Amino acid dipepetide frequency for Mucilaginibacter paludis DSM 18603

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.528AlaAla: 6.528 ± 0.073	0.659AlaCys: 0.659 ± 0.019	4.718AlaAsp: 4.718 ± 0.044	4.184AlaGlu: 4.184 ± 0.05	3.48AlaPhe: 3.48 ± 0.041	5.683AlaGly: 5.683 ± 0.073	1.257AlaHis: 1.257 ± 0.022	5.605AlaIle: 5.605 ± 0.057	4.657AlaLys: 4.657 ± 0.047	7.205AlaLeu: 7.205 ± 0.061	1.741AlaMet: 1.741 ± 0.027	4.073AlaAsn: 4.073 ± 0.049	2.462AlaPro: 2.462 ± 0.034	3.156AlaGln: 3.156 ± 0.037	2.676AlaArg: 2.676 ± 0.035	4.691AlaSer: 4.691 ± 0.054	4.439AlaThr: 4.439 ± 0.062	4.904AlaVal: 4.904 ± 0.045	0.842AlaTrp: 0.842 ± 0.021	3.088AlaTyr: 3.088 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.522CysAla: 0.522 ± 0.016	0.14CysCys: 0.14 ± 0.01	0.383CysAsp: 0.383 ± 0.014	0.347CysGlu: 0.347 ± 0.013	0.462CysPhe: 0.462 ± 0.015	0.632CysGly: 0.632 ± 0.018	0.186CysHis: 0.186 ± 0.01	0.621CysIle: 0.621 ± 0.018	0.534CysLys: 0.534 ± 0.016	0.831CysLeu: 0.831 ± 0.019	0.196CysMet: 0.196 ± 0.009	0.428CysAsn: 0.428 ± 0.015	0.299CysPro: 0.299 ± 0.013	0.258CysGln: 0.258 ± 0.01	0.358CysArg: 0.358 ± 0.014	0.538CysSer: 0.538 ± 0.016	0.451CysThr: 0.451 ± 0.015	0.425CysVal: 0.425 ± 0.013	0.086CysTrp: 0.086 ± 0.007	0.369CysTyr: 0.369 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.086AspAla: 4.086 ± 0.043	0.381AspCys: 0.381 ± 0.014	2.784AspAsp: 2.784 ± 0.041	3.209AspGlu: 3.209 ± 0.044	3.011AspPhe: 3.011 ± 0.039	3.768AspGly: 3.768 ± 0.046	1.095AspHis: 1.095 ± 0.021	3.969AspIle: 3.969 ± 0.042	3.708AspLys: 3.708 ± 0.047	4.963AspLeu: 4.963 ± 0.043	1.229AspMet: 1.229 ± 0.028	2.84AspAsn: 2.84 ± 0.04	2.118AspPro: 2.118 ± 0.033	2.09AspGln: 2.09 ± 0.028	2.114AspArg: 2.114 ± 0.031	2.941AspSer: 2.941 ± 0.038	2.755AspThr: 2.755 ± 0.036	3.495AspVal: 3.495 ± 0.04	0.744AspTrp: 0.744 ± 0.021	2.532AspTyr: 2.532 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	3.968GluAla: 3.968 ± 0.044	0.323GluCys: 0.323 ± 0.015	2.441GluAsp: 2.441 ± 0.039	2.972GluGlu: 2.972 ± 0.049	2.145GluPhe: 2.145 ± 0.031	2.899GluGly: 2.899 ± 0.041	1.098GluHis: 1.098 ± 0.027	3.967GluIle: 3.967 ± 0.046	4.106GluLys: 4.106 ± 0.054	5.43GluLeu: 5.43 ± 0.06	1.272GluMet: 1.272 ± 0.023	2.847GluAsn: 2.847 ± 0.041	1.666GluPro: 1.666 ± 0.03	2.459GluGln: 2.459 ± 0.041	2.35GluArg: 2.35 ± 0.038	2.584GluSer: 2.584 ± 0.034	2.686GluThr: 2.686 ± 0.033	3.407GluVal: 3.407 ± 0.039	0.568GluTrp: 0.568 ± 0.018	1.885GluTyr: 1.885 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.254PheAla: 3.254 ± 0.036	0.488PheCys: 0.488 ± 0.014	2.909PheAsp: 2.909 ± 0.038	2.495PheGlu: 2.495 ± 0.038	2.373PhePhe: 2.373 ± 0.04	3.242PheGly: 3.242 ± 0.038	0.801PheHis: 0.801 ± 0.019	3.371PheIle: 3.371 ± 0.044	3.476PheLys: 3.476 ± 0.039	4.159PheLeu: 4.159 ± 0.052	1.032PheMet: 1.032 ± 0.023	3.154PheAsn: 3.154 ± 0.037	1.689PhePro: 1.689 ± 0.027	1.365PheGln: 1.365 ± 0.025	1.766PheArg: 1.766 ± 0.027	3.508PheSer: 3.508 ± 0.041	3.233PheThr: 3.233 ± 0.036	2.677PheVal: 2.677 ± 0.033	0.568PheTrp: 0.568 ± 0.018	2.168PheTyr: 2.168 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.533GlyAla: 4.533 ± 0.057	0.585GlyCys: 0.585 ± 0.02	3.339GlyAsp: 3.339 ± 0.044	3.12GlyGlu: 3.12 ± 0.043	3.515GlyPhe: 3.515 ± 0.041	4.793GlyGly: 4.793 ± 0.068	1.232GlyHis: 1.232 ± 0.024	5.273GlyIle: 5.273 ± 0.055	5.07GlyLys: 5.07 ± 0.053	6.358GlyLeu: 6.358 ± 0.062	1.619GlyMet: 1.619 ± 0.029	3.789GlyAsn: 3.789 ± 0.05	1.618GlyPro: 1.618 ± 0.026	2.459GlyGln: 2.459 ± 0.035	2.512GlyArg: 2.512 ± 0.034	4.48GlySer: 4.48 ± 0.061	4.375GlyThr: 4.375 ± 0.068	4.233GlyVal: 4.233 ± 0.052	0.918GlyTrp: 0.918 ± 0.018	3.265GlyTyr: 3.265 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.185HisAla: 1.185 ± 0.028	0.2HisCys: 0.2 ± 0.009	0.986HisAsp: 0.986 ± 0.021	0.936HisGlu: 0.936 ± 0.021	1.141HisPhe: 1.141 ± 0.022	1.132HisGly: 1.132 ± 0.024	0.611HisHis: 0.611 ± 0.017	1.517HisIle: 1.517 ± 0.027	0.95HisLys: 0.95 ± 0.02	1.905HisLeu: 1.905 ± 0.031	0.345HisMet: 0.345 ± 0.013	0.973HisAsn: 0.973 ± 0.019	1.021HisPro: 1.021 ± 0.023	1.0HisGln: 1.0 ± 0.022	0.793HisArg: 0.793 ± 0.018	1.078HisSer: 1.078 ± 0.02	1.082HisThr: 1.082 ± 0.023	1.007HisVal: 1.007 ± 0.02	0.242HisTrp: 0.242 ± 0.01	0.927HisTyr: 0.927 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.029IleAla: 6.029 ± 0.053	0.707IleCys: 0.707 ± 0.018	4.177IleAsp: 4.177 ± 0.045	3.846IleGlu: 3.846 ± 0.048	2.946IlePhe: 2.946 ± 0.041	4.726IleGly: 4.726 ± 0.051	1.262IleHis: 1.262 ± 0.021	5.028IleIle: 5.028 ± 0.066	5.053IleLys: 5.053 ± 0.052	6.132IleLeu: 6.132 ± 0.062	1.302IleMet: 1.302 ± 0.027	4.527IleAsn: 4.527 ± 0.047	3.072IlePro: 3.072 ± 0.034	2.429IleGln: 2.429 ± 0.036	3.043IleArg: 3.043 ± 0.038	5.271IleSer: 5.271 ± 0.045	4.876IleThr: 4.876 ± 0.057	4.162IleVal: 4.162 ± 0.046	0.75IleTrp: 0.75 ± 0.018	2.766IleTyr: 2.766 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	5.342LysAla: 5.342 ± 0.055	0.333LysCys: 0.333 ± 0.012	3.749LysAsp: 3.749 ± 0.046	3.871LysGlu: 3.871 ± 0.047	2.592LysPhe: 2.592 ± 0.036	4.266LysGly: 4.266 ± 0.052	1.289LysHis: 1.289 ± 0.026	4.961LysIle: 4.961 ± 0.054	5.223LysLys: 5.223 ± 0.054	6.419LysLeu: 6.419 ± 0.058	1.728LysMet: 1.728 ± 0.032	4.172LysAsn: 4.172 ± 0.047	2.909LysPro: 2.909 ± 0.041	3.055LysGln: 3.055 ± 0.044	2.712LysArg: 2.712 ± 0.036	3.847LysSer: 3.847 ± 0.044	4.221LysThr: 4.221 ± 0.041	4.267LysVal: 4.267 ± 0.048	0.752LysTrp: 0.752 ± 0.021	2.778LysTyr: 2.778 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	7.02LeuAla: 7.02 ± 0.06	0.835LeuCys: 0.835 ± 0.021	4.667LeuAsp: 4.667 ± 0.046	4.402LeuGlu: 4.402 ± 0.052	4.652LeuPhe: 4.652 ± 0.052	5.579LeuGly: 5.579 ± 0.054	1.748LeuHis: 1.748 ± 0.03	6.731LeuIle: 6.731 ± 0.067	7.308LeuLys: 7.308 ± 0.062	9.681LeuLeu: 9.681 ± 0.083	2.275LeuMet: 2.275 ± 0.028	6.027LeuAsn: 6.027 ± 0.049	4.297LeuPro: 4.297 ± 0.048	3.794LeuGln: 3.794 ± 0.043	3.755LeuArg: 3.755 ± 0.042	7.252LeuSer: 7.252 ± 0.056	5.876LeuThr: 5.876 ± 0.052	5.435LeuVal: 5.435 ± 0.053	0.997LeuTrp: 0.997 ± 0.025	3.503LeuTyr: 3.503 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.949MetAla: 1.949 ± 0.029	0.138MetCys: 0.138 ± 0.008	1.24MetAsp: 1.24 ± 0.023	1.294MetGlu: 1.294 ± 0.029	0.774MetPhe: 0.774 ± 0.019	1.409MetGly: 1.409 ± 0.028	0.432MetHis: 0.432 ± 0.014	1.536MetIle: 1.536 ± 0.025	1.836MetLys: 1.836 ± 0.029	2.187MetLeu: 2.187 ± 0.032	0.616MetMet: 0.616 ± 0.017	1.187MetAsn: 1.187 ± 0.024	1.064MetPro: 1.064 ± 0.022	0.963MetGln: 0.963 ± 0.024	0.944MetArg: 0.944 ± 0.022	1.303MetSer: 1.303 ± 0.03	1.032MetThr: 1.032 ± 0.022	1.486MetVal: 1.486 ± 0.03	0.181MetTrp: 0.181 ± 0.009	0.667MetTyr: 0.667 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	4.144AsnAla: 4.144 ± 0.047	0.448AsnCys: 0.448 ± 0.014	2.914AsnAsp: 2.914 ± 0.036	2.729AsnGlu: 2.729 ± 0.033	2.681AsnPhe: 2.681 ± 0.036	4.277AsnGly: 4.277 ± 0.055	1.135AsnHis: 1.135 ± 0.022	4.29AsnIle: 4.29 ± 0.046	3.655AsnLys: 3.655 ± 0.044	5.26AsnLeu: 5.26 ± 0.049	1.225AsnMet: 1.225 ± 0.025	3.671AsnAsn: 3.671 ± 0.056	2.796AsnPro: 2.796 ± 0.04	2.459AsnGln: 2.459 ± 0.03	2.409AsnArg: 2.409 ± 0.032	3.606AsnSer: 3.606 ± 0.041	3.569AsnThr: 3.569 ± 0.044	3.209AsnVal: 3.209 ± 0.037	0.749AsnTrp: 0.749 ± 0.017	2.944AsnTyr: 2.944 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.443ProAla: 3.443 ± 0.048	0.243ProCys: 0.243 ± 0.011	2.712ProAsp: 2.712 ± 0.042	2.589ProGlu: 2.589 ± 0.035	1.934ProPhe: 1.934 ± 0.025	3.114ProGly: 3.114 ± 0.038	0.694ProHis: 0.694 ± 0.018	2.291ProIle: 2.291 ± 0.031	2.097ProLys: 2.097 ± 0.036	3.517ProLeu: 3.517 ± 0.04	0.754ProMet: 0.754 ± 0.019	2.02ProAsn: 2.02 ± 0.031	1.197ProPro: 1.197 ± 0.028	1.575ProGln: 1.575 ± 0.03	1.093ProArg: 1.093 ± 0.024	2.323ProSer: 2.323 ± 0.03	2.018ProThr: 2.018 ± 0.031	3.374ProVal: 3.374 ± 0.046	0.399ProTrp: 0.399 ± 0.015	1.642ProTyr: 1.642 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.006GlnAla: 3.006 ± 0.036	0.22GlnCys: 0.22 ± 0.01	1.757GlnAsp: 1.757 ± 0.028	1.845GlnGlu: 1.845 ± 0.031	1.778GlnPhe: 1.778 ± 0.027	2.182GlnGly: 2.182 ± 0.03	0.91GlnHis: 0.91 ± 0.02	2.833GlnIle: 2.833 ± 0.036	2.778GlnLys: 2.778 ± 0.037	4.207GlnLeu: 4.207 ± 0.045	0.973GlnMet: 0.973 ± 0.022	2.335GlnAsn: 2.335 ± 0.038	1.577GlnPro: 1.577 ± 0.029	2.425GlnGln: 2.425 ± 0.043	1.578GlnArg: 1.578 ± 0.025	2.56GlnSer: 2.56 ± 0.031	2.441GlnThr: 2.441 ± 0.031	2.618GlnVal: 2.618 ± 0.036	0.465GlnTrp: 0.465 ± 0.017	1.845GlnTyr: 1.845 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.593ArgAla: 2.593 ± 0.034	0.257ArgCys: 0.257 ± 0.011	1.967ArgAsp: 1.967 ± 0.03	2.162ArgGlu: 2.162 ± 0.03	2.077ArgPhe: 2.077 ± 0.032	2.144ArgGly: 2.144 ± 0.03	0.747ArgHis: 0.747 ± 0.019	2.984ArgIle: 2.984 ± 0.041	2.82ArgLys: 2.82 ± 0.037	4.044ArgLeu: 4.044 ± 0.044	1.061ArgMet: 1.061 ± 0.026	2.197ArgAsn: 2.197 ± 0.027	1.374ArgPro: 1.374 ± 0.03	1.678ArgGln: 1.678 ± 0.029	1.627ArgArg: 1.627 ± 0.034	2.321ArgSer: 2.321 ± 0.035	2.018ArgThr: 2.018 ± 0.03	2.424ArgVal: 2.424 ± 0.03	0.562ArgTrp: 0.562 ± 0.015	1.964ArgTyr: 1.964 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	5.087SerAla: 5.087 ± 0.057	0.583SerCys: 0.583 ± 0.017	3.174SerAsp: 3.174 ± 0.039	2.767SerGlu: 2.767 ± 0.035	3.482SerPhe: 3.482 ± 0.039	5.138SerGly: 5.138 ± 0.058	1.176SerHis: 1.176 ± 0.026	4.626SerIle: 4.626 ± 0.042	3.929SerLys: 3.929 ± 0.04	6.296SerLeu: 6.296 ± 0.063	1.299SerMet: 1.299 ± 0.022	3.468SerAsn: 3.468 ± 0.044	2.593SerPro: 2.593 ± 0.036	2.248SerGln: 2.248 ± 0.031	2.511SerArg: 2.511 ± 0.036	4.359SerSer: 4.359 ± 0.054	3.759SerThr: 3.759 ± 0.053	4.333SerVal: 4.333 ± 0.044	0.73SerTrp: 0.73 ± 0.017	2.901SerTyr: 2.901 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.959ThrAla: 4.959 ± 0.064	0.41ThrCys: 0.41 ± 0.015	3.659ThrAsp: 3.659 ± 0.045	2.913ThrGlu: 2.913 ± 0.039	2.733ThrPhe: 2.733 ± 0.034	5.057ThrGly: 5.057 ± 0.061	1.053ThrHis: 1.053 ± 0.026	4.438ThrIle: 4.438 ± 0.049	3.151ThrLys: 3.151 ± 0.038	5.751ThrLeu: 5.751 ± 0.054	1.026ThrMet: 1.026 ± 0.023	3.121ThrAsn: 3.121 ± 0.046	2.597ThrPro: 2.597 ± 0.035	2.113ThrGln: 2.113 ± 0.034	2.023ThrArg: 2.023 ± 0.03	3.783ThrSer: 3.783 ± 0.053	3.844ThrThr: 3.844 ± 0.066	4.15ThrVal: 4.15 ± 0.054	0.665ThrTrp: 0.665 ± 0.017	2.611ThrTyr: 2.611 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	4.612ValAla: 4.612 ± 0.051	0.589ValCys: 0.589 ± 0.017	3.331ValAsp: 3.331 ± 0.039	3.035ValGlu: 3.035 ± 0.039	3.095ValPhe: 3.095 ± 0.039	3.434ValGly: 3.434 ± 0.044	1.013ValHis: 1.013 ± 0.021	4.693ValIle: 4.693 ± 0.048	4.649ValLys: 4.649 ± 0.048	5.984ValLeu: 5.984 ± 0.06	1.469ValMet: 1.469 ± 0.03	3.904ValAsn: 3.904 ± 0.047	2.513ValPro: 2.513 ± 0.032	2.088ValGln: 2.088 ± 0.031	2.291ValArg: 2.291 ± 0.036	4.5ValSer: 4.5 ± 0.047	3.993ValThr: 3.993 ± 0.055	4.143ValVal: 4.143 ± 0.044	0.7ValTrp: 0.7 ± 0.019	2.629ValTyr: 2.629 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.829TrpAla: 0.829 ± 0.022	0.139TrpCys: 0.139 ± 0.008	0.649TrpAsp: 0.649 ± 0.017	0.57TrpGlu: 0.57 ± 0.015	0.596TrpPhe: 0.596 ± 0.018	0.754TrpGly: 0.754 ± 0.018	0.248TrpHis: 0.248 ± 0.012	0.744TrpIle: 0.744 ± 0.019	0.788TrpLys: 0.788 ± 0.018	1.244TrpLeu: 1.244 ± 0.021	0.329TrpMet: 0.329 ± 0.013	0.662TrpAsn: 0.662 ± 0.016	0.362TrpPro: 0.362 ± 0.013	0.602TrpGln: 0.602 ± 0.016	0.498TrpArg: 0.498 ± 0.017	0.647TrpSer: 0.647 ± 0.017	0.62TrpThr: 0.62 ± 0.017	0.7TrpVal: 0.7 ± 0.015	0.195TrpTrp: 0.195 ± 0.01	0.486TrpTyr: 0.486 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.961TyrAla: 2.961 ± 0.04	0.39TyrCys: 0.39 ± 0.012	2.276TyrAsp: 2.276 ± 0.037	1.786TyrGlu: 1.786 ± 0.031	2.261TyrPhe: 2.261 ± 0.031	2.858TyrGly: 2.858 ± 0.039	1.043TyrHis: 1.043 ± 0.021	2.624TyrIle: 2.624 ± 0.029	2.699TyrLys: 2.699 ± 0.033	4.264TyrLeu: 4.264 ± 0.052	0.746TyrMet: 0.746 ± 0.017	2.777TyrAsn: 2.777 ± 0.042	1.805TyrPro: 1.805 ± 0.029	2.119TyrGln: 2.119 ± 0.032	1.966TyrArg: 1.966 ± 0.033	2.865TyrSer: 2.865 ± 0.039	2.768TyrThr: 2.768 ± 0.044	2.212TyrVal: 2.212 ± 0.034	0.551TyrTrp: 0.551 ± 0.017	2.102TyrTyr: 2.102 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6864 proteins (2350594 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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