Amino acid dipepetide frequency for Paraperlucidibaca baekdonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.999AlaAla: 13.999 ± 0.222	1.331AlaCys: 1.331 ± 0.047	6.612AlaAsp: 6.612 ± 0.095	7.121AlaGlu: 7.121 ± 0.09	3.703AlaPhe: 3.703 ± 0.077	8.805AlaGly: 8.805 ± 0.125	2.757AlaHis: 2.757 ± 0.071	6.071AlaIle: 6.071 ± 0.097	4.302AlaLys: 4.302 ± 0.093	14.539AlaLeu: 14.539 ± 0.191	3.52AlaMet: 3.52 ± 0.073	3.577AlaAsn: 3.577 ± 0.082	4.934AlaPro: 4.934 ± 0.098	5.568AlaGln: 5.568 ± 0.103	7.243AlaArg: 7.243 ± 0.124	6.869AlaSer: 6.869 ± 0.118	5.732AlaThr: 5.732 ± 0.101	7.897AlaVal: 7.897 ± 0.109	1.723AlaTrp: 1.723 ± 0.06	2.61AlaTyr: 2.61 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.028CysAla: 1.028 ± 0.039	0.111CysCys: 0.111 ± 0.012	0.579CysAsp: 0.579 ± 0.024	0.53CysGlu: 0.53 ± 0.024	0.366CysPhe: 0.366 ± 0.021	0.92CysGly: 0.92 ± 0.043	0.369CysHis: 0.369 ± 0.023	0.463CysIle: 0.463 ± 0.025	0.232CysLys: 0.232 ± 0.019	1.023CysLeu: 1.023 ± 0.047	0.221CysMet: 0.221 ± 0.02	0.275CysAsn: 0.275 ± 0.024	0.466CysPro: 0.466 ± 0.03	0.437CysGln: 0.437 ± 0.026	0.623CysArg: 0.623 ± 0.032	0.552CysSer: 0.552 ± 0.028	0.459CysThr: 0.459 ± 0.024	0.738CysVal: 0.738 ± 0.035	0.146CysTrp: 0.146 ± 0.013	0.235CysTyr: 0.235 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.778AspAla: 6.778 ± 0.113	0.513AspCys: 0.513 ± 0.025	3.334AspAsp: 3.334 ± 0.091	3.26AspGlu: 3.26 ± 0.082	2.206AspPhe: 2.206 ± 0.059	4.394AspGly: 4.394 ± 0.088	1.211AspHis: 1.211 ± 0.046	3.393AspIle: 3.393 ± 0.072	1.873AspLys: 1.873 ± 0.05	5.404AspLeu: 5.404 ± 0.086	1.565AspMet: 1.565 ± 0.035	1.668AspAsn: 1.668 ± 0.061	2.374AspPro: 2.374 ± 0.055	1.834AspGln: 1.834 ± 0.056	2.876AspArg: 2.876 ± 0.065	2.965AspSer: 2.965 ± 0.059	2.72AspThr: 2.72 ± 0.064	3.974AspVal: 3.974 ± 0.074	0.985AspTrp: 0.985 ± 0.034	1.668AspTyr: 1.668 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	6.869GluAla: 6.869 ± 0.131	0.427GluCys: 0.427 ± 0.025	2.172GluAsp: 2.172 ± 0.06	2.188GluGlu: 2.188 ± 0.074	1.875GluPhe: 1.875 ± 0.057	3.382GluGly: 3.382 ± 0.078	1.568GluHis: 1.568 ± 0.051	2.83GluIle: 2.83 ± 0.066	2.106GluLys: 2.106 ± 0.064	6.288GluLeu: 6.288 ± 0.106	1.333GluMet: 1.333 ± 0.041	1.464GluAsn: 1.464 ± 0.049	2.3GluPro: 2.3 ± 0.063	3.102GluGln: 3.102 ± 0.073	4.315GluArg: 4.315 ± 0.09	2.791GluSer: 2.791 ± 0.064	2.536GluThr: 2.536 ± 0.064	3.774GluVal: 3.774 ± 0.092	0.634GluTrp: 0.634 ± 0.028	1.061GluTyr: 1.061 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.016PheAla: 4.016 ± 0.075	0.392PheCys: 0.392 ± 0.021	2.413PheAsp: 2.413 ± 0.057	1.768PheGlu: 1.768 ± 0.057	1.482PhePhe: 1.482 ± 0.052	3.04PheGly: 3.04 ± 0.077	0.747PheHis: 0.747 ± 0.029	1.993PheIle: 1.993 ± 0.056	1.199PheLys: 1.199 ± 0.042	3.086PheLeu: 3.086 ± 0.075	1.025PheMet: 1.025 ± 0.042	1.372PheAsn: 1.372 ± 0.042	1.388PhePro: 1.388 ± 0.045	1.206PheGln: 1.206 ± 0.035	1.91PheArg: 1.91 ± 0.058	2.486PheSer: 2.486 ± 0.061	1.931PheThr: 1.931 ± 0.054	2.426PheVal: 2.426 ± 0.059	0.544PheTrp: 0.544 ± 0.03	1.051PheTyr: 1.051 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	6.988GlyAla: 6.988 ± 0.113	0.821GlyCys: 0.821 ± 0.038	3.975GlyAsp: 3.975 ± 0.084	4.432GlyGlu: 4.432 ± 0.082	3.306GlyPhe: 3.306 ± 0.072	5.754GlyGly: 5.754 ± 0.119	2.017GlyHis: 2.017 ± 0.054	4.371GlyIle: 4.371 ± 0.08	2.998GlyLys: 2.998 ± 0.08	8.646GlyLeu: 8.646 ± 0.132	2.171GlyMet: 2.171 ± 0.067	2.21GlyAsn: 2.21 ± 0.063	2.393GlyPro: 2.393 ± 0.052	3.224GlyGln: 3.224 ± 0.064	4.505GlyArg: 4.505 ± 0.089	4.333GlySer: 4.333 ± 0.098	3.493GlyThr: 3.493 ± 0.089	6.04GlyVal: 6.04 ± 0.111	1.14GlyTrp: 1.14 ± 0.042	2.197GlyTyr: 2.197 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.767HisAla: 2.767 ± 0.068	0.283HisCys: 0.283 ± 0.022	1.426HisAsp: 1.426 ± 0.053	1.311HisGlu: 1.311 ± 0.046	0.982HisPhe: 0.982 ± 0.037	2.099HisGly: 2.099 ± 0.059	0.761HisHis: 0.761 ± 0.038	1.293HisIle: 1.293 ± 0.049	0.635HisLys: 0.635 ± 0.033	2.264HisLeu: 2.264 ± 0.06	0.597HisMet: 0.597 ± 0.03	0.63HisAsn: 0.63 ± 0.033	1.299HisPro: 1.299 ± 0.045	0.973HisGln: 0.973 ± 0.045	1.524HisArg: 1.524 ± 0.053	1.283HisSer: 1.283 ± 0.045	1.185HisThr: 1.185 ± 0.037	1.548HisVal: 1.548 ± 0.044	0.496HisTrp: 0.496 ± 0.03	0.751HisTyr: 0.751 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.661IleAla: 6.661 ± 0.095	0.545IleCys: 0.545 ± 0.029	3.77IleAsp: 3.77 ± 0.072	3.357IleGlu: 3.357 ± 0.077	1.579IlePhe: 1.579 ± 0.049	4.522IleGly: 4.522 ± 0.094	1.01IleHis: 1.01 ± 0.036	2.723IleIle: 2.723 ± 0.067	1.865IleLys: 1.865 ± 0.058	3.881IleLeu: 3.881 ± 0.074	1.127IleMet: 1.127 ± 0.043	2.019IleAsn: 2.019 ± 0.066	2.185IlePro: 2.185 ± 0.054	1.371IleGln: 1.371 ± 0.042	2.998IleArg: 2.998 ± 0.067	3.554IleSer: 3.554 ± 0.071	3.085IleThr: 3.085 ± 0.07	3.453IleVal: 3.453 ± 0.077	0.535IleTrp: 0.535 ± 0.028	1.235IleTyr: 1.235 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.327LysAla: 4.327 ± 0.102	0.214LysCys: 0.214 ± 0.021	1.645LysAsp: 1.645 ± 0.055	1.419LysGlu: 1.419 ± 0.051	0.968LysPhe: 0.968 ± 0.04	2.283LysGly: 2.283 ± 0.071	0.865LysHis: 0.865 ± 0.038	1.634LysIle: 1.634 ± 0.051	1.55LysLys: 1.55 ± 0.059	3.51LysLeu: 3.51 ± 0.079	0.924LysMet: 0.924 ± 0.041	1.086LysAsn: 1.086 ± 0.044	2.164LysPro: 2.164 ± 0.066	1.664LysGln: 1.664 ± 0.056	2.503LysArg: 2.503 ± 0.064	2.09LysSer: 2.09 ± 0.063	2.038LysThr: 2.038 ± 0.059	2.334LysVal: 2.334 ± 0.073	0.307LysTrp: 0.307 ± 0.019	0.699LysTyr: 0.699 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	14.295LeuAla: 14.295 ± 0.185	1.107LeuCys: 1.107 ± 0.041	5.861LeuAsp: 5.861 ± 0.091	4.818LeuGlu: 4.818 ± 0.097	3.705LeuPhe: 3.705 ± 0.08	8.039LeuGly: 8.039 ± 0.126	2.275LeuHis: 2.275 ± 0.062	5.384LeuIle: 5.384 ± 0.106	3.954LeuLys: 3.954 ± 0.079	11.914LeuLeu: 11.914 ± 0.189	3.116LeuMet: 3.116 ± 0.068	3.592LeuAsn: 3.592 ± 0.078	6.121LeuPro: 6.121 ± 0.103	4.177LeuGln: 4.177 ± 0.076	7.267LeuArg: 7.267 ± 0.116	8.19LeuSer: 8.19 ± 0.117	5.868LeuThr: 5.868 ± 0.084	7.318LeuVal: 7.318 ± 0.098	1.404LeuTrp: 1.404 ± 0.058	2.024LeuTyr: 2.024 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.596MetAla: 3.596 ± 0.073	0.192MetCys: 0.192 ± 0.015	1.14MetAsp: 1.14 ± 0.047	0.98MetGlu: 0.98 ± 0.039	0.599MetPhe: 0.599 ± 0.028	1.896MetGly: 1.896 ± 0.058	0.634MetHis: 0.634 ± 0.032	1.159MetIle: 1.159 ± 0.039	1.045MetLys: 1.045 ± 0.042	2.781MetLeu: 2.781 ± 0.072	0.693MetMet: 0.693 ± 0.032	0.921MetAsn: 0.921 ± 0.032	1.573MetPro: 1.573 ± 0.053	1.096MetGln: 1.096 ± 0.042	1.727MetArg: 1.727 ± 0.046	2.052MetSer: 2.052 ± 0.052	1.828MetThr: 1.828 ± 0.049	1.673MetVal: 1.673 ± 0.056	0.241MetTrp: 0.241 ± 0.018	0.416MetTyr: 0.416 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.671AsnAla: 3.671 ± 0.078	0.294AsnCys: 0.294 ± 0.023	1.897AsnAsp: 1.897 ± 0.057	1.572AsnGlu: 1.572 ± 0.049	1.041AsnPhe: 1.041 ± 0.042	2.51AsnGly: 2.51 ± 0.075	0.61AsnHis: 0.61 ± 0.03	1.64AsnIle: 1.64 ± 0.054	1.056AsnLys: 1.056 ± 0.041	2.923AsnLeu: 2.923 ± 0.074	0.659AsnMet: 0.659 ± 0.03	1.072AsnAsn: 1.072 ± 0.047	2.013AsnPro: 2.013 ± 0.066	1.148AsnGln: 1.148 ± 0.049	1.641AsnArg: 1.641 ± 0.049	1.641AsnSer: 1.641 ± 0.056	1.773AsnThr: 1.773 ± 0.059	1.995AsnVal: 1.995 ± 0.06	0.403AsnTrp: 0.403 ± 0.02	0.872AsnTyr: 0.872 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	5.695ProAla: 5.695 ± 0.117	0.338ProCys: 0.338 ± 0.024	2.833ProAsp: 2.833 ± 0.068	3.458ProGlu: 3.458 ± 0.069	1.571ProPhe: 1.571 ± 0.049	3.351ProGly: 3.351 ± 0.071	0.99ProHis: 0.99 ± 0.041	2.309ProIle: 2.309 ± 0.051	1.596ProLys: 1.596 ± 0.048	4.943ProLeu: 4.943 ± 0.089	1.34ProMet: 1.34 ± 0.048	1.527ProAsn: 1.527 ± 0.05	1.765ProPro: 1.765 ± 0.058	1.666ProGln: 1.666 ± 0.046	2.412ProArg: 2.412 ± 0.06	3.007ProSer: 3.007 ± 0.07	2.589ProThr: 2.589 ± 0.075	3.833ProVal: 3.833 ± 0.091	0.741ProTrp: 0.741 ± 0.038	1.14ProTyr: 1.14 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	6.246GlnAla: 6.246 ± 0.115	0.368GlnCys: 0.368 ± 0.02	1.52GlnAsp: 1.52 ± 0.045	1.504GlnGlu: 1.504 ± 0.056	1.471GlnPhe: 1.471 ± 0.049	3.071GlnGly: 3.071 ± 0.076	1.189GlnHis: 1.189 ± 0.046	1.835GlnIle: 1.835 ± 0.056	1.247GlnLys: 1.247 ± 0.045	5.033GlnLeu: 5.033 ± 0.09	0.955GlnMet: 0.955 ± 0.04	0.873GlnAsn: 0.873 ± 0.041	2.04GlnPro: 2.04 ± 0.054	2.462GlnGln: 2.462 ± 0.073	3.795GlnArg: 3.795 ± 0.085	2.155GlnSer: 2.155 ± 0.055	1.945GlnThr: 1.945 ± 0.049	3.143GlnVal: 3.143 ± 0.073	0.875GlnTrp: 0.875 ± 0.039	0.92GlnTyr: 0.92 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	6.683ArgAla: 6.683 ± 0.106	0.644ArgCys: 0.644 ± 0.035	3.899ArgAsp: 3.899 ± 0.084	4.195ArgGlu: 4.195 ± 0.094	2.679ArgPhe: 2.679 ± 0.06	3.917ArgGly: 3.917 ± 0.079	1.779ArgHis: 1.779 ± 0.052	3.502ArgIle: 3.502 ± 0.064	1.838ArgLys: 1.838 ± 0.059	7.588ArgLeu: 7.588 ± 0.127	1.55ArgMet: 1.55 ± 0.045	1.706ArgAsn: 1.706 ± 0.047	2.513ArgPro: 2.513 ± 0.067	3.055ArgGln: 3.055 ± 0.068	4.11ArgArg: 4.11 ± 0.088	3.074ArgSer: 3.074 ± 0.061	2.569ArgThr: 2.569 ± 0.062	5.056ArgVal: 5.056 ± 0.065	1.183ArgTrp: 1.183 ± 0.043	2.169ArgTyr: 2.169 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	7.405SerAla: 7.405 ± 0.118	0.552SerCys: 0.552 ± 0.028	3.282SerAsp: 3.282 ± 0.067	3.137SerGlu: 3.137 ± 0.06	2.123SerPhe: 2.123 ± 0.054	4.915SerGly: 4.915 ± 0.087	1.407SerHis: 1.407 ± 0.043	2.874SerIle: 2.874 ± 0.053	1.903SerLys: 1.903 ± 0.053	6.914SerLeu: 6.914 ± 0.109	1.503SerMet: 1.503 ± 0.048	1.757SerAsn: 1.757 ± 0.048	2.934SerPro: 2.934 ± 0.06	2.468SerGln: 2.468 ± 0.055	3.655SerArg: 3.655 ± 0.069	3.62SerSer: 3.62 ± 0.076	3.076SerThr: 3.076 ± 0.071	4.516SerVal: 4.516 ± 0.085	0.851SerTrp: 0.851 ± 0.035	1.499SerTyr: 1.499 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.467ThrAla: 5.467 ± 0.09	0.437ThrCys: 0.437 ± 0.025	2.647ThrAsp: 2.647 ± 0.07	2.551ThrGlu: 2.551 ± 0.063	1.535ThrPhe: 1.535 ± 0.045	4.415ThrGly: 4.415 ± 0.091	1.295ThrHis: 1.295 ± 0.042	2.259ThrIle: 2.259 ± 0.06	1.382ThrLys: 1.382 ± 0.042	6.629ThrLeu: 6.629 ± 0.104	1.014ThrMet: 1.014 ± 0.037	1.424ThrAsn: 1.424 ± 0.055	3.319ThrPro: 3.319 ± 0.08	2.248ThrGln: 2.248 ± 0.05	3.178ThrArg: 3.178 ± 0.073	2.805ThrSer: 2.805 ± 0.064	2.795ThrThr: 2.795 ± 0.073	3.889ThrVal: 3.889 ± 0.077	0.627ThrTrp: 0.627 ± 0.034	1.19ThrTyr: 1.19 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	8.383ValAla: 8.383 ± 0.11	0.761ValCys: 0.761 ± 0.035	3.989ValAsp: 3.989 ± 0.081	3.684ValGlu: 3.684 ± 0.078	2.706ValPhe: 2.706 ± 0.061	4.961ValGly: 4.961 ± 0.082	1.573ValHis: 1.573 ± 0.05	4.119ValIle: 4.119 ± 0.089	2.393ValLys: 2.393 ± 0.077	8.056ValLeu: 8.056 ± 0.128	2.086ValMet: 2.086 ± 0.052	2.238ValAsn: 2.238 ± 0.069	3.312ValPro: 3.312 ± 0.082	2.643ValGln: 2.643 ± 0.063	4.416ValArg: 4.416 ± 0.083	4.808ValSer: 4.808 ± 0.089	3.702ValThr: 3.702 ± 0.071	5.968ValVal: 5.968 ± 0.119	0.875ValTrp: 0.875 ± 0.037	1.602ValTyr: 1.602 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.241TrpAla: 1.241 ± 0.044	0.161TrpCys: 0.161 ± 0.017	0.555TrpAsp: 0.555 ± 0.027	0.461TrpGlu: 0.461 ± 0.026	0.551TrpPhe: 0.551 ± 0.029	0.797TrpGly: 0.797 ± 0.041	0.468TrpHis: 0.468 ± 0.028	0.576TrpIle: 0.576 ± 0.033	0.296TrpLys: 0.296 ± 0.024	2.359TrpLeu: 2.359 ± 0.074	0.383TrpMet: 0.383 ± 0.025	0.339TrpAsn: 0.339 ± 0.022	0.828TrpPro: 0.828 ± 0.044	1.306TrpGln: 1.306 ± 0.055	1.217TrpArg: 1.217 ± 0.05	0.79TrpSer: 0.79 ± 0.034	0.561TrpThr: 0.561 ± 0.029	0.927TrpVal: 0.927 ± 0.042	0.231TrpTrp: 0.231 ± 0.019	0.31TrpTyr: 0.31 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.798TyrAla: 2.798 ± 0.072	0.285TyrCys: 0.285 ± 0.02	1.445TyrAsp: 1.445 ± 0.047	1.268TyrGlu: 1.268 ± 0.046	1.028TyrPhe: 1.028 ± 0.042	1.944TyrGly: 1.944 ± 0.045	0.582TyrHis: 0.582 ± 0.029	1.044TyrIle: 1.044 ± 0.038	0.754TyrLys: 0.754 ± 0.033	2.648TyrLeu: 2.648 ± 0.055	0.459TyrMet: 0.459 ± 0.027	0.683TyrAsn: 0.683 ± 0.038	1.183TyrPro: 1.183 ± 0.047	0.999TyrGln: 0.999 ± 0.04	1.795TyrArg: 1.795 ± 0.055	1.326TyrSer: 1.326 ± 0.044	1.218TyrThr: 1.218 ± 0.045	1.773TyrVal: 1.773 ± 0.05	0.417TyrTrp: 0.417 ± 0.021	0.672TyrTyr: 0.672 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2146 proteins (709905 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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