: 0.926 ± 0.282
3.421ThrAsp: 3.421 ± 0.508
3.207ThrGlu: 3.207 ± 0.51
1.995ThrPhe: 1.995 ± 0.381
5.844ThrGly: 5.844 ± 0.528
1.212ThrHis: 1.212 ± 0.268
3.563ThrIle: 3.563 ± 0.629
3.92ThrLys: 3.92 ± 0.649
5.131ThrLeu: 5.131 ± 0.64
2.138ThrMet: 2.138 ± 0.322
1.71ThrAsn: 1.71 ± 0.355
3.563ThrPro: 3.563 ± 0.584
2.209ThrGln: 2.209 ± 0.335
3.991ThrArg: 3.991 ± 0.603
3.064ThrSer: 3.064 ± 0.351
3.991ThrThr: 3.991 ± 0.58
4.775ThrVal: 4.775 ± 0.487
0.926ThrTrp: 0.926 ± 0.252
1.639ThrTyr: 1.639 ± 0.292
0.0ThrXaa: 0.0 ± 0.0
Val
7.34ValAla: 7.34 ± 0.817
1.14ValCys: 1.14 ± 0.298
3.563ValAsp: 3.563 ± 0.544
4.347ValGlu: 4.347 ± 0.505
2.352ValPhe: 2.352 ± 0.388
4.418ValGly: 4.418 ± 0.644
1.425ValHis: 1.425 ± 0.342
4.062ValIle: 4.062 ± 0.435
4.917ValLys: 4.917 ± 0.548
3.064ValLeu: 3.064 ± 0.477
3.064ValMet: 3.064 ± 0.492
3.563ValAsn: 3.563 ± 0.651
2.494ValPro: 2.494 ± 0.469
2.851ValGln: 2.851 ± 0.365
4.062ValArg: 4.062 ± 0.588
4.133ValSer: 4.133 ± 0.52
5.131ValThr: 5.131 ± 0.575
6.058ValVal: 6.058 ± 0.712
0.855ValTrp: 0.855 ± 0.207
1.639ValTyr: 1.639 ± 0.521
0.0ValXaa: 0.0 ± 0.0
Trp
1.71TrpAla: 1.71 ± 0.312
0.143TrpCys: 0.143 ± 0.086
1.283TrpAsp: 1.283 ± 0.333
1.354TrpGlu: 1.354 ± 0.341
1.14TrpPhe: 1.14 ± 0.278
0.998TrpGly: 0.998 ± 0.249
0.499TrpHis: 0.499 ± 0.177
0.641TrpIle: 0.641 ± 0.194
0.57TrpLys: 0.57 ± 0.21
1.212TrpLeu: 1.212 ± 0.252
0.57TrpMet: 0.57 ± 0.224
0.998TrpAsn: 0.998 ± 0.322
0.356TrpPro: 0.356 ± 0.167
0.713TrpGln: 0.713 ± 0.24
0.926TrpArg: 0.926 ± 0.268
0.998TrpSer: 0.998 ± 0.292
0.998TrpThr: 0.998 ± 0.268
0.926TrpVal: 0.926 ± 0.228
0.0TrpTrp: 0.0 ± 0.0
0.356TrpTyr: 0.356 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.637TyrAla: 2.637 ± 0.446
0.641TyrCys: 0.641 ± 0.201
1.283TyrAsp: 1.283 ± 0.311
1.354TyrGlu: 1.354 ± 0.265
0.713TyrPhe: 0.713 ± 0.237
2.067TyrGly: 2.067 ± 0.482
0.57TyrHis: 0.57 ± 0.215
0.855TyrIle: 0.855 ± 0.271
0.998TyrLys: 0.998 ± 0.232
2.281TyrLeu: 2.281 ± 0.418
0.285TyrMet: 0.285 ± 0.145
0.926TyrAsn: 0.926 ± 0.303
0.713TyrPro: 0.713 ± 0.24
0.926TyrGln: 0.926 ± 0.263
2.566TyrArg: 2.566 ± 0.405
1.212TyrSer: 1.212 ± 0.393
1.283TyrThr: 1.283 ± 0.384
1.71TyrVal: 1.71 ± 0.331
0.214TyrTrp: 0.214 ± 0.12
0.57TyrTyr: 0.57 ± 0.2
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 80 proteins (14033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski