Amino acid dipepetide frequency for Aeromonas phage 51

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.511AlaAla: 12.511 ± 1.276
1.302AlaCys: 1.302 ± 0.316
5.641AlaAsp: 5.641 ± 0.586
7.015AlaGlu: 7.015 ± 0.637
3.254AlaPhe: 3.254 ± 0.426
8.606AlaGly: 8.606 ± 0.898
1.663AlaHis: 1.663 ± 0.356
7.232AlaIle: 7.232 ± 0.809
5.351AlaLys: 5.351 ± 0.707
7.955AlaLeu: 7.955 ± 0.816
3.688AlaMet: 3.688 ± 0.526
3.833AlaAsn: 3.833 ± 0.459
3.471AlaPro: 3.471 ± 0.443
4.628AlaGln: 4.628 ± 0.557
6.002AlaArg: 6.002 ± 0.669
5.713AlaSer: 5.713 ± 0.631
6.581AlaThr: 6.581 ± 0.807
6.725AlaVal: 6.725 ± 0.783
2.025AlaTrp: 2.025 ± 0.401
3.327AlaTyr: 3.327 ± 0.445
0.0AlaXaa: 0.0 ± 0.0
Cys
1.302CysAla: 1.302 ± 0.314
0.217CysCys: 0.217 ± 0.115
0.723CysAsp: 0.723 ± 0.253
1.085CysGlu: 1.085 ± 0.291
0.362CysPhe: 0.362 ± 0.148
1.302CysGly: 1.302 ± 0.396
0.217CysHis: 0.217 ± 0.129
0.506CysIle: 0.506 ± 0.17
0.94CysLys: 0.94 ± 0.28
0.868CysLeu: 0.868 ± 0.254
0.072CysMet: 0.072 ± 0.068
0.434CysAsn: 0.434 ± 0.176
0.506CysPro: 0.506 ± 0.204
0.723CysGln: 0.723 ± 0.274
1.157CysArg: 1.157 ± 0.274
0.868CysSer: 0.868 ± 0.26
0.723CysThr: 0.723 ± 0.195
0.94CysVal: 0.94 ± 0.242
0.289CysTrp: 0.289 ± 0.142
0.723CysTyr: 0.723 ± 0.236
0.0CysXaa: 0.0 ± 0.0
Asp
6.219AspAla: 6.219 ± 0.679
1.157AspCys: 1.157 ± 0.264
2.82AspAsp: 2.82 ± 0.576
3.471AspGlu: 3.471 ± 0.514
2.025AspPhe: 2.025 ± 0.385
6.075AspGly: 6.075 ± 0.583
0.723AspHis: 0.723 ± 0.204
3.254AspIle: 3.254 ± 0.355
2.603AspLys: 2.603 ± 0.461
3.76AspLeu: 3.76 ± 0.347
1.808AspMet: 1.808 ± 0.38
2.097AspAsn: 2.097 ± 0.335
3.327AspPro: 3.327 ± 0.53
1.446AspGln: 1.446 ± 0.391
2.386AspArg: 2.386 ± 0.378
4.267AspSer: 4.267 ± 0.555
2.242AspThr: 2.242 ± 0.322
3.544AspVal: 3.544 ± 0.588
1.591AspTrp: 1.591 ± 0.367
1.663AspTyr: 1.663 ± 0.337
0.0AspXaa: 0.0 ± 0.0
Glu
6.292GluAla: 6.292 ± 0.646
0.579GluCys: 0.579 ± 0.214
2.748GluAsp: 2.748 ± 0.429
3.182GluGlu: 3.182 ± 0.592
2.531GluPhe: 2.531 ± 0.444
3.544GluGly: 3.544 ± 0.432
1.374GluHis: 1.374 ± 0.369
4.05GluIle: 4.05 ± 0.581
3.11GluLys: 3.11 ± 0.515
6.436GluLeu: 6.436 ± 0.723
3.76GluMet: 3.76 ± 0.541
1.88GluAsn: 1.88 ± 0.369
2.603GluPro: 2.603 ± 0.36
3.182GluGln: 3.182 ± 0.449
4.05GluArg: 4.05 ± 0.583
2.531GluSer: 2.531 ± 0.415
2.603GluThr: 2.603 ± 0.399
3.544GluVal: 3.544 ± 0.527
1.808GluTrp: 1.808 ± 0.389
1.446GluTyr: 1.446 ± 0.302
0.0GluXaa: 0.0 ± 0.0
Phe
3.037PheAla: 3.037 ± 0.521
0.651PheCys: 0.651 ± 0.244
2.531PheAsp: 2.531 ± 0.471
1.519PheGlu: 1.519 ± 0.321
0.723PhePhe: 0.723 ± 0.222
2.386PheGly: 2.386 ± 0.29
0.289PheHis: 0.289 ± 0.146
0.94PheIle: 0.94 ± 0.275
2.242PheLys: 2.242 ± 0.386
1.663PheLeu: 1.663 ± 0.267
1.519PheMet: 1.519 ± 0.355
1.88PheAsn: 1.88 ± 0.359
1.953PhePro: 1.953 ± 0.366
1.157PheGln: 1.157 ± 0.244
1.736PheArg: 1.736 ± 0.357
1.808PheSer: 1.808 ± 0.431
2.386PheThr: 2.386 ± 0.455
1.88PheVal: 1.88 ± 0.331
0.651PheTrp: 0.651 ± 0.226
1.012PheTyr: 1.012 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
6.436GlyAla: 6.436 ± 0.672
1.012GlyCys: 1.012 ± 0.288
3.833GlyAsp: 3.833 ± 0.494
4.411GlyGlu: 4.411 ± 0.47
4.05GlyPhe: 4.05 ± 0.556
6.002GlyGly: 6.002 ± 0.931
1.374GlyHis: 1.374 ± 0.362
4.484GlyIle: 4.484 ± 0.596
3.977GlyLys: 3.977 ± 0.508
5.858GlyLeu: 5.858 ± 0.726
2.386GlyMet: 2.386 ± 0.471
2.893GlyAsn: 2.893 ± 0.476
2.314GlyPro: 2.314 ± 0.419
3.688GlyGln: 3.688 ± 0.478
4.845GlyArg: 4.845 ± 0.535
5.93GlySer: 5.93 ± 0.658
4.339GlyThr: 4.339 ± 0.609
6.292GlyVal: 6.292 ± 0.676
1.808GlyTrp: 1.808 ± 0.339
2.531GlyTyr: 2.531 ± 0.419
0.0GlyXaa: 0.0 ± 0.0
His
1.808HisAla: 1.808 ± 0.389
0.506HisCys: 0.506 ± 0.171
1.085HisAsp: 1.085 ± 0.262
0.94HisGlu: 0.94 ± 0.272
0.362HisPhe: 0.362 ± 0.145
1.374HisGly: 1.374 ± 0.312
0.579HisHis: 0.579 ± 0.204
0.868HisIle: 0.868 ± 0.249
0.868HisLys: 0.868 ± 0.258
1.953HisLeu: 1.953 ± 0.377
0.362HisMet: 0.362 ± 0.162
0.362HisAsn: 0.362 ± 0.163
0.579HisPro: 0.579 ± 0.171
0.506HisGln: 0.506 ± 0.172
0.94HisArg: 0.94 ± 0.254
1.157HisSer: 1.157 ± 0.343
0.579HisThr: 0.579 ± 0.227
0.723HisVal: 0.723 ± 0.228
0.145HisTrp: 0.145 ± 0.102
0.434HisTyr: 0.434 ± 0.191
0.0HisXaa: 0.0 ± 0.0
Ile
5.351IleAla: 5.351 ± 0.613
0.651IleCys: 0.651 ± 0.246
3.688IleAsp: 3.688 ± 0.452
4.267IleGlu: 4.267 ± 0.538
1.085IlePhe: 1.085 ± 0.257
4.122IleGly: 4.122 ± 0.543
0.651IleHis: 0.651 ± 0.187
2.676IleIle: 2.676 ± 0.418
3.471IleLys: 3.471 ± 0.425
3.471IleLeu: 3.471 ± 0.43
0.868IleMet: 0.868 ± 0.264
2.676IleAsn: 2.676 ± 0.46
2.459IlePro: 2.459 ± 0.424
2.17IleGln: 2.17 ± 0.4
2.676IleArg: 2.676 ± 0.439
4.05IleSer: 4.05 ± 0.547
4.484IleThr: 4.484 ± 0.698
2.893IleVal: 2.893 ± 0.502
0.506IleTrp: 0.506 ± 0.192
1.663IleTyr: 1.663 ± 0.359
0.0IleXaa: 0.0 ± 0.0
Lys
5.785LysAla: 5.785 ± 0.591
0.651LysCys: 0.651 ± 0.202
2.676LysAsp: 2.676 ± 0.42
3.399LysGlu: 3.399 ± 0.454
1.953LysPhe: 1.953 ± 0.371
3.76LysGly: 3.76 ± 0.592
0.94LysHis: 0.94 ± 0.251
1.953LysIle: 1.953 ± 0.291
3.037LysLys: 3.037 ± 0.392
4.628LysLeu: 4.628 ± 0.591
2.314LysMet: 2.314 ± 0.444
1.591LysAsn: 1.591 ± 0.297
2.893LysPro: 2.893 ± 0.403
2.82LysGln: 2.82 ± 0.435
3.399LysArg: 3.399 ± 0.616
2.893LysSer: 2.893 ± 0.47
2.82LysThr: 2.82 ± 0.458
2.82LysVal: 2.82 ± 0.548
1.157LysTrp: 1.157 ± 0.254
1.446LysTyr: 1.446 ± 0.29
0.0LysXaa: 0.0 ± 0.0
Leu
9.763LeuAla: 9.763 ± 0.822
0.868LeuCys: 0.868 ± 0.23
4.411LeuAsp: 4.411 ± 0.515
5.207LeuGlu: 5.207 ± 0.554
1.953LeuPhe: 1.953 ± 0.321
5.641LeuGly: 5.641 ± 0.703
1.446LeuHis: 1.446 ± 0.337
4.194LeuIle: 4.194 ± 0.488
3.254LeuLys: 3.254 ± 0.443
5.062LeuLeu: 5.062 ± 0.743
2.386LeuMet: 2.386 ± 0.403
3.905LeuAsn: 3.905 ± 0.414
4.05LeuPro: 4.05 ± 0.57
3.11LeuGln: 3.11 ± 0.425
3.616LeuArg: 3.616 ± 0.522
5.568LeuSer: 5.568 ± 0.629
4.411LeuThr: 4.411 ± 0.582
5.279LeuVal: 5.279 ± 0.511
1.012LeuTrp: 1.012 ± 0.279
1.88LeuTyr: 1.88 ± 0.272
0.0LeuXaa: 0.0 ± 0.0
Met
4.918MetAla: 4.918 ± 0.563
0.434MetCys: 0.434 ± 0.163
1.519MetAsp: 1.519 ± 0.339
1.953MetGlu: 1.953 ± 0.379
0.579MetPhe: 0.579 ± 0.195
2.17MetGly: 2.17 ± 0.372
0.289MetHis: 0.289 ± 0.141
1.302MetIle: 1.302 ± 0.322
1.736MetLys: 1.736 ± 0.319
2.676MetLeu: 2.676 ± 0.507
0.868MetMet: 0.868 ± 0.266
1.663MetAsn: 1.663 ± 0.296
1.374MetPro: 1.374 ± 0.32
1.446MetGln: 1.446 ± 0.321
2.459MetArg: 2.459 ± 0.454
2.459MetSer: 2.459 ± 0.392
2.603MetThr: 2.603 ± 0.442
1.374MetVal: 1.374 ± 0.348
0.217MetTrp: 0.217 ± 0.139
0.579MetTyr: 0.579 ± 0.156
0.0MetXaa: 0.0 ± 0.0
Asn
3.833AsnAla: 3.833 ± 0.554
0.289AsnCys: 0.289 ± 0.115
1.519AsnAsp: 1.519 ± 0.375
2.242AsnGlu: 2.242 ± 0.398
1.012AsnPhe: 1.012 ± 0.223
3.688AsnGly: 3.688 ± 0.529
0.217AsnHis: 0.217 ± 0.111
1.953AsnIle: 1.953 ± 0.425
1.88AsnLys: 1.88 ± 0.35
2.965AsnLeu: 2.965 ± 0.525
1.157AsnMet: 1.157 ± 0.275
1.808AsnAsn: 1.808 ± 0.352
2.386AsnPro: 2.386 ± 0.496
1.519AsnGln: 1.519 ± 0.332
1.88AsnArg: 1.88 ± 0.364
2.82AsnSer: 2.82 ± 0.421
2.603AsnThr: 2.603 ± 0.376
2.965AsnVal: 2.965 ± 0.45
0.579AsnTrp: 0.579 ± 0.168
1.157AsnTyr: 1.157 ± 0.289
0.0AsnXaa: 0.0 ± 0.0
Pro
5.785ProAla: 5.785 ± 0.456
0.434ProCys: 0.434 ± 0.169
3.471ProAsp: 3.471 ± 0.487
2.748ProGlu: 2.748 ± 0.451
1.953ProPhe: 1.953 ± 0.356
3.905ProGly: 3.905 ± 0.568
0.795ProHis: 0.795 ± 0.297
1.953ProIle: 1.953 ± 0.354
2.17ProLys: 2.17 ± 0.374
2.531ProLeu: 2.531 ± 0.444
0.94ProMet: 0.94 ± 0.25
1.229ProAsn: 1.229 ± 0.352
2.242ProPro: 2.242 ± 0.436
2.17ProGln: 2.17 ± 0.426
1.591ProArg: 1.591 ± 0.333
3.182ProSer: 3.182 ± 0.467
2.82ProThr: 2.82 ± 0.518
3.399ProVal: 3.399 ± 0.553
0.651ProTrp: 0.651 ± 0.223
1.229ProTyr: 1.229 ± 0.294
0.0ProXaa: 0.0 ± 0.0
Gln
5.641GlnAla: 5.641 ± 0.535
1.157GlnCys: 1.157 ± 0.403
2.386GlnAsp: 2.386 ± 0.425
2.386GlnGlu: 2.386 ± 0.392
1.591GlnPhe: 1.591 ± 0.29
2.965GlnGly: 2.965 ± 0.565
0.506GlnHis: 0.506 ± 0.192
3.037GlnIle: 3.037 ± 0.525
1.808GlnLys: 1.808 ± 0.342
3.399GlnLeu: 3.399 ± 0.584
1.519GlnMet: 1.519 ± 0.33
1.591GlnAsn: 1.591 ± 0.271
1.157GlnPro: 1.157 ± 0.282
3.037GlnGln: 3.037 ± 0.824
2.459GlnArg: 2.459 ± 0.458
2.459GlnSer: 2.459 ± 0.426
1.88GlnThr: 1.88 ± 0.363
3.616GlnVal: 3.616 ± 0.57
0.651GlnTrp: 0.651 ± 0.277
1.736GlnTyr: 1.736 ± 0.397
0.0GlnXaa: 0.0 ± 0.0
Arg
4.99ArgAla: 4.99 ± 0.578
1.012ArgCys: 1.012 ± 0.243
2.82ArgAsp: 2.82 ± 0.424
2.82ArgGlu: 2.82 ± 0.484
2.097ArgPhe: 2.097 ± 0.293
3.254ArgGly: 3.254 ± 0.498
1.157ArgHis: 1.157 ± 0.324
2.82ArgIle: 2.82 ± 0.503
4.05ArgLys: 4.05 ± 0.593
4.339ArgLeu: 4.339 ± 0.496
1.953ArgMet: 1.953 ± 0.366
1.736ArgAsn: 1.736 ± 0.423
2.314ArgPro: 2.314 ± 0.403
2.965ArgGln: 2.965 ± 0.464
2.965ArgArg: 2.965 ± 0.52
3.688ArgSer: 3.688 ± 0.492
2.603ArgThr: 2.603 ± 0.429
3.544ArgVal: 3.544 ± 0.54
1.229ArgTrp: 1.229 ± 0.284
1.808ArgTyr: 1.808 ± 0.457
0.0ArgXaa: 0.0 ± 0.0
Ser
7.159SerAla: 7.159 ± 0.664
0.362SerCys: 0.362 ± 0.196
3.471SerAsp: 3.471 ± 0.473
3.254SerGlu: 3.254 ± 0.446
2.097SerPhe: 2.097 ± 0.496
6.147SerGly: 6.147 ± 0.732
1.519SerHis: 1.519 ± 0.348
3.977SerIle: 3.977 ± 0.574
3.688SerLys: 3.688 ± 0.445
4.05SerLeu: 4.05 ± 0.431
2.242SerMet: 2.242 ± 0.363
2.242SerAsn: 2.242 ± 0.39
2.893SerPro: 2.893 ± 0.391
3.11SerGln: 3.11 ± 0.497
2.82SerArg: 2.82 ± 0.41
4.122SerSer: 4.122 ± 0.56
2.531SerThr: 2.531 ± 0.424
4.556SerVal: 4.556 ± 0.661
1.374SerTrp: 1.374 ± 0.331
2.314SerTyr: 2.314 ± 0.384
0.0SerXaa: 0.0 ± 0.0
Thr
5.858ThrAla: 5.858 ± 0.719
0.362ThrCys: 0.362 ± 0.147
3.616ThrAsp: 3.616 ± 0.524
3.037ThrGlu: 3.037 ± 0.484
1.446ThrPhe: 1.446 ± 0.338
5.858ThrGly: 5.858 ± 0.734
0.868ThrHis: 0.868 ± 0.227
3.254ThrIle: 3.254 ± 0.526
2.025ThrLys: 2.025 ± 0.431
5.207ThrLeu: 5.207 ± 0.709
0.795ThrMet: 0.795 ± 0.242
1.808ThrAsn: 1.808 ± 0.398
3.399ThrPro: 3.399 ± 0.472
2.17ThrGln: 2.17 ± 0.394
1.953ThrArg: 1.953 ± 0.363
3.76ThrSer: 3.76 ± 0.491
2.965ThrThr: 2.965 ± 0.581
4.628ThrVal: 4.628 ± 0.767
1.302ThrTrp: 1.302 ± 0.286
1.808ThrTyr: 1.808 ± 0.304
0.0ThrXaa: 0.0 ± 0.0
Val
6.653ValAla: 6.653 ± 0.941
1.012ValCys: 1.012 ± 0.233
4.122ValAsp: 4.122 ± 0.51
5.351ValGlu: 5.351 ± 0.768
1.085ValPhe: 1.085 ± 0.316
3.833ValGly: 3.833 ± 0.543
0.579ValHis: 0.579 ± 0.196
3.76ValIle: 3.76 ± 0.527
4.845ValLys: 4.845 ± 0.652
5.207ValLeu: 5.207 ± 0.64
2.603ValMet: 2.603 ± 0.451
2.965ValAsn: 2.965 ± 0.537
2.676ValPro: 2.676 ± 0.397
2.097ValGln: 2.097 ± 0.437
3.544ValArg: 3.544 ± 0.447
4.556ValSer: 4.556 ± 0.511
4.845ValThr: 4.845 ± 0.582
4.484ValVal: 4.484 ± 0.577
1.012ValTrp: 1.012 ± 0.229
1.591ValTyr: 1.591 ± 0.356
0.0ValXaa: 0.0 ± 0.0
Trp
1.519TrpAla: 1.519 ± 0.295
0.579TrpCys: 0.579 ± 0.191
1.591TrpAsp: 1.591 ± 0.289
1.229TrpGlu: 1.229 ± 0.308
0.723TrpPhe: 0.723 ± 0.212
1.519TrpGly: 1.519 ± 0.352
0.579TrpHis: 0.579 ± 0.255
0.723TrpIle: 0.723 ± 0.189
0.795TrpLys: 0.795 ± 0.249
1.953TrpLeu: 1.953 ± 0.445
0.217TrpMet: 0.217 ± 0.132
0.506TrpAsn: 0.506 ± 0.186
1.374TrpPro: 1.374 ± 0.264
1.157TrpGln: 1.157 ± 0.246
1.374TrpArg: 1.374 ± 0.397
0.506TrpSer: 0.506 ± 0.219
0.434TrpThr: 0.434 ± 0.155
1.519TrpVal: 1.519 ± 0.313
0.651TrpTrp: 0.651 ± 0.226
0.506TrpTyr: 0.506 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.663TyrAla: 1.663 ± 0.303
0.723TyrCys: 0.723 ± 0.224
1.808TyrAsp: 1.808 ± 0.377
1.736TyrGlu: 1.736 ± 0.378
1.085TyrPhe: 1.085 ± 0.233
2.314TyrGly: 2.314 ± 0.372
0.362TyrHis: 0.362 ± 0.17
0.94TyrIle: 0.94 ± 0.218
1.085TyrLys: 1.085 ± 0.256
3.037TyrLeu: 3.037 ± 0.478
1.085TyrMet: 1.085 ± 0.236
1.374TyrAsn: 1.374 ± 0.293
1.229TyrPro: 1.229 ± 0.317
1.88TyrGln: 1.88 ± 0.347
2.314TyrArg: 2.314 ± 0.377
1.591TyrSer: 1.591 ± 0.417
1.663TyrThr: 1.663 ± 0.322
2.17TyrVal: 2.17 ± 0.45
0.795TyrTrp: 0.795 ± 0.231
0.795TyrTyr: 0.795 ± 0.244
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 84 proteins (13829 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski