Amino acid dipepetide frequency for Prosthecobacter debontii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.127AlaAla: 11.127 ± 0.12
1.02AlaCys: 1.02 ± 0.027
5.361AlaAsp: 5.361 ± 0.058
6.492AlaGlu: 6.492 ± 0.095
3.569AlaPhe: 3.569 ± 0.054
7.834AlaGly: 7.834 ± 0.1
2.023AlaHis: 2.023 ± 0.04
4.532AlaIle: 4.532 ± 0.061
4.486AlaLys: 4.486 ± 0.075
10.555AlaLeu: 10.555 ± 0.095
2.519AlaMet: 2.519 ± 0.052
2.873AlaAsn: 2.873 ± 0.063
4.782AlaPro: 4.782 ± 0.065
4.134AlaGln: 4.134 ± 0.059
5.411AlaArg: 5.411 ± 0.072
6.262AlaSer: 6.262 ± 0.07
5.536AlaThr: 5.536 ± 0.101
6.558AlaVal: 6.558 ± 0.066
1.648AlaTrp: 1.648 ± 0.043
2.332AlaTyr: 2.332 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.909CysAla: 0.909 ± 0.02
0.136CysCys: 0.136 ± 0.009
0.493CysAsp: 0.493 ± 0.017
0.525CysGlu: 0.525 ± 0.018
0.446CysPhe: 0.446 ± 0.019
0.853CysGly: 0.853 ± 0.023
0.36CysHis: 0.36 ± 0.02
0.465CysIle: 0.465 ± 0.016
0.281CysLys: 0.281 ± 0.013
1.13CysLeu: 1.13 ± 0.026
0.194CysMet: 0.194 ± 0.01
0.229CysAsn: 0.229 ± 0.012
0.504CysPro: 0.504 ± 0.022
0.386CysGln: 0.386 ± 0.014
0.598CysArg: 0.598 ± 0.019
0.626CysSer: 0.626 ± 0.018
0.469CysThr: 0.469 ± 0.019
0.679CysVal: 0.679 ± 0.02
0.16CysTrp: 0.16 ± 0.009
0.3CysTyr: 0.3 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
5.197AspAla: 5.197 ± 0.059
0.466AspCys: 0.466 ± 0.02
2.701AspAsp: 2.701 ± 0.053
3.414AspGlu: 3.414 ± 0.051
2.342AspPhe: 2.342 ± 0.037
4.644AspGly: 4.644 ± 0.077
1.392AspHis: 1.392 ± 0.031
2.518AspIle: 2.518 ± 0.036
2.024AspLys: 2.024 ± 0.046
5.831AspLeu: 5.831 ± 0.056
1.011AspMet: 1.011 ± 0.023
1.487AspAsn: 1.487 ± 0.043
3.027AspPro: 3.027 ± 0.043
1.989AspGln: 1.989 ± 0.035
2.952AspArg: 2.952 ± 0.043
2.882AspSer: 2.882 ± 0.05
2.575AspThr: 2.575 ± 0.042
3.518AspVal: 3.518 ± 0.045
1.006AspTrp: 1.006 ± 0.026
1.694AspTyr: 1.694 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.793GluAla: 6.793 ± 0.105
0.481GluCys: 0.481 ± 0.017
2.919GluAsp: 2.919 ± 0.041
3.824GluGlu: 3.824 ± 0.062
2.117GluPhe: 2.117 ± 0.034
4.57GluGly: 4.57 ± 0.058
1.317GluHis: 1.317 ± 0.029
3.337GluIle: 3.337 ± 0.047
3.533GluLys: 3.533 ± 0.071
5.795GluLeu: 5.795 ± 0.076
1.648GluMet: 1.648 ± 0.035
1.997GluAsn: 1.997 ± 0.038
2.718GluPro: 2.718 ± 0.05
2.379GluGln: 2.379 ± 0.048
3.703GluArg: 3.703 ± 0.066
3.336GluSer: 3.336 ± 0.047
3.458GluThr: 3.458 ± 0.046
4.308GluVal: 4.308 ± 0.063
1.024GluTrp: 1.024 ± 0.028
1.27GluTyr: 1.27 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.387PheAla: 3.387 ± 0.047
0.439PheCys: 0.439 ± 0.016
2.311PheAsp: 2.311 ± 0.039
2.162PheGlu: 2.162 ± 0.037
1.636PhePhe: 1.636 ± 0.032
3.144PheGly: 3.144 ± 0.049
0.892PheHis: 0.892 ± 0.024
1.988PheIle: 1.988 ± 0.033
1.476PheLys: 1.476 ± 0.03
3.646PheLeu: 3.646 ± 0.054
0.799PheMet: 0.799 ± 0.02
1.355PheAsn: 1.355 ± 0.032
1.743PhePro: 1.743 ± 0.032
1.39PheGln: 1.39 ± 0.028
2.184PheArg: 2.184 ± 0.038
2.671PheSer: 2.671 ± 0.042
2.504PheThr: 2.504 ± 0.055
2.41PheVal: 2.41 ± 0.039
0.609PheTrp: 0.609 ± 0.022
1.109PheTyr: 1.109 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
6.729GlyAla: 6.729 ± 0.11
0.921GlyCys: 0.921 ± 0.028
4.16GlyAsp: 4.16 ± 0.06
4.324GlyGlu: 4.324 ± 0.059
3.288GlyPhe: 3.288 ± 0.045
7.026GlyGly: 7.026 ± 0.132
1.811GlyHis: 1.811 ± 0.035
4.168GlyIle: 4.168 ± 0.054
4.002GlyLys: 4.002 ± 0.062
7.923GlyLeu: 7.923 ± 0.077
2.009GlyMet: 2.009 ± 0.035
2.758GlyAsn: 2.758 ± 0.089
2.939GlyPro: 2.939 ± 0.035
3.323GlyGln: 3.323 ± 0.045
4.539GlyArg: 4.539 ± 0.053
5.464GlySer: 5.464 ± 0.128
5.224GlyThr: 5.224 ± 0.177
5.582GlyVal: 5.582 ± 0.072
1.464GlyTrp: 1.464 ± 0.035
2.439GlyTyr: 2.439 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
2.136HisAla: 2.136 ± 0.041
0.282HisCys: 0.282 ± 0.013
1.209HisAsp: 1.209 ± 0.028
1.436HisGlu: 1.436 ± 0.036
1.027HisPhe: 1.027 ± 0.025
1.978HisGly: 1.978 ± 0.042
0.742HisHis: 0.742 ± 0.023
1.033HisIle: 1.033 ± 0.026
0.641HisLys: 0.641 ± 0.02
2.646HisLeu: 2.646 ± 0.054
0.432HisMet: 0.432 ± 0.017
0.602HisAsn: 0.602 ± 0.019
1.591HisPro: 1.591 ± 0.035
0.919HisGln: 0.919 ± 0.023
1.473HisArg: 1.473 ± 0.034
1.246HisSer: 1.246 ± 0.028
1.103HisThr: 1.103 ± 0.026
1.459HisVal: 1.459 ± 0.032
0.456HisTrp: 0.456 ± 0.016
0.731HisTyr: 0.731 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.936IleAla: 4.936 ± 0.064
0.554IleCys: 0.554 ± 0.019
2.29IleAsp: 2.29 ± 0.039
3.145IleGlu: 3.145 ± 0.049
1.703IlePhe: 1.703 ± 0.027
3.807IleGly: 3.807 ± 0.058
1.259IleHis: 1.259 ± 0.027
2.356IleIle: 2.356 ± 0.039
1.81IleLys: 1.81 ± 0.034
4.693IleLeu: 4.693 ± 0.06
0.869IleMet: 0.869 ± 0.024
1.591IleAsn: 1.591 ± 0.046
2.551IlePro: 2.551 ± 0.038
2.111IleGln: 2.111 ± 0.037
2.963IleArg: 2.963 ± 0.043
3.322IleSer: 3.322 ± 0.048
3.433IleThr: 3.433 ± 0.066
3.402IleVal: 3.402 ± 0.05
0.611IleTrp: 0.611 ± 0.022
1.304IleTyr: 1.304 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.675LysAla: 4.675 ± 0.076
0.246LysCys: 0.246 ± 0.012
2.47LysAsp: 2.47 ± 0.045
2.79LysGlu: 2.79 ± 0.054
1.251LysPhe: 1.251 ± 0.029
3.178LysGly: 3.178 ± 0.056
0.99LysHis: 0.99 ± 0.028
2.143LysIle: 2.143 ± 0.037
2.518LysLys: 2.518 ± 0.056
4.545LysLeu: 4.545 ± 0.062
1.113LysMet: 1.113 ± 0.029
1.478LysAsn: 1.478 ± 0.033
2.844LysPro: 2.844 ± 0.049
1.599LysGln: 1.599 ± 0.035
2.598LysArg: 2.598 ± 0.044
2.327LysSer: 2.327 ± 0.036
2.758LysThr: 2.758 ± 0.039
3.02LysVal: 3.02 ± 0.052
0.572LysTrp: 0.572 ± 0.018
0.85LysTyr: 0.85 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
10.808LeuAla: 10.808 ± 0.116
1.138LeuCys: 1.138 ± 0.028
5.5LeuAsp: 5.5 ± 0.059
5.951LeuGlu: 5.951 ± 0.071
3.548LeuPhe: 3.548 ± 0.053
7.706LeuGly: 7.706 ± 0.082
2.392LeuHis: 2.392 ± 0.043
4.928LeuIle: 4.928 ± 0.057
4.958LeuLys: 4.958 ± 0.064
10.381LeuLeu: 10.381 ± 0.121
2.412LeuMet: 2.412 ± 0.039
3.518LeuAsn: 3.518 ± 0.058
5.966LeuPro: 5.966 ± 0.073
3.841LeuGln: 3.841 ± 0.053
6.436LeuArg: 6.436 ± 0.077
6.882LeuSer: 6.882 ± 0.07
6.702LeuThr: 6.702 ± 0.094
6.508LeuVal: 6.508 ± 0.07
1.488LeuTrp: 1.488 ± 0.034
2.342LeuTyr: 2.342 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.355MetAla: 2.355 ± 0.04
0.164MetCys: 0.164 ± 0.009
1.201MetAsp: 1.201 ± 0.026
1.308MetGlu: 1.308 ± 0.031
0.659MetPhe: 0.659 ± 0.021
1.626MetGly: 1.626 ± 0.037
0.492MetHis: 0.492 ± 0.019
1.16MetIle: 1.16 ± 0.028
1.491MetLys: 1.491 ± 0.033
2.217MetLeu: 2.217 ± 0.041
0.6MetMet: 0.6 ± 0.02
0.954MetAsn: 0.954 ± 0.024
1.462MetPro: 1.462 ± 0.03
0.869MetGln: 0.869 ± 0.022
1.493MetArg: 1.493 ± 0.036
1.496MetSer: 1.496 ± 0.027
1.52MetThr: 1.52 ± 0.031
1.382MetVal: 1.382 ± 0.029
0.236MetTrp: 0.236 ± 0.01
0.293MetTyr: 0.293 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.183AsnAla: 3.183 ± 0.057
0.296AsnCys: 0.296 ± 0.013
1.703AsnAsp: 1.703 ± 0.039
1.702AsnGlu: 1.702 ± 0.033
1.208AsnPhe: 1.208 ± 0.032
3.138AsnGly: 3.138 ± 0.109
0.731AsnHis: 0.731 ± 0.022
1.553AsnIle: 1.553 ± 0.035
1.056AsnLys: 1.056 ± 0.024
3.285AsnLeu: 3.285 ± 0.052
0.557AsnMet: 0.557 ± 0.018
1.225AsnAsn: 1.225 ± 0.06
2.291AsnPro: 2.291 ± 0.036
1.245AsnGln: 1.245 ± 0.03
1.856AsnArg: 1.856 ± 0.032
1.955AsnSer: 1.955 ± 0.066
1.906AsnThr: 1.906 ± 0.069
2.085AsnVal: 2.085 ± 0.045
0.547AsnTrp: 0.547 ± 0.018
0.915AsnTyr: 0.915 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
5.544ProAla: 5.544 ± 0.071
0.386ProCys: 0.386 ± 0.013
3.275ProAsp: 3.275 ± 0.052
4.331ProGlu: 4.331 ± 0.069
1.888ProPhe: 1.888 ± 0.033
4.308ProGly: 4.308 ± 0.055
1.19ProHis: 1.19 ± 0.031
2.18ProIle: 2.18 ± 0.031
2.291ProLys: 2.291 ± 0.043
4.948ProLeu: 4.948 ± 0.061
1.254ProMet: 1.254 ± 0.03
1.753ProAsn: 1.753 ± 0.036
3.0ProPro: 3.0 ± 0.059
2.163ProGln: 2.163 ± 0.038
2.518ProArg: 2.518 ± 0.04
3.393ProSer: 3.393 ± 0.052
3.135ProThr: 3.135 ± 0.058
3.94ProVal: 3.94 ± 0.052
0.869ProTrp: 0.869 ± 0.025
1.195ProTyr: 1.195 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
4.497GlnAla: 4.497 ± 0.065
0.319GlnCys: 0.319 ± 0.013
1.866GlnAsp: 1.866 ± 0.032
2.342GlnGlu: 2.342 ± 0.044
1.297GlnPhe: 1.297 ± 0.025
2.995GlnGly: 2.995 ± 0.039
0.909GlnHis: 0.909 ± 0.025
2.153GlnIle: 2.153 ± 0.034
1.917GlnLys: 1.917 ± 0.041
3.512GlnLeu: 3.512 ± 0.052
1.049GlnMet: 1.049 ± 0.025
1.23GlnAsn: 1.23 ± 0.029
2.347GlnPro: 2.347 ± 0.044
1.843GlnGln: 1.843 ± 0.042
2.81GlnArg: 2.81 ± 0.048
2.3GlnSer: 2.3 ± 0.035
2.385GlnThr: 2.385 ± 0.043
2.958GlnVal: 2.958 ± 0.042
0.701GlnTrp: 0.701 ± 0.02
0.769GlnTyr: 0.769 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
5.05ArgAla: 5.05 ± 0.067
0.597ArgCys: 0.597 ± 0.019
3.188ArgAsp: 3.188 ± 0.046
3.957ArgGlu: 3.957 ± 0.071
2.614ArgPhe: 2.614 ± 0.034
3.881ArgGly: 3.881 ± 0.046
1.469ArgHis: 1.469 ± 0.035
3.02ArgIle: 3.02 ± 0.047
2.28ArgLys: 2.28 ± 0.045
6.842ArgLeu: 6.842 ± 0.086
1.529ArgMet: 1.529 ± 0.029
1.722ArgAsn: 1.722 ± 0.036
2.804ArgPro: 2.804 ± 0.042
2.734ArgGln: 2.734 ± 0.056
3.939ArgArg: 3.939 ± 0.066
3.566ArgSer: 3.566 ± 0.051
2.827ArgThr: 2.827 ± 0.038
4.087ArgVal: 4.087 ± 0.056
1.155ArgTrp: 1.155 ± 0.023
1.8ArgTyr: 1.8 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.962SerAla: 5.962 ± 0.066
0.599SerCys: 0.599 ± 0.019
3.117SerAsp: 3.117 ± 0.051
3.173SerGlu: 3.173 ± 0.047
2.616SerPhe: 2.616 ± 0.043
5.983SerGly: 5.983 ± 0.16
1.403SerHis: 1.403 ± 0.032
2.954SerIle: 2.954 ± 0.047
2.297SerLys: 2.297 ± 0.04
7.04SerLeu: 7.04 ± 0.069
1.355SerMet: 1.355 ± 0.03
2.008SerAsn: 2.008 ± 0.055
3.598SerPro: 3.598 ± 0.059
2.397SerGln: 2.397 ± 0.046
3.534SerArg: 3.534 ± 0.05
4.543SerSer: 4.543 ± 0.107
3.721SerThr: 3.721 ± 0.094
4.132SerVal: 4.132 ± 0.054
0.957SerTrp: 0.957 ± 0.022
1.7SerTyr: 1.7 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.949ThrAla: 5.949 ± 0.105
0.483ThrCys: 0.483 ± 0.016
3.021ThrAsp: 3.021 ± 0.055
3.138ThrGlu: 3.138 ± 0.042
2.295ThrPhe: 2.295 ± 0.044
5.558ThrGly: 5.558 ± 0.153
1.28ThrHis: 1.28 ± 0.027
2.71ThrIle: 2.71 ± 0.07
1.978ThrLys: 1.978 ± 0.034
6.947ThrLeu: 6.947 ± 0.12
1.019ThrMet: 1.019 ± 0.028
1.838ThrAsn: 1.838 ± 0.069
3.874ThrPro: 3.874 ± 0.06
2.326ThrGln: 2.326 ± 0.037
3.153ThrArg: 3.153 ± 0.038
3.805ThrSer: 3.805 ± 0.084
3.688ThrThr: 3.688 ± 0.117
4.358ThrVal: 4.358 ± 0.094
1.05ThrTrp: 1.05 ± 0.026
1.491ThrTyr: 1.491 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
6.253ValAla: 6.253 ± 0.067
0.784ValCys: 0.784 ± 0.019
3.497ValAsp: 3.497 ± 0.046
4.082ValGlu: 4.082 ± 0.055
2.639ValPhe: 2.639 ± 0.037
4.754ValGly: 4.754 ± 0.071
1.407ValHis: 1.407 ± 0.027
3.737ValIle: 3.737 ± 0.044
3.302ValLys: 3.302 ± 0.056
6.797ValLeu: 6.797 ± 0.063
1.688ValMet: 1.688 ± 0.029
2.384ValAsn: 2.384 ± 0.055
3.53ValPro: 3.53 ± 0.041
2.48ValGln: 2.48 ± 0.033
4.033ValArg: 4.033 ± 0.046
4.508ValSer: 4.508 ± 0.06
4.602ValThr: 4.602 ± 0.087
4.881ValVal: 4.881 ± 0.062
1.051ValTrp: 1.051 ± 0.027
1.566ValTyr: 1.566 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.269TrpAla: 1.269 ± 0.028
0.168TrpCys: 0.168 ± 0.01
0.822TrpAsp: 0.822 ± 0.019
0.866TrpGlu: 0.866 ± 0.024
0.657TrpPhe: 0.657 ± 0.021
1.022TrpGly: 1.022 ± 0.031
0.431TrpHis: 0.431 ± 0.015
0.79TrpIle: 0.79 ± 0.021
0.852TrpLys: 0.852 ± 0.022
2.014TrpLeu: 2.014 ± 0.042
0.492TrpMet: 0.492 ± 0.016
0.601TrpAsn: 0.601 ± 0.021
0.699TrpPro: 0.699 ± 0.021
0.888TrpGln: 0.888 ± 0.027
1.08TrpArg: 1.08 ± 0.028
0.994TrpSer: 0.994 ± 0.027
0.944TrpThr: 0.944 ± 0.025
1.079TrpVal: 1.079 ± 0.03
0.31TrpTrp: 0.31 ± 0.013
0.339TrpTyr: 0.339 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.298TyrAla: 2.298 ± 0.037
0.264TyrCys: 0.264 ± 0.012
1.568TyrAsp: 1.568 ± 0.044
1.563TyrGlu: 1.563 ± 0.036
1.054TyrPhe: 1.054 ± 0.024
2.088TyrGly: 2.088 ± 0.034
0.656TyrHis: 0.656 ± 0.019
0.985TyrIle: 0.985 ± 0.025
0.77TyrLys: 0.77 ± 0.025
2.659TyrLeu: 2.659 ± 0.039
0.428TyrMet: 0.428 ± 0.014
0.836TyrAsn: 0.836 ± 0.023
1.289TyrPro: 1.289 ± 0.029
1.18TyrGln: 1.18 ± 0.026
1.787TyrArg: 1.787 ± 0.037
1.512TyrSer: 1.512 ± 0.042
1.469TyrThr: 1.469 ± 0.045
1.631TyrVal: 1.631 ± 0.027
0.402TyrTrp: 0.402 ± 0.014
0.82TyrTyr: 0.82 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5106 proteins (1895760 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski