Amino acid dipepetide frequency for Falsibacillus albus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.181AlaAla: 6.181 ± 0.101
0.58AlaCys: 0.58 ± 0.022
3.517AlaAsp: 3.517 ± 0.064
4.421AlaGlu: 4.421 ± 0.068
3.322AlaPhe: 3.322 ± 0.06
5.352AlaGly: 5.352 ± 0.079
1.252AlaHis: 1.252 ± 0.028
5.625AlaIle: 5.625 ± 0.08
4.823AlaLys: 4.823 ± 0.066
6.753AlaLeu: 6.753 ± 0.07
2.074AlaMet: 2.074 ± 0.038
2.619AlaAsn: 2.619 ± 0.042
2.117AlaPro: 2.117 ± 0.046
2.091AlaGln: 2.091 ± 0.045
2.474AlaArg: 2.474 ± 0.047
4.285AlaSer: 4.285 ± 0.074
2.909AlaThr: 2.909 ± 0.067
5.278AlaVal: 5.278 ± 0.075
0.592AlaTrp: 0.592 ± 0.025
2.227AlaTyr: 2.227 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.472CysAla: 0.472 ± 0.024
0.099CysCys: 0.099 ± 0.01
0.384CysAsp: 0.384 ± 0.018
0.515CysGlu: 0.515 ± 0.02
0.363CysPhe: 0.363 ± 0.017
0.669CysGly: 0.669 ± 0.02
0.215CysHis: 0.215 ± 0.012
0.511CysIle: 0.511 ± 0.021
0.349CysLys: 0.349 ± 0.018
0.749CysLeu: 0.749 ± 0.022
0.202CysMet: 0.202 ± 0.014
0.254CysAsn: 0.254 ± 0.014
0.385CysPro: 0.385 ± 0.019
0.259CysGln: 0.259 ± 0.014
0.316CysArg: 0.316 ± 0.017
0.6CysSer: 0.6 ± 0.023
0.382CysThr: 0.382 ± 0.018
0.403CysVal: 0.403 ± 0.019
0.085CysTrp: 0.085 ± 0.008
0.233CysTyr: 0.233 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.556AspAla: 3.556 ± 0.052
0.392AspCys: 0.392 ± 0.019
2.7AspAsp: 2.7 ± 0.053
4.341AspGlu: 4.341 ± 0.063
2.597AspPhe: 2.597 ± 0.041
3.757AspGly: 3.757 ± 0.078
1.408AspHis: 1.408 ± 0.035
4.042AspIle: 4.042 ± 0.057
3.094AspLys: 3.094 ± 0.053
5.306AspLeu: 5.306 ± 0.072
1.412AspMet: 1.412 ± 0.035
1.696AspAsn: 1.696 ± 0.033
2.214AspPro: 2.214 ± 0.046
2.373AspGln: 2.373 ± 0.046
2.272AspArg: 2.272 ± 0.043
2.814AspSer: 2.814 ± 0.051
2.236AspThr: 2.236 ± 0.043
3.674AspVal: 3.674 ± 0.062
0.762AspTrp: 0.762 ± 0.025
2.123AspTyr: 2.123 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.099GluAla: 5.099 ± 0.08
0.39GluCys: 0.39 ± 0.018
3.782GluAsp: 3.782 ± 0.068
6.49GluGlu: 6.49 ± 0.095
2.633GluPhe: 2.633 ± 0.046
4.427GluGly: 4.427 ± 0.067
1.587GluHis: 1.587 ± 0.038
5.29GluIle: 5.29 ± 0.074
6.887GluLys: 6.887 ± 0.091
6.821GluLeu: 6.821 ± 0.085
2.419GluMet: 2.419 ± 0.046
3.578GluAsn: 3.578 ± 0.054
1.804GluPro: 1.804 ± 0.041
2.886GluGln: 2.886 ± 0.051
3.42GluArg: 3.42 ± 0.061
3.591GluSer: 3.591 ± 0.062
3.447GluThr: 3.447 ± 0.053
4.682GluVal: 4.682 ± 0.07
0.839GluTrp: 0.839 ± 0.028
2.204GluTyr: 2.204 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.012PheAla: 3.012 ± 0.048
0.377PheCys: 0.377 ± 0.017
2.453PheAsp: 2.453 ± 0.046
2.886PheGlu: 2.886 ± 0.051
2.479PhePhe: 2.479 ± 0.051
3.327PheGly: 3.327 ± 0.053
1.233PheHis: 1.233 ± 0.033
4.115PheIle: 4.115 ± 0.074
2.555PheLys: 2.555 ± 0.041
4.756PheLeu: 4.756 ± 0.073
1.346PheMet: 1.346 ± 0.036
2.006PheAsn: 2.006 ± 0.041
1.772PhePro: 1.772 ± 0.038
1.809PheGln: 1.809 ± 0.037
1.618PheArg: 1.618 ± 0.036
3.501PheSer: 3.501 ± 0.054
2.462PheThr: 2.462 ± 0.046
3.065PheVal: 3.065 ± 0.055
0.522PheTrp: 0.522 ± 0.021
1.736PheTyr: 1.736 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.864GlyAla: 4.864 ± 0.085
0.643GlyCys: 0.643 ± 0.023
3.331GlyAsp: 3.331 ± 0.057
4.404GlyGlu: 4.404 ± 0.074
3.56GlyPhe: 3.56 ± 0.062
4.907GlyGly: 4.907 ± 0.087
1.483GlyHis: 1.483 ± 0.044
6.185GlyIle: 6.185 ± 0.08
5.451GlyLys: 5.451 ± 0.068
6.534GlyLeu: 6.534 ± 0.094
2.278GlyMet: 2.278 ± 0.042
2.846GlyAsn: 2.846 ± 0.069
1.779GlyPro: 1.779 ± 0.037
2.333GlyGln: 2.333 ± 0.043
2.644GlyArg: 2.644 ± 0.049
4.297GlySer: 4.297 ± 0.072
4.033GlyThr: 4.033 ± 0.061
4.925GlyVal: 4.925 ± 0.068
0.896GlyTrp: 0.896 ± 0.026
2.77GlyTyr: 2.77 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
1.374HisAla: 1.374 ± 0.031
0.227HisCys: 0.227 ± 0.014
1.148HisAsp: 1.148 ± 0.035
1.56HisGlu: 1.56 ± 0.034
1.231HisPhe: 1.231 ± 0.034
1.526HisGly: 1.526 ± 0.038
0.778HisHis: 0.778 ± 0.026
1.599HisIle: 1.599 ± 0.034
1.138HisLys: 1.138 ± 0.031
2.252HisLeu: 2.252 ± 0.046
0.547HisMet: 0.547 ± 0.023
0.807HisAsn: 0.807 ± 0.022
1.26HisPro: 1.26 ± 0.033
0.993HisGln: 0.993 ± 0.036
0.907HisArg: 0.907 ± 0.03
1.402HisSer: 1.402 ± 0.035
1.058HisThr: 1.058 ± 0.031
1.444HisVal: 1.444 ± 0.031
0.258HisTrp: 0.258 ± 0.014
0.938HisTyr: 0.938 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.606IleAla: 5.606 ± 0.068
0.658IleCys: 0.658 ± 0.025
4.4IleAsp: 4.4 ± 0.064
5.442IleGlu: 5.442 ± 0.069
3.677IlePhe: 3.677 ± 0.066
6.004IleGly: 6.004 ± 0.082
1.92IleHis: 1.92 ± 0.041
6.034IleIle: 6.034 ± 0.084
4.705IleLys: 4.705 ± 0.062
7.394IleLeu: 7.394 ± 0.084
1.888IleMet: 1.888 ± 0.046
3.256IleAsn: 3.256 ± 0.047
3.47IlePro: 3.47 ± 0.055
3.078IleGln: 3.078 ± 0.049
3.054IleArg: 3.054 ± 0.049
5.407IleSer: 5.407 ± 0.067
3.963IleThr: 3.963 ± 0.059
5.266IleVal: 5.266 ± 0.078
0.666IleTrp: 0.666 ± 0.024
2.499IleTyr: 2.499 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.783LysAla: 4.783 ± 0.063
0.368LysCys: 0.368 ± 0.02
4.313LysAsp: 4.313 ± 0.063
6.809LysGlu: 6.809 ± 0.085
2.107LysPhe: 2.107 ± 0.041
4.989LysGly: 4.989 ± 0.063
1.383LysHis: 1.383 ± 0.035
4.88LysIle: 4.88 ± 0.07
6.488LysLys: 6.488 ± 0.096
5.949LysLeu: 5.949 ± 0.073
2.437LysMet: 2.437 ± 0.045
3.612LysAsn: 3.612 ± 0.059
2.379LysPro: 2.379 ± 0.042
2.935LysGln: 2.935 ± 0.047
3.301LysArg: 3.301 ± 0.051
4.002LysSer: 4.002 ± 0.06
3.533LysThr: 3.533 ± 0.049
4.702LysVal: 4.702 ± 0.062
0.962LysTrp: 0.962 ± 0.028
2.261LysTyr: 2.261 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
6.866LeuAla: 6.866 ± 0.068
0.702LeuCys: 0.702 ± 0.032
4.876LeuAsp: 4.876 ± 0.07
6.373LeuGlu: 6.373 ± 0.083
4.796LeuPhe: 4.796 ± 0.074
6.273LeuGly: 6.273 ± 0.086
2.047LeuHis: 2.047 ± 0.039
7.335LeuIle: 7.335 ± 0.093
7.138LeuLys: 7.138 ± 0.08
9.935LeuLeu: 9.935 ± 0.119
2.75LeuMet: 2.75 ± 0.049
4.41LeuAsn: 4.41 ± 0.061
3.905LeuPro: 3.905 ± 0.053
3.486LeuGln: 3.486 ± 0.058
3.394LeuArg: 3.394 ± 0.061
7.137LeuSer: 7.137 ± 0.076
5.325LeuThr: 5.325 ± 0.071
5.884LeuVal: 5.884 ± 0.072
0.884LeuTrp: 0.884 ± 0.03
3.068LeuTyr: 3.068 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
2.142MetAla: 2.142 ± 0.04
0.171MetCys: 0.171 ± 0.012
1.692MetAsp: 1.692 ± 0.039
2.246MetGlu: 2.246 ± 0.045
1.142MetPhe: 1.142 ± 0.032
1.922MetGly: 1.922 ± 0.044
0.464MetHis: 0.464 ± 0.018
2.379MetIle: 2.379 ± 0.043
2.836MetLys: 2.836 ± 0.049
2.614MetLeu: 2.614 ± 0.043
0.995MetMet: 0.995 ± 0.035
1.766MetAsn: 1.766 ± 0.034
1.126MetPro: 1.126 ± 0.041
0.868MetGln: 0.868 ± 0.028
1.08MetArg: 1.08 ± 0.032
1.676MetSer: 1.676 ± 0.041
1.707MetThr: 1.707 ± 0.037
1.832MetVal: 1.832 ± 0.043
0.19MetTrp: 0.19 ± 0.014
0.71MetTyr: 0.71 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.694AsnAla: 2.694 ± 0.044
0.304AsnCys: 0.304 ± 0.014
2.383AsnAsp: 2.383 ± 0.041
3.655AsnGlu: 3.655 ± 0.065
1.602AsnPhe: 1.602 ± 0.036
3.714AsnGly: 3.714 ± 0.063
1.148AsnHis: 1.148 ± 0.029
3.273AsnIle: 3.273 ± 0.053
2.903AsnLys: 2.903 ± 0.049
3.747AsnLeu: 3.747 ± 0.057
1.22AsnMet: 1.22 ± 0.034
1.768AsnAsn: 1.768 ± 0.048
2.115AsnPro: 2.115 ± 0.042
2.064AsnGln: 2.064 ± 0.06
2.072AsnArg: 2.072 ± 0.048
2.37AsnSer: 2.37 ± 0.045
1.93AsnThr: 1.93 ± 0.045
2.914AsnVal: 2.914 ± 0.048
0.522AsnTrp: 0.522 ± 0.02
1.372AsnTyr: 1.372 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
2.422ProAla: 2.422 ± 0.053
0.217ProCys: 0.217 ± 0.013
2.242ProAsp: 2.242 ± 0.042
2.907ProGlu: 2.907 ± 0.042
2.174ProPhe: 2.174 ± 0.051
2.387ProGly: 2.387 ± 0.053
0.836ProHis: 0.836 ± 0.028
2.898ProIle: 2.898 ± 0.049
2.235ProLys: 2.235 ± 0.045
3.485ProLeu: 3.485 ± 0.065
0.959ProMet: 0.959 ± 0.031
1.684ProAsn: 1.684 ± 0.039
1.062ProPro: 1.062 ± 0.031
1.187ProGln: 1.187 ± 0.036
1.128ProArg: 1.128 ± 0.034
2.468ProSer: 2.468 ± 0.047
1.757ProThr: 1.757 ± 0.037
2.857ProVal: 2.857 ± 0.061
0.414ProTrp: 0.414 ± 0.022
1.503ProTyr: 1.503 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.522GlnAla: 2.522 ± 0.05
0.212GlnCys: 0.212 ± 0.014
1.785GlnAsp: 1.785 ± 0.034
2.682GlnGlu: 2.682 ± 0.053
1.636GlnPhe: 1.636 ± 0.038
2.134GlnGly: 2.134 ± 0.044
0.862GlnHis: 0.862 ± 0.025
2.575GlnIle: 2.575 ± 0.052
3.061GlnLys: 3.061 ± 0.057
3.896GlnLeu: 3.896 ± 0.064
1.196GlnMet: 1.196 ± 0.031
1.823GlnAsn: 1.823 ± 0.048
1.266GlnPro: 1.266 ± 0.04
1.658GlnGln: 1.658 ± 0.044
1.455GlnArg: 1.455 ± 0.03
2.398GlnSer: 2.398 ± 0.046
1.939GlnThr: 1.939 ± 0.04
2.217GlnVal: 2.217 ± 0.044
0.428GlnTrp: 0.428 ± 0.02
1.363GlnTyr: 1.363 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.302ArgAla: 2.302 ± 0.047
0.276ArgCys: 0.276 ± 0.015
1.999ArgAsp: 1.999 ± 0.039
2.96ArgGlu: 2.96 ± 0.058
1.985ArgPhe: 1.985 ± 0.038
2.338ArgGly: 2.338 ± 0.052
0.864ArgHis: 0.864 ± 0.027
3.101ArgIle: 3.101 ± 0.053
3.327ArgLys: 3.327 ± 0.056
3.84ArgLeu: 3.84 ± 0.065
1.329ArgMet: 1.329 ± 0.035
1.966ArgAsn: 1.966 ± 0.054
1.322ArgPro: 1.322 ± 0.03
1.466ArgGln: 1.466 ± 0.033
1.839ArgArg: 1.839 ± 0.046
2.301ArgSer: 2.301 ± 0.04
1.966ArgThr: 1.966 ± 0.042
2.453ArgVal: 2.453 ± 0.047
0.435ArgTrp: 0.435 ± 0.018
1.469ArgTyr: 1.469 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
3.967SerAla: 3.967 ± 0.06
0.476SerCys: 0.476 ± 0.021
3.078SerAsp: 3.078 ± 0.048
3.805SerGlu: 3.805 ± 0.063
3.539SerPhe: 3.539 ± 0.057
4.797SerGly: 4.797 ± 0.077
1.345SerHis: 1.345 ± 0.034
5.472SerIle: 5.472 ± 0.067
4.162SerLys: 4.162 ± 0.061
6.422SerLeu: 6.422 ± 0.071
1.921SerMet: 1.921 ± 0.038
2.616SerAsn: 2.616 ± 0.044
2.36SerPro: 2.36 ± 0.047
2.161SerGln: 2.161 ± 0.052
2.305SerArg: 2.305 ± 0.041
4.413SerSer: 4.413 ± 0.07
3.219SerThr: 3.219 ± 0.054
4.114SerVal: 4.114 ± 0.056
0.687SerTrp: 0.687 ± 0.025
2.25SerTyr: 2.25 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
3.74ThrAla: 3.74 ± 0.067
0.35ThrCys: 0.35 ± 0.017
2.611ThrAsp: 2.611 ± 0.055
3.09ThrGlu: 3.09 ± 0.051
2.6ThrPhe: 2.6 ± 0.048
4.038ThrGly: 4.038 ± 0.079
0.983ThrHis: 0.983 ± 0.031
4.301ThrIle: 4.301 ± 0.065
3.26ThrLys: 3.26 ± 0.049
4.814ThrLeu: 4.814 ± 0.067
1.349ThrMet: 1.349 ± 0.032
2.158ThrAsn: 2.158 ± 0.044
2.085ThrPro: 2.085 ± 0.045
1.26ThrGln: 1.26 ± 0.029
1.734ThrArg: 1.734 ± 0.037
3.218ThrSer: 3.218 ± 0.054
2.576ThrThr: 2.576 ± 0.051
3.714ThrVal: 3.714 ± 0.064
0.504ThrTrp: 0.504 ± 0.019
1.74ThrTyr: 1.74 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
4.324ValAla: 4.324 ± 0.069
0.605ValCys: 0.605 ± 0.022
3.615ValAsp: 3.615 ± 0.064
4.585ValGlu: 4.585 ± 0.07
3.171ValPhe: 3.171 ± 0.063
4.4ValGly: 4.4 ± 0.068
1.466ValHis: 1.466 ± 0.036
5.358ValIle: 5.358 ± 0.077
4.883ValLys: 4.883 ± 0.063
6.655ValLeu: 6.655 ± 0.081
2.006ValMet: 2.006 ± 0.041
2.946ValAsn: 2.946 ± 0.055
2.709ValPro: 2.709 ± 0.055
2.37ValGln: 2.37 ± 0.044
2.52ValArg: 2.52 ± 0.044
4.377ValSer: 4.377 ± 0.067
3.423ValThr: 3.423 ± 0.062
4.663ValVal: 4.663 ± 0.068
0.603ValTrp: 0.603 ± 0.024
2.207ValTyr: 2.207 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.654TrpAla: 0.654 ± 0.028
0.084TrpCys: 0.084 ± 0.008
0.534TrpAsp: 0.534 ± 0.021
0.679TrpGlu: 0.679 ± 0.023
0.546TrpPhe: 0.546 ± 0.02
0.757TrpGly: 0.757 ± 0.026
0.218TrpHis: 0.218 ± 0.013
0.915TrpIle: 0.915 ± 0.031
0.876TrpLys: 0.876 ± 0.027
1.171TrpLeu: 1.171 ± 0.031
0.355TrpMet: 0.355 ± 0.017
0.62TrpAsn: 0.62 ± 0.025
0.289TrpPro: 0.289 ± 0.014
0.337TrpGln: 0.337 ± 0.016
0.42TrpArg: 0.42 ± 0.019
0.643TrpSer: 0.643 ± 0.023
0.56TrpThr: 0.56 ± 0.024
0.672TrpVal: 0.672 ± 0.024
0.173TrpTrp: 0.173 ± 0.012
0.351TrpTyr: 0.351 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.909TyrAla: 1.909 ± 0.041
0.314TyrCys: 0.314 ± 0.017
1.924TyrAsp: 1.924 ± 0.042
2.425TyrGlu: 2.425 ± 0.043
1.869TyrPhe: 1.869 ± 0.042
2.445TyrGly: 2.445 ± 0.046
0.957TyrHis: 0.957 ± 0.027
2.498TyrIle: 2.498 ± 0.046
2.022TyrLys: 2.022 ± 0.044
3.493TyrLeu: 3.493 ± 0.056
0.876TyrMet: 0.876 ± 0.028
1.339TyrAsn: 1.339 ± 0.039
1.405TyrPro: 1.405 ± 0.033
1.493TyrGln: 1.493 ± 0.034
1.584TyrArg: 1.584 ± 0.038
2.211TyrSer: 2.211 ± 0.045
1.699TyrThr: 1.699 ± 0.041
2.127TyrVal: 2.127 ± 0.04
0.43TyrTrp: 0.43 ± 0.019
1.424TyrTyr: 1.424 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4350 proteins (1257474 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski