Amino acid dipepetide frequency for Aeromonas phage 14AhydR10PP

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.964AlaAla: 11.964 ± 1.089
0.974AlaCys: 0.974 ± 0.247
5.008AlaAsp: 5.008 ± 0.677
6.26AlaGlu: 6.26 ± 0.716
2.852AlaPhe: 2.852 ± 0.471
8.068AlaGly: 8.068 ± 1.099
1.252AlaHis: 1.252 ± 0.339
6.19AlaIle: 6.19 ± 0.652
6.469AlaLys: 6.469 ± 0.746
10.572AlaLeu: 10.572 ± 0.927
4.66AlaMet: 4.66 ± 0.552
3.06AlaAsn: 3.06 ± 0.711
3.895AlaPro: 3.895 ± 0.487
3.408AlaGln: 3.408 ± 0.499
5.634AlaArg: 5.634 ± 0.622
6.399AlaSer: 6.399 ± 0.777
5.564AlaThr: 5.564 ± 0.777
5.982AlaVal: 5.982 ± 0.762
0.626AlaTrp: 0.626 ± 0.25
2.434AlaTyr: 2.434 ± 0.503
0.0AlaXaa: 0.0 ± 0.0
Cys
1.391CysAla: 1.391 ± 0.383
0.209CysCys: 0.209 ± 0.102
0.696CysAsp: 0.696 ± 0.259
0.904CysGlu: 0.904 ± 0.263
0.278CysPhe: 0.278 ± 0.13
1.391CysGly: 1.391 ± 0.301
0.348CysHis: 0.348 ± 0.177
0.904CysIle: 0.904 ± 0.265
0.626CysLys: 0.626 ± 0.221
1.739CysLeu: 1.739 ± 0.385
0.209CysMet: 0.209 ± 0.128
0.278CysAsn: 0.278 ± 0.132
1.182CysPro: 1.182 ± 0.328
0.556CysGln: 0.556 ± 0.225
1.113CysArg: 1.113 ± 0.28
0.765CysSer: 0.765 ± 0.188
0.904CysThr: 0.904 ± 0.249
0.696CysVal: 0.696 ± 0.256
0.556CysTrp: 0.556 ± 0.259
0.626CysTyr: 0.626 ± 0.214
0.0CysXaa: 0.0 ± 0.0
Asp
6.051AspAla: 6.051 ± 0.573
0.974AspCys: 0.974 ± 0.215
2.295AspAsp: 2.295 ± 0.406
2.852AspGlu: 2.852 ± 0.499
1.948AspPhe: 1.948 ± 0.429
5.425AspGly: 5.425 ± 0.572
0.974AspHis: 0.974 ± 0.267
2.921AspIle: 2.921 ± 0.423
2.574AspLys: 2.574 ± 0.519
5.008AspLeu: 5.008 ± 0.636
1.53AspMet: 1.53 ± 0.307
2.226AspAsn: 2.226 ± 0.399
2.504AspPro: 2.504 ± 0.492
1.808AspGln: 1.808 ± 0.381
3.965AspArg: 3.965 ± 0.592
2.156AspSer: 2.156 ± 0.361
1.878AspThr: 1.878 ± 0.372
4.73AspVal: 4.73 ± 0.563
1.113AspTrp: 1.113 ± 0.361
1.461AspTyr: 1.461 ± 0.32
0.0AspXaa: 0.0 ± 0.0
Glu
5.982GluAla: 5.982 ± 0.67
0.765GluCys: 0.765 ± 0.229
2.852GluAsp: 2.852 ± 0.452
3.895GluGlu: 3.895 ± 0.613
2.087GluPhe: 2.087 ± 0.375
5.008GluGly: 5.008 ± 0.575
1.669GluHis: 1.669 ± 0.368
2.713GluIle: 2.713 ± 0.491
3.895GluLys: 3.895 ± 0.521
6.19GluLeu: 6.19 ± 0.734
1.878GluMet: 1.878 ± 0.417
1.461GluAsn: 1.461 ± 0.323
2.087GluPro: 2.087 ± 0.357
2.574GluGln: 2.574 ± 0.577
4.312GluArg: 4.312 ± 0.684
3.826GluSer: 3.826 ± 0.461
3.408GluThr: 3.408 ± 0.407
5.147GluVal: 5.147 ± 0.631
1.113GluTrp: 1.113 ± 0.303
1.808GluTyr: 1.808 ± 0.433
0.0GluXaa: 0.0 ± 0.0
Phe
2.504PheAla: 2.504 ± 0.397
0.487PheCys: 0.487 ± 0.166
1.878PheAsp: 1.878 ± 0.419
1.6PheGlu: 1.6 ± 0.327
0.348PhePhe: 0.348 ± 0.142
3.686PheGly: 3.686 ± 0.568
1.043PheHis: 1.043 ± 0.237
2.156PheIle: 2.156 ± 0.356
1.669PheLys: 1.669 ± 0.353
2.574PheLeu: 2.574 ± 0.384
0.417PheMet: 0.417 ± 0.16
0.835PheAsn: 0.835 ± 0.248
1.461PhePro: 1.461 ± 0.307
1.461PheGln: 1.461 ± 0.344
1.948PheArg: 1.948 ± 0.284
1.391PheSer: 1.391 ± 0.291
2.434PheThr: 2.434 ± 0.433
1.6PheVal: 1.6 ± 0.315
0.626PheTrp: 0.626 ± 0.21
0.626PheTyr: 0.626 ± 0.243
0.0PheXaa: 0.0 ± 0.0
Gly
5.843GlyAla: 5.843 ± 0.688
1.252GlyCys: 1.252 ± 0.27
3.686GlyAsp: 3.686 ± 0.593
5.704GlyGlu: 5.704 ± 0.696
3.547GlyPhe: 3.547 ± 0.64
5.843GlyGly: 5.843 ± 0.816
1.808GlyHis: 1.808 ± 0.351
4.452GlyIle: 4.452 ± 0.476
4.799GlyLys: 4.799 ± 0.617
6.677GlyLeu: 6.677 ± 0.76
3.2GlyMet: 3.2 ± 0.488
2.782GlyAsn: 2.782 ± 0.511
3.269GlyPro: 3.269 ± 0.533
2.991GlyGln: 2.991 ± 0.62
4.243GlyArg: 4.243 ± 0.579
5.008GlySer: 5.008 ± 0.607
3.965GlyThr: 3.965 ± 0.718
5.495GlyVal: 5.495 ± 0.558
1.252GlyTrp: 1.252 ± 0.33
1.878GlyTyr: 1.878 ± 0.361
0.0GlyXaa: 0.0 ± 0.0
His
2.017HisAla: 2.017 ± 0.365
0.487HisCys: 0.487 ± 0.172
1.322HisAsp: 1.322 ± 0.279
0.974HisGlu: 0.974 ± 0.265
0.765HisPhe: 0.765 ± 0.265
1.391HisGly: 1.391 ± 0.31
0.904HisHis: 0.904 ± 0.274
1.113HisIle: 1.113 ± 0.241
1.043HisLys: 1.043 ± 0.272
1.948HisLeu: 1.948 ± 0.392
0.417HisMet: 0.417 ± 0.145
0.556HisAsn: 0.556 ± 0.246
1.113HisPro: 1.113 ± 0.276
0.974HisGln: 0.974 ± 0.324
1.739HisArg: 1.739 ± 0.422
0.974HisSer: 0.974 ± 0.295
1.182HisThr: 1.182 ± 0.324
1.182HisVal: 1.182 ± 0.298
0.626HisTrp: 0.626 ± 0.249
1.043HisTyr: 1.043 ± 0.268
0.0HisXaa: 0.0 ± 0.0
Ile
5.078IleAla: 5.078 ± 0.66
0.556IleCys: 0.556 ± 0.201
2.713IleAsp: 2.713 ± 0.417
3.895IleGlu: 3.895 ± 0.514
1.043IlePhe: 1.043 ± 0.257
2.921IleGly: 2.921 ± 0.468
1.043IleHis: 1.043 ± 0.225
2.295IleIle: 2.295 ± 0.538
3.269IleLys: 3.269 ± 0.544
3.478IleLeu: 3.478 ± 0.504
1.391IleMet: 1.391 ± 0.317
2.087IleAsn: 2.087 ± 0.388
1.878IlePro: 1.878 ± 0.342
1.948IleGln: 1.948 ± 0.375
3.826IleArg: 3.826 ± 0.545
3.06IleSer: 3.06 ± 0.53
4.104IleThr: 4.104 ± 0.453
2.852IleVal: 2.852 ± 0.371
0.904IleTrp: 0.904 ± 0.25
1.182IleTyr: 1.182 ± 0.306
0.0IleXaa: 0.0 ± 0.0
Lys
9.32LysAla: 9.32 ± 0.928
0.696LysCys: 0.696 ± 0.217
3.617LysAsp: 3.617 ± 0.497
3.826LysGlu: 3.826 ± 0.58
1.808LysPhe: 1.808 ± 0.431
5.495LysGly: 5.495 ± 0.721
0.974LysHis: 0.974 ± 0.243
2.226LysIle: 2.226 ± 0.364
2.365LysLys: 2.365 ± 0.449
4.312LysLeu: 4.312 ± 0.606
2.574LysMet: 2.574 ± 0.409
1.113LysAsn: 1.113 ± 0.286
2.713LysPro: 2.713 ± 0.368
2.713LysGln: 2.713 ± 0.545
3.547LysArg: 3.547 ± 0.461
2.434LysSer: 2.434 ± 0.492
3.269LysThr: 3.269 ± 0.396
4.312LysVal: 4.312 ± 0.559
0.696LysTrp: 0.696 ± 0.254
0.974LysTyr: 0.974 ± 0.28
0.0LysXaa: 0.0 ± 0.0
Leu
6.956LeuAla: 6.956 ± 0.809
1.182LeuCys: 1.182 ± 0.322
5.425LeuAsp: 5.425 ± 0.871
6.469LeuGlu: 6.469 ± 0.599
1.808LeuPhe: 1.808 ± 0.382
4.799LeuGly: 4.799 ± 0.637
1.878LeuHis: 1.878 ± 0.396
3.756LeuIle: 3.756 ± 0.404
4.938LeuLys: 4.938 ± 0.675
5.982LeuLeu: 5.982 ± 0.619
2.574LeuMet: 2.574 ± 0.423
3.408LeuAsn: 3.408 ± 0.494
4.104LeuPro: 4.104 ± 0.495
2.156LeuGln: 2.156 ± 0.417
5.982LeuArg: 5.982 ± 0.834
6.747LeuSer: 6.747 ± 0.573
7.164LeuThr: 7.164 ± 0.8
5.912LeuVal: 5.912 ± 0.683
1.391LeuTrp: 1.391 ± 0.32
1.669LeuTyr: 1.669 ± 0.365
0.0LeuXaa: 0.0 ± 0.0
Met
4.312MetAla: 4.312 ± 0.559
0.209MetCys: 0.209 ± 0.112
2.017MetAsp: 2.017 ± 0.41
1.669MetGlu: 1.669 ± 0.362
0.626MetPhe: 0.626 ± 0.197
2.365MetGly: 2.365 ± 0.436
0.417MetHis: 0.417 ± 0.161
1.182MetIle: 1.182 ± 0.285
2.852MetLys: 2.852 ± 0.411
1.948MetLeu: 1.948 ± 0.383
0.765MetMet: 0.765 ± 0.23
1.182MetAsn: 1.182 ± 0.35
1.252MetPro: 1.252 ± 0.349
1.322MetGln: 1.322 ± 0.252
1.182MetArg: 1.182 ± 0.382
2.782MetSer: 2.782 ± 0.426
2.921MetThr: 2.921 ± 0.357
2.504MetVal: 2.504 ± 0.39
0.348MetTrp: 0.348 ± 0.173
0.487MetTyr: 0.487 ± 0.161
0.0MetXaa: 0.0 ± 0.0
Asn
2.295AsnAla: 2.295 ± 0.42
0.626AsnCys: 0.626 ± 0.232
1.391AsnAsp: 1.391 ± 0.28
2.017AsnGlu: 2.017 ± 0.387
0.835AsnPhe: 0.835 ± 0.231
3.13AsnGly: 3.13 ± 0.512
0.974AsnHis: 0.974 ± 0.253
1.391AsnIle: 1.391 ± 0.352
2.991AsnLys: 2.991 ± 0.394
2.852AsnLeu: 2.852 ± 0.458
0.835AsnMet: 0.835 ± 0.231
1.252AsnAsn: 1.252 ± 0.32
2.295AsnPro: 2.295 ± 0.329
2.017AsnGln: 2.017 ± 0.347
1.6AsnArg: 1.6 ± 0.304
1.53AsnSer: 1.53 ± 0.27
2.574AsnThr: 2.574 ± 0.623
2.852AsnVal: 2.852 ± 0.458
0.556AsnTrp: 0.556 ± 0.183
0.904AsnTyr: 0.904 ± 0.311
0.0AsnXaa: 0.0 ± 0.0
Pro
4.521ProAla: 4.521 ± 0.662
0.556ProCys: 0.556 ± 0.19
3.269ProAsp: 3.269 ± 0.476
3.686ProGlu: 3.686 ± 0.544
1.808ProPhe: 1.808 ± 0.337
2.574ProGly: 2.574 ± 0.414
0.904ProHis: 0.904 ± 0.26
1.878ProIle: 1.878 ± 0.369
2.365ProLys: 2.365 ± 0.381
3.478ProLeu: 3.478 ± 0.414
0.487ProMet: 0.487 ± 0.176
1.322ProAsn: 1.322 ± 0.284
2.087ProPro: 2.087 ± 0.424
1.252ProGln: 1.252 ± 0.318
1.739ProArg: 1.739 ± 0.372
2.782ProSer: 2.782 ± 0.413
3.478ProThr: 3.478 ± 0.693
3.965ProVal: 3.965 ± 0.595
0.487ProTrp: 0.487 ± 0.186
1.461ProTyr: 1.461 ± 0.36
0.0ProXaa: 0.0 ± 0.0
Gln
5.217GlnAla: 5.217 ± 0.633
0.974GlnCys: 0.974 ± 0.281
1.461GlnAsp: 1.461 ± 0.309
2.365GlnGlu: 2.365 ± 0.441
0.556GlnPhe: 0.556 ± 0.217
3.478GlnGly: 3.478 ± 0.438
1.182GlnHis: 1.182 ± 0.315
1.669GlnIle: 1.669 ± 0.37
1.808GlnLys: 1.808 ± 0.531
2.713GlnLeu: 2.713 ± 0.527
1.391GlnMet: 1.391 ± 0.361
1.252GlnAsn: 1.252 ± 0.295
0.974GlnPro: 0.974 ± 0.247
1.182GlnGln: 1.182 ± 0.287
1.878GlnArg: 1.878 ± 0.339
2.574GlnSer: 2.574 ± 0.384
2.017GlnThr: 2.017 ± 0.401
2.991GlnVal: 2.991 ± 0.443
0.765GlnTrp: 0.765 ± 0.226
1.043GlnTyr: 1.043 ± 0.253
0.0GlnXaa: 0.0 ± 0.0
Arg
5.634ArgAla: 5.634 ± 0.643
1.182ArgCys: 1.182 ± 0.298
3.269ArgAsp: 3.269 ± 0.428
3.06ArgGlu: 3.06 ± 0.644
2.295ArgPhe: 2.295 ± 0.448
3.547ArgGly: 3.547 ± 0.374
1.53ArgHis: 1.53 ± 0.395
2.295ArgIle: 2.295 ± 0.477
3.686ArgLys: 3.686 ± 0.477
6.816ArgLeu: 6.816 ± 0.78
2.295ArgMet: 2.295 ± 0.308
3.13ArgAsn: 3.13 ± 0.436
2.991ArgPro: 2.991 ± 0.544
2.017ArgGln: 2.017 ± 0.478
3.478ArgArg: 3.478 ± 0.789
3.478ArgSer: 3.478 ± 0.609
2.782ArgThr: 2.782 ± 0.485
4.591ArgVal: 4.591 ± 0.649
1.252ArgTrp: 1.252 ± 0.253
1.182ArgTyr: 1.182 ± 0.266
0.0ArgXaa: 0.0 ± 0.0
Ser
6.19SerAla: 6.19 ± 0.703
1.391SerCys: 1.391 ± 0.408
3.617SerAsp: 3.617 ± 0.414
2.852SerGlu: 2.852 ± 0.399
1.808SerPhe: 1.808 ± 0.326
5.217SerGly: 5.217 ± 0.694
1.113SerHis: 1.113 ± 0.293
3.13SerIle: 3.13 ± 0.546
2.991SerLys: 2.991 ± 0.373
5.564SerLeu: 5.564 ± 0.583
2.434SerMet: 2.434 ± 0.359
2.087SerAsn: 2.087 ± 0.484
2.504SerPro: 2.504 ± 0.419
2.434SerGln: 2.434 ± 0.406
3.2SerArg: 3.2 ± 0.474
3.339SerSer: 3.339 ± 0.556
3.2SerThr: 3.2 ± 0.44
3.408SerVal: 3.408 ± 0.522
1.043SerTrp: 1.043 ± 0.265
1.53SerTyr: 1.53 ± 0.326
0.0SerXaa: 0.0 ± 0.0
Thr
5.843ThrAla: 5.843 ± 0.796
1.043ThrCys: 1.043 ± 0.309
2.921ThrAsp: 2.921 ± 0.457
3.2ThrGlu: 3.2 ± 0.461
2.365ThrPhe: 2.365 ± 0.395
5.495ThrGly: 5.495 ± 0.529
0.904ThrHis: 0.904 ± 0.234
3.13ThrIle: 3.13 ± 0.512
4.034ThrLys: 4.034 ± 0.623
5.773ThrLeu: 5.773 ± 0.546
2.226ThrMet: 2.226 ± 0.507
1.808ThrAsn: 1.808 ± 0.421
3.826ThrPro: 3.826 ± 0.682
2.017ThrGln: 2.017 ± 0.364
3.826ThrArg: 3.826 ± 0.533
2.574ThrSer: 2.574 ± 0.373
4.869ThrThr: 4.869 ± 0.821
4.382ThrVal: 4.382 ± 0.601
0.904ThrTrp: 0.904 ± 0.271
1.739ThrTyr: 1.739 ± 0.314
0.0ThrXaa: 0.0 ± 0.0
Val
6.538ValAla: 6.538 ± 0.76
1.043ValCys: 1.043 ± 0.264
4.382ValAsp: 4.382 ± 0.7
4.869ValGlu: 4.869 ± 0.628
2.226ValPhe: 2.226 ± 0.411
4.73ValGly: 4.73 ± 0.604
1.6ValHis: 1.6 ± 0.411
4.173ValIle: 4.173 ± 0.5
4.938ValLys: 4.938 ± 0.605
3.547ValLeu: 3.547 ± 0.473
2.295ValMet: 2.295 ± 0.349
3.13ValAsn: 3.13 ± 0.61
2.434ValPro: 2.434 ± 0.378
2.782ValGln: 2.782 ± 0.383
3.826ValArg: 3.826 ± 0.495
5.078ValSer: 5.078 ± 0.53
4.73ValThr: 4.73 ± 0.571
5.982ValVal: 5.982 ± 0.819
1.252ValTrp: 1.252 ± 0.278
1.669ValTyr: 1.669 ± 0.468
0.0ValXaa: 0.0 ± 0.0
Trp
1.808TrpAla: 1.808 ± 0.426
0.209TrpCys: 0.209 ± 0.113
1.252TrpAsp: 1.252 ± 0.356
0.974TrpGlu: 0.974 ± 0.269
0.974TrpPhe: 0.974 ± 0.241
0.904TrpGly: 0.904 ± 0.226
0.417TrpHis: 0.417 ± 0.163
0.765TrpIle: 0.765 ± 0.245
0.765TrpLys: 0.765 ± 0.212
1.043TrpLeu: 1.043 ± 0.271
0.417TrpMet: 0.417 ± 0.158
0.974TrpAsn: 0.974 ± 0.3
0.487TrpPro: 0.487 ± 0.174
0.765TrpGln: 0.765 ± 0.254
0.904TrpArg: 0.904 ± 0.236
0.835TrpSer: 0.835 ± 0.228
0.765TrpThr: 0.765 ± 0.241
0.974TrpVal: 0.974 ± 0.211
0.139TrpTrp: 0.139 ± 0.083
0.487TrpTyr: 0.487 ± 0.185
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.808TyrAla: 1.808 ± 0.37
0.556TyrCys: 0.556 ± 0.182
1.322TyrAsp: 1.322 ± 0.302
1.6TyrGlu: 1.6 ± 0.313
0.765TyrPhe: 0.765 ± 0.2
2.226TyrGly: 2.226 ± 0.406
0.835TyrHis: 0.835 ± 0.215
1.182TyrIle: 1.182 ± 0.387
0.904TyrLys: 0.904 ± 0.256
2.087TyrLeu: 2.087 ± 0.39
0.278TyrMet: 0.278 ± 0.137
0.974TyrAsn: 0.974 ± 0.314
1.043TyrPro: 1.043 ± 0.256
1.113TyrGln: 1.113 ± 0.284
2.574TyrArg: 2.574 ± 0.428
1.391TyrSer: 1.391 ± 0.425
1.669TyrThr: 1.669 ± 0.337
1.669TyrVal: 1.669 ± 0.358
0.209TyrTrp: 0.209 ± 0.116
0.696TyrTyr: 0.696 ± 0.191
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 82 proteins (14378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski